| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chigure Suzuki, Junji Yamaguchi, Shun Mitsui, Takahito Sanada, Juan Alejandro Oliva Trejo, Soichirou Kakuta, Kenichi Tanaka, Yukari Suda, Taku Hatano, Nobutaka Hattori, Isei Tanida, Yasuo Uchiyam. Direct evidence for ultrastructures of the α-synuclein-associated synaptic vesicle pool in presynaptic terminals. Biochimica et biophysica acta. Molecular basis of disease. vol 1870. issue 8. 2024-09-05. PMID:39233262. |
α-synuclein-mkate2 accumulated in presynaptic terminals, particularly between purkinje cells in the cerebellum and neurons in cerebellar nuclei. |
2024-09-05 |
2024-09-08 |
mouse |
| Simon Bossi, Hervé Daniel, Heather McLea. Interplay between metabotropic glutamate type 4 and adenosine type 1 receptors modulate synaptic transmission in the cerebellar cortex. Frontiers in pharmacology. vol 15. 2024-08-30. PMID:39211784. |
the synapses between parallel fibers and purkinje cells play a pivotal role in cerebellar function. |
2024-08-30 |
2024-09-04 |
mouse |
| Simon Bossi, Hervé Daniel, Heather McLea. Interplay between metabotropic glutamate type 4 and adenosine type 1 receptors modulate synaptic transmission in the cerebellar cortex. Frontiers in pharmacology. vol 15. 2024-08-30. PMID:39211784. |
employing a combination of whole-cell patch clamp recordings of purkinje cells and parallel fiber presynaptic fluorometric calcium measurements in acute rat and mouse cerebellar cortical slices, our results reveal functional interactions between these receptor types. |
2024-08-30 |
2024-09-04 |
mouse |
| Mustafa Ozkaraca, Selcuk Ozdemir, Selim Comakli, Mehmet Ozkan Timurka. Roles of apoptosis and autophagy in natural rabies infections. Veterinarni medicina. vol 67. issue 1. 2024-08-22. PMID:39169958. |
lc3b immunopositivity was detected in the cytoplasm of the purkinje cells in the cerebellum of the cows, horses and donkeys, and also in the cytoplasm of the neurons in the cornu ammonis of the dogs and cats. |
2024-08-22 |
2024-08-24 |
Not clear |
| Ioannis Mavroudis, Foivos Petridi. Neuropathological findings in essential tremor. Folia neuropathologica. 2024-08-21. PMID:39165215. |
two brain areas have been consistently found to present neuropathological alterations in patients with et: the brainstem, for presence of lewy bodies or neuronal depletion, and the cerebellum, regarding purkinje cells' morphology and density. |
2024-08-21 |
2024-08-23 |
Not clear |
| Guochao Yang, Yinghong Yang, Zhihong Song, Liping Chen, Fengjiao Liu, Ying Li, Shaofei Jiang, Saisai Xue, Jie Pei, Yan Wu, Yuanlin He, Bo Chu, Haitao W. Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration. Neuron. 2024-08-17. PMID:39153477. |
here, we demonstrate that specific ablation of eftud2 in cerebellar purkinje cells (pcs) in mice results in severe ferroptosis, pc degeneration, dyskinesia, and cerebellar atrophy, which recapitulates phenotypes observed in patients with mfdm. |
2024-08-17 |
2024-08-20 |
mouse |
| Riya Elizabeth Thomas, Franziska Mudlaff, Kyra Schweers, W Todd Farmer, Aparna Suvratha. Heterogeneity in slow synaptic transmission diversifies Purkinje cell timing. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-08-15. PMID:39147589. |
here, we describe a previously unappreciated form of synaptic heterogeneity at parallel fiber synapses to purkinje cells in the mouse cerebellum (both sexes). |
2024-08-15 |
2024-08-18 |
mouse |
