| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A B Klein, M A Santini, S Aznar, G M Knudsen, M Rio. Changes in 5-HT2A-mediated behavior and 5-HT2A- and 5-HT1A receptor binding and expression in conditional brain-derived neurotrophic factor knock-out mice. Neuroscience. vol 169. issue 3. 2010-12-16. PMID:20576498. |
they exhibited lower 5-ht(2a) receptor binding in frontal cortex but increased binding in hippocampus. |
2010-12-16 |
2023-08-12 |
mouse |
| A B Klein, M A Santini, S Aznar, G M Knudsen, M Rio. Changes in 5-HT2A-mediated behavior and 5-HT2A- and 5-HT1A receptor binding and expression in conditional brain-derived neurotrophic factor knock-out mice. Neuroscience. vol 169. issue 3. 2010-12-16. PMID:20576498. |
additionally, 5-ht(1a) receptor binding was decreased in hippocampus of bdnf mutants, but unchanged in frontal cortex. |
2010-12-16 |
2023-08-12 |
mouse |
| Nicole Baganz, Rebecca Horton, Kathryn Martin, Andrew Holmes, Lynette C Daw. Repeated swim impairs serotonin clearance via a corticosterone-sensitive mechanism: organic cation transporter 3, the smoking gun. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 45. 2010-12-13. PMID:21068324. |
consistent with this idea, we found that 5-ht clearance rate in hippocampus was dramatically reduced in mice exposed to repeated swim, a stimulus known to activate the hpa axis. |
2010-12-13 |
2023-08-12 |
mouse |
| Mark J Millan, Anne Dekeyne, Alain Gobert, Clotilde Mannoury la Cour, Mauricette Brocco, Jean-Michel Rivet, Benjamin Di Cara, Françoise Lejeune, Thomas I Cremers, Gunnar Flik, Trynke R de Jong, Berend Olivier, Guillaume de Nanteui. S41744, a dual neurokinin (NK)1 receptor antagonist and serotonin (5-HT) reuptake inhibitor with potential antidepressant properties: a comparison to aprepitant (MK869) and paroxetine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 9. 2010-12-08. PMID:20483567. |
like paroxetine, s41744 recognised h5-ht transporters, reduced synaptosomal uptake of 5-ht (pk(b), 7.9), and dose-dependently (0.63-10.0 mg/kg) elevated dialysis levels of 5-ht in the hippocampus and frontal cortex of freely-moving guinea pigs. |
2010-12-08 |
2023-08-12 |
mouse |
| Mark J Millan, Anne Dekeyne, Alain Gobert, Clotilde Mannoury la Cour, Mauricette Brocco, Jean-Michel Rivet, Benjamin Di Cara, Françoise Lejeune, Thomas I Cremers, Gunnar Flik, Trynke R de Jong, Berend Olivier, Guillaume de Nanteui. S41744, a dual neurokinin (NK)1 receptor antagonist and serotonin (5-HT) reuptake inhibitor with potential antidepressant properties: a comparison to aprepitant (MK869) and paroxetine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 9. 2010-12-08. PMID:20483567. |
further, s41744 increased extracellular levels of 5-ht in frontal cortex and hippocampus of rats to a greater extent than paroxetine, and its inhibitory influence upon serotonergic perikarya was blunted relative to its affinity for 5-ht transporters. |
2010-12-08 |
2023-08-12 |
mouse |
| Francis Rodriguez Bambico, Tommaso Cassano, Sergio Dominguez-Lopez, Noam Katz, Claire Dominique Walker, Daniele Piomelli, Gabriella Gobb. Genetic deletion of fatty acid amide hydrolase alters emotional behavior and serotonergic transmission in the dorsal raphe, prefrontal cortex, and hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 10. 2010-12-06. PMID:20571484. |
the hippocampal pyramidal response to the 5-ht(1a) antagonist, way-100635, indicates enhanced tonus on the hippocampal 5-ht(1a) heteroreceptors, a hallmark of antidepressant-like action. |
2010-12-06 |
2023-08-12 |
mouse |
| S J Mathew, R B Price, D C Shungu, X Mao, E L P Smith, J M Amiel, J D Copla. A pilot study of the effects of chronic paroxetine administration on hippocampal N-acetylaspartate in generalized anxiety disorder. Journal of psychopharmacology (Oxford, England). vol 24. issue 8. 2010-12-02. PMID:19204062. |
