| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuanjun Luo, Yuhan Chao, Richard Nana Abankwah Owusu-Mensah, Jingyun Zhang, Tatsumi Hirata, Izumi Sugihar. Neurogenic timing of the inferior olive subdivisions is related to the olivocerebellar projection topography. Scientific reports. vol 13. issue 1. 2023-05-02. PMID:37130860. |
the olivocerebellar projection is organized into an intricate topographical connection from the inferior olive (io) subdivisions to the longitudinally-striped compartments of cerebellar purkinje cells (pcs), to play an essential role in cerebellar coordination and learning. |
2023-05-02 |
2023-08-14 |
mouse |
| Ferit Durankuş, Korkut Budak, Yakup Albayrak, İbrahim H Sever, Bahattin Özkul, Yigit Uyanıkgil, Neslihan Albayrak, Oytun Erba. Atorvastatin Improves the Propionic Acid-Induced Autism in Rats: The Roles of Sphingosine-1-Phosphate and Anti-inflammatory Action. Cureus. vol 15. issue 3. 2023-05-01. PMID:37123681. |
in histopathology assessments, the ppa+atorvastatin group was found to have significantly higher neuronal counts of ca1 and ca2 in the hippocampus, and purkinje cells in the cerebellum. |
2023-05-01 |
2023-08-14 |
rat |
| Fengjiao Liu, Shen Li, Xin Zhao, Saisai Xue, Hao Li, Guochao Yang, Ying Li, Yan Wu, Lingling Zhu, Liping Chen, Haitao W. O-GlcNAcylation Is Required for the Survival of Cerebellar Purkinje Cells by Inhibiting ROS Generation. Antioxidants (Basel, Switzerland). vol 12. issue 4. 2023-04-28. PMID:37107182. |
purkinje cells (pcs), as a unique type of neurons output from the cerebellar cortex, are essential for the development and physiological function of the cerebellum. |
2023-04-28 |
2023-08-14 |
mouse |
| An Cheng, Ichiro Kawahata, Yifei Wang, Wenbin Jia, Wang Haoyang, Tomoki Sekimori, Yi Chen, Hiroyoshi Suzuki, Atsushi Takeda, Nadia Stefanova, David I Finkelstein, Wenbo Ma, Min Chen, Takuya Sasaki, Kohji Fukunag. Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagation. Brain : a journal of neurology. 2023-04-21. PMID:37082980. |
moreover, the injected fabp7/αsyn hetero-aggregates in mice selectively accumulated only in oligodendrocytes and purkinje neurons, causing cerebellar dysfunction. |
2023-04-21 |
2023-08-14 |
mouse |
| An Cheng, Ichiro Kawahata, Yifei Wang, Wenbin Jia, Wang Haoyang, Tomoki Sekimori, Yi Chen, Hiroyoshi Suzuki, Atsushi Takeda, Nadia Stefanova, David I Finkelstein, Wenbo Ma, Min Chen, Takuya Sasaki, Kohji Fukunag. Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagation. Brain : a journal of neurology. 2023-04-21. PMID:37082980. |
lastly, aav5-dependent epsin-2 knock-down mice exhibited decreased levels of αsyn aggregate accumulation in purkinje neurons and oligodendrocytes, as well as improved myelin levels and purkinje neuron function in the cerebellum and motor performance. |
2023-04-21 |
2023-08-14 |
mouse |
| Svethna Ribeiro, Rachel M Sherrar. Cerebellum and neurodevelopmental disorders: RORα is a unifying force. Frontiers in cellular neuroscience. vol 17. 2023-04-17. PMID:37066074. |
evidence has been assembled from cerebellar abnormalities in autistic patients, as well as a range of genetic mutations identified in human patients that affect the cerebellar circuit, particularly purkinje cells, and are associated with deficits of motor function, learning and social behavior; traits that are commonly associated with autism and schizophrenia. |
2023-04-17 |
2023-08-14 |
human |
| Sung Won Hur, Karen Safaryan, Long Yang, Hugh T Blair, Sotiris C Masmanidis, Paul J Mathews, Daniel Aharoni, Peyman Golshan. Correlated signatures of social behavior in cerebellum and anterior cingulate cortex. bioRxiv : the preprint server for biology. 2023-04-17. PMID:37066345. |
