| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D González-Tapia, N Vázquez-Hernández, F Urmeneta-Ortiz, N Navidad-Hernandez, M Lazo-Yepez, A Tejeda-Martínez, M Flores-Soto, I González-Burgo. 3-Acetylpyridine-induced ataxic-like motor impairments are associated with plastic changes in the Purkinje cells of the rat cerebellum. Neurologia. vol 39. issue 5. 2024-06-03. PMID:38830720. |
findings suggest a limited capacity of purkinje cells to acquire and consolidate afferent excitatory inputs and an aberrant, rigid profile in the movement-related output patterns of purkinje neurons that likely contributes to the motor-related impairments characteristic of cerebellar ataxias. |
2024-06-03 |
2024-06-06 |
rat |
| Rhydham Karnik, Aliasgar Vohra, Mahamadtezib Khatri, Nilay Dalvi, Hitarthi S Vyas, Helly Shah, Sujitsinh Gohil, Smit Kanojiya, Ranjitsinh Devka. Diet/photoperiod mediated changes in cerebellar clock genes causes locomotor shifts and imperative changes in BDNF-TrkB pathway. Neuroscience letters. 2024-05-31. PMID:38821201. |
nuclear pyknosis of purkinje cells, their derangement and inflammation were the hallmark of cerebellar tissue of all the three experimental groups. |
2024-05-31 |
2024-06-02 |
Not clear |
| Ting-Feng Lin, Silas E Busch, Christian Hanse. Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum. Nature communications. vol 15. issue 1. 2024-05-31. PMID:38821918. |
intrinsic and synaptic determinants of receptive field plasticity in purkinje cells of the mouse cerebellum. |
2024-05-31 |
2024-06-02 |
mouse |
| b' Eirik Tveit Solheim, Yola Gerking, Torbj\xf8rn Kr\xe5kenes, Ida Herdlev\xe6r, Even Birkeland, Cecilie Totland, Fiona Dick, Christian Alexander Vedele. Multi-omics profiling reveals dysregulated ribosome biogenesis and impaired cell proliferation following knockout of CDR2L. BMC cancer. vol 24. issue 1. 2024-05-28. PMID:38802745.' |
cerebellar degeneration-related (cdr) proteins are associated with paraneoplastic cerebellar degeneration (pcd) - a rare, neurodegenerative disease caused by tumour-induced autoimmunity against neural antigens resulting in degeneration of purkinje neurons in the cerebellum. |
2024-05-28 |
2024-05-31 |
Not clear |
| Xiaolin Liang, Meng Gong, Zhikai Wang, Jie Wang, Weiwei Guo, Aoling Cai, Zhenye Yang, Xing Liu, Fuqiang Xu, Wei Xiong, Chuanhai Fu, Xiangting Wan. LncRNA TubAR complexes with TUBB4A and TUBA1A to promote microtubule assembly and maintain myelination. Cell discovery. vol 10. issue 1. 2024-05-23. PMID:38769343. |
tubar knockdown in mouse cerebellum causes loss of oligodendrocytes and purkinje cells, demyelination, and decreased locomotor activity. |
2024-05-23 |
2024-05-27 |
mouse |
| D Alwyn Dart, Charlotte L Bevan, Pinar Uysal-Onganer, Wen Guo Jian. Analysis of androgen receptor expression and activity in the mouse brain. Scientific reports. vol 14. issue 1. 2024-05-15. PMID:38750183. |
ar-driven luciferase activity and distinct nuclear staining for ar were seen in several key brain areas including the thalamus, hypothalamus, olfactory bulb, cerebral cortex, purkinje cells of the cerebellum and the hindbrain. |
2024-05-15 |
2024-05-27 |
mouse |
| Yuxin Zhang, Xiaoqing Pei, Lingyang Jing, Qingyu Zhang, Hongfeng Zha. Lead induced cerebellar toxicology of developmental Japanese quail (Coturnix japonica) via oxidative stress-based Nrf2/Keap1 pathway inhibition and glutathione-mediated apoptosis signaling activation. Environmental pollution (Barking, Essex : 1987). vol 352. 2024-05-10. PMID:38718965. |
the results showed pb caused cerebellar microstructural damages charactered by deformation of neuroglia cells, granule cells and purkinje cells with nissl body changes. |
2024-05-10 |
2024-05-27 |
Not clear |
| Joan S Baize. Neuroanatomy of autism: what is the role of the cerebellum? Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 13. 2024-05-02. PMID:38696597. |
both neuropathological and imaging studies found differences in the cerebellum in autism spectrum disorder, the most widely documented being a decreased density of purkinje cells in the cerebellar cortex. |
2024-05-02 |
2024-05-05 |
Not clear |
| Anna Niewiadomska-Cimicka, Lorraine Fievet, Magdalena Surdyka, Ewelina Jesion, Céline Keime, Elisabeth Singer, Aurélie Eisenmann, Zaneta Kalinowska-Poska, Hoa Huu Phuc Nguyen, Agnieszka Fiszer, Maciej Figiel, Yvon Trottie. AAV-Mediated CAG-Targeting Selectively Reduces Polyglutamine-Expanded Protein and Attenuates Disease Phenotypes in a Spinocerebellar Ataxia Mouse Model. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673939. |
polyq-expanded sca proteins are toxic for cerebellar neurons, with purkinje cells (pcs) being the most vulnerable. |
2024-04-27 |
2024-04-29 |
mouse |
| Ke Zhang, Zhen Yang, Michael A Gaffield, Garrett G Gross, Don B Arnold, Jason M Christi. Molecular layer disinhibition unlocks climbing-fiber-instructed motor learning in the cerebellum. bioRxiv : the preprint server for biology. 2024-04-26. PMID:38654827. |
