| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stefano Masoli, Diana Sanchez-Ponce, Nora Vrieler, Karin Abu-Haya, Vitaly Lerner, Tal Shahar, Hermina Nedelescu, Martina Francesca Rizza, Ruth Benavides-Piccione, Javier DeFelipe, Yosef Yarom, Alberto Munoz, Egidio D'Angel. Human Purkinje cells outperform mouse Purkinje cells in dendritic complexity and computational capacity. Communications biology. vol 7. issue 1. 2024-01-03. PMID:38168772. |
purkinje cells in the cerebellum are among the largest neurons in the brain and have been extensively investigated in rodents. |
2024-01-03 |
2024-01-06 |
mouse |
| Mojtaba Mohammadpanah, Sheida Farrokhi, Mojtaba Sani, Meysam Hassani Moghaddam, Amir-Hossein Bayat, Mahdi Eskandarian Boroujeni, Mohammad-Amin Abdollahifar, Mobina Fathi, Kimia Vakili, Fatemeh Nikpour, Hossein Salehi Omran, Hossein Ahmadirad, Zeynab Ghorbani, Ali Asghar Peyvandi, Abbas Aliaghae. Exposure to Δ9-tetrahydrocannabinol leads to a rise in caspase-3, morphological changes in microglial, and astrocyte reactivity in the cerebellum of rats. Toxicology research. vol 12. issue 6. 2023-12-25. PMID:38145099. |
a decrease in the number of purkinje neurons and the thickness of the granular layer in the cerebellum was reported in thc-treated rats. |
2023-12-25 |
2023-12-27 |
rat |
| Ajith Cherian, K P Divya, A R Swathy Krishna. Familial adult myoclonus epilepsy: a pragmatic approach. Acta neurologica Belgica. 2023-12-20. PMID:38114875. |
diagnosis is based on specific neurophysiological testing, namely jerk-locked back-averaging, somatosensory evoked potentials, long latency reflex, and motor evoked potentials, among others. imaging data, including functional magnetic resonance imaging, indicate a cortical origin of the cortical myoclonic tremor and decreased cerebellar activation. cerebellar changes in purkinje cells have been noted, from few neuropathology reports, in patients from isolated pedigrees. |
2023-12-20 |
2023-12-23 |
Not clear |
| David S Ruff, Ilaria Balbo, Ruo-Yah Lai, Diarra Dieng, Charlotte Hennessey, Krish Vennam, Andrew J Dwork, Morgan McCreary, Elan D Louis, Phyllis L Faust, Sheng-Han Ku. Reduced Bergmann glial process terminations and lateral appendages in essential tremor. Annals of clinical and translational neurology. 2023-12-15. PMID:38098226. |
postmortem examination of the essential tremor cerebellum has revealed a variety of pathological changes centered in and around purkinje cells. |
2023-12-15 |
2023-12-17 |
Not clear |
| Anna A Cook, Tsz Chui Sophia Leung, Max Rice, Maya Nachman, Élyse Zadigue-Dube, Alanna Jean Wat. Endosomal dysfunction contributes to cerebellar deficits in spinocerebellar ataxia type 6. eLife. vol 12. 2023-12-12. PMID:38084749. |
patients have progressive motor coordination impairment, and postmortem brain tissue reveals degeneration of cerebellar purkinje cells and a reduced level of cerebellar brain-derived neurotrophic factor (bdnf). |
2023-12-12 |
2023-12-17 |
mouse |
| Shani Blumenreich, Doreen Padan Ben-Yashar, Tali Shalit, Meital Kupervaser, Ivan Milenkovic, Tammar Joseph, Anthony H Futerma. Proteomics analysis of the brain from a Gaucher disease mouse identifies pathological pathways including a possible role for transglutaminase 1. Journal of neurochemistry. 2023-12-10. PMID:38071490. |
one protein, transglutaminase 1 (tgm1), which is elevated in a number of neurodegenerative diseases, was absent from the control group but was found at high levels in cbe-injected mice, and located in the extracellular matrix (ecm) in layer v of the cortex and intracellularly in purkinje cells in the cerebellum. |
2023-12-10 |
2023-12-17 |
mouse |
