| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Zhang, Xin-Yan Huang, Min-Li Ye, Chun-Xia Luo, Hai-Yin Wu, Yao Hu, Qi-Gang Zhou, Dan-Lian Wu, Li-Juan Zhu, Dong-Ya Zh. Neuronal nitric oxide synthase alteration accounts for the role of 5-HT1A receptor in modulating anxiety-related behaviors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 7. 2010-03-19. PMID:20164327. |
here, we show that 5-ht(1a)r-selective agonist 8-oh-dpat and selective serotonin reuptake inhibitor (ssri) fluoxetine downregulated hippocampal neuronal nitric oxide synthase (nnos) expression, whereas 5-ht(1a)r-selective antagonist nan-190 upregulated hippocampal nnos expression. |
2010-03-19 |
2023-08-12 |
mouse |
| Jing Zhang, Xin-Yan Huang, Min-Li Ye, Chun-Xia Luo, Hai-Yin Wu, Yao Hu, Qi-Gang Zhou, Dan-Lian Wu, Li-Juan Zhu, Dong-Ya Zh. Neuronal nitric oxide synthase alteration accounts for the role of 5-HT1A receptor in modulating anxiety-related behaviors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 7. 2010-03-19. PMID:20164327. |
these findings indicate that both hippocampal nnos and creb activity mediate the anxiolytic effects of 5-ht(1a)r agonists and ssris. |
2010-03-19 |
2023-08-12 |
mouse |
| Dhanisha J Jhaveri, Eirinn W Mackay, Adam S Hamlin, Swananda V Marathe, L Sanjay Nandam, Vidita A Vaidya, Perry F Bartlet. Norepinephrine directly activates adult hippocampal precursors via beta3-adrenergic receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 7. 2010-03-19. PMID:20164362. |
here we show that norepinephrine but not serotonin directly activates self-renewing and multipotent neural precursors, including stem cells, from the hippocampus of adult mice. |
2010-03-19 |
2023-08-12 |
mouse |
| Dhanisha J Jhaveri, Eirinn W Mackay, Adam S Hamlin, Swananda V Marathe, L Sanjay Nandam, Vidita A Vaidya, Perry F Bartlet. Norepinephrine directly activates adult hippocampal precursors via beta3-adrenergic receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 7. 2010-03-19. PMID:20164362. |
finally, using a novel ex vivo "slice-sphere" assay that maintains an intact neurogenic niche, we demonstrate that antidepressants that selectively block the reuptake of norepinephrine, but not serotonin, robustly increase hippocampal precursor activity via beta-adrenergic receptors. |
2010-03-19 |
2023-08-12 |
mouse |
| K Isoda, M Morimoto, F Matsui, T Hasegawa, T Tozawa, S Morioka, T Chiyonobu, A Nishimura, K Yoshimoto, H Hoso. Postnatal changes in serotonergic innervation to the hippocampus of methyl-CpG-binding protein 2-null mice. Neuroscience. vol 165. issue 4. 2010-03-12. PMID:19932741. |
the levels of hippocampal serotonin (5-ht) and its main metabolite, 5-hydroxyindoleacetic acid (5-hiaa), were significantly lower in mecp2-null mice than in age-matched wild-type mice on p28, p42 and p56. |
2010-03-12 |
2023-08-12 |
mouse |
| K Isoda, M Morimoto, F Matsui, T Hasegawa, T Tozawa, S Morioka, T Chiyonobu, A Nishimura, K Yoshimoto, H Hoso. Postnatal changes in serotonergic innervation to the hippocampus of methyl-CpG-binding protein 2-null mice. Neuroscience. vol 165. issue 4. 2010-03-12. PMID:19932741. |
significant decreases in hippocampal 5-ht and 5-hiaa contents in mecp2-heterozygous mice were revealed, and these were not accompanied by changes in 5-ht or noradrenaline contents in the raphe region. |
2010-03-12 |
2023-08-12 |
mouse |
| Dominik K Biezonski, Jerrold S Meye. Effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin transporter and vesicular monoamine transporter 2 protein and gene expression in rats: implications for MDMA neurotoxicity. Journal of neurochemistry. vol 112. issue 4. 2010-03-08. PMID:20002520. |
