| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Tanti, C Belzun. Open questions in current models of antidepressant action. British journal of pharmacology. vol 159. issue 6. 2010-07-12. PMID:20132212. |
different symptomatic and pathophysiological features have been proposed as end points of the depressive phenotype and of the antidepressant action, including anhedonia, depressed mood, alterations in morphology and activity of some brain areas (amygdala, nucleus accumbens, hippocampus, prefrontal cortex and cingulate cortex), modifications in the connectivity between brain structures, changes in neurotransmitters (serotonin, noradrenaline, glutamate and neuropeptides), brain plasticity (neurogenesis, neurotrophins) and abnormal function of the hypothalamic-pituitary adrenal axis. |
2010-07-12 |
2023-08-12 |
Not clear |
| Thomas Frodl, Elena Reinhold, Nikolaos Koutsouleris, Gary Donohoe, Brigitta Bondy, Maximilian Reiser, Hans-Jürgen Möller, Eva M Meisenzah. Childhood stress, serotonin transporter gene and brain structures in major depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 6. 2010-07-12. PMID:20147891. |
we investigated, in a multimodal high-resolution magnetic resonance imaging (mri) genetic study, whether reduced hippocampal volumes and other brain alterations are associated with the tri-allelic polymorphism of the serotonin transporter and childhood stress in patients with md and healthy subjects. |
2010-07-12 |
2023-08-12 |
human |
| Curtis E Grace, Tori L Schaefer, Gary A Gudelsky, Michael T Williams, Charles V Vorhee. Neonatal methamphetamine-induced corticosterone release in rats is inhibited by adrenal autotransplantation without altering the effect of the drug on hippocampal serotonin. Neurotoxicology and teratology. vol 32. issue 3. 2010-07-02. PMID:20153424. |
neonatal methamphetamine-induced corticosterone release in rats is inhibited by adrenal autotransplantation without altering the effect of the drug on hippocampal serotonin. |
2010-07-02 |
2023-08-12 |
rat |
| Curtis E Grace, Tori L Schaefer, Gary A Gudelsky, Michael T Williams, Charles V Vorhee. Neonatal methamphetamine-induced corticosterone release in rats is inhibited by adrenal autotransplantation without altering the effect of the drug on hippocampal serotonin. Neurotoxicology and teratology. vol 32. issue 3. 2010-07-02. PMID:20153424. |
previous attempts to test the role of corticosterone release after methamphetamine using corticosterone inhibitors were unsuccessful and adrenalectomy caused reductions in hippocampal serotonin greater than those caused by methamphetamine alone. |
2010-07-02 |
2023-08-12 |
rat |
| Curtis E Grace, Tori L Schaefer, Gary A Gudelsky, Michael T Williams, Charles V Vorhee. Neonatal methamphetamine-induced corticosterone release in rats is inhibited by adrenal autotransplantation without altering the effect of the drug on hippocampal serotonin. Neurotoxicology and teratology. vol 32. issue 3. 2010-07-02. PMID:20153424. |
plasma corticosterone and hippocampal serotonin and 5-hydroxyindoleacetic acid were determined 30min following the first treatment on each day between postnatal days 11-20. |
2010-07-02 |
2023-08-12 |
rat |
| Curtis E Grace, Tori L Schaefer, Gary A Gudelsky, Michael T Williams, Charles V Vorhee. Neonatal methamphetamine-induced corticosterone release in rats is inhibited by adrenal autotransplantation without altering the effect of the drug on hippocampal serotonin. Neurotoxicology and teratology. vol 32. issue 3. 2010-07-02. PMID:20153424. |
methamphetamine reduced serotonin and 5-hydroxyindoleacetic acid in the hippocampus in the adxa rats to the same degree as in sham rats. |
2010-07-02 |
2023-08-12 |
rat |
| Anthony Laugeray, Jean-Marie Launay, Jacques Callebert, Alexandre Surget, Catherine Belzung, Pascal R Baron. Peripheral and cerebral metabolic abnormalities of the tryptophan-kynurenine pathway in a murine model of major depression. Behavioural brain research. vol 210. issue 1. 2010-06-30. PMID:20153778. |