| Shuangchan Wu, Pingting Liu, Marija Cvetanovic, Wensheng Li. Endoplasmic reticulum associated degradation preserves neurons viability by maintaining endoplasmic reticulum homeostasis. Frontiers in neuroscience. vol 18. 2024-08-14. PMID:39135735. |
moreover, we found that cerebellar and hippocampal atrophy in these mice resulted from degeneration of purkinje neurons and hippocampal neurons, respectively. |
2024-08-14 |
2024-08-16 |
mouse |
| Omnia I Ismail, Hala Mohamed Hassani. Ameliorative effects of gallic acid on tebuconazole-induced adverse effects in the cerebellum of adult albino rats: histopathological and immunohistochemical evidence. Ultrastructural pathology. 2024-08-06. PMID:39105544. |
teb exposure led to neuronal damage in the form of degenerated purkinje cells with vacuolated cytoplasm, areas of lost purkinje cells, the basket cells appeared vacuolated with degenerated neuropil, the granule cells clumped with congested areas between them, dilated cerebellar islands, weak positive bcl2 immunoreactions in the purkinje cells, and numerous gfap-positive astrocytes. |
2024-08-06 |
2024-08-08 |
rat |
| Yuki Yoshioka, Yong Huang, Xiaocen Jin, Kien Xuan Ngo, Tomohiro Kumaki, Meihua Jin, Saori Toyoda, Sumire Takayama, Maiko Inotsume, Kyota Fujita, Hidenori Homma, Toshio Ando, Hikari Tanaka, Hitoshi Okazaw. PQBP3 prevents senescence by suppressing PSME3-mediated proteasomal Lamin B1 degradation. The EMBO journal. 2024-08-05. PMID:39103492. |
consistently, knock-in mice expressing mutant atxn1 exhibit decreased nuclear pqbp3 and a senescence phenotype in purkinje cells of the cerebellum. |
2024-08-05 |
2024-08-08 |
mouse |
| Kaelin Sbrocco, Ella Borgenheimer, Ying Zhang, Mike Koob, Marija Cvetanovi. Cerebellar contribution to cognitive deficits and prefrontal cortex dysfunction in Spinocerebellar Ataxia Type 1 (SCA1). bioRxiv : the preprint server for biology. 2024-07-19. PMID:39026827. |
spinocerebellar ataxia type 1 (sca1), is an inherited, fatal neurodegenerative disease caused by an abnormal expansion of glutamine (q) encoding cag repeats in the gene ataxin-1 (atxn1) and characterized by severe loss of purkinje cells (pcs) in the cerebellum. |
2024-07-19 |
2024-07-21 |
mouse |
| Lin-Yan Huang, Yi-Ning Liu, Jie Chen, Hai-Xue Zhu, Li-Li Li, Zhi-Yan Liang, Jin-Xiu Song, Yu-Jie Li, Zhao-Li Hu, Dieter Demon, Andy Wullaert, Wan Wang, Su-Hua Q. Caspase-12 is Expressed in Purkinje Neurons and Prevents Psychiatric-Like Behavior in Mice. Molecular neurobiology. 2024-07-18. PMID:39023795. |
strikingly, these reporter mice showed that caspase-12 is expressed explicitly in purkinje neurons of the cerebellum. |
2024-07-18 |
2024-07-20 |
mouse |
| Kim M Gruver, Jenny W Y Jiao, Eviatar Fields, Sen Song, Per Jesper Sjöström, Alanna J Wat. Structured connectivity in the output of the cerebellar cortex. Nature communications. vol 15. issue 1. 2024-07-09. PMID:38982047. |
in the cerebellum, the major output of the cerebellar cortex are synapses made from purkinje cells onto neurons in the cerebellar nuclei, yet little has been known about the spatial organization of these synapses. |
2024-07-09 |
2024-07-12 |
mouse |
| Hisako Nakayama, Taisuke Miyazaki, Manabu Abe, Maya Yamazaki, Yoshinobu Kawamura, Myeongjeong Choo, Kohtarou Konno, Shinya Kawata, Naofumi Uesaka, Kouichi Hashimoto, Mariko Miyata, Kenji Sakimura, Masahiko Watanabe, Masanobu Kan. Direct and indirect pathways for heterosynaptic interaction underlying developmental synapse elimination in the mouse cerebellum. Communications biology. vol 7. issue 1. 2024-07-04. PMID:38961250. |
