| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eleni Païzanis, Thibault Renoir, Vincent Lelievre, Françoise Saurini, Maxette Melfort, Cecilia Gabriel, Nicholas Barden, Elisabeth Mocaër, Michel Hamon, Laurence Lanfume. Behavioural and neuroplastic effects of the new-generation antidepressant agomelatine compared to fluoxetine in glucocorticoid receptor-impaired mice. The international journal of neuropsychopharmacology. vol 13. issue 6. 2010-09-29. PMID:19775499. |
glucocorticoid receptor-impaired (gr-i) mice, a transgenic model for affective disorders with hypothalamic-pituitary-adrenal (hpa) axis feedback control deficit, were used to assess the antidepressant-like effects of the mixed melatonin receptor agonist/5-ht(2c) receptor antagonist, agomelatine, compared to the selective 5-ht reuptake inhibitor (ssri), fluoxetine, on hippocampal neurogenesis, gr and bdnf expression and antidepressant-responsive behaviour (tail suspension test, tst). |
2010-09-29 |
2023-08-12 |
mouse |
| Thomas I F H Cremers, Eliyahu Dremencov, Fokko J Bosker, Ben H C Westerin. Oxazepam and temazepam attenuate paroxetine-induced elevation of serotonin levels in guinea-pig hippocampus. The international journal of neuropsychopharmacology. vol 13. issue 6. 2010-09-29. PMID:20047712. |
oxazepam and temazepam attenuate paroxetine-induced elevation of serotonin levels in guinea-pig hippocampus. |
2010-09-29 |
2023-08-12 |
Not clear |
| Thomas I F H Cremers, Eliyahu Dremencov, Fokko J Bosker, Ben H C Westerin. Oxazepam and temazepam attenuate paroxetine-induced elevation of serotonin levels in guinea-pig hippocampus. The international journal of neuropsychopharmacology. vol 13. issue 6. 2010-09-29. PMID:20047712. |
this study aimed to assess, using in-vivo microdialysis, the effects of the benzodiazepines oxazepam or temazepan on the ssri paroxetine-induced 5-ht increase in the hippocampus of freely moving guinea-pigs. |
2010-09-29 |
2023-08-12 |
Not clear |
| Thomas I F H Cremers, Eliyahu Dremencov, Fokko J Bosker, Ben H C Westerin. Oxazepam and temazepam attenuate paroxetine-induced elevation of serotonin levels in guinea-pig hippocampus. The international journal of neuropsychopharmacology. vol 13. issue 6. 2010-09-29. PMID:20047712. |
it was concluded that benzodiazepines attenuate the ability of ssris to elevate hippocampal 5-ht levels. |
2010-09-29 |
2023-08-12 |
Not clear |
| Bruno P Guiard, Mostafa El Mansari, Pierre Blie. Prospect of a dopamine contribution in the next generation of antidepressant drugs: the triple reuptake inhibitors. Current drug targets. vol 10. issue 11. 2010-09-27. PMID:19702555. |
several arguments favour this hypothesis and particularly the observation that da may promote neurotrophic processes in the adult hippocampus, as 5-ht and ne do. |
2010-09-27 |
2023-08-12 |
Not clear |
| Ricardo Llorente, Esther O'Shea, M Dolores Gutierrez-Lopez, Alvaro Llorente-Berzal, María Isabel Colado, María-Paz Vivero. Sex-dependent maternal deprivation effects on brain monoamine content in adolescent rats. Neuroscience letters. vol 479. issue 2. 2010-09-27. PMID:20493239. |
in this study we have addressed the effects of md on the levels of serotonin (5-ht), dopamine (da) and their respective metabolites in prefrontal cortex, hippocampus, striatum, midbrain and cerebellum of male and female periadolescent wistar rats. |
2010-09-27 |
2023-08-12 |
rat |
| Jun-Sheng Tian, Yuan-Lu Cui, Li-Min Hu, Shan Gao, Wei Chi, Tian-Jiao Dong, Lu-Ping Li. Antidepressant-like effect of genipin in mice. Neuroscience letters. vol 479. issue 3. 2010-09-27. PMID:20561935. |
a possible mechanism, at least in part, is the regulation of the 5-ht and ne levels in the hippocampus. |
2010-09-27 |
2023-08-12 |
mouse |
| Shunit Gal, Zaid A Abassi, Moussa B H Youdi. limited potentiation of blood pressure in response to oral tyramine by the anti-Parkinson brain selective multifunctional monoamine oxidase-AB inhibitor, M30. Neurotoxicity research. vol 18. issue 2. 2010-09-20. PMID:19894083. |
