| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D J Haleem, G A Kennett, G Curzo. Hippocampal 5-hydroxytryptamine synthesis is greater in female rats than in males and more decreased by the 5-HT1A agonist 8-OH-DPAT. Journal of neural transmission. General section. vol 79. issue 1-2. 1990-03-09. PMID:1688708. |
brain regional 5-hydroxytryptamine (5-ht) and/or 5-hydroxyindoleacetic acid (5-hiaa) concentrations tended to be slightly higher in female rats than in males but differences were substantial only in the hippocampus where female values were 34% and 36% higher respectively. |
1990-03-09 |
2023-08-11 |
rat |
| D J Haleem, G A Kennett, G Curzo. Hippocampal 5-hydroxytryptamine synthesis is greater in female rats than in males and more decreased by the 5-HT1A agonist 8-OH-DPAT. Journal of neural transmission. General section. vol 79. issue 1-2. 1990-03-09. PMID:1688708. |
the 5-ht1a agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat, 1 mg/kg sc) caused comparable decreases of 5-ht synthesis rate in both sexes and in all regions studied except the hippocampus where the percentage decrease was twice as large in the females (-64%) as in the males (-32%) so that the sex difference in 5-ht synthesis in this region largely disappeared. |
1990-03-09 |
2023-08-11 |
rat |
| D E Nichols, W K Brewster, M P Johnson, R Oberlender, R M Rigg. Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA). Journal of medicinal chemistry. vol 33. issue 2. 1990-03-09. PMID:1967651. |
sacrifice at 1 week showed that neither 3a nor 3b depressed rat cortical or hippocampal 5-ht or 5-hiaa levels nor were the number of binding sites (bmax) depressed for [3h]paroxetine. |
1990-03-09 |
2023-08-11 |
rat |
| M Elphick, S M Anderson, K F Hallis, D G Grahame-Smit. Effects of carbamazepine on 5-hydroxytryptamine function in rodents. Psychopharmacology. vol 100. issue 1. 1990-02-13. PMID:2136952. |
however, after 14 days oral treatment no change in this measure of 5-ht synthesis was seen, in either hippocampus or frontal cortex. |
1990-02-13 |
2023-08-11 |
mouse |
| S G Beck, P M Hallora. Imipramine alters beta-adrenergic, but not serotonergic, mediated responses in rat hippocampal pyramidal cells. Brain research. vol 504. issue 1. 1990-02-06. PMID:2557127. |
this study investigated acute and chronic effects of imipramine on intracellularly-recorded responses mediated by 5-ht and beta-adrenergic receptors on pyramidal cells from area ca1 of rat hippocampal slices maintained in vitro. |
1990-02-06 |
2023-08-11 |
rat |
| P B Crino, B A Vogt, J C Chen, L Volice. Neurotoxic effects of partially oxidized serotonin: tryptamine-4,5-dione. Brain research. vol 504. issue 2. 1990-02-06. PMID:2598027. |
neurotoxicity of tryptamine-4,5-dione (4,5-dkt), a partially oxidized form of serotonin, was assessed after microinjection into the lateral ventricle, hippocampus, or cingulate cortex of rats followed by fink-heimer staining for axon terminal degeneration. |
1990-02-06 |
2023-08-11 |
rat |
| M Kokaia, P Kalén, J Bengzon, O Lindval. Noradrenaline and 5-hydroxytryptamine release in the hippocampus during seizures induced by hippocampal kindling stimulation: an in vivo microdialysis study. Neuroscience. vol 32. issue 3. 1990-02-01. PMID:2481243. |
noradrenaline and 5-hydroxytryptamine release in the hippocampus during seizures induced by hippocampal kindling stimulation: an in vivo microdialysis study. |
1990-02-01 |
2023-08-11 |
rat |
| M Kokaia, P Kalén, J Bengzon, O Lindval. Noradrenaline and 5-hydroxytryptamine release in the hippocampus during seizures induced by hippocampal kindling stimulation: an in vivo microdialysis study. Neuroscience. vol 32. issue 3. 1990-02-01. PMID:2481243. |
the intracerebral microdialysis technique has been used to monitor extracellular levels of noradrenaline, 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the rat hippocampus in vivo in response to focal and generalized seizures induced by hippocampal kindling stimulation. |
1990-02-01 |
2023-08-11 |
rat |
| L Volicer, J C Chen, P B Crino, B A Vogt, J Fishman, J Rubins, P W Schenepper, N Wolf. Neurotoxic properties of a serotonin oxidation product: possible role in Alzheimer's disease. Progress in clinical and biological research. vol 317. 1990-01-31. PMID:2481322. |
administration of 4,5-dkt resulted in a significant depletion of 5-ht and 5-hydroxyindoleacetic acid (5-hiaa) levels in prefrontal cortex, striatum and hippocampus. |
1990-01-31 |
2023-08-11 |
rat |
| L Volicer, J C Chen, P B Crino, B A Vogt, J Fishman, J Rubins, P W Schenepper, N Wolf. Neurotoxic properties of a serotonin oxidation product: possible role in Alzheimer's disease. Progress in clinical and biological research. vol 317. 1990-01-31. PMID:2481322. |
in brain fragment perfusion and incubation experiments, 4,5-dkt increased dose dependently 5-ht efflux from rat hippocampus and striatum. |
1990-01-31 |
2023-08-11 |
rat |
| L Volicer, J C Chen, P B Crino, B A Vogt, J Fishman, J Rubins, P W Schenepper, N Wolf. Neurotoxic properties of a serotonin oxidation product: possible role in Alzheimer's disease. Progress in clinical and biological research. vol 317. 1990-01-31. PMID:2481322. |
