| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ya Chen, Luke Bury, Fu Chen, Kimberly A Aldinger, Helen C Miranda, Anthony Wynshaw-Bori. Generation of advanced cerebellar organoids for neurogenesis and neuronal network development. Human molecular genetics. 2023-06-30. PMID:37387247. |
this will provide a means to study the generation of several more mature cerebellar cell types, including purkinje cells, granule cells, interneurons expression as well as neuronal communication for biomedical, clinical, and pharmaceutical application. |
2023-06-30 |
2023-08-14 |
human |
| Toru Yasuda, Toru Uchiyama, Nobuyuki Watanabe, Noriko Ito, Kazuhiko Nakabayashi, Hideki Mochizuki, Masafumi Onoder. Peripheral immune system modulates Purkinje cell degeneration in Niemann-Pick disease type C1. Life science alliance. vol 6. issue 9. 2023-06-27. PMID:37369603. |
moreover, the peripheral infusion of cd4-positive cells (specifically, of regulatory t cells) from normal healthy donor ameliorated the cerebellar ataxic phenotype and enhanced the survival of purkinje cells. |
2023-06-27 |
2023-08-14 |
mouse |
| Regina T Martuscello, Meng-Ling Chen, Steven Reiken, Leah R Sittenfeld, David S Ruff, Chun-Lun Ni, Chih-Chun Lin, Ming-Kai Pan, Elan D Louis, Andrew R Marks, Sheng-Han Kuo, Phyllis L Faus. Defective cerebellar ryanodine receptor type 1 and endoplasmic reticulum calcium 'leak' in tremor pathophysiology. Acta neuropathologica. 2023-06-19. PMID:37335342. |
clinical data suggest the importance of the cerebellum in disease pathophysiology, and pathological studies indicate purkinje cells (pcs) incur damage. |
2023-06-19 |
2023-08-14 |
Not clear |
| Juli Jain, Whidul Hasan, Deepali Jat, Pronit Biswas, Rajesh Singh Yada. Delayed in sensorimotor reflex ontogeny, slow physical growth, and impairments in behaviour as well as dopaminergic neuronal death in mice offspring following prenatally rotenone administration. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2023-06-19. PMID:37337287. |
histological examination of the cerebellum revealed a decrease in purkinje neurons in the rotenone exposed group as compared to the control. |
2023-06-19 |
2023-08-14 |
mouse |
| Yu Chen, Wei L. Rapid eye movement sleep contributes to the formation of new axonal varicosities in mouse cerebellar parallel fibers after motor training. Neuroscience letters. 2023-06-16. PMID:37327855. |
however, the synaptic structural dynamics between parallel and purkinje cells after motor training and the function of sleep in cerebellar synaptic plasticity remain unclear. |
2023-06-16 |
2023-08-14 |
mouse |
| Federica Pilotto, Christopher Douthwaite, Rim Diab, XiaoQian Ye, Zahraa Al Qassab, Christoph Tietje, Meriem Mounassir, Adolfo Odriozola, Aishwarya Thapa, Ronald A M Buijsen, Sophie Lagache, Anne-Christine Uldry, Manfred Heller, Stefan Müller, Willeke M C van Roon-Mom, Benoît Zuber, Sabine Liebscher, Smita Saxen. Early molecular layer interneuron hyperactivity triggers Purkinje neuron degeneration in SCA1. Neuron. 2023-06-15. PMID:37321222. |
using in vivo two-photon imaging in behaving spinocerebellar ataxia type 1 (sca1) mice, wherein purkinje neurons (pns) degenerate, we identify an inhibitory circuit element (molecular layer interneurons [mlins]) that becomes prematurely hyperexcitable, compromising sensorimotor signals in the cerebellum at early stages. |
2023-06-15 |
2023-08-14 |
mouse |