climbing fibers supervise cerebellar learning by providing signals to purkinje cells (pcs) that instruct adaptive changes to mistakenly performed movements. |
2024-04-26 |
2024-04-28 |
mouse |
| Jay S Pi, Mohammad Amin Fakharian, Paul Hage, Ehsan Sedaghat-Nejad, Salomon Z Muller, Reza Shadmeh. The olivary input to the cerebellum dissociates sensory events from movement plans. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 17. 2024-04-17. PMID:38630714. |
neurons in the inferior olive are thought to anatomically organize the purkinje cells (p-cells) of the cerebellum into computational modules, but what is computed by each module? |
2024-04-17 |
2024-04-20 |
human |
| C'iana P Cooper, Liam H Cheng, Jafar A Bhatti, Edward L Rivera, Derek Huell, Cristina Banuelos, Evelyn J Perez, Jeffrey M Long, Peter R Rap. Cerebellum Purkinje cell vulnerability in aged rats with memory impairment. The Journal of comparative neurology. vol 532. issue 4. 2024-04-12. PMID:38605461. |
to interrogate potential substrates of the relationship between cerebellar structure and memory in aging, here we target the purkinje cells (pcs). |
2024-04-12 |
2024-04-14 |
rat |
| Emre Kul, Uchechi Okoroafor, Amanda Dougherty, Lauren Palkovic, Hao Li, Paula Valiño-Ramos, Leah Aberman, Samuel M Youn. Development of adenoviral vectors that transduce Purkinje cells and other cerebellar cell-types in the cerebellum of a humanized mouse model. Molecular therapy. Methods & clinical development. vol 32. issue 2. 2024-04-12. PMID:38605812. |
development of adenoviral vectors that transduce purkinje cells and other cerebellar cell-types in the cerebellum of a humanized mouse model. |
2024-04-12 |
2024-04-14 |
mouse |
| Emre Kul, Uchechi Okoroafor, Amanda Dougherty, Lauren Palkovic, Hao Li, Paula Valiño-Ramos, Leah Aberman, Samuel M Youn. Development of adenoviral vectors that transduce Purkinje cells and other cerebellar cell-types in the cerebellum of a humanized mouse model. Molecular therapy. Methods & clinical development. vol 32. issue 2. 2024-04-12. PMID:38605812. |
using a "humanized" hcd46 mouse model, we demonstrate these ad vectors transduce cerebellar cell types, including purkinje cells, that are refractory to ad5 transduction. |
2024-04-12 |
2024-04-14 |
mouse |
| Aïda Padilla-Ferrer, Alex Carrete, Anne Simon, Delphine Meffre, Mehrnaz Jafarian-Tehran. A disintegrin and Metalloprotease 10 expression within the murine central nervous system. Brain research. 2024-03-28. PMID:38548249. |
we observed adam10 expression through the whole cns, with a strong expression in the hippocampus, in the hypothalamus and in the cerebral and piriform cortex in the brain, in the purkinje and in granular cell layers in the cerebellum and in the spinal cord to a lower extent. |
2024-03-28 |
2024-03-31 |
mouse |
| Tariq Zaman, Daniel Vogt, Jeremy Prokop, Qusai Abdulkhaliq Alsabia, Gabriel Simms, April Stafford, Bryan W Luikart, Michael R William. Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje cells. eLife. vol 12. 2024-03-27. PMID:38536959. |
kit is enriched in molecular layer interneurons (mlis) of the cerebellar cortex (i.e., stellate and basket cells), while cerebellar kit ligand is selectively expressed by a target of their inhibition, purkinje cells (pcs). |
2024-03-27 |
2024-03-30 |
mouse |
| Spencer T Brown, Mauricio Medina-Pizarro, Meghana Holla, Christopher E Vaaga, Indira M Rama. Simple spike patterns and synaptic mechanisms encoding sensory and motor signals in Purkinje cells and the cerebellar nuclei. Neuron. 2024-03-16. PMID:38492575. |
synchrony thus allows the cbn to high-pass filter purkinje inputs, facilitating sensory-evoked cerebellar outputs that can drive movements. |
2024-03-16 |
2024-03-19 |
mouse |
| Aalok Varma, Sathvik Udupa, Mohini Sengupta, Prasanta Kumar Ghosh, Vatsala Thirumala. A machine-learning tool to identify bistable states from calcium imaging data. The Journal of physiology. 2024-03-14. PMID:38482722. |
purkinje neurons in the larval zebrafish cerebellum exhibit membrane potential bistability, firing either tonically or in bursts. |
2024-03-14 |
2024-03-16 |
mouse |
| Aalok Varma, Sathvik Udupa, Mohini Sengupta, Prasanta Kumar Ghosh, Vatsala Thirumala. A machine-learning tool to identify bistable states from calcium imaging data. The Journal of physiology. 2024-03-14. PMID:38482722. |
key points: calcium imaging, compriising the gold standard of inferring neuronal activity, does not report cellular state in neurons that are bistable, such as purkinje neurons in the cerebellum of larval zebrafish. |
2024-03-14 |
2024-03-16 |
mouse |
| Le Gui, Vasiliki Tellios, Yun-Yan Xiang, Qingping Feng, Wataru Inoue, Wei-Yang L. Neuronal Nitric Oxide Synthase Regulates Cerebellar Parallel Fiber Slow EPSC in Purkinje Neurons by Modulating STIM1-Gated TRPC3-Containing Channels. Cerebellum (London, England). 2024-03-13. PMID:38472628. |
neuronal nitric oxide synthase regulates cerebellar parallel fiber slow epsc in purkinje neurons by modulating stim1-gated trpc3-containing channels. |
2024-03-13 |
2024-03-15 |
Not clear |