we also measured mao-a and b in the striatum, hippocampus, liver, and small intestine and determined brain levels of dopamine, noradrenaline, and serotonin. |
2010-09-20 |
2023-08-12 |
rat |
| Arindam Dalal, Mrinal K Podda. Involvement of high plasma corticosterone status and activation of brain regional serotonin metabolism in long-term erythrosine-induced rearing motor hyper activity in young adult male rats. Toxicology mechanisms and methods. vol 20. issue 6. 2010-09-17. PMID:20465369. |
erythrosine-induced stimulation in brain regional (medulla-pons, hypothalamus, hippocampus, and corpus striatum) serotonin metabolism (measuring steady state levels of 5-ht and 5-hiaa, mao-a activity), including its turnover (pargyline-induced 5-ht accumulation and 5-hiaa declination rate), as well as plasma corticosterone were also observed depending on dosage(s) and duration(s) of erythrosine administration under similar experimental conditions. |
2010-09-17 |
2023-08-12 |
human |
| Ausaf Ahmad, Naila Rasheed, Naheed Banu, Gautam Pali. Alterations in monoamine levels and oxidative systems in frontal cortex, striatum, and hippocampus of the rat brain during chronic unpredictable stress. Stress (Amsterdam, Netherlands). vol 13. issue 4. 2010-09-13. PMID:20536337. |
in the present study, alterations in the concentrations of dopamine (da), serotonin (5-ht) and their metabolites, and simultaneous changes in the antioxidant defense system and lipid peroxidation in different brain regions (frontal cortex, striatum, and hippocampus) were investigated immediately and 24 h after exposure to chronic unpredictable stress (cus). |
2010-09-13 |
2023-08-12 |
rat |
| Ausaf Ahmad, Naila Rasheed, Naheed Banu, Gautam Pali. Alterations in monoamine levels and oxidative systems in frontal cortex, striatum, and hippocampus of the rat brain during chronic unpredictable stress. Stress (Amsterdam, Netherlands). vol 13. issue 4. 2010-09-13. PMID:20536337. |
the altered redox state in the striatum and frontal cortex might be related to the perturbed da and/or 5ht levels, while the hippocampus seems to be less influenced by cus in terms of monoamine metabolite changes. |
2010-09-13 |
2023-08-12 |
rat |
| Chad E Beyer, Jason M Dwyer, Michael J Piesla, Brian J Platt, Ru Shen, Zia Rahman, Karen Chan, Melissa T Manners, Tarek A Samad, Jeffrey D Kennedy, Brendan Bingham, Garth T Whitesid. Depression-like phenotype following chronic CB1 receptor antagonism. Neurobiology of disease. vol 39. issue 2. 2010-09-10. PMID:20381618. |
additionally, chronic treatment with rimonabant produced decreases in frontal cortex serotonin levels, marked reductions in hippocampal cell proliferation, survival, and bdnf levels, and elevations in the concentrations of pro-inflammatory cytokines including interferon gamma and tnf alpha. |
2010-09-10 |
2023-08-12 |
rat |
| Susana Aznar, Anders B Klein, Martin A Santini, Gitte M Knudsen, Fritz Henn, Peter Gass, Barbara Vollmay. Aging and depression vulnerability interaction results in decreased serotonin innervation associated with reduced BDNF levels in hippocampus of rats bred for learned helplessness. Synapse (New York, N.Y.). vol 64. issue 7. 2010-09-08. PMID:20222154. |
aging and depression vulnerability interaction results in decreased serotonin innervation associated with reduced bdnf levels in hippocampus of rats bred for learned helplessness. |
2010-09-08 |
2023-08-12 |
rat |
| Susana Aznar, Anders B Klein, Martin A Santini, Gitte M Knudsen, Fritz Henn, Peter Gass, Barbara Vollmay. Aging and depression vulnerability interaction results in decreased serotonin innervation associated with reduced BDNF levels in hippocampus of rats bred for learned helplessness. Synapse (New York, N.Y.). vol 64. issue 7. 2010-09-08. PMID:20222154. |
