| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Glass, M Dragunow, R L Faul. The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease. Neuroscience. vol 97. issue 3. 2000-09-14. PMID:10828533. |
in order to investigate the sequence and pattern of neurodegeneration in huntington's disease, the distribution and density of cannabinoid cb(1), dopamine d(1) and d(2), adenosine a(2a) and gaba(a) receptor changes were studied in the basal ganglia in early (grade 0), intermediate (grades 1, 2) and advanced (grade 3) neuropathological grades of huntington's disease. |
2000-09-14 |
2023-08-12 |
human |
| J Hewett, C Gonzalez-Agosti, D Slater, P Ziefer, S Li, D Bergeron, D J Jacoby, L J Ozelius, V Ramesh, X O Breakefiel. Mutant torsinA, responsible for early-onset torsion dystonia, forms membrane inclusions in cultured neural cells. Human molecular genetics. vol 9. issue 9. 2000-08-29. PMID:10814722. |
early-onset torsion dystonia is a hereditary movement disorder thought to be caused by decreased release of dopamine into the basal ganglia, without apparent neuronal degeneration. |
2000-08-29 |
2023-08-12 |
mouse |
| R H Mach, M A Nader, R L Ehrenkaufer, H D Gage, S R Childers, L M Hodges, M M Hodges, H M Davie. Fluorine-18-labeled tropane analogs for PET imaging studies of the dopamine transporter. Synapse (New York, N.Y.). vol 37. issue 2. 2000-08-24. PMID:10881032. |
both compounds possessed a high affinity and selectivity for the dopamine transporter and had a higher accumulation in the basal ganglia, a brain region having a high density of the dopamine transporter (dat) than the cerebellum, a reference region devoid of dopaminergic terminals. |
2000-08-24 |
2023-08-12 |
Not clear |
| Proceedings of a symposium on the neurobiology of the basal ganglia. Glasgow, United Kingdom, July 1999. Journal of anatomy. vol 196 ( Pt 4). 2000-08-22. PMID:10960285. |
the invited speakers were chosen to be wide ranging and contributions encompassed evolution, circuitry and receptors of the basal ganglia, striatal remodelling after dopamine loss, striatal functioning in humans with huntington's disease and in primate models after midbrain fetal transplants, and the genetics of basal ganglia disorders. |
2000-08-22 |
2023-08-12 |
Not clear |
| M Quik, S Police, L He, D A Di Monte, J W Langsto. Expression of D(3) receptor messenger RNA and binding sites in monkey striatum and substantia nigra after nigrostriatal degeneration: effect of levodopa treatment. Neuroscience. vol 98. issue 2. 2000-08-18. PMID:10854757. |
in the present experiments, we investigated the relationship between d(3) receptor mrna, d(3) receptor sites and the dopamine transporter in monkey basal ganglia by comparing their distribution in the brain of control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated monkeys (samirai sciureus). |
2000-08-18 |
2023-08-12 |
monkey |
| M Quik, S Police, L He, D A Di Monte, J W Langsto. Expression of D(3) receptor messenger RNA and binding sites in monkey striatum and substantia nigra after nigrostriatal degeneration: effect of levodopa treatment. Neuroscience. vol 98. issue 2. 2000-08-18. PMID:10854757. |
chronic mptp administration, which selectively destroys the nigrostriatal system, resulted in a 70 to 99% depletion of the dopamine transporter in the basal ganglia. |
2000-08-18 |
2023-08-12 |
monkey |
| W Hauber, H Fuch. Dopamine release in the rat globus pallidus characterised by in vivo microdialysis. Behavioural brain research. vol 111. issue 1-2. 2000-08-10. PMID:10840130. |
the data further suggest that dopamine in basal ganglia structures downstream the striatum as the gp is involved in signalling of important stimuli in the environment, e.g. |
2000-08-10 |
2023-08-12 |
rat |
| C S Lee, M A Cenci, M Schulzer, A Björklun. Embryonic ventral mesencephalic grafts improve levodopa-induced dyskinesia in a rat model of Parkinson's disease. Brain : a journal of neurology. vol 123 ( Pt 7). 2000-08-07. PMID:10869049. |
brain sections at the level of the basal ganglia were processed for autoradiography using a ligand for dopamine transporter, and in situ hybridization histochemistry for mrnas encoding postsynaptic markers. |
2000-08-07 |
2023-08-12 |
rat |
| H Steiner, S T Kita. Regulation of rat cortex function by D1 dopamine receptors in the striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 14. 2000-08-03. PMID:10884328. |
in the present study, we used immediate-early genes (c-fos, zif 268) as functional markers to investigated how basal ganglia output altered by stimulation/blockade of d1 dopamine receptors in the striatum affects cortical function. |
2000-08-03 |