5-ht and kyn were found to be strongly negatively correlated in all brain structures of control mice and of ucms mice except in the hippocampus. |
2010-06-30 |
2023-08-12 |
mouse |
| L A Ruocco, U A Gironi Carnevale, C Treno, A G Sadile, D Melisi, C Arra, M Ibba, C Schirru, E Carbon. Prepuberal subchronic methylphenidate and atomoxetine induce different long-term effects on adult behaviour and forebrain dopamine, norepinephrine and serotonin in Naples high-excitability rats. Behavioural brain research. vol 210. issue 1. 2010-06-30. PMID:20156489. |
the high-performance liquid chromatography (hplc) tissue content assessment of dopamine, norepinephrine, serotonin and relative metabolites in the prefrontal cortex (pfc), cortical motor area (mc), dorsal striatum (ds), ventral striatum (vs), hippocampus and mesencephalon indicated that methylphenidate decreased (i) dopamine, dopac, norepinephrine, mhpg, 5-ht and 5-hiaa in the pfc, (ii) dopamine, dopac, hva, serotonin, 5-hiaa in the ds, (iii) dopamine, dopac, hva and mhpg (but increased norepinephrine) in the vs and (iv) norepinephrine, mhpg, serotonin and 5-hiaa in the hippocampus. |
2010-06-30 |
2023-08-12 |
rat |
| Jiu-yu Tang, Yuan-shan Zeng, Qiao-ge Chen, Ya-jing Qin, Sui-jun Chen, Zhi-qiang Zhon. [Effects of Valerian on the level of 5-hydroxytryptamine, cell proliferation and neurons in cerebral hippocampus of rats with depression induced by chronic mild stress]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. vol 6. issue 3. 2010-06-24. PMID:18334150. |
[effects of valerian on the level of 5-hydroxytryptamine, cell proliferation and neurons in cerebral hippocampus of rats with depression induced by chronic mild stress]. |
2010-06-24 |
2023-08-12 |
rat |
| Jiu-yu Tang, Yuan-shan Zeng, Qiao-ge Chen, Ya-jing Qin, Sui-jun Chen, Zhi-qiang Zhon. [Effects of Valerian on the level of 5-hydroxytryptamine, cell proliferation and neurons in cerebral hippocampus of rats with depression induced by chronic mild stress]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. vol 6. issue 3. 2010-06-24. PMID:18334150. |
to explore the effects of valerian on the level of 5-hydroxytryptamine (5-ht), cell proliferation and neuron number in cerebral hippocampus of rats with depression induced by chronic mild stress. |
2010-06-24 |
2023-08-12 |
rat |
| Marie-Claude Audet, Hymie Anisma. Neuroendocrine and neurochemical impact of aggressive social interactions in submissive and dominant mice: implications for stress-related disorders. The international journal of neuropsychopharmacology. vol 13. issue 3. 2010-06-24. PMID:19545478. |
three minutes after single and repeated confrontations, plasma corticosterone levels and 5-ht utilization within the prefrontal cortex (pfc) and hippocampus were increased to a comparable extent in submissive and dominant animals. |
2010-06-24 |
2023-08-12 |
mouse |
| Marie-Claude Audet, Hymie Anisma. Neuroendocrine and neurochemical impact of aggressive social interactions in submissive and dominant mice: implications for stress-related disorders. The international journal of neuropsychopharmacology. vol 13. issue 3. 2010-06-24. PMID:19545478. |
these results suggest that 5-ht neuronal functioning was generally responsive to aggressive events, irrespective of social rank, whereas ne neuronal activity within the pfc and hippocampus was more sensitive to the submissive/dominance attributes of the social situation. |
2010-06-24 |
2023-08-12 |
mouse |
| Stephen J Kish, Jason Lerch, Yoshiaki Furukawa, Junchao Tong, Tina McCluskey, Diana Wilkins, Sylvain Houle, Jeffrey Meyer, Emanuela Mundo, Alan A Wilson, Pablo M Rusjan, Jean A Saint-Cyr, Mark Guttman, D Louis Collins, Colin Shapiro, Jerry J Warsh, Isabelle Boilea. Decreased cerebral cortical serotonin transporter binding in ecstasy users: a positron emission tomography/[(11)C]DASB and structural brain imaging study. Brain : a journal of neurology. vol 133. issue Pt 6. 2010-06-22. PMID:20483717. |