the effect of chronic administration (12 weeks) of paroxetine, a selective serotonin reuptake inhibitor, on n-acetylaspartate (naa), a marker of neuronal viability, was evaluated in adults with gad using proton magnetic resonance spectroscopic imaging ((1)h mrsi) at 1.5 t. we hypothesized that, pretreatment abnormalities in hippocampal naa/creatine (naa/cr) would normalize with symptomatic improvement. |
2010-12-02 |
2023-08-12 |
human |
| T Inagaki, C Gautreaux, V Luin. Acute estrogen treatment facilitates recognition memory consolidation and alters monoamine levels in memory-related brain areas. Hormones and behavior. vol 58. issue 3. 2010-11-30. PMID:20553724. |
estrogen elevated 5ht, ne metabolite mhpg, turnover ratio of ne to mhpg, and da metabolite dopac levels in the prefrontal cortex, while ne and mhpg were decreased in the hippocampus. |
2010-11-30 |
2023-08-12 |
human |
| Dervila Glynn, Helen E Gibson, Michael K Harte, Kerstin Reim, Susan Jones, Gavin P Reynolds, A Jennifer Morto. Clorgyline-mediated reversal of neurological deficits in a Complexin 2 knockout mouse. Human molecular genetics. vol 19. issue 17. 2010-11-16. PMID:20584925. |
since neurotransmitter deficiencies are thought to underlie depression, we examined neurotransmitter levels in cplx2-/- mice and found a significant decrease in levels of noradrenaline and the serotonin metabolite 5-hydroxyindoleacetic acid in the hippocampus. |
2010-11-16 |
2023-08-12 |
mouse |
| Ronise M Santiago, Janaína Barbieiro, Marcelo M S Lima, Patrícia A Dombrowski, Roberto Andreatini, Maria A B F Vita. Depressive-like behaviors alterations induced by intranigral MPTP, 6-OHDA, LPS and rotenone models of Parkinson's disease are predominantly associated with serotonin and dopamine. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 6. 2010-11-02. PMID:20547199. |
additionally, decreases on the hippocampal serotonin (5-ht) content were detected for the mptp, 6-ohda and rotenone groups. |
2010-11-02 |
2023-08-12 |
Not clear |
| Ronise M Santiago, Janaína Barbieiro, Marcelo M S Lima, Patrícia A Dombrowski, Roberto Andreatini, Maria A B F Vita. Depressive-like behaviors alterations induced by intranigral MPTP, 6-OHDA, LPS and rotenone models of Parkinson's disease are predominantly associated with serotonin and dopamine. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 6. 2010-11-02. PMID:20547199. |
our data indicate that mptp, 6-ohda and rotenone, but not lps were able to produce depressive-like behaviors accompanied primarily by hippocampal 5-ht reductions. |
2010-11-02 |
2023-08-12 |
Not clear |
| Eugene Oh, Takashi Maejima, Chen Liu, Evan Deneris, Stefan Herlitz. Substitution of 5-HT1A receptor signaling by a light-activated G protein-coupled receptor. The Journal of biological chemistry. vol 285. issue 40. 2010-10-26. PMID:20643652. |
rh-ct(5-ht1a) activates g protein-coupled inward rectifying k(+) channels in response to light and causes membrane hyperpolarization in hippocampal neurons, similar to the agonist-induced responses of the 5-ht(1a) receptor. |
2010-10-26 |
2023-08-12 |
mouse |
| Tie-Yuan Zhang, Ian C Hellstrom, Rosemary C Bagot, Xianglan Wen, Josie Diorio, Michael J Meane. Maternal care and DNA methylation of a glutamic acid decarboxylase 1 promoter in rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 39. 2010-10-25. PMID:20881131. |
pup lg increases hippocampal serotonin (5-ht) and nerve growth factor-inducible factor a (ngfi-a) expression. |
2010-10-25 |
2023-08-12 |
human |
| Tie-Yuan Zhang, Ian C Hellstrom, Rosemary C Bagot, Xianglan Wen, Josie Diorio, Michael J Meane. Maternal care and DNA methylation of a glutamic acid decarboxylase 1 promoter in rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 39. 2010-10-25. PMID:20881131. |