in the neonatal mouse cerebellum, purkinje cells (pcs) receive excitatory synaptic inputs from multiple climbing fibers (cfs) and synapses from all but one cf are eliminated by around postnatal day 20. |
2024-07-04 |
2024-07-08 |
mouse |
| Hélène Cwerman-Thibault, Vassilissa Malko-Baverel, Gwendoline Le Guilloux, Isabel Torres-Cuevas, Edward Ratcliffe, Djmila Mouri, Virginie Mignon, Bruno Saubaméa, Odile Boespflug-Tanguy, Pierre Gressens, Marisol Corral-Debrinsk. Harlequin mice exhibit cognitive impairment, severe loss of Purkinje cells and a compromised bioenergetic status due to the absence of Apoptosis Inducing Factor. Biochimica et biophysica acta. Molecular basis of disease. 2024-06-19. PMID:38897257. |
we evaluated the progression of cerebellar degeneration in harlequin mice, especially for purkinje cells and its relationship with bioenergetics failure and behavioral damage. |
2024-06-19 |
2024-06-22 |
mouse |
| Martha G Garcia-Garcia, Akash Kapoor, Oluwatobi Akinwale, Lina Takemaru, Tony Hyun Kim, Casey Paton, Ashok Litwin-Kumar, Mark J Schnitzer, Liqun Luo, Mark J Wagne. A cerebellar granule cell-climbing fiber computation to learn to track long time intervals. Neuron. 2024-06-13. PMID:38870929. |
in classical cerebellar learning, purkinje cells (pkcs) associate climbing fiber (cf) error signals with predictive granule cells (grcs) that were active just prior (∼150 ms). |
2024-06-13 |
2024-06-16 |
mouse |
| Yuhao Yan, Timothy H Murph. Decoding state-dependent cortical-cerebellar cellular functional connectivity in the mouse brain. Cell reports. vol 43. issue 6. 2024-06-12. PMID:38865245. |
these cortical-cerebellar connectivity features are observed in mossy fibers and purkinje cells as well as neurons in different cerebellar lobules, albeit with variations across cell types and regions. |
2024-06-12 |
2024-06-15 |
mouse |
| Jennifer L Fessler, Megan A Stiles, Martin-Paul Agbaga, Mohiuddin Ahmad, David M Sherr. The Spinocerebellar Ataxia 34-Causing W246G ELOVL4 Mutation Does Not Alter Cerebellar Neuron Populations in a Rat Model. Cerebellum (London, England). 2024-06-08. PMID:38850484. |
to test whether w246g elovl4 altered neuronal generation or survival in the cerebellum, we compared the numbers of purkinje cells, unipolar brush cells, molecular layer interneurons, granule and displaced granule cells in the cerebellum of wildtype, heterozygous, and homozygous sca34-ki rats at four months of age, when motor impairment is already present. |
2024-06-08 |
2024-06-11 |
human |
| D González-Tapia, N Vázquez-Hernández, F Urmeneta-Ortiz, N Navidad-Hernandez, M Lazo-Yepez, A Tejeda-Martínez, M Flores-Soto, I González-Burgo. 3-Acetylpyridine-induced ataxic-like motor impairments are associated with plastic changes in the Purkinje cells of the rat cerebellum. Neurologia. vol 39. issue 5. 2024-06-03. PMID:38830720. |
3-acetylpyridine-induced ataxic-like motor impairments are associated with plastic changes in the purkinje cells of the rat cerebellum. |
2024-06-03 |
2024-06-06 |
rat |
| D González-Tapia, N Vázquez-Hernández, F Urmeneta-Ortiz, N Navidad-Hernandez, M Lazo-Yepez, A Tejeda-Martínez, M Flores-Soto, I González-Burgo. 3-Acetylpyridine-induced ataxic-like motor impairments are associated with plastic changes in the Purkinje cells of the rat cerebellum. Neurologia. vol 39. issue 5. 2024-06-03. PMID:38830720. |
in addition, in purkinje cells from lobules v-vii of the cerebellar vermis studied by the golgi method, the density of dendritic spines decreased, especially the thin and mushroom types. |
2024-06-03 |
2024-06-06 |
rat |