| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jonathan Kasdin, Alison Duffy, Nathan Nadler, Arnav Raha, Adrienne L Fairhall, Kimberly L Stachenfeld, Vikram Gadagka. Natural behaviour is learned through dopamine-mediated reinforcement. Nature. 2025-03-13. PMID:40074908. |
dopamine in the basal ganglia is thought to guide reward-based trial-and-error learning by encoding reward prediction errors |
2025-03-13 |
2025-03-15 |
Not clear |
| Christopher R Kelley, Jeffrey L Kauffma. Does Excessive Tonic Inhibition Cause Unstable Feedback in Parkinson's Disease? Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2024. 2025-03-05. PMID:40039286. |
parkinson's disease is characterized by decreased dopamine in the basal ganglia, which causes excessive tonic inhibition of the thalamus. |
2025-03-05 |
2025-03-07 |
Not clear |
| Hsin-Yung Chen, Ya-Ju Tsai, Syu-Jyun Pen. Interpretation of basal nuclei in brain dopamine transporter scans using a deep convolutional neural network. Nuclear medicine communications. 2025-02-18. PMID:39962871. |
interpretation of basal nuclei in brain dopamine transporter scans using a deep convolutional neural network. |
2025-02-18 |
2025-02-23 |
Not clear |
| Caroline Cowan, Richard Walke. A Podcast on the Rhythms of Healing: Patient and Physician Insights on Art, Music, Dance Therapy and Creativity in Parkinson's Disease. Neurology and therapy. 2025-01-18. PMID:39826004. |
parkinson's disease (pd) is a progressive neurodegenerative disease in which there is increasing loss of dopamine neurones from the basal ganglia (simon et al. |
2025-01-18 |
2025-01-21 |
Not clear |
| Caroline Cowan, Richard Walke. A Podcast on the Rhythms of Healing: Patient and Physician Insights on Art, Music, Dance Therapy and Creativity in Parkinson's Disease. Neurology and therapy. 2025-01-18. PMID:39826004. |
pd is primarily a clinical diagnosis although a datscan, which if positive shows asymmetrical loss of dopamine uptake in the basal ganglia, is helpful in cases of doubt (tsang and walker j neurol 270(5):2550-2558). |
2025-01-18 |
2025-01-21 |
Not clear |
| Alberto Avila-Luna, Antonio Verduzco-Mendoza, Adriana Olmos-Hernández, José Luis Cortes-Altamirano, Alfonso Alfaro-Rodríguez, José-Antonio Arias-Montaño, Antonio Bueno-Nav. The Interaction of Histamine H Pharmaceuticals (Basel, Switzerland). vol 17. issue 12. 2025-01-08. PMID:39770568. |
l-dopa-induced dyskinesias (lids) manifest as abnormal involuntary movements and are produced by elevated striatal dopamine levels, which lead to increased activity of the basal ganglia direct striato-nigral pathway. |
2025-01-08 |
2025-01-13 |
Not clear |
| Nilufar Ali, Afshin Beheshti, Greg Hampikia. Space exploration and risk of Parkinson's disease: a perspective review. NPJ microgravity. vol 11. issue 1. 2025-01-03. PMID:39753605. |
systemic mitochondrial dysfunction, dopamine loss, sustained structural changes in the basal ganglia including reduced tyrosine hydroxylase, and altered gait- these effects observed in space-flown animals and astronauts mirrors parkinson's disease (pd). |
2025-01-03 |
2025-01-06 |
human |
| Anna Sara Liberati, Giulio Perrott. Neuroanatomical and functional correlates in tic disorders and Tourette's syndrome: A narrative review. Ibrain. vol 10. issue 4. 2024-12-18. PMID:39691418. |