| Collin M MacLeod, Fawad A K Yousufzai, Liam T Spencer, Sarah Kim, Lucianne A Rivera-Rosario, Zerian D Barrera, Lindsay Walsh, Claude Krummenacher, Benjamin Carone, Ileana Sot. Trehalose enhances mitochondria deficits in human NPC1 mutant fibroblasts but disrupts mouse Purkinje cell dendritic growth ex vivo. PloS one. vol 18. issue 11. 2023-11-30. PMID:38033125. |
however, trehalose treatment in cerebellar organotypic slices (coscs) from wild-type and npc1nmf164 mice caused mitochondria fragmentation and lack of dendritic growth and degeneration in developmental purkinje cells. |
2023-11-30 |
2023-12-10 |
mouse |
| Caio Sérgio Galina Spilla, Ana Luiza Decanini Miranda de Souza, Leila Maria Guissoni Campos, Sanseray da Silveira Cruz-Machado, Luciana Pinat. LPS-induced inflammation in rats during pregnancy reduces maternal melatonin and impairs neurochemistry and behavior of adult male offspring. Brain research. 2023-11-30. PMID:38036237. |
immunohistochemical analysis indicated a decline in calbindin immunoreactivity in purkinje cells in the cerebellum. |
2023-11-30 |
2023-12-10 |
human |
| Adaze Bijou Enogieru, Etinosa Nathan Iyoh. Role of Nitric Oxide, TNF-α and Caspase-3 in Lead Acetate-Exposed Rats Pretreated with Aqueous Rosmarinus officinalis Leaf Extract. Biological trace element research. 2023-11-27. PMID:38012512. |
cerebellar histology of the pb-exposed rats showed severe degeneration of the purkinje cells whereas the ro-pretreated rats showed better cerebellar architecture. |
2023-11-27 |
2023-11-29 |
rat |
| Peipei Zhai, Vincenzo Romano, Giulia Soggia, Staf Bauer, Nathalie van Wingerden, Thomas Jacobs, Annabel van der Horst, Joshua J White, Roberta Mazza, Chris I De Zeeu. Whisker kinematics in the cerebellum. The Journal of physiology. 2023-11-21. PMID:37987552. |
purkinje cells in the crus regions of the cerebellum have been reported to linearly encode whisker midpoint, but it is unknown whether the paramedian and simplex lobules as well as their target neurons in the cerebellar nuclei also encode whisker kinematics and if so which ones. |
2023-11-21 |
2023-11-29 |
mouse |
| Peipei Zhai, Vincenzo Romano, Giulia Soggia, Staf Bauer, Nathalie van Wingerden, Thomas Jacobs, Annabel van der Horst, Joshua J White, Roberta Mazza, Chris I De Zeeu. Whisker kinematics in the cerebellum. The Journal of physiology. 2023-11-21. PMID:37987552. |
key points: excitation of purkinje cells throughout the cerebellar hemispheres induces whisker movement, with the shortest latency and longest duration within the paramedian lobe. |
2023-11-21 |
2023-11-29 |
mouse |
| Hiroshi Nishiyama, Naoko Nishiyama, Boris V Zemelma. Loss of Purkinje cells in the developing cerebellum strengthens the cerebellothalamic synapses. bioRxiv : the preprint server for biology. 2023-11-14. PMID:37961231. |
loss of purkinje cells in the developing cerebellum strengthens the cerebellothalamic synapses. |
2023-11-14 |
2023-11-20 |
Not clear |
| Akinleye Akinrinde, Kabirat Adigun, Oluwaseun Mustaph. Cobalt-induced neuro-behavioural alterations are accompanied by profound Purkinje cell and gut-associated responses in rats. Environmental analysis, health and toxicology. vol 38. issue 2. 2023-11-07. PMID:37933104. |
histopathological examination revealed chromatolysis of purkinje cells in the cerebellum, although no significant lesions were present in the vagus nerve isolated from all the groups. |
2023-11-07 |
2023-11-08 |
rat |
| Christopher H Chen, Leannah N Newman, Amanda P Stark, Katherine E Bond, Dawei Zhang, Stefano Nardone, Charles R Vanderburg, Naeem M Nadaf, Zhiyi Yao, Kefiloe Mutume, Isabella Flaquer, Bradford B Lowell, Evan Z Macosko, Wade G Regeh. A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain. Nature neuroscience. vol 26. issue 11. 2023-11-03. PMID:37919612. |
