| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Erika Ueda, Tomoko Ohta, Ayumu Konno, Hirokazu Hirai, Yuki Kurauchi, Hiroshi Katsuki, Takahiro Sek. D-Cysteine Activates Chaperone-Mediated Autophagy in Cerebellar Purkinje Cells via the Generation of Hydrogen Sulfide and Nrf2 Activation. Cells. vol 11. issue 7. 2022-04-12. PMID:35406792. |
d-cysteine activated cma in purkinje cells (pcs) of primary cerebellar cultures where dao was expressed, while it failed to activate cma in dao-deficient ad293 cells. |
2022-04-12 |
2023-08-13 |
mouse |
| Elizabeth Mercado-Ayón, Nathan Warren, Sarah Halawani, Layne N Rodden, Lucie Ngaba, Yi Na Dong, Joshua C Chang, Carlos Fonck, Fulvio Mavilio, David R Lynch, Hong Li. Cerebellar Pathology in an Inducible Mouse Model of Friedreich Ataxia. Frontiers in neuroscience. vol 16. 2022-04-11. PMID:35401081. |
loss of cerebellar purkinje neurons and large dn principal neurons are observed in the frdakd mouse cerebellum. |
2022-04-11 |
2023-08-13 |
mouse |
| Ludovic Spaeth, Philippe Isop. What Can We Learn from Synaptic Connectivity Maps about Cerebellar Internal Models? Cerebellum (London, England). 2022-04-08. PMID:35391650. |
we, here, review recent advances on how the description of the functional synaptic connectivity between granule cells and purkinje cells support the hypothesis that the cerebellum stores internal models of the body coordinates. |
2022-04-08 |
2023-08-13 |
Not clear |
| Marion Coolen, Nami Altin, Karthyayani Rajamani, Eva Pereira, Karine Siquier-Pernet, Emilia Puig Lombardi, Nadjeda Moreno, Giulia Barcia, Marianne Yvert, Annie Laquerrière, Aurore Pouliet, Patrick Nitschké, Nathalie Boddaert, Antonio Rausell, Féréchté Razavi, Alexandra Afenjar, Thierry Billette de Villemeur, Almundher Al-Maawali, Khalid Al-Thihli, Julia Baptista, Ana Beleza-Meireles, Catherine Garel, Marine Legendre, Antoinette Gelot, Lydie Burglen, Sébastien Moutton, Vincent Cantagre. Recessive PRDM13 mutations cause fatal perinatal brainstem dysfunction with cerebellar hypoplasia and disrupt Purkinje cells differentiation. American journal of human genetics. 2022-04-07. PMID:35390279. |
recessive prdm13 mutations cause fatal perinatal brainstem dysfunction with cerebellar hypoplasia and disrupt purkinje cells differentiation. |
2022-04-07 |
2023-08-13 |
mouse |
| Marion Coolen, Nami Altin, Karthyayani Rajamani, Eva Pereira, Karine Siquier-Pernet, Emilia Puig Lombardi, Nadjeda Moreno, Giulia Barcia, Marianne Yvert, Annie Laquerrière, Aurore Pouliet, Patrick Nitschké, Nathalie Boddaert, Antonio Rausell, Féréchté Razavi, Alexandra Afenjar, Thierry Billette de Villemeur, Almundher Al-Maawali, Khalid Al-Thihli, Julia Baptista, Ana Beleza-Meireles, Catherine Garel, Marine Legendre, Antoinette Gelot, Lydie Burglen, Sébastien Moutton, Vincent Cantagre. Recessive PRDM13 mutations cause fatal perinatal brainstem dysfunction with cerebellar hypoplasia and disrupt Purkinje cells differentiation. American journal of human genetics. 2022-04-07. PMID:35390279. |
snrna-seq data mining and in situ hybridization in humans show that prdm13 is expressed at early stages in the progenitors of the cerebellar ventricular zone, which gives rise to cerebellar gabaergic neurons, including purkinje cells. |
2022-04-07 |
2023-08-13 |
mouse |
| Dylan Todd, Michael Clapp, Parker Dains, Bahri Karacay, Daniel J Bonthiu. Purkinje cell-specific deletion of CREB worsens alcohol-induced cerebellar neuronal losses and motor deficits. Alcohol (Fayetteville, N.Y.). 2022-04-04. PMID:35378204. |
purkinje cell-specific deletion of creb worsens alcohol-induced cerebellar neuronal losses and motor deficits. |
