| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Rodsiri, A R Green, C A Marsden, K C F Fon. Effect of acute brain tyrosine depletion on MDMA-induced changes in brain 5-HT. Journal of psychopharmacology (Oxford, England). vol 24. issue 2. 2010-04-26. PMID:19965941. |
the results confirmed the ability of systemic mdma to acutely increase brain tyrosine content, but also indicated that a marked acute reduction of brain tyrosine does not directly affect either immediate 5-ht release (as measured by tissue depletion) or long-term hippocampal serotonergic neurotoxicity produced by mdma. |
2010-04-26 |
2023-08-12 |
rat |
| T V Zanelati, C Biojone, F A Moreira, F S Guimarães, Sâmia R L Joc. Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors. British journal of pharmacology. vol 159. issue 1. 2010-04-23. PMID:20002102. |
we also investigated if these responses depended on the activation of 5-ht(1a) receptors and on hippocampal expression of brain-derived neurotrophic factor (bdnf). |
2010-04-23 |
2023-08-12 |
mouse |
| Béla Kiss, Attila Horváth, Zsolt Némethy, Eva Schmidt, István Laszlovszky, Gyula Bugovics, Károly Fazekas, Katalin Hornok, Szabolcs Orosz, István Gyertyán, Eva Agai-Csongor, György Domány, Károly Tihanyi, Nika Adham, Zsolt Szombathely. Cariprazine (RGH-188), a dopamine D(3) receptor-preferring, D(3)/D(2) dopamine receptor antagonist-partial agonist antipsychotic candidate: in vitro and neurochemical profile. The Journal of pharmacology and experimental therapeutics. vol 333. issue 1. 2010-04-22. PMID:20093397. |
cariprazine had lower affinity at human and rat hippocampal 5-ht(1a) receptors (pk(i) 8.59 and 8.34, respectively) and demonstrated low intrinsic efficacy. |
2010-04-22 |
2023-08-12 |
human |
| Ying Pan, Fu-Meng Wang, Li-Qin Qiang, Dong-Mei Zhang, Ling-Dong Kon. Icariin attenuates chronic mild stress-induced dysregulation of the LHPA stress circuit in rats. Psychoneuroendocrinology. vol 35. issue 2. 2010-04-16. PMID:19631474. |
moreover, the levels of cyclic adenosine 3',5'-monophosphate (camp) response element binding protein (creb), glucocorticoid receptor (gr) and 5-hydroxytryptamine 1a receptor (5-htr1a) in hypothalamus, hippocampus and frontal cortex were simultaneously evaluated for their participations in crf system in this model. |
2010-04-16 |
2023-08-12 |
rat |
| I G Sil'ki. Paradoxical sleep as a tool for understanding the hippocampal mechanisms of contextual memory. Neuroscience and behavioral physiology. vol 40. issue 1. 2010-04-16. PMID:20012489. |
existing data on the involvement of the hippocampus in contextual memory and the fact that contextual memory is impaired in dreams occurring during paradoxical sleep allowed us to suggest that one of the causes of this impairment consists of changes in the efficiency of synaptic transmission in the hippocampus due to increases (as compared with waking) in the concentrations of acetylcholine, dopamine, and cortisol, as well as the absence of serotonin and noradrenaline. |
2010-04-16 |
2023-08-12 |
Not clear |
| Ping Lu, Takayoshi Mamiya, Lingling Lu, Akihiro Mouri, Minae Niwa, Hyoung-Chun Kim, Li-Bo Zou, Taku Nagai, Kiyofumi Yamada, Takashi Ikejima, Toshitaka Nabeshim. Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment. Behavioural brain research. vol 207. issue 2. 2010-04-13. PMID:19857526. |
tissue levels of dopamine and serotonin as well as their metabolites in the prefrontal cortex and hippocampus were measured 1 day after nort. |
2010-04-13 |
2023-08-12 |
mouse |
| Ping Lu, Takayoshi Mamiya, Lingling Lu, Akihiro Mouri, Minae Niwa, Hyoung-Chun Kim, Li-Bo Zou, Taku Nagai, Kiyofumi Yamada, Takashi Ikejima, Toshitaka Nabeshim. Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment. Behavioural brain research. vol 207. issue 2. 2010-04-13. PMID:19857526. |
