| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takahiro Fujimoto, Kirsten Stam, Takeshi Yaoi, Kenta Nakano, Tetsuya Arai, Tadashi Okamura, Kyoko Ito. Dystrophin Short Product, Dp71, Interacts with AQP4 and Kir4.1 Channels in the Mouse Cerebellar Glial Cells in Contrast to Dp427 at Inhibitory Postsynapses in the Purkinje Neurons. Molecular neurobiology. 2023-03-15. PMID:36918517. |
taken together, different cell-types, glial cells and purkinje neurons, in the cerebellum express different dystrophin molecular complexes, which may contribute to pathological and physiological processes through the regulation of the water/ion channel and inhibitory postsynapses. |
2023-03-15 |
2023-08-14 |
mouse |
| Felicity R Sterling, Jon D'Amico, Alexandria M Brumfield, Kara L Huegel, Patricia S Vaughan, Kathryn Morris, Shelby Schwarz, Michelle V Joyce, Bill Boggess, Matthew M Champion, Kevin Maciuba, Philip Allen, Eric Marasco, Grant Koch, Peter Gonzalez, Shannon Hodges, Shannon Leahy, Erica Gerstbauer, Edward H Hinchcliffe, Kevin T Vaugha. StARD9 is a novel lysosomal kinesin required for membrane tubulation, cholesterol transport and Purkinje cell survival. Journal of cell science. vol 136. issue 5. 2023-03-02. PMID:36861884. |
finally, a novel stard9 knock-out mouse recapitulates the progressive loss of purkinje cells in the cerebellum. |
2023-03-02 |
2023-08-14 |
mouse |
| Gerrit C Beekhof, Martijn Schonewill. Lobule-Related Action Potential Shape- and History-Dependent Current Integration in Purkinje Cells of Adult and Developing Mice. Cells. vol 12. issue 4. 2023-02-25. PMID:36831290. |
purkinje cells (pcs) are the principal cells of the cerebellar cortex and form a central element in the modular organization of the cerebellum. |
2023-02-25 |
2023-08-14 |
mouse |
| Kaaya Tamura, Yuki Yamamoto, Taira Kobayashi, Rin Kuriyama, Tadashi Yamazak. Discrimination and learning of temporal input sequences in a cerebellar Purkinje cell model. Frontiers in cellular neuroscience. vol 17. 2023-02-23. PMID:36816857. |
although we have extensive evidence that cerebellar circuits play a vital role in motor control, studies investigating the computational ability of single purkinje cells are few. |
2023-02-23 |
2023-08-14 |
Not clear |
| Yaiza M Arenas, Vicente Felip. Sustained Hyperammonemia Activates NF-κB in Purkinje Neurons Through Activation of the TrkB-PI3K-AKT Pathway by Microglia-Derived BDNF in a Rat Model of Minimal Hepatic Encephalopathy. Molecular neurobiology. 2023-02-15. PMID:36790604. |
it is shown that, in the cerebellum of hyperammonemic rats, increased bdnf levels enhance trkb activation in purkinje neurons leading to activation of pi3k, which enhances phosphorylation of akt and of iκb, leading to increased nuclear translocation of nf-κb which enhances tnfα, hmgb1, and glutaminase i content. |
2023-02-15 |
2023-08-14 |
rat |
| Moritoshi Hirono, Masanori Nakat. Ghrelin signaling in the cerebellar cortex enhances GABAergic transmission onto Purkinje cells. Scientific reports. vol 13. issue 1. 2023-02-08. PMID:36750743. |
previous studies showed that ghs-r1a exists in the cerebellum, and ghrelin facilitates spontaneous firing of purkinje cells (pcs). |
2023-02-08 |
2023-08-14 |
mouse |
| Yuki Yonenobu, Goichi Beck, Kansuke Kido, Norihisa Maeda, Rika Yamashita, Kimiko Inoue, Yuko Saito, Masato Hasegawa, Hidefumi Ito, Kazuko Hasegawa, Eiichi Morii, Toru Iwaki, Shigeo Murayama, Hideki Mochizuk. Neuropathology of spinocerebellar ataxia type 8: Common features and unique tauopathy. Neuropathology : official journal of the Japanese Society of Neuropathology. 2023-01-27. PMID:36703300. |