2022-04-04 |
2023-08-13 |
Not clear |
| Dylan Todd, Michael Clapp, Parker Dains, Bahri Karacay, Daniel J Bonthiu. Purkinje cell-specific deletion of CREB worsens alcohol-induced cerebellar neuronal losses and motor deficits. Alcohol (Fayetteville, N.Y.). 2022-04-04. PMID:35378204. |
in this study, creb was specifically disrupted in cerebellar purkinje cells to study its role in protection of cerebellar neurons against alcohol toxicity. |
2022-04-04 |
2023-08-13 |
Not clear |
| Naveen Sendhilnathan, Michael E Goldberg, Anna E Ipat. Mixed Selectivity in the Cerebellar Purkinje-Cell Response during Visuomotor Association Learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-03-30. PMID:35351828. |
here, we studied the simple spike activity of purkinje cells in the mid-lateral cerebellum when 2 male monkeys learned to associate a right or left-hand movement with one of two visual symbolic cues. |
2022-03-30 |
2023-08-13 |
monkey |
| Christiane S Hampe, Hiroshi Mitom. A Breakdown of Immune Tolerance in the Cerebellum. Brain sciences. vol 12. issue 3. 2022-03-25. PMID:35326284. |
the underlying cause for this vulnerability is unclear, but it may be a result of region-specific differences in blood-brain barrier permeability, the high concentration of neurons in the cerebellum and the presence of autoantigens on purkinje cells. |
2022-03-25 |
2023-08-13 |
Not clear |
| Tuancheng Feng, Lin Luan, Isabel Iscol Katz, Mohammed Ullah, Vivianna M Van Deerlin, John Q Trojanowski, Edward B Lee, Fenghua H. TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss. Acta neuropathologica communications. vol 10. issue 1. 2022-03-15. PMID:35287730. |
we found that tmem106b is ubiquitously expressed in neurons in the cerebellum, with the highest levels in the purkinje neurons. |
2022-03-15 |
2023-08-13 |
mouse |
| Junxiao Zheng, Qinzhu Yang, Nikos Makris, Kaibin Huang, Jianwen Liang, Chenfei Ye, Xiaxia Yu, Mu Tian, Ting Ma, Tian Mou, Wenlong Guo, Ron Kikinis, Yi Ga. Three-Dimensional Digital Reconstruction of the Cerebellar Cortex: Lobule Thickness, Surface Area Measurements, and Layer Architecture. Cerebellum (London, England). 2022-03-14. PMID:35286708. |
we found that the overall surface area of the cerebellar granular layer (including purkinje cells) was 1,732 cm |
2022-03-14 |
2023-08-13 |
Not clear |
| Yasmin Fidler, Jose Rosa Gome. Effects of a Single Dose of X-Ray Irradiation on MMP-9 Expression and Morphology of the Cerebellum Cortex of Adult Rats. Cerebellum (London, England). 2022-03-09. PMID:35262839. |
the cerebellum of the control and irradiated groups was submitted for an analysis of cell purkinje count, nuclear perimeter, and chromatin density using morphometric estimatives obtained from the feulgen histochemistry reaction. |
2022-03-09 |
2023-08-13 |
rat |
| Yasmin Fidler, Jose Rosa Gome. Effects of a Single Dose of X-Ray Irradiation on MMP-9 Expression and Morphology of the Cerebellum Cortex of Adult Rats. Cerebellum (London, England). 2022-03-09. PMID:35262839. |
we conclude that the effects of a single dose of 15-gy x-ray irradiation in the cerebellum were an increase in mmp-9 expression in the first 2 weeks after irradiation, especially surrounding the purkinje cells and in the molecular layers, with morphological changes in the purkinje cell and granular cell layers, suggesting a continuous cell loss throughout the days evaluated after irradiation. |
2022-03-09 |
2023-08-13 |
rat |
| Chunping Hu, Susu Wang, Deqing Wu, Chonghuai Yan, Meiqin W. Subclinical hypothyroidism in pregnancy rats impaired offspring's spatial learning and memory and the cerebellar development. Biochemical and biophysical research communications. vol 602. 2022-03-07. PMID:35255435. |
