| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xu Zhang, Roeland Hancock, Sabato Santaniell. Transcranial direct current stimulation of cerebellum alters spiking precision in cerebellar cortex: A modeling study of cellular responses. PLoS computational biology. vol 17. issue 12. 2021-12-09. PMID:34882680. |
altogether, the acute effects of tdcs on cerebellum mainly focus on purkinje cells and modulate the precision of the response to synaptic stimuli, thus having the largest impact when the cerebellar cortex is active. |
2021-12-09 |
2023-08-13 |
Not clear |
| Sameh M Farouk, Ahmed M Abdellatif, Elsayed Metwall. Outer and inner mitochondrial membrane proteins TOMM40 and TIMM50 are intensively concentrated and localized at Purkinje and pyramidal neurons in the New Zealand white rabbit brain. Anatomical record (Hoboken, N.J. : 2007). vol 305. issue 1. 2021-12-08. PMID:34041863. |
sections from brain specimens were initially stained for cytochrome c oxidase (cox), a well-known mitochondrial marker, which was found to be homogeneously expressed in the cerebrum, but localized to the purkinje and pyramidal neurons of the cerebellum and hippocampus, respectively. |
2021-12-08 |
2023-08-13 |
rabbit |
| Sameh M Farouk, Ahmed M Abdellatif, Elsayed Metwall. Outer and inner mitochondrial membrane proteins TOMM40 and TIMM50 are intensively concentrated and localized at Purkinje and pyramidal neurons in the New Zealand white rabbit brain. Anatomical record (Hoboken, N.J. : 2007). vol 305. issue 1. 2021-12-08. PMID:34041863. |
meanwhile, purkinje cells in the cerebellum and pyramidal neurons in the hippocampus displayed higher intensities in their cytoplasm. |
2021-12-08 |
2023-08-13 |
rabbit |
| Ester Pérez-Martín, Rodrigo Muñoz-Castañeda, Marie-Jo Moutin, Carmelo A Ávila-Zarza, José M Muñoz-Castañeda, Carlos Del Pilar, José R Alonso, Annie Andrieux, David Díaz, Eduardo Weruag. Oleoylethanolamide Delays the Dysfunction and Death of Purkinje Cells and Ameliorates Behavioral Defects in a Mouse Model of Cerebellar Neurodegeneration. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 18. issue 3. 2021-12-04. PMID:33829414. |
oleoylethanolamide delays the dysfunction and death of purkinje cells and ameliorates behavioral defects in a mouse model of cerebellar neurodegeneration. |
2021-12-04 |
2023-08-13 |
mouse |
| Ester Pérez-Martín, Rodrigo Muñoz-Castañeda, Marie-Jo Moutin, Carmelo A Ávila-Zarza, José M Muñoz-Castañeda, Carlos Del Pilar, José R Alonso, Annie Andrieux, David Díaz, Eduardo Weruag. Oleoylethanolamide Delays the Dysfunction and Death of Purkinje Cells and Ameliorates Behavioral Defects in a Mouse Model of Cerebellar Neurodegeneration. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 18. issue 3. 2021-12-04. PMID:33829414. |
these mice exhibit cerebellar degeneration, displaying microtubule alterations that trigger the selective loss of purkinje cells and consequent behavioral impairments. |
2021-12-04 |
2023-08-13 |
mouse |
| Martijn Schonewille, Allison E Girasole, Philippe Rostaing, Caroline Mailhes-Hamon, Annick Ayon, Alexandra B Nelson, Antoine Triller, Mariano Casado, Chris I De Zeeuw, Guy Bouvie. NMDARs in granule cells contribute to parallel fiber-Purkinje cell synaptic plasticity and motor learning. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 37. 2021-12-03. PMID:34507990. |
in young rodents, at the cerebellar synapse between granule cells (gc) and purkinje cells (pc), bidirectional plasticity is shaped by the balance between transcellular nitric oxide (no) driven by presynaptic |
2021-12-03 |
2023-08-13 |