serotonin transporter binding in ecstasy users was significantly decreased throughout all cerebral cortices (range -19 to -46%) and hippocampus (-21%) and related to the extent of drug use (years, maximum dose), but was normal in basal ganglia and midbrain. |
2010-06-22 |
2023-08-12 |
human |
| L A W Jans, G A H Korte-Bouws, S M Korte, A Bloklan. The effects of acute tryptophan depletion on affective behaviour and cognition in Brown Norway and Sprague Dawley rats. Journal of psychopharmacology (Oxford, England). vol 24. issue 4. 2010-06-18. PMID:19074537. |
both strains showed about 60% decrease in plasma trp/sigmalnaa levels, whereas hippocampal 5-ht levels were lower after trp- in bn but not sd rats. |
2010-06-18 |
2023-08-12 |
rat |
| Jamie R Doyle, Bryan K Yamamot. Serotonin 2 receptor modulation of hyperthermia, corticosterone, and hippocampal serotonin depletions following serial exposure to chronic stress and methamphetamine. Psychoneuroendocrinology. vol 35. issue 4. 2010-06-17. PMID:19879056. |
serotonin 2 receptor modulation of hyperthermia, corticosterone, and hippocampal serotonin depletions following serial exposure to chronic stress and methamphetamine. |
2010-06-17 |
2023-08-12 |
Not clear |
| Jamie R Doyle, Bryan K Yamamot. Serotonin 2 receptor modulation of hyperthermia, corticosterone, and hippocampal serotonin depletions following serial exposure to chronic stress and methamphetamine. Psychoneuroendocrinology. vol 35. issue 4. 2010-06-17. PMID:19879056. |
furthermore, the combination of stress and methamphetamine depletes 5-ht content in the hippocampus 7 days after methamphetamine administration which is blocked by the 5-ht2 antagonist ketanserin. |
2010-06-17 |
2023-08-12 |
Not clear |
| Jamie R Doyle, Bryan K Yamamot. Serotonin 2 receptor modulation of hyperthermia, corticosterone, and hippocampal serotonin depletions following serial exposure to chronic stress and methamphetamine. Psychoneuroendocrinology. vol 35. issue 4. 2010-06-17. PMID:19879056. |
overall, these results indicate a pharmacological mechanism for the depletion of hippocampal 5-ht by the serial exposure to stress and methamphetamine and further illustrate the deleterious interactions between chronic stress and methamphetamine use. |
2010-06-17 |
2023-08-12 |
Not clear |
| Narihiro Toda, Tsugio Kaneko, Hiroshi Koge. Development of an efficient therapeutic agent for Alzheimer's disease: design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter. Chemical & pharmaceutical bulletin. vol 58. issue 3. 2010-06-15. PMID:20190429. |
the simultaneous elevation of extracellular levels of acetylcholine and serotonin in the rat hippocampus was actually confirmed by microdialysis. |
2010-06-15 |
2023-08-12 |
mouse |
| Sun-Hee Park, Dong Koo Li. Increases in serotonergic neuronal activity following intracerebroventricular administration of AF64A in rats. Archives of pharmacal research. vol 33. issue 2. 2010-06-14. PMID:20195832. |
however, the hippocampal levels of total 5-ht were decreased without changes in the levels of 5-hiaa and the hippocampal turnover rates of 5-ht increased. |
2010-06-14 |
2023-08-12 |
rat |
| Katsunori Kobayashi, Yumiko Ikeda, Atsushi Sakai, Nobuyuki Yamasaki, Eisuke Haneda, Tsuyoshi Miyakawa, Hidenori Suzuk. Reversal of hippocampal neuronal maturation by serotonergic antidepressants. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 18. 2010-06-08. PMID:20404165. |
our results suggest that serotonergic antidepressants can reverse the established state of neuronal maturation in the adult hippocampus, and up-regulation of 5-ht(4) receptor-mediated signaling may play a critical role in this distinct action of antidepressants. |
2010-06-08 |
2023-08-12 |
mouse |