2023-08-12 |
rat |
| P De Deurwaèrdere, M F Chessele. Nigrostriatal lesions alter oral dyskinesia and c-Fos expression induced by the serotonin agonist 1-(m-chlorophenyl)piperazine in adult rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 13. 2000-07-26. PMID:10864974. |
in the present study, we sought to determine the effects of chronic dopamine (da) depletion on responses mediated by stimulation of serotonergic 2c (5-ht(2c)) receptors, a serotonergic receptor subtype present in discrete regions of the basal ganglia. |
2000-07-26 |
2023-08-12 |
rat |
| R J Jakel, W F Marago. Neuronal cell death in Huntington's disease: a potential role for dopamine. Trends in neurosciences. vol 23. issue 6. 2000-07-21. PMID:10838590. |
there are accumulating data indicating that under specific circumstances, dopamine, which occurs in high concentrations in the basal ganglia, might be neurotoxic. |
2000-07-21 |
2023-08-12 |
Not clear |
| M C Sañudo-Peña, K Tsou, J Romero, K Mackie, J M Walke. Role of the superior colliculus in the motor effects of cannabinoids and dopamine. Brain research. vol 853. issue 2. 2000-06-21. PMID:10640618. |
the levels of turning obtained with the intracollicular administration of the cannabinoid were comparable to the highest levels obtained with dopamine agonists in the basal ganglia. |
2000-06-21 |
2023-08-12 |
rat |
| J E Visser, P R Bär, H A Jinna. Lesch-Nyhan disease and the basal ganglia. Brain research. Brain research reviews. vol 32. issue 2-3. 2000-06-21. PMID:10760551. |
though neuropathologic studies of autopsy specimens have revealed no obvious neuroanatomical abnormalities in lnd, neurochemical studies have demonstrated 60-90% reductions in the dopamine content of the basal ganglia. |
2000-06-21 |
2023-08-12 |
Not clear |
| J E Visser, P R Bär, H A Jinna. Lesch-Nyhan disease and the basal ganglia. Brain research. Brain research reviews. vol 32. issue 2-3. 2000-06-21. PMID:10760551. |
in addition, recent pet studies have documented significant reductions in dopamine transporters and [18f]fluorodopa uptake in the basal ganglia. |
2000-06-21 |
2023-08-12 |
Not clear |
| B Spil. [Present views on pathogenesis of schizophrenia]. Psychiatria polska. vol 33. issue 3. 2000-06-14. PMID:10786237. |
particularly, the author suggests that diathesis for schizophrenia involves functional excess of dopamine activity in the basal ganglia. |
2000-06-14 |
2023-08-12 |
Not clear |
| K Steece-Collier, L K Chambers, S S Jaw-Tsai, F S Menniti, J T Greenamyr. Antiparkinsonian actions of CP-101,606, an antagonist of NR2B subunit-containing N-methyl-d-aspartate receptors. Experimental neurology. vol 163. issue 1. 2000-06-13. PMID:10785463. |
in the setting of nigrostriatal dopamine depletion, glutamatergic pathways to the striatum and basal ganglia output nuclei become overactive. |
2000-06-13 |
2023-08-12 |
rat |
| R Bauer, P Brust, B Walter, G Vorwieger, R Bergmann, F Füchtner, J Steinbach, E el-Hallag, A Fritz, B Johannsen, U Zwiene. Relation between brain tissue pO2 and dopamine synthesis of basal ganglia--a 18FDOPA-PET study in newborn piglets. Journal of perinatal medicine. vol 28. issue 1. 2000-06-08. PMID:10765515. |
relation between brain tissue po2 and dopamine synthesis of basal ganglia--a 18fdopa-pet study in newborn piglets. |
2000-06-08 |
2023-08-12 |
Not clear |
| R J McPherson, J F Marshal. Substantia nigra glutamate antagonists produce contralateral turning and basal ganglia Fos expression: interactions with D1 and D2 dopamine receptor agonists. Synapse (New York, N.Y.). vol 36. issue 3. 2000-06-06. PMID:10819899. |
experiments measuring behavior and immediate-early gene expression in the basal ganglia can reveal interactions between dopamine (da) and glutamate neurotransmission. |
2000-06-06 |
2023-08-12 |
rat |
| S Z Meng, J Ohyu, M Itoh, S Takashim. Dopamine transporter and nitric oxide synthase in hypoxic-ischemic brain. Pediatric neurology. vol 22. issue 2. 2000-05-11. PMID:10738916. |
changes in dopamine transporter and neuronal nitric oxide synthase (nnos) were investigated by immunohistochemistry in 18 cases of hypoxic-ischemic basal ganglia necrosis. |
2000-05-11 |
2023-08-12 |
human |
| S Z Meng, J Ohyu, M Itoh, S Takashim. Dopamine transporter and nitric oxide synthase in hypoxic-ischemic brain. Pediatric neurology. vol 22. issue 2. 2000-05-11. PMID:10738916. |
neuropil dopamine transporter immunostaining in the striatum was increased in seven cases, with relatively mild basal ganglia necrosis, and decreased in four cases, with marked basal ganglia necrosis, compared with age-matched control subjects. |
2000-05-11 |
2023-08-12 |
human |