severe neuronal loss in the substantia nigra and prominent loss of purkinje cells, atrophy of the molecular layer, and proliferation of bergmann glia in the cerebellum were common features. |
2023-01-27 |
2023-08-14 |
Not clear |
| Ksenia S Marinina, Ilya B Bezprozvanny, Polina A Egorov. Cognitive Decline and Mood Alterations in the Mouse Model of Spinocerebellar Ataxia Type 2. Cerebellum (London, England). 2023-01-21. PMID:36680704. |
the expression of the mutant ataxin-2 specifically in the cerebellar purkinje cells (pcs) in sca2-58q mice allowed us to study the direct involvement of the cerebellum into the cognitive and affective control. |
2023-01-21 |
2023-08-14 |
mouse |
| Sandra Furlan, Beatrice Paradiso, Elisa Greotti, Pompeo Volpe, Alessandra Nor. Calsequestrin in Purkinje cells of mammalian cerebellum. Acta histochemica. vol 125. issue 2. 2023-01-20. PMID:36669254. |
calsequestrin in purkinje cells of mammalian cerebellum. |
2023-01-20 |
2023-08-14 |
human |
| Ida Margrethe Uggerud, Torbjørn Kråkenes, Hirokazu Hirai, Christian Alexander Vedeler, Manja Schuber. Development and Optimization of a Multilayer Rat Purkinje Neuron Culture. Cerebellum (London, England). 2023-01-10. PMID:36626013. |
elucidation of the mechanisms involved in neurodegenerative diseases of the cerebellum has been hampered by the lack of robust single cell models to study purkinje neurons and replicate at the same time in vivo features. |
2023-01-10 |
2023-08-14 |
rat |
| Gabriella Meier Bürgisser, Dorothea M Heuberger, Nicola Schaffner, Pietro Giovanoli, Maurizio Calcagni, Johanna Buschman. Delineation of the healthy rabbit heart by immunohistochemistry - A technical note. Acta histochemica. vol 125. issue 1. 2022-12-30. PMID:36584538. |
as for the purkinje cells that were depicted in the heart and the cerebellum (purkinje neurons), we found gt staining most suitable to depict them in the heart, while he as well as el staining was ideal to depict purkinje neurons in the cerebellum. |
2022-12-30 |
2023-08-14 |
rabbit |
| Sophia S Loschky, Giovanna Maria Spano, William Marshall, Andrea Schroeder, Kelsey Marie Nemec, Shannon Sandra Schiereck, Luisa de Vivo, Michele Bellesi, Sebastian Weyn Banningh, Giulio Tononi, Chiara Cirell. Ultrastructural effects of sleep and wake on the parallel fiber synapses of the cerebellum. eLife. vol 11. 2022-12-28. PMID:36576248. |
the cerebellum is highly plastic and the purkinje cells, the sole output neurons of the cerebellar cortex, are endowed with a staggering number of excitatory parallel fiber synapses. |
2022-12-28 |
2023-08-14 |
mouse |
| Magdalena Gąssowska-Dobrowolska, Agnieszka Kolasa, David Q Beversdorf, Agata Adamczy. Alterations in Cerebellar Microtubule Cytoskeletal Network in a ValproicAcid-Induced Rat Model of Autism Spectrum Disorders. Biomedicines. vol 10. issue 12. 2022-12-23. PMID:36551785. |
immunohistochemical staining showed chromatolysis in the cerebellum of autistic-like rats and loss of purkinje cells shedding light on one of the possible molecular mechanisms underpinning neuroplasticity alterations in the asd brain. |
2022-12-23 |
2023-08-14 |
rat |
