| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seth A Ament, Marcia Cortes-Gutierrez, Brian R Herb, Evelina Mocci, Carlo Colantuoni, Margaret M McCarth. A single-cell genomic atlas for maturation of the human cerebellum during early childhood. Science translational medicine. 2023-10-12. PMID:37824600. |
our analyses revealed that inflammation and postnatal cerebellar maturation are associated with extensive, overlapping transcriptional changes primarily in two subtypes of inhibitory neurons: purkinje neurons and golgi neurons. |
2023-10-12 |
2023-10-15 |
human |
| Carmen Nanclares, Jose Antonio Noriega-Prieto, Francisco E Labrada-Moncada, Marija Cvetanovic, Alfonso Araque, Paulo Kofuj. Altered calcium signaling in Bergmann glia contributes to spinocerebellar ataxia type-1 in a mouse model of SCA1. Neurobiology of disease. 2023-10-06. PMID:37802154. |
sca1 shows severe degeneration of cerebellar purkinje cells (pcs) and activation of bergmann glia (bg), a type of cerebellar astroglia closely associated with pcs. |
2023-10-06 |
2023-10-15 |
mouse |
| Laura Vidal-Palencia, Cristina Font, Agustín Rebollada-Merino, Gabriel Santpere, Pol Andrés-Benito, Isidro Ferrer, Martí Pumarol. Primary Feline Tauopathy: Clinical, Morphological, Immunohistochemical, and Genetic Studies. Animals : an open access journal from MDPI. vol 13. issue 18. 2023-09-28. PMID:37760385. |
neuropathological lesions were characterized by massive neuronal loss with marked spongiosis and associated moderate reactive gliosis in the parietal cortex, being less severe in other areas of the cerebral cortex, and the loss of purkinje cells of the cerebellum. |
2023-09-28 |
2023-10-07 |
cat |
| Franziska Auer, Katherine Nardone, Koji Matsuda, Masahiko Hibi, David Schoppi. Purkinje Cells Control Posture in Larval Zebrafish ( bioRxiv : the preprint server for biology. 2023-09-25. PMID:37745506. |
purkinje cells control posture in larval zebrafish ( cerebellar dysfunction leads to postural instability. |
2023-09-25 |
2023-10-07 |
zebrafish |
| Roberta Maria Lorenzi, Alice Geminiani, Yann Zerlaut, Marialaura De Grazia, Alain Destexhe, Claudia A M Gandini Wheeler-Kingshott, Fulvia Palesi, Claudia Casellato, Egidio D'Angel. A multi-layer mean-field model of the cerebellum embedding microstructure and population-specific dynamics. PLoS computational biology. vol 19. issue 9. 2023-09-01. PMID:37656758. |
here we have designed and simulated a multi-layer mf of the cerebellar microcircuit (including granule cells, golgi cells, molecular layer interneurons, and purkinje cells) and validated it against experimental data and the corresponding spiking neural network (snn) microcircuit model. |
2023-09-01 |
2023-09-07 |
mouse |
| Takamasa Kamei, Atsushi Tamada, Toshiya Kimura, Akira Kakizuka, Akio Asai, Keiko Mugurum. Survival and process outgrowth of human iPSC-derived cells expressing Purkinje cell markers in a mouse model for spinocerebellar degenerative disease. Experimental neurology. 2023-08-27. PMID:37634697. |
the loss or dysfunction of purkinje cells due to cerebellar atrophy leads to severe ataxia. |
2023-08-27 |
2023-09-07 |
mouse |
| Yuki Fujiwara, Yuhei Miyasaka, Ayane Ninomiya, Wataru Miyazaki, Toshiharu Iwasaki, Winda Ariyani, Izuki Amano, Noriyuki Koibuch. Effects of Perfluorooctane Sulfonate on Cerebellar Cells via Inhibition of Type 2 Iodothyronine Deiodinase Activity. International journal of molecular sciences. vol 24. issue 16. 2023-08-26. PMID:37628946. |
we investigated the change in thyroid hormone (th)-induced dendrite arborization of purkinje cells in the primary culture of newborn rat cerebellum. |
2023-08-26 |
2023-09-07 |
rat |
| Ting-Feng Lin, Silas E Busch, Christian Hanse. Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37502848. |
intrinsic and synaptic determinants of receptive field plasticity in purkinje cells of the mouse cerebellum. |
2023-07-28 |
2023-08-14 |
mouse |
| Silas E Busch, Christian Hanse. Climbing fiber multi-innervation of mouse Purkinje dendrites with arborization common to human. Science (New York, N.Y.). vol 381. issue 6656. 2023-07-27. PMID:37499000. |
underlying current theories of cerebellar function is the notion that this highly conserved one-to-one relationship renders purkinje dendrites into a single computational compartment. |
2023-07-27 |
2023-08-14 |
mouse |
| Josiane Mann, Valter Malaguido Clímaco, Seigo Nagashima, Daniel Wolff Stanczyk, Melania Santer, Ilton Silva, Luiz Fernando Pereir. The enriched environment prevents degeneration of cerebellum Purkinje cells layer of rats. Acta neurobiologiae experimentalis. vol 83. issue 2. 2023-07-26. PMID:37493533. |
