| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F S Pidcock, A H Hoon, M V Johnsto. Trihexyphenidyl in posthemorrhagic dystonia: motor and language effects. Pediatric neurology. vol 20. issue 3. 1999-06-07. PMID:10207932. |
the mechanism of action of trihexyphenidyl is believed to be in the basal ganglia where it inhibits muscarinic cholinergic receptors and increases the turnover of dopamine. |
1999-06-07 |
2023-08-12 |
Not clear |
| T Nagatsu, H Ichinos. Molecular biology of catecholamine-related enzymes in relation to Parkinson's disease. Cellular and molecular neurobiology. vol 19. issue 1. 1999-06-04. PMID:10079965. |
in juvenile parkinsonism and parkinson's disease, which have dopamine deficiency in the basal ganglia as hpd/drd, the gch gene may be normal, and the molecular mechanism of the dopamine deficiency in the basal ganglia is different from that in hpd/drd. |
1999-06-04 |
2023-08-12 |
Not clear |
| L Matuszewich, B K Yamamot. Modulation of GABA release by dopamine in the substantia nigra. Synapse (New York, N.Y.). vol 32. issue 1. 1999-06-01. PMID:10188635. |
local interactions between dopamine and gaba in the substantia nigra may have important implications for the direct regulation of basal ganglia efferent activity and motor behavior. |
1999-06-01 |
2023-08-12 |
rat |
| M Morissette, M Goulet, R Grondin, P Blanchet, P J Bédard, T Di Paolo, D Lévesqu. Associative and limbic regions of monkey striatum express high levels of dopamine D3 receptors: effects of MPTP and dopamine agonist replacement therapies. The European journal of neuroscience. vol 10. issue 8. 1999-05-26. PMID:9767387. |
in the present study, we investigated the functional neuroanatomy of the dopamine d3 receptor subtype in the monkey (macaca fascicularis) basal ganglia. |
1999-05-26 |
2023-08-12 |
rat |
| R D Todd, J S Perlmutte. Mutational and biochemical analysis of dopamine in dystonia: evidence for decreased dopamine D2 receptor inhibition. Molecular neurobiology. vol 16. issue 2. 1999-05-21. PMID:9588625. |
we recently proposed that hypofunction of dopamine d2 receptor-mediated inhibition of the indirect output pathway of the basal ganglia can result in dystonia. |
1999-05-21 |
2023-08-12 |
mouse |
| H Miwa, K Nishi, T Fuwa, Y Mizun. Globus pallidus lesions inhibit the induction of c-Fos by haloperidol in the basal ganglia output nuclei in rats. Neuroscience letters. vol 250. issue 1. 1999-05-19. PMID:9696058. |
since it has been suggested that c-fos expression in the snr/ep is caused by increased excitatory inputs from the subthalamic nucleus (stn), the present results provide functional evidence indicating that neuronal activities of the basal ganglia output nuclei are not increased by gp ablation, unlike d2 receptor blockade, supporting the recently proposed hypothesis that overactivity of the stn resulting from dopamine depletion is not solely a result of disinhibition from inhibitory gp efferents. |
1999-05-19 |
2023-08-12 |
rat |
| Y Hurd, N Lindefor. [Increasing abuse of psychostimulants is alarming. New findings confirm the mechanisms behind cocaine and amphetamine addiction]. Lakartidningen. vol 96. issue 15. 1999-05-19. PMID:10319645. |
dopamine pathways extending from the brain stem to the basal ganglia, limbic structures, and cerebral cortex are generally considered to constitute the neuroanatomical substrates underlying motivation, reward, and motor function. |
1999-05-19 |
2023-08-12 |
human |
| D Wirtshafter, K E Asi. Unilateral dopamine depletion paradoxically enhances amphetamine-induced Fos expression in basal ganglia output structures. Brain research. vol 824. issue 1. 1999-05-05. PMID:10095045. |
unilateral dopamine depletion paradoxically enhances amphetamine-induced fos expression in basal ganglia output structures. |
1999-05-05 |
2023-08-12 |
Not clear |
| R A Hanel, M C Sandmann, M Kranich, P R De Bittencour. [Neuroleptic malignant syndrome: case report with recurrence associated with the use of olanzapine]. Arquivos de neuro-psiquiatria. vol 56. issue 4. 1999-05-03. PMID:10029891. |
the neuroleptic malignant syndrome (nms) consists in an idiosyncratic reaction to neuroleptic drugs, probably related to a blockage of dopamine receptors in basal ganglia. |
1999-05-03 |
2023-08-12 |
Not clear |
| M Jaber, B Bloch, M G Caron, B Giro. [Behavioral, cellular and molecular consequences of the dopamine transporter gene inactivation]. Comptes rendus des seances de la Societe de biologie et de ses filiales. vol 192. issue 6. 1999-05-03. PMID:10101608. |
mice lacking the the plasma membrane dopamine transporter (dat), following gene inactivation or knock out, show an increase in their spontaneous locomotor activity that is of the same magnitude than in normal mice treated with amphetamine or cocaine, known to increase levels of dopamine in the basal ganglia. |
1999-05-03 |
2023-08-12 |
mouse |