silibinin significantly attenuated the decreases in the dopamine content of the prefrontal cortex and serotonin content of the hippocampus caused by meth treatment. |
2010-04-13 |
2023-08-12 |
mouse |
| Ping Lu, Takayoshi Mamiya, Lingling Lu, Akihiro Mouri, Minae Niwa, Hyoung-Chun Kim, Li-Bo Zou, Taku Nagai, Kiyofumi Yamada, Takashi Ikejima, Toshitaka Nabeshim. Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment. Behavioural brain research. vol 207. issue 2. 2010-04-13. PMID:19857526. |
we also found a correlation between the recognition values and dopamine and serotonin contents of the prefrontal cortex and hippocampus. |
2010-04-13 |
2023-08-12 |
mouse |
| Ping Lu, Takayoshi Mamiya, Lingling Lu, Akihiro Mouri, Minae Niwa, Hyoung-Chun Kim, Li-Bo Zou, Taku Nagai, Kiyofumi Yamada, Takashi Ikejima, Toshitaka Nabeshim. Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment. Behavioural brain research. vol 207. issue 2. 2010-04-13. PMID:19857526. |
the effect of silibinin on cognitive impairment may be associated with an amelioration of decreases in dopamine and serotonin levels in the prefrontal cortex and hippocampus, respectively. |
2010-04-13 |
2023-08-12 |
mouse |
| N K Popova, V S Naumenko, R V Kozhemyakina, I Z Plyusnin. Functional characteristics of serotonin 5-HT2A and 5-HT2C receptors in the brain and the expression of the 5-HT2A and 5-HT2C receptor genes in aggressive and non-aggressive rats. Neuroscience and behavioral physiology. vol 40. issue 4. 2010-04-13. PMID:20336385. |
there were no significant differences in the levels of 5-ht(2a) receptor mrna in the midbrain, frontal cortex, and hippocampus and the extents of head twitching evoked by the 5-ht(2a) agonist doi in rats with and without genetically determined high levels of aggression. |
2010-04-13 |
2023-08-12 |
rat |
| N K Popova, V S Naumenko, R V Kozhemyakina, I Z Plyusnin. Functional characteristics of serotonin 5-HT2A and 5-HT2C receptors in the brain and the expression of the 5-HT2A and 5-HT2C receptor genes in aggressive and non-aggressive rats. Neuroscience and behavioral physiology. vol 40. issue 4. 2010-04-13. PMID:20336385. |
increases in the level of 5-ht(2c) receptor mrna were seen in the frontal cortex and hippocampus in non-aggressive rats as compared with aggressive animals. |
2010-04-13 |
2023-08-12 |
rat |
| Haihong Li, Lei Zhang, Zeman Fang, Linyun Lin, Cairu Wu, Qingjun Huan. Behavioral and neurobiological studies on the male progeny of maternal rats exposed to chronic unpredictable stress before pregnancy. Neuroscience letters. vol 469. issue 2. 2010-04-12. PMID:20018228. |
the level of 5-hydroxytryptamine (5-ht) in the hypothalamus was reduced but the level of norepinephrine (ne) in the hippocampus was increased in cus progeny when compared to the control (p<0.05). |
2010-04-12 |
2023-08-12 |
rat |
| Haihong Li, Lei Zhang, Zeman Fang, Linyun Lin, Cairu Wu, Qingjun Huan. Behavioral and neurobiological studies on the male progeny of maternal rats exposed to chronic unpredictable stress before pregnancy. Neuroscience letters. vol 469. issue 2. 2010-04-12. PMID:20018228. |
there were significant positive correlations between sucrose consumption percentage and the level of 5-ht in hypothalamus p<0.05) or the level of p-creb in hippocampus (p<0.05). |
2010-04-12 |
2023-08-12 |
rat |
| Shingo Matsuda, Shizuko Saika, Keiko Amano, Eiji Shimizu, Junko Sajik. Changes in brain monoamine levels in neonatal rats exposed to bisphenol A at low doses. Chemosphere. vol 78. issue 7. 2010-04-08. PMID:20006895. |