these facts demonstrate that the enriched environment appears to protect the purkinje cells layer of cerebellum from possible degeneration. |
2023-07-26 |
2023-08-14 |
rat |
| Mizuki Kato, Erik De Schutte. Models of Purkinje cell dendritic tree selection during early cerebellar development. PLoS computational biology. vol 19. issue 7. 2023-07-24. PMID:37486917. |
we investigate the relationship between primary dendrite selection of purkinje cells and migration of their presynaptic partner granule cells during early cerebellar development. |
2023-07-24 |
2023-08-14 |
Not clear |
| Xiaolu Wang, Zhiqiang Liu, Milen Angelov, Zhao Feng, Xiangning Li, Anan Li, Yan Yang, Hui Gong, Zhenyu Ga. Excitatory nucleo-olivary pathway shapes cerebellar outputs for motor control. Nature neuroscience. 2023-07-20. PMID:37474638. |
activating the excitatory nucleo-olivary pathway induces well-timed internal feedback complex spike signals in purkinje cells to shape cerebellar outputs. |
2023-07-20 |
2023-08-14 |
Not clear |
| b' Margarita Belem Santana-Bejarano, Paula Romina Grosso-Mart\\xc3\\xadnez, Ana Graciela Puebla-Mora, Mar\\xc3\\xada Guadalupe Mart\\xc3\\xadnez-Silva, Mario Nava-Villalba, Ana Laura M\\xc3\\xa1rquez-Aguirre, Daniel Ortu\\xc3\\xb1o-Sahag\\xc3\\xban, Marisol God\\xc3\\xadnez-Rub\\xc3\\xa. Pleiotrophin and the Expression of Its Receptors during Development of the Human Cerebellar Cortex. Cells. vol 12. issue 13. 2023-07-14. PMID:37443767.' |
these results suggest that, in the fetal and neonatal human cerebellum, ptn is involved in cell communication through granule cell precursors, bergmann glia, and purkinje cells via ptprz1, nrp-1, and alk signaling. |
2023-07-14 |
2023-08-14 |
human |
| Rui Zheng, Fang-Xiao Xu, Lin Zhou, Junyu Xu, Ying Shen, Ke Hao, Xin-Tai Wang, Junjie Den. Ablation of KIF2C in Purkinje cells impairs metabotropic glutamate receptor trafficking and motor coordination in male mice. The Journal of physiology. 2023-07-11. PMID:37431690. |
kif2c is extensively expressed in the cerebellum, and we investigated its functions in development and synaptic transmission of cerebellar purkinje cells. |
2023-07-11 |
2023-08-14 |
mouse |
| Robijanto Soetedjo, Gregory D Horwit. Closed-loop optogenetic perturbation of macaque oculomotor cerebellum: evidence for an internal saccade model. bioRxiv : the preprint server for biology. 2023-07-10. PMID:37425739. |
to investigate the role of the cerebellum in these two aspects of saccade production, we delivered saccade-triggered light pulses to channelrhodopsin-2-expressing purkinje cells in the oculomotor vermis (omv) of two macaque monkeys. |
2023-07-10 |
2023-08-14 |
monkey |
| Josef P Kapfhammer, Etsuko Shimobayash. Viewpoint: spinocerebellar ataxias as diseases of Purkinje cell dysfunction rather than Purkinje cell loss. Frontiers in molecular neuroscience. vol 16. 2023-07-10. PMID:37426070. |
we will then widen the scope and propose a concept of sca pathogenesis which is not primarily driven by cell death and loss of purkinje cells but rather by dysfunction of purkinje cells which are still present and alive in the cerebellum. |
2023-07-10 |
2023-08-14 |
Not clear |
| Hail Kim, Minji Choi, Sanghee Han, Sang-Yoon Park, Myoungseok Jeong, Sang Ryong Kim, Eun Mi Hwang, Seok-Geun Le. Expression patterns of AEG-1 in the normal brain. Brain structure & function. 2023-07-08. PMID:37421418. |
additionally, aeg-1 was expressed in the cytoplasm of purkinje cells in both the mouse and human cerebellum, suggesting its potential role in this brain region. |
2023-07-08 |
2023-08-14 |
mouse |
| Fei Hao, Ye Bu, Shasha Huang, Wanqi Li, Huiwen Feng, Yuan Wan. Effects of pyrethroids on the cerebellum and related mechanisms: a narrative review. Critical reviews in toxicology. 2023-07-07. PMID:37417402. |
by some studies, pyrs may affect granule cells and purkinje cells, causing damage to cerebellar structures. |
2023-07-07 |
2023-08-14 |
rat |
| Fei Hao, Ye Bu, Shasha Huang, Wanqi Li, Huiwen Feng, Yuan Wan. Effects of pyrethroids on the cerebellum and related mechanisms: a narrative review. Critical reviews in toxicology. 2023-07-07. PMID:37417402. |
destruction of cerebellar structures and morphological defects in purkinje cells are known to be directly related to functional impairment of motor coordination. |
2023-07-07 |
2023-08-14 |
rat |
| Masashi Nishikawa, Tohru Matsuki, Nanako Hamada, Atsuo Nakayama, Hidenori Ito, Koh-Ichi Nagat. Expression analyses of WAC, a responsible gene for neurodevelopmental disorders, during mouse brain development. Medical molecular morphology. 2023-07-04. PMID:37402055. |
in cerebellum, wac was detected in the nucleus of purkinje cells and granule cells, and possibly interneurons in the molecular layer. |
2023-07-04 |
2023-08-14 |
mouse |