from a neurophysiological perspective, the disorder has classically been associated with neurochemical imbalances (particularly dopamine and serotonin) and structural and functional alterations affecting, in particular, brain areas and circuits involved in the processing and coordination of movements: the basal ganglia, thalamus, motor cortical area, and cingulate cortex; however, more recent research is demonstrating the involvement of many more brain regions and neurotransmission systems than previously observed, such as the prefrontal cortex and cerebellum. |
2024-12-18 |
2024-12-21 |
Not clear |
| José L Lanciego, José A Obes. Functional Neuroanatomy of the Normal and Pathological Basal Ganglia. Cold Spring Harbor perspectives in medicine. 2024-12-18. PMID:39694693. |
dopamine released from the substantia nigra is the underlying driving force keeping the basal ganglia network under proper equilibrium and, indeed, reduction of dopamine levels triggers basal ganglia dysfunction, setting the groundwork for several movement disorders. |
2024-12-18 |
2024-12-21 |
Not clear |
| Correction for Wärnberg and Kumar, Feasibility of dopamine as a vector-valued feedback signal in the basal ganglia. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 52. 2024-12-16. PMID:39680785. |
correction for wärnberg and kumar, feasibility of dopamine as a vector-valued feedback signal in the basal ganglia. |
2024-12-16 |
2024-12-21 |
Not clear |
| Desirée Conti, Giulia Bechi Gabrielli, Massimiliano Panigutti, Giulia Zazzaro, Giuseppe Bruno, Gaspare Galati, Fabrizia D'Antoni. Neuroanatomical and clinical correlates of prodromal dementia with Lewy bodies: a systematic literature review of neuroimaging findings. Journal of neurology. vol 272. issue 1. 2024-12-12. PMID:39666108. |
subcortically, atrophy and microstructural damage in the nucleus basalis of meynert were reported, and dopamine transporter uptake was reduced in the basal ganglia. |
2024-12-12 |
2024-12-14 |
Not clear |
| Emily Hueske, Carrie Stine, Tomoko Yoshida, Jill R Crittenden, Akshay Gupta, Joseph C Johnson, Ananya S Achanta, Smitha Bhagavatula, Johnny Loftus, Ara Mahar, Dan Hu, Jesus Azocar, Ryan J Gray, Michael R Bruchas, Ann M Graybie. Developmental and Adult Striatal Patterning of Nociceptin Ligand Marks Striosomal Population With Direct Dopamine Projections. The Journal of comparative neurology. vol 532. issue 12. 2024-12-10. PMID:39656141. |
recent developments in the study of neuropeptide systems have enabled high-resolution investigations of the intersection of neuromodulatory signals with basal ganglia circuitry, identifying the nociceptin/orphanin fq (n/ofq) endogenous opioid peptide system as a prospective regulator of striatal dopamine signaling. |
2024-12-10 |
2024-12-12 |
mouse |
| Muhammad Khalid Iqbal, Bakhtawar Khan, Hifsa, Ge YuXuan, Muhammad Mujahid, Mubin Mustafa Kiyani, Hamid Khan, Shahid Bashi. The Impact of the Blood-Brain Barrier and Its Dysfunction in Parkinson's Disease: Contributions to Pathogenesis and Progression. ACS omega. vol 9. issue 46. 2024-11-25. PMID:39583664. |
parkinson's disease (pd) is a brain disorder in which neuronal cells responsible for the release of dopamine, a neurotransmitter that controls movement, are degenerated or impaired in the substantia nigra and basal ganglia. |
2024-11-25 |
2024-11-27 |
Not clear |
| Yuxin Wang, Zhiqi Jiang, Chunguang Chu, Zhen Zhang, Jiang Wang, Dianyou Li, Naying He, Chris Fietkiewicz, Changsong Zhou, Marcus Kaiser, Xuze Bai, Chencheng Zhang, Chen Li. Push-pull effects of basal ganglia network in Parkinson's disease inferred by functional MRI. NPJ Parkinson's disease. vol 10. issue 1. 2024-11-20. PMID:39567536. |