except for e14, the proliferation of pups' cerebellar granule cells (gcs), and the migration of pups' purkinje cells (pcs) in the sch group was significantly inhibited compared with that in the con group at other time points (p < 0.05 or p < 0.01), and the differentiation of cerebellar astrocytes (as) in sch group was higher than that in con group at p3 and p10. |
2022-03-07 |
2023-08-13 |
rat |
| Maryam Rahimi-Balaei, Hassan Marzban, Richard Hawke. Early Cerebellar Development in Relation to the Trigeminal System. Cerebellum (London, England). 2022-03-03. PMID:35237930. |
conventionally, it is believed that afferents from the vestibular system are the first to invade the cerebellum, at embryonic days (e) 11-e12/13 in mice, where they target the new born purkinje cells. |
2022-03-03 |
2023-08-13 |
mouse |
| Maryam Rahimi-Balaei, Hassan Marzban, Richard Hawke. Early Cerebellar Development in Relation to the Trigeminal System. Cerebellum (London, England). 2022-03-03. PMID:35237930. |
the finding that trigeminal ganglion-derived pioneer axons enter the cerebellar primordium before purkinje cells are born and target the cerebellar nuclei, reveals a novel perspective on the development of early cerebellar connectivity. |
2022-03-03 |
2023-08-13 |
mouse |
| Anastasia Rumyantseva, Milica Popovic, Aleksandra Trifunovi. CLPP deficiency ameliorates neurodegeneration caused by impaired mitochondrial protein synthesis. Brain : a journal of neurology. 2022-03-03. PMID:35240691. |
here, we build upon this finding by showing that clpp depletion is indeed beneficial in vivo for various types of neuronal populations, including purkinje cells in the cerebellum and cortical and hippocampal neurons in the forebrain, as it strongly improves distinct phenotypes of mitochondria encephalopathy, driven by the deficiency of the mitochondrial aspartyl trna synthase dars2. |
2022-03-03 |
2023-08-13 |
mouse |
| Xiang Chen, Tong Chen, Chen Dong, Huiyao Chen, Xinran Dong, Lin Yang, Liyuan Hu, Huijun Wang, Bingbing Wu, Ye Yao, Yu Xiong, Man Xiong, Yifeng Lin, Wenhao Zho. Deletion of CHD8 in cerebellar granule neuron progenitors leads to severe cerebellar hypoplasia, ataxia and psychiatric behavior in mice. Journal of genetics and genomics = Yi chuan xue bao. 2022-03-01. PMID:35231638. |
however, no substantial cerebellar dysplasia is detected in mice with purkinje neuron- or oligodendrocyte-specific chd8 ablation. |
2022-03-01 |
2023-08-13 |
mouse |
| Satoshi Akinaga, Sayaka Harada, Miyuki Takahashi, Aosa Kaneko, Papachan Kolattukudy, Yoshio Goshima, Toshio Ohshim. Loss of CRMP1 and CRMP2 results in migration defects of Purkinje cells in the X lobule of the mouse cerebellum. Brain research. 2022-02-27. PMID:35219721. |
loss of crmp1 and crmp2 results in migration defects of purkinje cells in the x lobule of the mouse cerebellum. |
2022-02-27 |
2023-08-13 |
mouse |
| Yu Liu, Samuel S McAfee, Meike E Van Der Heijden, Mukesh Dhamala, Roy V Sillitoe, Detlef H Hec. Causal Evidence for a Role of Cerebellar Lobulus Simplex in Prefrontal-Hippocampal Interaction in Spatial Working Memory Decision-Making. Cerebellum (London, England). 2022-02-26. PMID:35218525. |
with recent evidence that purkinje cells in the cerebellar lobulus simplex (ls) represent information about the phase and phase differences of gamma oscillations in the mpfc and dorsal hippocampus, we hypothesized that ls might be involved in the modulation of mpfc-hippocampal gamma coherence. |
2022-02-26 |
2023-08-13 |
mouse |