| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rosario Baltazar-Lara, Janeth Mora Zenil, Martha Carranza, José Ávila-Mendoza, Carlos G Martínez-Moreno, Carlos Arámburo, Maricela Lun. Growth Hormone (GH) Crosses the Blood-Brain Barrier (BBB) and Induces Neuroprotective Effects in the Embryonic Chicken Cerebellum after a Hypoxic Injury. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232848. |
histological analysis showed that hypoxia provoked a significant modification in the size and organization of cerebellar layers; however, gh administration restored the width of external granular layer (egl) and molecular layer (ml) and improved the purkinje and granular neurons survival. |
2022-10-14 |
2023-08-14 |
chicken |
| Yaiza M Arenas, Mar Martínez-García, Marta Llansola, Vicente Felip. Enhanced BDNF and TrkB Activation Enhance GABA Neurotransmission in Cerebellum in Hyperammonemia. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36233065. |
in the cerebellum of hyperammonemic rats, increased bdnf levels enhance trkb activation in purkinje neurons, leading to increased gad65, gad67 and gaba levels. |
2022-10-14 |
2023-08-14 |
rat |
| Magdalena Surdyka, Ewelina Jesion, Anna Niewiadomska-Cimicka, Yvon Trottier, Żaneta Kalinowska-Pośka, Maciej Figie. Selective transduction of cerebellar Purkinje and granule neurons using delivery of AAV-PHP.eB and AAVrh10 vectors at axonal terminal locations. Frontiers in molecular neuroscience. vol 15. 2022-09-30. PMID:36176957. |
the cerebellum and its cell populations, including granule and purkinje cells, are vulnerable to neurodegeneration; hence, conditions to deliver the therapy to specific cell populations selectively remain challenging. |
2022-09-30 |
2023-08-14 |
Not clear |
| Elizabeth J Apsley, Esther B E Becke. Purkinje Cell Patterning-Insights from Single-Cell Sequencing. Cells. vol 11. issue 18. 2022-09-23. PMID:36139493. |
we describe how this detailed transcriptomic data has increased our understanding of the intricate development and function of purkinje cells and provides first clues into features specific to human cerebellar development. |
2022-09-23 |
2023-08-14 |
mouse |
| Hoda Ranjbar, Monavareh Soti, Moazamehosadat Razavinasab, Kristi A Kohlmeier, Mohammad Shaban. The neglected role of endocannabinoid actions at TRPC channels in ataxia. Neuroscience and biobehavioral reviews. 2022-09-10. PMID:36087758. |
transient receptor potential (trp) channels are highly expressed in cells of the cerebellum including in the dendr and somas of purkinje cells (pcs). |
2022-09-10 |
2023-08-14 |
Not clear |
| Michael Winklehner, Jan Bauer, Verena Endmayr, Carmen Schwaiger, Gerda Ricken, Masakatsu Motomura, Shunsuke Yoshimura, Hiroshi Shintaku, Kinya Ishikawa, Yukio Tsuura, Takahiro Iizuka, Takanori Yokota, Takashi Irioka, Romana Höftberge. Paraneoplastic Cerebellar Degeneration With P/Q-VGCC vs Yo Autoantibodies. Neurology(R) neuroimmunology & neuroinflammation. vol 9. issue 4. 2022-09-07. PMID:36070310. |
paraneoplastic cerebellar degeneration (pcd) is characterized by a widespread loss of purkinje cells (pcs) and may be associated with autoantibodies against intracellular antigens such as yo or cell surface neuronal antigens such as the p/q-type voltage-gated calcium channel (p/q-vgcc). |
2022-09-07 |
2023-08-14 |
Not clear |
| Pallavi Asthana, Gajendra Kumar, Lukasz M Milanowski, Ngan Pan Bennett Au, Siu Chung Chan, Jianpan Huang, Hemin Feng, Kin Ming Kwan, Jufang He, Kannie Wai Yan Chan, Zbigniew K Wszolek, Chi Him Eddie M. Cerebellar glutamatergic system impacts spontaneous motor recovery by regulating Gria1 expression. NPJ Regenerative medicine. vol 7. issue 1. 2022-09-06. PMID:36064798. |