| Yang Hee Kim, Tae-Kyeong Lee, Jae-Chul Lee, Dae Won Kim, Seongkweon Hong, Jun Hwi Cho, Myoung Cheol Shin, Soo Young Choi, Moo-Ho Won, Il Jun Kan. Therapeutic Administration of Oxcarbazepine Saves Cerebellar Purkinje Cells from Ischemia and Reperfusion Injury Induced by Cardiac Arrest through Attenuation of Oxidative Stress. Antioxidants (Basel, Switzerland). vol 11. issue 12. 2022-12-23. PMID:36552657. |
in brief, this study shows that therapeutic treatment with oxcarbazepine after ca apparently saved cerebellar neurons (purkinje cells) from ca-induced neuronal death by attenuating oxidative stress and suggests that oxcarbazepine can be utilized as a therapeutic medicine for ischemia and reperfusion brain (cerebellar) injury induced by ca. |
2022-12-23 |
2023-08-14 |
rat |
| Mohamed Gaber Shala. Amelioration of mercuric chloride-induced physiologic and histopathologic alterations in rats using vitamin E and zinc chloride supplement. Heliyon. vol 8. issue 12. 2022-12-22. PMID:36544834. |
shrinkage and deterioration of purkinje cells of the cerebellum were observed in response to mercuric chloride toxicity. |
2022-12-22 |
2023-08-14 |
rat |
| Mario Mant. The underpinnings of cerebellar ataxias. Clinical neurophysiology practice. vol 7. 2022-12-12. PMID:36504687. |
the layer of purkinje neurons inhibit cerebellar nuclei, the sole output of the cerebellar circuitry, as well as vestibular nuclei. |
2022-12-12 |
2023-08-14 |
human |
| Akbar A Fidahussain, Ali Abid, Awais A Paracha, Varun E Jeevan, Joseph Rueve, Mckimmon Engelhardt, Cody Schrock, Sofia Ghani, Hari K Nai. An Etiological Investigation of Paraneoplastic Cerebellar Degeneration in Ovarian Cancer Patients: A Systematic Review. Cureus. vol 14. issue 11. 2022-12-09. PMID:36483902. |
paraneoplastic cerebellar degeneration (pcd) is a pns that is described as an autoimmune response targeting purkinje cells in the cerebellum. |
2022-12-09 |
2023-08-14 |
human |
| Hunter E Halverson, Jinsook Kim, Andrei Khilkevich, Michael D Mauk, George J Augustin. Feedback inhibition underlies new computational functions of cerebellar interneurons. eLife. vol 11. 2022-12-08. PMID:36480240. |
the function of a feedback inhibitory circuit between cerebellar purkinje cells and molecular layer interneurons (mlis) was defined by combining optogenetics, neuronal activity recordings both in cerebellar slices and |
2022-12-08 |
2023-08-14 |
Not clear |
| Ella Borgenheimer, Katherine Hamel, Carrie Sheeler, Francisco Labrada Moncada, Kaelin Sbrocco, Ying Zhang, Marija Cvetanovi. Single nuclei RNA sequencing investigation of the Purkinje cell and glial changes in the cerebellum of transgenic Spinocerebellar ataxia type 1 mice. Frontiers in cellular neuroscience. vol 16. 2022-12-02. PMID:36457352. |
spinocerebellar ataxia type 1 (sca1) is a progressive neurodegenerative disease characterized by a severe degeneration of cerebellar purkinje cells (pcs) and cerebellar gliosis. |
2022-12-02 |
2023-08-14 |
mouse |
| Aysegul Dilsizoglu Senol, Giulia Pinto, Maxime Beau, Vincent Guillemot, Jeffrey L Dupree, Christine Stadelmann, Jonas Ranft, Catherine Lubetzki, Marc Davenn. Alterations of the axon initial segment in multiple sclerosis grey matter. Brain communications. vol 4. issue 6. 2022-12-01. PMID:36451656. |
using immunohistochemistry, we analysed axon initial segments from control and multiple sclerosis tissue, focusing on layer 5/6 pyramidal neurons in the neocortex and purkinje cells in the cerebellum and performed analysis on the parameters known to control neuronal excitability, i.e. |
2022-12-01 |
2023-08-14 |
Not clear |