during social behavior, we recorded the spike timing of multiple single units in cerebellar right crus i (rcrus i) purkinje cells (pcs) or dentate nucleus (dn) neurons while synchronously imaging calcium transients in contralateral acc neurons. |
2023-04-17 |
2023-08-14 |
mouse |
| Shu-Tao Xie, Wen-Chu Fan, Xian-Sen Zhao, Xiao-Yang Ma, Ze-Lin Li, Yan-Ran Zhao, Fa Yang, Ying Shi, Hui Rong, Zhi-San Cui, Jun-Yi Chen, Hong-Zhao Li, Chao Yan, Qipeng Zhang, Jian-Jun Wang, Xiao-Yang Zhang, Xiao-Ping Gu, Zheng-Liang Ma, Jing-Ning Zh. Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia. Pharmacological research. 2023-04-17. PMID:37068531. |
proinflammatory activation of microglia in the cerebellum hyperexcites purkinje cells to trigger ataxia. |
2023-04-17 |
2023-08-14 |
mouse |
| Shu-Tao Xie, Wen-Chu Fan, Xian-Sen Zhao, Xiao-Yang Ma, Ze-Lin Li, Yan-Ran Zhao, Fa Yang, Ying Shi, Hui Rong, Zhi-San Cui, Jun-Yi Chen, Hong-Zhao Li, Chao Yan, Qipeng Zhang, Jian-Jun Wang, Xiao-Yang Zhang, Xiao-Ping Gu, Zheng-Liang Ma, Jing-Ning Zh. Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia. Pharmacological research. 2023-04-17. PMID:37068531. |
mechanistically, cerebellar microglial proinflammatory activation induced by either chemogenetic m3d(gq) stimulation or 3-ap modeling hyperexcites purkinje cells (pcs), which consequently triggers ataxia. |
2023-04-17 |
2023-08-14 |
mouse |
| Samar Ramadan Mohammed, Khaled Elmasry, Randa El-Gamal, Mona A El-Shahat, Rania Naeem Sheri. Alteration of Aquaporins 1 and 4 immunohistochemical and gene expression in the cerebellum of diabetic albino rat. Tissue & cell. vol 82. 2023-03-29. PMID:36989704. |
diabetes caused degenerative changes in purkinje cells with a significant increase in the cerebellar level of mda and aqp1 immunoreactivity and a significant decrease in gsh level and aqp4 expression levels. |
2023-03-29 |
2023-08-14 |
rat |
| Maxine D Rouvroye, Hetty J Bontkes, John G J M Bol, Birgit Lissenberg-Witte, Valerie Byrnes, Fadel Bennani, Ekaterina S Jordanova, Micha M M Wilhelmus, Chris J Mulder, Paul van der Valk, Annemieke J M Rozemuller, Gerd Bouma, Anne-Marie Van Da. Cerebellar presence of immune cells in patients with neuro-coeliac disease. Acta neuropathologica communications. vol 11. issue 1. 2023-03-25. PMID:36966322. |
our aim was to determine if the loss of neurons, especially purkinje cells, coincides with microglia activation and t- and b-cell infiltration in the cerebellum of patients with cd and a concomitant idiopathic neurological disease affecting the cerebellum (neurocd). |
2023-03-25 |
2023-08-14 |
Not clear |
| Maxine D Rouvroye, Hetty J Bontkes, John G J M Bol, Birgit Lissenberg-Witte, Valerie Byrnes, Fadel Bennani, Ekaterina S Jordanova, Micha M M Wilhelmus, Chris J Mulder, Paul van der Valk, Annemieke J M Rozemuller, Gerd Bouma, Anne-Marie Van Da. Cerebellar presence of immune cells in patients with neuro-coeliac disease. Acta neuropathologica communications. vol 11. issue 1. 2023-03-25. PMID:36966322. |
these findings demonstrate that the massive loss of purkinje cells in the cerebellum of neuro cd patients is accompanied by local innate and t-cell mediated immune responses. |
2023-03-25 |
2023-08-14 |
Not clear |
| Sunmi Yoon, Napissara Boonpraman, Chae Young Kim, Jong-Seok Moon, Sun Shin Y. Reduction of fetuin-A levels contributes to impairment of Purkinje cells in cerebella of patients with Parkinson's disease. BMB reports. 2023-03-20. PMID:36935573. |
along with the establishment of a pd mouse model, abnormal shapes such as arrangement and number of purkinje cells in the cerebellum were confirmed based on histological finding, consistent with those of cerebellums of pd patients. |
2023-03-20 |
2023-08-14 |
mouse |
| Sunmi Yoon, Napissara Boonpraman, Chae Young Kim, Jong-Seok Moon, Sun Shin Y. Reduction of fetuin-A levels contributes to impairment of Purkinje cells in cerebella of patients with Parkinson's disease. BMB reports. 2023-03-20. PMID:36935573. |