finally, we found a correlative decrease in human gria1 mrna expression in the cerebellum of patients with ataxia-telangiectasia and spinocerebellar ataxia type 6 patient ipsc-derived purkinje cells, pointing to the clinical relevance of glutamatergic system. |
2022-09-06 |
2023-08-14 |
mouse |
| Nanako Hamada, Ikuko Iwamoto, Mariko Noda, Masashi Nishikawa, Koh-Ichi Nagat. Expression analyses of polo-like kinase 4 (Plk4), a gene product responsible for autosomal recessive microcephaly and Seckel syndrome, during mouse brain development. Developmental neuroscience. 2022-09-06. PMID:36067731. |
plk4 was then diffusely distributed in the cell body of cortical neurons at p7 while it was enriched in the neuropil as well as soma of excitatory neurons in cerebral cortex and hippocampus, and purkinje cells in the cerebellum at p30. |
2022-09-06 |
2023-08-14 |
mouse |
| Ilknur Özen, Hongcheng Mai, Alessandro De Maio, Karsten Ruscher, Georgios Michalettos, Fredrik Clausen, Michael Gottschalk, Saema Ansar, Sertan Arkan, Ali Erturk, Niklas Marklun. Purkinje cell vulnerability induced by diffuse traumatic brain injury is linked to disruption of long-range neuronal circuits. Acta neuropathologica communications. vol 10. issue 1. 2022-09-05. PMID:36064443. |
to address the hypothesis that degeneration of purkinje cells (pcs), which constitute the sole output from the cerebellum, is linked to long-range axonal injury and demyelination, we used the central fluid percussion injury (cfpi) model of widespread traumatic axonal injury in mice. |
2022-09-05 |
2023-08-14 |
mouse |
| Li-Ping Shen, Wei Li, Ling-Zhu Pei, Jun Yin, Shu-Tao Xie, Hong-Zhao Li, Chao Yan, Jian-Jun Wang, Qipeng Zhang, Xiao-Yang Zhang, Jing-Ning Zh. Oxytocin Receptor in Cerebellar Purkinje Cells Does Not Engage in Autism-Related Behaviors. Cerebellum (London, England). 2022-08-30. PMID:36040660. |
here, we report a localization of oxytocin receptor (oxtr) in purkinje cells (pcs) of cerebellar lobule crus i, which is functionally connected with asd-implicated circuits. |
2022-08-30 |
2023-08-14 |
mouse |
| Szilvia E Mezey, Josef P Kapfhammer, Etsuko Shimobayash. Transcriptome Profile of a New Mouse Model of Spinocerebellar Ataxia Type 14 Implies Changes in Cerebellar Development. Genes. vol 13. issue 8. 2022-08-26. PMID:36011327. |
the autosomal dominant inherited spinocerebellar ataxias (scas) are a group of neurodegenerative disorders characterized by cerebellar atrophy and loss of purkinje neurons. |
2022-08-26 |
2023-08-14 |
mouse |
| J Martí-Clu. Times of neuron origin and neurogenetic gradients in mice Purkinje cells and deep cerebellar nuclei neurons during the development of the cerebellum. A review. Tissue & cell. vol 78. 2022-08-22. PMID:35994919. |
times of neuron origin and neurogenetic gradients in mice purkinje cells and deep cerebellar nuclei neurons during the development of the cerebellum. |
2022-08-22 |
2023-08-14 |
mouse |
| Mehak M Khan, Shuting Wu, Christopher H Chen, Wade G Regeh. Unusually slow spike frequency adaptation in deep cerebellar nuclei neurons preserves linear transformations on the sub-second timescale. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-08-22. PMID:35995561. |
purkinje cells (pcs) are spontaneously active neurons of the cerebellar cortex that inhibit glutamatergic projection neurons within the deep cerebellar nuclei (dcn) that provide the primary cerebellar output. |
2022-08-22 |
2023-08-14 |
mouse |
| Yusra Mansour, Alyson Burchell, Randy Kulesz. Abnormal vestibular brainstem structure and function in an animal model of autism spectrum disorder. Brain research. 2022-08-19. PMID:35985362. |