| B J Wilkes, R Z Adury, D Berryman, L R Concepcion, Y Liu, F Yokoi, C Maugee, Y Li, D E Vaillancour. Cell-specific Dyt1 ∆GAG knock-in to basal ganglia and cerebellum reveal differential effects on motor behavior and sensorimotor network function. Experimental neurology. 2023-06-15. PMID:37321386. |
in order to achieve this goal, we generated two genetically modified mouse models: in model 1 we performed dyt1 ∆gag conditional knock-in (ki) in neurons that express dopamine-2 receptors (d2-ki), and in model 2 we performed dyt1 ∆gag conditional ki in purkinje cells of the cerebellum (pcp2-ki). |
2023-06-15 |
2023-08-14 |
mouse |
| B J Wilkes, R Z Adury, D Berryman, L R Concepcion, Y Liu, F Yokoi, C Maugee, Y Li, D E Vaillancour. Cell-specific Dyt1 ∆GAG knock-in to basal ganglia and cerebellum reveal differential effects on motor behavior and sensorimotor network function. Experimental neurology. 2023-06-15. PMID:37321386. |
these findings suggest that (1) d2 cell-specific dyt1 ∆gag mediated torsina dysfunction in the basal ganglia results in detrimental effects on the sensorimotor network and motor output, and (2) purkinje cell-specific dyt1 ∆gag mediated torsina dysfunction in the cerebellum results in compensatory changes in the sensorimotor network that protect against dystonia-like motor deficits. |
2023-06-15 |
2023-08-14 |
mouse |
| Juan Pablo Zanin, Mansi A Pandya, Diego Espinoza, Wilma J Friedman, Michael W Shiflet. Excess cerebellar granule neurons induced by the absence of p75NTR during development elicit social behavior deficits in mice. Frontiers in molecular neuroscience. vol 16. 2023-06-12. PMID:37305555. |
the cerebellar granule neurons (cgn) are essential for cerebellar function since they provide sensorimotor, proprioceptive, and contextual information to purkinje cells to modify behavior in different contexts. |
2023-06-12 |
2023-08-14 |
mouse |
| Rogelio Revuelta-Gutiérrez, Alejandro Serrano-Rubio, Rodrigo López-Rodríguez, Héctor A Rodríguez-Rubio, Alfredo Bonilla-Suastegui, Citlaltepetl Salinas Lara, Edgar Natha. Lhermitte-Duclos disease: A rare case of cerebellar tumor with successful surgical treatment. Surgical neurology international. vol 14. 2023-06-09. PMID:37292412. |
lhermitte-duclos disease (ldd) or dysplastic gangliocytoma of the posterior fossa is a slow-growing and extremely rare mass lesion that involves the purkinje neurons and the granular layer of the cerebellum. |
2023-06-09 |
2023-08-14 |
Not clear |
| Setsuya Fujita, Takanori Hattori, Masaru Fukuda, Tadahisa Kitamur. DNA CONTENTS IN PURKINJE CELLS AND INNER GRANULE NEURONS IN THE DEVELOPING RAT CEREBELLUM. Development, growth & differentiation. vol 16. issue 3. 2023-06-07. PMID:37281651. |
dna contents in purkinje cells and inner granule neurons in the developing rat cerebellum. |
2023-06-07 |
2023-08-14 |
rat |
| Setsuya Fujita, Takanori Hattori, Masaru Fukuda, Tadahisa Kitamur. DNA CONTENTS IN PURKINJE CELLS AND INNER GRANULE NEURONS IN THE DEVELOPING RAT CEREBELLUM. Development, growth & differentiation. vol 16. issue 3. 2023-06-07. PMID:37281651. |
cytophotometric studies revealed that the content of feulgen dna in purkinje cells in the developing rat cerebellum remains at the diploid level throughout the postnatal life. |
2023-06-07 |
2023-08-14 |
rat |
| Harikrishna Rallapalli, N Sumru Bayin, Hannah Goldman, Dragan Maric, Brian J Nieman, Alan P Koretsky, Alexandra L Joyner, Daniel H Turnbul. Cell Specificity of Manganese-enhanced MRI Signal in the Cerebellum. NeuroImage. 2023-05-28. PMID:37245561. |
in this study, we quantified the effects of selective ablation of purkinje cells or bergmann glia on cerebellar memri signal to determine whether signal could be assigned to one cell type. |