treatment of hippocampal neuronal cultures with either 5-ht or an ngfi-a expression plasmid significantly increased gad1 mrna levels. |
2010-10-25 |
2023-08-12 |
human |
| A Czubak, E Nowakowska, K Golembiowska, K Kus, K Burda, J Metelsk. Effect of venlafaxine and nicotine on the level of neurotransmitters and their metabolites in rat brains. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 61. issue 3. 2010-10-21. PMID:20610865. |
the effect of antidepressant doses of nic and ven (our previous results) on noradrenergic (na), dopaminergic (da), serotoninergic (5-ht) neurotransmitters and their metabolites: dopac, hva and 5-hiaa in rats' hippocampus in freely moving rats were determined by microdialysis technique and hplc method. |
2010-10-21 |
2023-08-12 |
human |
| Bethann N Johnson, Bryan K Yamamot. Chronic stress enhances the corticosterone response and neurotoxicity to +3,4-methylenedioxymethamphetamine (MDMA): the role of ambient temperature. The Journal of pharmacology and experimental therapeutics. vol 335. issue 1. 2010-10-21. PMID:20634423. |
prior exposure to cus augmented mdma-induced hyperthermia and plasma cort secretion and the long-term depletions in 5-ht content in striatum, hippocampus, and frontal cortex and da content in striatum. |
2010-10-21 |
2023-08-12 |
rat |
| Ramez Ghanbari, Mostafa El Mansari, Pierre Blie. Sustained administration of trazodone enhances serotonergic neurotransmission: in vivo electrophysiological study in the rat brain. The Journal of pharmacology and experimental therapeutics. vol 335. issue 1. 2010-10-21. PMID:20647493. |
prolonged trazodone administration did not change the sensitivity of postsynaptic 5-ht(1a) and α(2)-adrenergic receptors in hippocampus, but enhanced synaptic 5-ht levels because the 5-ht(1a) antagonist n-{2-[4 (2-methoxyphenyl)-1-piperazinyl]ethyl}-n-(2-pyridinyl) cyclohexanecarboxamide trihydrochloride (way-100635) enhanced hippocampal firing in treated rats, but not in controls. |
2010-10-21 |
2023-08-12 |
rat |
| Peter Holm, Anders Ettrup, Anders B Klein, Martin A Santini, Mona El-Sayed, Anders B Elvang, Tine B Stensbøl, Jens D Mikkelsen, Gitte M Knudsen, Susana Azna. Plaque deposition dependent decrease in 5-HT2A serotonin receptor in AbetaPPswe/PS1dE9 amyloid overexpressing mice. Journal of Alzheimer's disease : JAD. vol 20. issue 4. 2010-10-12. PMID:20413853. |
[3h]-mdl100907, [3h]-escitalopram, and [11c]-pib autoradiography was performed for measuring 5-ht2a receptor, serotonin transporter (sert), and abeta plaque levels in medial prefrontal cortex (mpfc), prefrontal cortex (pfc), frontoparietal cortex (fpc), dorsal and ventral hippocampus, and somatosensory cortex. |
2010-10-12 |
2023-08-12 |
mouse |
| Fumihiro Matsui, Masafumi Morimoto, Kanji Yoshimoto, Yasuhito Nakatomi, Hiroto Syoji, Akira Nishimura, Kenichi Isoda, Kouichi Tanda, Hajime Hoso. Effects of stress of postnatal development on corticosterone, serotonin and behavioral changes. Brain & development. vol 32. issue 7. 2010-10-08. PMID:19818569. |
in the hypothalamus, amygdala and hippocampus, 5-hydroxytryptamine (5-ht) and 5-hydroxyindole acetic acid (5-hiaa) increased in the rats stressed from pnd 11 to 15, and decreased in the rats stressed from pnd 16 to 20. |
2010-10-08 |
2023-08-12 |
rat |
| Fumihiro Matsui, Masafumi Morimoto, Kanji Yoshimoto, Yasuhito Nakatomi, Hiroto Syoji, Akira Nishimura, Kenichi Isoda, Kouichi Tanda, Hajime Hoso. Effects of stress of postnatal development on corticosterone, serotonin and behavioral changes. Brain & development. vol 32. issue 7. 2010-10-08. PMID:19818569. |
there were no significant changes in 5-ht and 5-hiaa in hypothalamus, amygdala and hippocampus after restraint stress in adults. |
2010-10-08 |
2023-08-12 |
rat |