significant increases of serotonin (5-ht) in hippocampus, 5-hiaa and 5-hiaa/5-ht in brain stem, dopamine (da) and dopac in striatum were observed at 28d after the injection on postnatal day 2. |
2010-04-08 |
2023-08-12 |
rat |
| Shingo Matsuda, Shizuko Saika, Keiko Amano, Eiji Shimizu, Junko Sajik. Changes in brain monoamine levels in neonatal rats exposed to bisphenol A at low doses. Chemosphere. vol 78. issue 7. 2010-04-08. PMID:20006895. |
at 7d after the injection, increases in 5-ht and norepinephrine (ne) and decreases in dopac and 5-hiaa were observed in hippocampus. |
2010-04-08 |
2023-08-12 |
rat |
| Diane Dufour-Rainfray, Patrick Vourc'h, Anne-Marie Le Guisquet, Lucette Garreau, David Ternant, Sylvie Bodard, Emilie Jaumain, Zuhal Gulhan, Catherine Belzung, Christian R Andres, Sylvie Chalon, Denis Guillotea. Behavior and serotonergic disorders in rats exposed prenatally to valproate: a model for autism. Neuroscience letters. vol 470. issue 1. 2010-04-06. PMID:20036713. |
the serotonin levels of these animals at pnd50 were decreased (-46%) in the hippocampus, a structure involved in social behavior. |
2010-04-06 |
2023-08-12 |
rat |
| Daniela Popa, Julie Cerdan, Christelle Repérant, Bruno P Guiard, Jean-Philippe Guilloux, Denis J David, Alain M Gardie. A longitudinal study of 5-HT outflow during chronic fluoxetine treatment using a new technique of chronic microdialysis in a highly emotional mouse strain. European journal of pharmacology. vol 628. issue 1-3. 2010-04-05. PMID:19944680. |
we report that the anxiolytic-like effects of fluoxetine correlate in time and amplitude with 5-ht1a autoreceptor desensitization, but neither with the extracellular levels of 5-ht in the raphe nuclei, nor in the hippocampus. |
2010-04-05 |
2023-08-12 |
mouse |
| Daniela Popa, Julie Cerdan, Christelle Repérant, Bruno P Guiard, Jean-Philippe Guilloux, Denis J David, Alain M Gardie. A longitudinal study of 5-HT outflow during chronic fluoxetine treatment using a new technique of chronic microdialysis in a highly emotional mouse strain. European journal of pharmacology. vol 628. issue 1-3. 2010-04-05. PMID:19944680. |
our study suggests that the beneficial anxiolytic/antidepressant-like effects of chronic ssri treatment indeed depend on 5-ht1a autoreceptor internalization, but do not require a sustained increase in extracellular 5-ht levels in a territory of 5-ht projection such as hippocampus. |
2010-04-05 |
2023-08-12 |
mouse |
| Agnieszka Cichy, Magdalena Sowa-Kućma, Beata Legutko, Lucyna Pomierny-Chamioło, Agata Siwek, Anna Piotrowska, Bernadeta Szewczyk, Ewa Poleszak, Andrzej Pilc, Gabriel Nowa. Zinc-induced adaptive changes in NMDA/glutamatergic and serotonergic receptors. Pharmacological reports : PR. vol 61. issue 6. 2010-03-30. PMID:20081255. |
chronic zinc administration reduced the affinity of glycine to glycine/nmda receptors in the rat frontal cortex and increased the density of 5-ht(1a) and 5-ht(2a) serotonin receptors in the hippocampus and frontal cortex, respectively. |
2010-03-30 |
2023-08-12 |
rat |
| Ying Xu, Shan Li, Ruijie Chen, Gaowen Li, Philip A Barish, Wenting You, Ling Chen, Mengmeng Lin, Baoshan Ku, Jianchun Pan, William O Ogl. Antidepressant-like effect of low molecular proanthocyanidin in mice: involvement of monoaminergic system. Pharmacology, biochemistry, and behavior. vol 94. issue 3. 2010-03-23. PMID:19857512. |
in addition, the neurochemical and neuropharmacological assays showed that proanthocyanidin produced a marked increase of 5-ht levels at 25 and 50mg/kg in three brain regions, the frontal cortex, hippocampus and hypothalamus. |
2010-03-23 |
2023-08-12 |
mouse |