we found that suppressing the firing of cerebellar purkinje cells (pcs) rapidly excites forebrain areas that contribute to such functions (including the amygdala, basal forebrain and septum), but that the classic cerebellar outputs, the deep cerebellar nuclei, do not directly project there. |
2023-11-03 |
2023-11-08 |
Not clear |
| Sumit S Rathod, Yogeeta O Agrawal, Kartik T Nakhate, M F Nagoor Meeran, Shreesh Ojha, Sameer N Goya. Neuroinflammation in the Central Nervous System: Exploring the Evolving Influence of Endocannabinoid System. Biomedicines. vol 11. issue 10. 2023-10-30. PMID:37893016. |
the presence of cb2 receptors in certain brain components, like cultured cerebellar granular cells, purkinje fibers, and microglia, as well as in the areas like the cerebral cortex, hippocampus, and cerebellum is also evidenced by immunoblotting assays, radioligand binding, and autoradiography studies. |
2023-10-30 |
2023-11-08 |
Not clear |
| Nisa Vorasoot, Madeleine Scharf, Ramona Miske, Smathorn Thakolwiboon, Divyanshu Dubey, John R Mills, Sean J Pittock, Anastasia Zekeridou, Anthonina Ott, Andrew McKeo. CDR2 and CDR2L line blot performance in PCA-1/anti-Yo paraneoplastic autoimmunity. Frontiers in immunology. vol 14. 2023-10-16. PMID:37841252. |
purkinje cytoplasmic autoantibody type 1 (pca-1)/anti-yo autoimmunity is a common high-risk paraneoplastic neurological disorder, traditionally attributed antigenically to cerebellar degeneration-related protein 2 (cdr2), predominantly affecting women with gynecologic or breast adenocarcinoma. |
2023-10-16 |
2023-11-08 |
Not clear |
| Xiping Zhan, Ly V Do, Li Zou, Ryan Shu Zhan, Michael Jones, Saba Nawaz, Kebreten Manay. Harmaline Toxicity on Dorsal Striatal Neurons and its Role in Tremor. Neurotoxicology. 2023-10-14. PMID:37838252. |
exogenous harmaline exposure in high concentration has myriad consequences, including inducing tremor, and causing neurodegeneration of purkinje cells in the cerebellum. |
2023-10-14 |
2023-11-08 |
human |
| Carlo Alberto Cesaroni, Giulia Pisanò, Gabriele Trimarchi, Stefano Giuseppe Caraffi, Giulia Scandolo, Martina Gnazzo, Daniele Frattini, Carlotta Spagnoli, Susanna Rizzi, Claudia Dittadi, Giulia Sigona, Livia Garavelli, Carlo Fusc. Severe Neurodevelopmental Disorder in Autosomal Recessive Spinocerebellar Ataxia 13 (SCAR13) Caused by Two Novel Frameshift Variants in GRM1. Cerebellum (London, England). 2023-10-13. PMID:37831383. |
scar13 is caused by pathogenic variants in the grm1 gene encoding the metabotropic receptor of glutamate type 1 (mglur1), which is highly expressed in purkinje cerebellar cells, where it plays a fundamental role in cerebellar development. |
2023-10-13 |
2023-10-15 |
Not clear |
| Lan Zhang, Kun Yang, Xiao Tan, Yazhu Cai, Haie Ding, Rui Li, Yiyang Zhang, Manlin Zhou, Zuli Ben, Qian Zhang, Zilin Qia. Analysis of age-related differences in hypoxia-related factors in yak brain tissue. Folia morphologica. 2023-10-12. PMID:37822067. |
immunohistochemical results showed that hif-1α, epo, vegf, and vcam were expressed in the pyramidal cell layer of the yak cerebrum, and distributed in the cerebellum granulose cell layer, purkinje cell layer and medulla layer, and were mainly positive in purkinje cells and medulla. |
2023-10-12 |
2023-10-15 |
Not clear |
| Seth A Ament, Marcia Cortes-Gutierrez, Brian R Herb, Evelina Mocci, Carlo Colantuoni, Margaret M McCarth. A single-cell genomic atlas for maturation of the human cerebellum during early childhood. Science translational medicine. 2023-10-12. PMID:37824600. |
our analyses revealed that inflammation and postnatal cerebellar maturation are associated with extensive, overlapping transcriptional changes primarily in two subtypes of inhibitory neurons: purkinje neurons and golgi neurons. |
2023-10-12 |
2023-10-15 |
human |