many human subjects with asd have cerebellar hypoplasia, fewer purkinje cells, difficulties with balance, ophthalmic dysfunction and abnormal responses to vestibular stimulation and such vestibular difficulties are likely under reported in asd. |
2022-08-19 |
2023-08-14 |
human |
| Yusra Mansour, Alyson Burchell, Randy Kulesz. Abnormal vestibular brainstem structure and function in an animal model of autism spectrum disorder. Brain research. 2022-08-19. PMID:35985362. |
we have recently shown that animals exposed to vpa in utero have fewer neurons in their auditory brainstem, reduced axonal projections to the auditory midbrain and thalamus, reduced expression of the calcium binding protein calbindin (cb) in the brainstem and cerebellum, smaller and occasionally ectopic cerebellar purkinje cells and ataxia on several motor tasks. |
2022-08-19 |
2023-08-14 |
human |
| Sharon Baughman Shively, Nancy A Edwards, Tobey J MacDonald, Kory R Johnson, Natalia M Diaz-Rodriguez, Marsha J Merrill, Alexander O Vortmeye. Developmentally Arrested Basket/Stellate Cells in Postnatal Human Brain as Potential Tumor Cells of Origin for Cerebellar Hemangioblastoma in von Hippel-Lindau Patients. Journal of neuropathology and experimental neurology. 2022-08-18. PMID:35980299. |
vhl cerebellar cortices also revealed pax2-positive cells in purkinje and molecular layers, resembling the histological and molecular development of basket/stellate cells in postnatal non-vhl mouse and human cerebella. |
2022-08-18 |
2023-08-14 |
mouse |
| Kimberly Luttik, Leon Tejwani, Hyoungseok Ju, Terri Driessen, Cleo J L M Smeets, Chandrakanth Reddy Edamakanti, Aryaan Khan, Joy Yun, Puneet Opal, Janghoo Li. Differential effects of Wnt-β-catenin signaling in Purkinje cells and Bergmann glia in spinocerebellar ataxia type 1. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 34. 2022-08-15. PMID:35969780. |
spinocerebellar ataxia type 1 (sca1) is a dominantly inherited neurodegenerative disease characterized by progressive ataxia and degeneration of specific neuronal populations, including purkinje cells (pcs) in the cerebellum. |
2022-08-15 |
2023-08-14 |
mouse |
| John E Greenlee, H Robert Brashea. The Discovery of Anti-Yo (Anti-PCA1) Antibody in Patients with Paraneoplastic Cerebellar Degeneration: Opening a Window into Autoimmune Neurological Disease. Cerebellum (London, England). 2022-07-26. PMID:35881322. |
these studies revealed that patients with ovarian cancer and cerebellar degeneration had high titers of antibodies directed against cytoplasmic antigens of purkinje cells and deep cerebellar nuclei-a previously undescribed pattern of antibody response which was subsequently found not to be present in ovarian cancer patients who remained neurologically normal. |
2022-07-26 |
2023-08-14 |
human |
| Tabita Kreko-Pierce, Jason R Pug. Altered Synaptic Transmission and Excitability of Cerebellar Nuclear Neurons in a Mouse Model of Duchenne Muscular Dystrophy. Frontiers in cellular neuroscience. vol 16. 2022-07-22. PMID:35865113. |
previous studies have identified the cerebellar circuit, and aberrant inhibitory transmission in purkinje cells, in particular, as a potential site of dysfunction in the central nervous system (cns). |
2022-07-22 |
2023-08-14 |
mouse |
| Yuning Liu, Hong Xing, Alexis F Ernst, Canna Liu, Christian Maugee, Fumiaki Yokoi, Madepalli Lakshmana, Yuqing L. Hyperactivity of Purkinje cell and motor deficits in C9orf72 knockout mice. Molecular and cellular neurosciences. 2022-07-17. PMID:35843530. |
purkinje cells are the sole output neurons in the cerebellum, and we next determined their involvement in the motor phenotypes. |
2022-07-17 |
2023-08-14 |
mouse |