both reduced hippocampal serotonin neurotransmission and brain-derived neurotrophic factor (bdnf) levels have been associated with increased depression vulnerability and are also regulated during aging. |
2010-09-08 |
2023-08-12 |
rat |
| Susana Aznar, Anders B Klein, Martin A Santini, Gitte M Knudsen, Fritz Henn, Peter Gass, Barbara Vollmay. Aging and depression vulnerability interaction results in decreased serotonin innervation associated with reduced BDNF levels in hippocampus of rats bred for learned helplessness. Synapse (New York, N.Y.). vol 64. issue 7. 2010-09-08. PMID:20222154. |
brains from young (5 months old) and old (13 months old) congenital learned helplessness rats (clh), and congenital non learned helplessness rats (cnlh) were immunohistochemically stained for the serotonin transporter and subsequently stereologically quantified for estimating hippocampal serotonin fiber density. |
2010-09-08 |
2023-08-12 |
rat |
| Susana Aznar, Anders B Klein, Martin A Santini, Gitte M Knudsen, Fritz Henn, Peter Gass, Barbara Vollmay. Aging and depression vulnerability interaction results in decreased serotonin innervation associated with reduced BDNF levels in hippocampus of rats bred for learned helplessness. Synapse (New York, N.Y.). vol 64. issue 7. 2010-09-08. PMID:20222154. |
an exacerbated age-related loss of serotonin fiber density specific for the ca1 area was observed in the clh animals, whereas reduced hippocampal bdnf levels were seen in young and old clh when compared with age-matched cnlh controls. |
2010-09-08 |
2023-08-12 |
rat |
| Jan Kehr, Xiao-Jing Hu, Takashi Yoshitake, Fu-Hua Wang, Peter Osborne, Carina Stenfors, Sven Ove Ogre. The selective 5-HT(1A) receptor antagonist NAD-299 increases acetylcholine release but not extracellular glutamate levels in the frontal cortex and hippocampus of awake rat. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 7. 2010-09-08. PMID:20413275. |
the selective 5-ht(1a) receptor antagonist nad-299 increases acetylcholine release but not extracellular glutamate levels in the frontal cortex and hippocampus of awake rat. |
2010-09-08 |
2023-08-12 |
rat |
| Janusz Szyndler, Piotr Maciejak, Danuta Turzyńska, Alicja Sobolewska, Andrzej Bidziński, Adam Płaźni. Time course of changes in the concentrations of monoamines in the brain structures of pentylenetetrazole-kindled rats. Journal of neural transmission (Vienna, Austria : 1996). vol 117. issue 6. 2010-09-08. PMID:20449617. |
we observed substantial changes in the levels of noradrenaline (na), 5-hydroxytryptamine (5-ht), dopamine (da), and their metabolites in the brain structures known to be recruited in the course of kindling, i.e., the piriform, entorhinal and prefrontal cortices, and the hippocampus (in vitro). |
2010-09-08 |
2023-08-12 |
rat |
| Sigeng Chen, Geoffrey C Owens, Helen Makarenkova, David B Edelma. HDAC6 regulates mitochondrial transport in hippocampal neurons. PloS one. vol 5. issue 5. 2010-09-07. PMID:20520769. |
we have shown previously that the neuromodulator serotonin increases mitochondrial movement in hippocampal neurons via the akt-gsk3beta signaling pathway. |
2010-09-07 |
2023-08-12 |
Not clear |
| Jean Mazella, Olivier Pétrault, Guillaume Lucas, Emmanuel Deval, Sophie Béraud-Dufour, Carine Gandin, Malika El-Yacoubi, Catherine Widmann, Alice Guyon, Eric Chevet, Said Taouji, Grégory Conductier, Alain Corinus, Thierry Coppola, Gabriella Gobbi, Jean-Louis Nahon, Catherine Heurteaux, Marc Borsott. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS biology. vol 8. issue 4. 2010-09-01. PMID:20405001. |
more importantly, an intravenous 4-d treatment with spadin not only induced a strong antidepressant effect but also enhanced hippocampal phosphorylation of creb protein and neurogenesis, considered to be key markers of antidepressant action after chronic treatment with selective serotonin reuptake inhibitors. |
2010-09-01 |
2023-08-12 |
mouse |