experiment 1 investigated mdma-induced changes in levels of the serotonin transporter (sert) and the vesicular monoamine transporter 2 (vmat-2) in the hippocampus, a region with sparse dopaminergic innervation, after lesioning noradrenergic input with n-(2-chloroethyl)-n-ethyl-2-bromobenzylamine (dsp-4). |
2010-03-08 |
2023-08-12 |
rat |
| Bénédicte Amilhon, Eve Lepicard, Thibault Renoir, Raymond Mongeau, Daniela Popa, Odile Poirel, Stéphanie Miot, Christelle Gras, Alain M Gardier, Jorge Gallego, Michel Hamon, Laurence Lanfumey, Bruno Gasnier, Bruno Giros, Salah El Mestikaw. VGLUT3 (vesicular glutamate transporter type 3) contribution to the regulation of serotonergic transmission and anxiety. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 6. 2010-03-05. PMID:20147547. |
on the other hand, vglut3 positively modulated 5-ht transmission of a specific subset of 5-ht terminals from the hippocampus and the cerebral cortex. |
2010-03-05 |
2023-08-12 |
mouse |
| Sylvia Navailles, Abdelhamid Benazzouz, Bernard Bioulac, Christian Gross, Philippe De Deurwaerdèr. High-frequency stimulation of the subthalamic nucleus and L-3,4-dihydroxyphenylalanine inhibit in vivo serotonin release in the prefrontal cortex and hippocampus in a rat model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 6. 2010-03-05. PMID:20147561. |
high-frequency stimulation of the subthalamic nucleus and l-3,4-dihydroxyphenylalanine inhibit in vivo serotonin release in the prefrontal cortex and hippocampus in a rat model of parkinson's disease. |
2010-03-05 |
2023-08-12 |
rat |
| Sylvia Navailles, Abdelhamid Benazzouz, Bernard Bioulac, Christian Gross, Philippe De Deurwaerdèr. High-frequency stimulation of the subthalamic nucleus and L-3,4-dihydroxyphenylalanine inhibit in vivo serotonin release in the prefrontal cortex and hippocampus in a rat model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 6. 2010-03-05. PMID:20147561. |
by using a microdialysis approach in anesthetized rats, we investigated the ability of stn-hfs (130 hz, 30 mua, 20 min) and l-dopa (6-12 mg/kg) to change extracellular levels of serotonin (5-ht) monitored simultaneously in the prefrontal cortex (pfc) and hippocampus (hipp), two brain regions involved in the regulation of mood and cognition that receive a distinct 5-ht innervation. |
2010-03-05 |
2023-08-12 |
rat |
| Sylvia Navailles, Abdelhamid Benazzouz, Bernard Bioulac, Christian Gross, Philippe De Deurwaerdèr. High-frequency stimulation of the subthalamic nucleus and L-3,4-dihydroxyphenylalanine inhibit in vivo serotonin release in the prefrontal cortex and hippocampus in a rat model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 6. 2010-03-05. PMID:20147561. |
the results show that stn-hfs inhibited 5-ht levels in the pfc and hipp of sham-lesioned and 6-hydroxydopamine (6-ohda)-lesioned rats. |
2010-03-05 |
2023-08-12 |
rat |
| Sylvia Navailles, Abdelhamid Benazzouz, Bernard Bioulac, Christian Gross, Philippe De Deurwaerdèr. High-frequency stimulation of the subthalamic nucleus and L-3,4-dihydroxyphenylalanine inhibit in vivo serotonin release in the prefrontal cortex and hippocampus in a rat model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 6. 2010-03-05. PMID:20147561. |
l-dopa (6 and 12 mg/kg) reduced 5-ht levels in the pfc and hipp of 6-ohda rats. |
2010-03-05 |
2023-08-12 |
rat |
| Sylvia Navailles, Abdelhamid Benazzouz, Bernard Bioulac, Christian Gross, Philippe De Deurwaerdèr. High-frequency stimulation of the subthalamic nucleus and L-3,4-dihydroxyphenylalanine inhibit in vivo serotonin release in the prefrontal cortex and hippocampus in a rat model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 6. 2010-03-05. PMID:20147561. |