as a result of proteome profiling for neuroinflammation using pd mouse cerebellar tissues, fetuin-a, a type of cytokine, was found to be significantly reduced in purkinje cells. |
2023-03-20 |
2023-08-14 |
mouse |
| Sunmi Yoon, Napissara Boonpraman, Chae Young Kim, Jong-Seok Moon, Sun Shin Y. Reduction of fetuin-A levels contributes to impairment of Purkinje cells in cerebella of patients with Parkinson's disease. BMB reports. 2023-03-20. PMID:36935573. |
in this study, we found a functional gene called fetuin-a in the pd model's cerebellum, which was closely related to the role of cerebellar purkinje cells of mouse and human pd. |
2023-03-20 |
2023-08-14 |
mouse |
| Sunmi Yoon, Napissara Boonpraman, Chae Young Kim, Jong-Seok Moon, Sun Shin Y. Reduction of fetuin-A levels contributes to impairment of Purkinje cells in cerebella of patients with Parkinson's disease. BMB reports. 2023-03-20. PMID:36935573. |
in conclusion, morphological abnormalities of purkinje cells in pd mice and patients have a close relationship with a decrease of fetuin-a, suggesting that diagnosis and treatment of cerebellar functions of pd patients might be possible through regulation of fetuin-a. |
2023-03-20 |
2023-08-14 |
mouse |
| Polina A Egorova, Ksenia S Marinina, Ilya B Bezprozvann. Chronic suppression of STIM1-mediated calcium signaling in Purkinje cells rescues the cerebellar pathology in spinocerebellar ataxia type 2. Biochimica et biophysica acta. Molecular cell research. 2023-03-20. PMID:36940741. |
chronic suppression of stim1-mediated calcium signaling in purkinje cells rescues the cerebellar pathology in spinocerebellar ataxia type 2. |
2023-03-20 |
2023-08-14 |
mouse |
| Luana Abballe, Vincenzo Alfano, Celeste Antonacci, Maria Giuseppina Cefalo, Antonella Cacchione, Giada Del Baldo, Marco Pezzullo, Agnese Po, Marta Moretti, Angela Mastronuzzi, Enrico De Smaele, Elisabetta Ferretti, Franco Locatelli, Evelina Miel. β-arrestin1-E2F1-ac axis regulates physiological apoptosis and cell cycle exit in cellular models of early postnatal cerebellum. Frontiers in cell and developmental biology. vol 11. 2023-03-16. PMID:36923256. |
development of the cerebellum is characterized by rapid proliferation of cerebellar granule cell precursors (gcps) induced by paracrine stimulation of sonic hedgehog (shh) signaling from purkinje cells, in the external granular layer (egl). |
2023-03-16 |
2023-08-14 |
Not clear |
| Takahiro Fujimoto, Kirsten Stam, Takeshi Yaoi, Kenta Nakano, Tetsuya Arai, Tadashi Okamura, Kyoko Ito. Dystrophin Short Product, Dp71, Interacts with AQP4 and Kir4.1 Channels in the Mouse Cerebellar Glial Cells in Contrast to Dp427 at Inhibitory Postsynapses in the Purkinje Neurons. Molecular neurobiology. 2023-03-15. PMID:36918517. |
dystrophin short product, dp71, interacts with aqp4 and kir4.1 channels in the mouse cerebellar glial cells in contrast to dp427 at inhibitory postsynapses in the purkinje neurons. |
2023-03-15 |
2023-08-14 |
mouse |
| Takahiro Fujimoto, Kirsten Stam, Takeshi Yaoi, Kenta Nakano, Tetsuya Arai, Tadashi Okamura, Kyoko Ito. Dystrophin Short Product, Dp71, Interacts with AQP4 and Kir4.1 Channels in the Mouse Cerebellar Glial Cells in Contrast to Dp427 at Inhibitory Postsynapses in the Purkinje Neurons. Molecular neurobiology. 2023-03-15. PMID:36918517. |
in order to investigate the dp71 expression profile in cerebellum, we employed dp71-specific tag-insertion mice, which allowed for the specific detection of endogenous dp71 in the immunohistochemical analysis and found its expressions in the glial cells, bergmann glial (bg) cells, and astrocytes, whereas dp427 was exclusively expressed in the inhibitory postsynapses within cerebellar purkinje cells (pcs). |
2023-03-15 |
2023-08-14 |
mouse |