in hippocampal preparations, fluoxetine decreased 4,5-dkt-stimulated efflux of 5-ht by 24%, and pargyline did not affect it. |
1990-01-31 |
2023-08-11 |
rat |
| S A Welner, C De Montigny, J Desroches, P Desjardins, B E Suranyi-Cadott. Autoradiographic quantification of serotonin1A receptors in rat brain following antidepressant drug treatment. Synapse (New York, N.Y.). vol 4. issue 4. 1990-01-31. PMID:2532423. |
conversely, fluoxetine (10 mg/kg/day), a selective blocker of 5-ht reuptake, and gepirone (10 mg/kg/day), a 5-ht1a agonist, both administered for 21 days, significantly reduced [3h]8-oh-dpat binding measured by autoradiography in the nucleus raphe dorsalis without altering hippocampal binding sites. |
1990-01-31 |
2023-08-11 |
rat |
| M S Kleven, L S Seide. D-, L- and DL-fenfluramine cause long-lasting depletions of serotonin in rat brain. Brain research. vol 505. issue 2. 1990-01-30. PMID:2598057. |
d-fenfluramine (1.6-12.5 mg/kg), l-fenfluramine (1.6-25 mg/kg), and dl-fenfluramine (1.6-25 mg/kg) injected s.c. twice daily for 4 consecutive days produced dose-related depletions of serotonin (5-ht) levels in somatosensory cortex, striatum, hypothalamus, and hippocampus of rats (n = 5-8/group) sacrificed two weeks after the last injection. |
1990-01-30 |
2023-08-11 |
rat |
| L A Matsuda, G R Hanson, J W Gib. Neurochemical effects of amphetamine metabolites on central dopaminergic and serotonergic systems. The Journal of pharmacology and experimental therapeutics. vol 251. issue 3. 1990-01-30. PMID:2600821. |
in contrast, only hypothalamic and hippocampal serotonin stores were altered significantly in rats treated with p-oha systemically. |
1990-01-30 |
2023-08-11 |
rat |
| E Domański, F Przekop, L Chomicka, A Ostrowsk. Effect of stress on the course of oestrous cycle and the release of luteinizing hormone; the role of endorphin in these processes. Acta physiologica Polonica. vol 40. issue 1. 1990-01-26. PMID:2532447. |
footshocking in rats induced significant decrease in 5-ht concentrations in the fronto-parietal brain cortex, hippocampus, striatum, medial basal hypothalamus and the preoptic-anterior hypothalamic area. |
1990-01-26 |
2023-08-11 |
rat |
| b' F Radja, G Daval, M B Emerit, M C Gallissot, M Hamon, D Verg\\xc3\\xa. Selective irreversible blockade of 5-hydroxytryptamine1A and 5-hydroxytryptamine1C receptor binding sites in the rat brain by 8-MeO-2\'-chloro-PAT: a quantitative autoradiographic study. Neuroscience. vol 31. issue 3. 1990-01-25. PMID:2531850.' |
a marked reduction (-50% to -75%) of [3h]8-oh-dpat and [125i]bh-8-meo-n-pat specific binding to 5-hydroxytryptamine1a sites in the hippocampus (ca1 area) and the dorsal raphe nucleus, and of [3h]5-hydroxytryptamine specific binding to 5-hydroxytryptamine1c sites in the choroid plexus was found in sections exposed to 1 microm 8-meo-2'-chloro-pat and then washed extensively. |
1990-01-25 |
2023-08-11 |
rat |
| T Sharp, S R Bramwell, S Hjorth, D G Grahame-Smit. Pharmacological characterization of 8-OH-DPAT-induced inhibition of rat hippocampal 5-HT release in vivo as measured by microdialysis. British journal of pharmacology. vol 98. issue 3. 1990-01-25. PMID:2574066. |
pharmacological characterization of 8-oh-dpat-induced inhibition of rat hippocampal 5-ht release in vivo as measured by microdialysis. |
1990-01-25 |
2023-08-11 |
rat |
| T Sharp, S R Bramwell, S Hjorth, D G Grahame-Smit. Pharmacological characterization of 8-OH-DPAT-induced inhibition of rat hippocampal 5-HT release in vivo as measured by microdialysis. British journal of pharmacology. vol 98. issue 3. 1990-01-25. PMID:2574066. |
we have previously found that the putative 5-ht1a agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat) decreases hippocampal 5-hydroxytryptamine (5-ht) release in the anaesthetized rat, as measured by brain microdialysis. |
1990-01-25 |
2023-08-11 |
rat |
| T Sharp, S R Bramwell, S Hjorth, D G Grahame-Smit. Pharmacological characterization of 8-OH-DPAT-induced inhibition of rat hippocampal 5-HT release in vivo as measured by microdialysis. British journal of pharmacology. vol 98. issue 3. 1990-01-25. PMID:2574066. |
we conclude from these data that the decrease of hippocampal 5-ht output induced by 8-ohdpat does not involve 5-ht2, 5-ht3, adrenoceptors or dopamine d2-receptors and that activation of a 5-ht1 class of receptor seems probable. |
1990-01-25 |
2023-08-11 |
rat |
| K T Finnegan, J J Skratt, I Irwin, J W Langsto. The N-methyl-D-aspartate (NMDA) receptor antagonist, dextrorphan, prevents the neurotoxic effects of 3,4-methylenedioxymethamphetamine (MDMA) in rats. Neuroscience letters. vol 105. issue 3. 1990-01-25. PMID:2574428. |
rats were treated with mdma, dextrorphan, or the combination of mdma and increasing doses of dextrorphan, and then killed 10 days later for the assay of serotonin and dopamine in the striatum, hippocampus, and cortex. |
1990-01-25 |
2023-08-11 |
rat |