specifically, increased gabaergic projection into the thalamus from basal ganglia worsens rigidity, while reduced gabaergic projection within the cortex exacerbates bradykinesia, suggesting that the dopamine deficiency induces the chain coupling variations to "push" the network to an abnormal state. |
2024-11-20 |
2024-11-23 |
Not clear |
| Beren Millidge, Yuhang Song, Armin Lak, Mark E Walton, Rafal Bogac. Reward Bases: A simple mechanism for adaptive acquisition of multiple reward types. PLoS computational biology. vol 20. issue 11. 2024-11-19. PMID:39561186. |
we also proposed a possible implementation of the model in the basal ganglia network, and demonstrated how the striatal system can learn values in multiple dimensions, even when dopamine neurons encode mixtures of prediction error from different dimensions. |
2024-11-19 |
2024-11-23 |
Not clear |
| Percy S Agogo-Mawuli, Joseph Mendez, Emily A Oestreich, Dustin E Bosch, David P Siderovsk. Molecular Modeling and In Vitro Functional Analysis of the RGS12 PDZ Domain Variant Associated with High-Penetrance Familial Bipolar Disorder. International journal of molecular sciences. vol 25. issue 21. 2024-11-09. PMID:39518985. |
we previously demonstrated that rgs12 loss removes negative regulation on the kappa opioid receptor, disrupting basal ganglia dopamine homeostasis and dampening responses to dopamine-eliciting psychostimulants. |
2024-11-09 |
2024-11-17 |
Not clear |
| Melissa Serranilla, Jessica C Pressey, Melanie A Woodi. Restoring Compromised Cl The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-11-05. PMID:39500579. |
early stages of the disease are characterized by the loss of dopamine 2 receptor-expressing msns (d2 msns) followed by degeneration of dopamine 1 receptor-expressing msns (d1 msns), leading to aberrant basal ganglia signaling. |
2024-11-05 |
2024-11-08 |
Not clear |
| Iakovos Lazaridis, Jill R Crittenden, Gun Ahn, Kojiro Hirokane, Ian R Wickersham, Tomoko Yoshida, Ara Mahar, Vasiliki Skara, Johnny H Loftus, Krishna Parvataneni, Konstantinos Meletis, Jonathan T Ting, Emily Hueske, Ayano Matsushima, Ann M Graybie. Striosomes control dopamine via dual pathways paralleling canonical basal ganglia circuits. Current biology : CB. 2024-10-24. PMID:39447573. |
striosomes control dopamine via dual pathways paralleling canonical basal ganglia circuits. |
2024-10-24 |
2024-10-28 |
Not clear |
| Manami Yamaoka, Shuichiro Neshige, Kenta Sasaki, Hirofumi Maruyam. Multiple System Atrophy Masquerading as Drug-Resistant Orthostatic Hypotension. Cureus. vol 16. issue 9. 2024-10-21. PMID:39429427. |
however, a brain magnetic resonance imaging (mri) scan revealed a possible "cross sign" in the pons. subsequent dopamine transporter single-photon emission computed tomography (dat-spect) showed reduced uptake in the basal ganglia. |
2024-10-21 |
2024-10-23 |
Not clear |
| Chelsea M Haakenson, Jacques Balthazart, Jonathan W VanRyzin, Ashley E Marquardt, Sydney E Ashton, Margaret M McCarthy, Gregory F Bal. Neurochemical Characterization of Dopaminoceptive Cells in Song Control Nuclei of Canaries and Their Activation During Song Production: A Multiplex Fluorescent In Situ Hybridization Study. The Journal of comparative neurology. vol 532. issue 10. 2024-10-10. PMID:39387367. |
highly sensitive in situ hybridization procedures (rnascope) were used to quantify the expression of three dopamine receptors (drd1, drd2, and drd3) in two song control nuclei (hvc and the area x of the basal ganglia) that are known to receive dopaminergic inputs and in the periaqueductal gray (pag) of male and female canaries. |
2024-10-10 |
2024-10-16 |
Not clear |