| M A Gorriti, F Rodríguez de Fonseca, M Navarro, T Palom. Chronic (-)-delta9-tetrahydrocannabinol treatment induces sensitization to the psychomotor effects of amphetamine in rats. European journal of pharmacology. vol 365. issue 2-3. 1999-04-29. PMID:9988095. |
since (-)-delta9-tetrahydrocannabinol is a cannabinoid cb1 receptor agonist, densely present in limbic and basal ganglia circuits, and since amphetamine enhances monoaminergic inputs (i.e., dopamine, serotonin) in these brain areas, the present data support the hypothesis of a role for the cannabinoid cb1 receptor as a regulatory mechanism of monoaminergic neuron-mediated psychomotor activation. |
1999-04-29 |
2023-08-12 |
rat |
| N Hayase, N Miyashita, K Endo, H Narabayash. Neuronal activity in GP and Vim of parkinsonian patients and clinical changes of tremor through surgical interventions. Stereotactic and functional neurosurgery. vol 71. issue 1. 1999-04-27. PMID:10072670. |
basal ganglia pathology due to dopamine depletion could generate oscillatory neuronal activity in gpi, which may cause tremor. |
1999-04-27 |
2023-08-12 |
human |
| A Stefani, P Mazzone, A Bassi, G Bernardi, M G Altibrandi, A Peppe, M Pierantozzi, P Stanzion. Electrophysiological and clinical desensitization to apomorphine administration in parkinsonian patients undergoing stereotaxic neurosurgery. Experimental neurology. vol 156. issue 1. 1999-04-21. PMID:10192792. |
our data support the proposition that fast postsynaptic desensitization to dopamine agonists may take place in the basal ganglia nuclei and play a role in the physiopathology of levodopa long-term treatment syndrome. |
1999-04-21 |
2023-08-12 |
Not clear |
| b' M Casas, G Prat, P Robledo, M Barbanoj, J Kulisevsky, F Jan\\xc3\\xa. Scopolamine prevents tolerance to the effects of caffeine on rotational behavior in 6-hydroxydopamine-denervated rats. European journal of pharmacology. vol 366. issue 1. 1999-04-14. PMID:10064145.' |
the results are interpreted in terms of the possible interactions between dopamine, adenosine and acetylcholine neurotransmitter systems within the basal ganglia circuitry involved in motor behavior. |
1999-04-14 |
2023-08-12 |
rat |
| S Shaunak, E O'Sullivan, S Blunt, M Lawden, T Crawford, L Henderson, C Kennar. Remembered saccades with variable delay in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 14. issue 1. 1999-04-01. PMID:9918348. |
hypometria of primary saccades is compatible with dysfunction in striato-collicular inhibitory pathways in parkinson's disease, arising as a functional consequence of dopamine deficiency in the basal ganglia. |
1999-04-01 |
2023-08-12 |
human |
| P Vezina, J H Ki. Metabotropic glutamate receptors and the generation of locomotor activity: interactions with midbrain dopamine. Neuroscience and biobehavioral reviews. vol 23. issue 4. 1999-03-26. PMID:10073895. |
interactions between excitatory amino acid (eaa) and dopamine (da) pathways in the basal ganglia have been known for some time to contribute importantly to the generation of motor behaviors. |
1999-03-26 |
2023-08-12 |
Not clear |
| W Timmerman, F Westerhof, T I van der Wal, B H Westerin. Striatal dopamine-glutamate interactions reflected in substantia nigra reticulata firing. Neuroreport. vol 9. issue 17. 1999-03-24. PMID:9875713. |
to gain insight into the role of striatal dopamine in basal ganglia functioning, dopaminergic drugs alone and in combination with the glutamate receptor agonist kainic acid were infused in the lateral striatum via a microdialysis probe, while single-unit recordings of substantia nigra reticulata neurons were made in chloral hydrate-anaesthetized rats. |
1999-03-24 |
2023-08-12 |
rat |
| W Timmerman, F Westerhof, T I van der Wal, B H Westerin. Striatal dopamine-glutamate interactions reflected in substantia nigra reticulata firing. Neuroreport. vol 9. issue 17. 1999-03-24. PMID:9875713. |
dopamine potentiated the inhibitory effect of striatal kainic acid on the firing rate of the basal ganglia output neurons. |
1999-03-24 |
2023-08-12 |
rat |
| W T O'Conno. Functional neuroanatomy of the basal ganglia as studied by dual-probe microdialysis. Nuclear medicine and biology. vol 25. issue 8. 1999-03-23. PMID:9863560. |
the data provide functional in vivo evidence for a selective dopamine d1 receptor-mediated activation of the direct strionigral gaba pathway and a selective dopamine d2 receptor inhibition of the indirect striopallidal gaba pathway and provides a neuronal substrate for parallel processing in the basal ganglia regulation of motor function. |
1999-03-23 |
2023-08-12 |
rat |
| A M Gray, J H Connic. Clozapine-induced dopamine levels in the rat striatum and nucleus accumbens are not affected by muscarinic antagonism. European journal of pharmacology. vol 362. issue 2-3. 1999-03-18. PMID:9874162. |
our data suggest that the increased efflux of dopamine and its metabolites in the rat basal ganglia following clozapine administration is not significantly dependent upon the interaction of clozapine with muscarinic receptors. |
1999-03-18 |
2023-08-12 |
rat |