stn-hfs did not further decrease 5-ht levels induced by l-dopa, but attenuated l-dopa-induced dopamine release in the pfc and hipp. |
2010-03-05 |
2023-08-12 |
rat |
| Jacobus J Dudok, Alexander J A Groffen, Menno P Witter, Pieter Voorn, Matthijs Verhag. Chronic activation of the 5-HT(2) receptor reduces 5-HT neurite density as studied in organotypic slice cultures. Brain research. vol 1302. 2010-02-23. PMID:19728996. |
here we studied the effect of serotonin and serotonin pharmacological compounds on the outgrowth of serotonergic projections using organotypic slice co-cultures of hippocampus and dorsal raphe nuclei. |
2010-02-23 |
2023-08-12 |
Not clear |
| Jeanelle Portelli, Najat Aourz, Dimitri De Bundel, Alfred Meurs, Ilse Smolders, Yvette Michotte, Ralph Clincker. Intrastrain differences in seizure susceptibility, pharmacological response and basal neurochemistry of Wistar rats. Epilepsy research. vol 87. issue 2-3. 2010-02-18. PMID:19833479. |
in the present retrospective study we evaluated the impact of these vendor changes on ketamine dosing to establish anaesthesia, on pilocarpine-induced seizure susceptibility, and on basal extracellular hippocampal noradrenaline, dopamine, serotonin, gamma-amino butyric acid, and glutamate levels of all pilocarpine-treated rats included in our studies. |
2010-02-18 |
2023-08-12 |
rat |
| P J West, V R Marcy, M J Marino, H Schaffhause. Activation of the 5-HT(6) receptor attenuates long-term potentiation and facilitates GABAergic neurotransmission in rat hippocampus. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19660530. |
activation of the 5-ht(6) receptor attenuates long-term potentiation and facilitates gabaergic neurotransmission in rat hippocampus. |
2010-02-12 |
2023-08-12 |
rat |
| P J West, V R Marcy, M J Marino, H Schaffhause. Activation of the 5-HT(6) receptor attenuates long-term potentiation and facilitates GABAergic neurotransmission in rat hippocampus. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19660530. |
systemic administration of 5-ht(6) antagonists increases the release of acetylcholine and glutamate in the frontal cortex and dorsal hippocampus. |
2010-02-12 |
2023-08-12 |
rat |
| P J West, V R Marcy, M J Marino, H Schaffhause. Activation of the 5-HT(6) receptor attenuates long-term potentiation and facilitates GABAergic neurotransmission in rat hippocampus. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19660530. |
the reported behavioral and neurochemical effects of 5-ht(6) receptor ligands raise the possibility that the 5-ht(6) receptor may modulate synaptic plasticity in the hippocampus. |
2010-02-12 |
2023-08-12 |
rat |
| P J West, V R Marcy, M J Marino, H Schaffhause. Activation of the 5-HT(6) receptor attenuates long-term potentiation and facilitates GABAergic neurotransmission in rat hippocampus. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19660530. |
in the present study, selective pharmacological tools were employed to determine the effect of 5-ht(6) receptor activation on long-term potentiation (ltp) in brain slices containing area ca1 of the hippocampus. |
2010-02-12 |
2023-08-12 |
rat |
| P J West, V R Marcy, M J Marino, H Schaffhause. Activation of the 5-HT(6) receptor attenuates long-term potentiation and facilitates GABAergic neurotransmission in rat hippocampus. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19660530. |
taken together, these results suggest that the 5-ht(6) receptor plays a role in the modulation of synaptic plasticity in hippocampal area ca1 and that the regulation of gabaergic interneuron activity may underlie the cognition enhancing effects of 5-ht(6) antagonists. |
2010-02-12 |
2023-08-12 |
rat |