2023-05-28 |
2023-08-14 |
Not clear |
| Dan Liu, Jun Wang, Liuqing Zhou, E Tian, Jingyu Chen, Weijia Kong, Yisheng Lu, Sulin Zhan. Differential Modulation of Cerebellar Flocculus Unipolar Brush Cells during Vestibular Compensation. Biomedicines. vol 11. issue 5. 2023-05-27. PMID:37238967. |
ubcs are excitatory interneurons targeting granule cells to provide feedforward innervation to the purkinje cells, the primary output neurons in the cerebellum. |
2023-05-27 |
2023-08-14 |
Not clear |
| Chandrakanth Reddy Edamakanti, Vishwa Mohan, Puneet Opa. Reactive Bergmann glia play a central role in spinocerebellar ataxia inflammation via the JNK pathway. Journal of neuroinflammation. vol 20. issue 1. 2023-05-26. PMID:37237366. |
using human sca autopsy samples we have discovered that bergmann glia-the radial glia of the cerebellum, which form intimate functional connections with cerebellar purkinje neurons-display inflammatory jnk-dependent c-jun phosphorylation. |
2023-05-26 |
2023-08-14 |
mouse |
| MaKenna Y Cealie, James C Douglas, Linh H D Le, Erik D Vonkaenel, Matthew N McCall, Paul D Drew, Ania K Majewsk. Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence. Frontiers in neuroscience. vol 17. 2023-05-23. PMID:37214408. |
developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with purkinje cells during adolescence. |
2023-05-23 |
2023-08-14 |
Not clear |
| MaKenna Y Cealie, James C Douglas, Linh H D Le, Erik D Vonkaenel, Matthew N McCall, Paul D Drew, Ania K Majewsk. Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence. Frontiers in neuroscience. vol 17. 2023-05-23. PMID:37214408. |
to better understand these mechanisms, we examined the cerebellum on a cellular level by studying microglia, the principal immune cells of the central nervous system, and purkinje cells, the sole output of the cerebellum. |
2023-05-23 |
2023-08-14 |
Not clear |
| Nicholas C Cottam, Tiffany Bamfo, Melissa A Harrington, Christine J Charvet, Khan Hekmatyar, Nikita Tulin, Jianli Su. Cerebellar structural, astrocytic, and neuronal abnormalities in the SMNΔ7 mouse model of spinal muscular atrophy. Brain pathology (Zurich, Switzerland). 2023-05-23. PMID:37218083. |
we found a significant disproportionate loss in cerebellar volume, decrease in afferent cerebellar tracts, selective lobule-specific degeneration of purkinje cells, abnormal lobule foliation and astrocyte integrity, and a decrease in spontaneous firing of cerebellar output neurons in the sma mice compared to controls. |
2023-05-23 |
2023-08-14 |
mouse |
| América Vera-Montecinos, Jordi Galiano-Landeira, Mònica Roldán, Francisco Vidal-Domènech, Enrique Claro, Belén Ramo. A Novel Localization of METTL7A in Bergmann Glial Cells in Human Cerebellum. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37176112. |
the localization of mettl7a in the human cerebellar glia limitans could suggest a putative role in maintaining the cerebellar parenchyma homeostasis and in the regulation of internal cerebellar circuits by modulating the synaptic activity of purkinje neurons. |
2023-05-14 |
2023-08-14 |
human |
| José Gazulla, Elena Bellosta-Diago, Silvia Izquierdo-Alvarez, José Bercian. Spinocerebellar ataxia type 15 caused by missense variants in the ITPR1 gene. European journal of neurology. 2023-05-08. PMID:37154409. |
it plays a pivotal role in excitatory and inhibitory actions on purkinje cells, and alterations in their balance cause cerebellar dysfunction in itpr1 knock-out mice. |
2023-05-08 |
2023-08-14 |
mouse |