Not clear |
| D S Kalinina, M A Ptukha, A V Goriainova, N S Merkulyeva, A A Kozlova, R Z Murtazina, T S Shemiakova, S R Kuvarzin, A N Vaganova, A B Volnova, R R Gainetdinov, P E Musienk. Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions. Scientific reports. vol 11. issue 1. 2021-12-03. PMID:34845253. |
using trace amine-associated receptor 5 knockout (taar5-ko) mice, that express beta-galactosidase mapping its localization, we observed taar5 expression in the purkinje cells of the cerebellum and the medial vestibular nucleus, suggesting that taar5 might be involved in the vestibular and motor control. |
2021-12-03 |
2023-08-13 |
mouse |
| François G C Blot, Wilhelmina H J J Krijnen, Sandra Den Hoedt, Catarina Osório, Joshua J White, Monique T Mulder, Martijn Schonewill. Sphingolipid metabolism governs Purkinje cell patterned degeneration in Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 36. 2021-12-02. PMID:34479994. |
sphingolipid metabolism governs purkinje cell patterned degeneration in patterned degeneration of purkinje cells (pcs) can be observed in a wide range of neuropathologies, but mechanisms behind nonrandom cerebellar neurodegeneration remain unclear. |
2021-12-02 |
2023-08-13 |
Not clear |
| Anastasiia Bohush, Agnieszka Góral, Małgorzata Sierant, Barbara Nawrot, Wiesława Leśniak, Anna Filipe. Sgt1 Regulates α-Synuclein Subcellular Localization and Expression of Parkinson's Disease Related Genes, Biomolecules. vol 11. issue 11. 2021-11-30. PMID:34827672. |
sgt1 regulates α-synuclein subcellular localization and expression of parkinson's disease related genes, the sgt1 protein is highly expressed in the mammalian brain, particularly in neurons of the hippocampus and cortex, and in purkinje cells of the cerebellum. |
2021-11-30 |
2023-08-13 |
Not clear |
| Weipang Chang, Andrea Pedroni, Reinhard W Köster, Stefania Giacomello, Konstantinos Ampatzi. Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses. Scientific reports. vol 11. issue 1. 2021-11-26. PMID:34526620. |
purkinje cells are critically involved in processing the cerebellar functions by shaping and coordinating commands that they receive. |
2021-11-26 |
2023-08-13 |
zebrafish |
| Weipang Chang, Andrea Pedroni, Reinhard W Köster, Stefania Giacomello, Konstantinos Ampatzi. Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses. Scientific reports. vol 11. issue 1. 2021-11-26. PMID:34526620. |
here, we demonstrate experimentally that in the adult zebrafish valvular part of the cerebellum, the purkinje cells exhibited variable firing and functional responses and allowed the categorization into three firing classes. |
2021-11-26 |
2023-08-13 |
zebrafish |
| Mehdi Hooshmandi, Vinh Tai Truong, Eviatar Fields, Riya Elizabeth Thomas, Calvin Wong, Vijendra Sharma, Ilse Gantois, Patricia Soriano Roque, Kleanthi Chalkiadaki, Neil Wu, Anindyo Chakraborty, Soroush Tahmasebi, Masha Prager-Khoutorsky, Nahum Sonenberg, Aparna Suvrathan, Alanna J Watt, Christos G Gkogkas, Arkady Khoutorsk. 4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors. Cell reports. vol 35. issue 4. 2021-11-24. PMID:33910008. |
recent studies have demonstrated that selective activation of mammalian target of rapamycin complex 1 (mtorc1) in the cerebellum by deletion of the mtorc1 upstream repressors tsc1 or phosphatase and tensin homolog (pten) in purkinje cells (pcs) causes autism-like features and cognitive deficits. |
2021-11-24 |
2023-08-13 |
mouse |
| Takanori Ikenaga, Rinko Shimomai, Hanako Hagio, Satoru Kimura, Kazumasa Matsumoto, Dai-Ichiro Kato, Kentaro Uesugi, Akihisa Takeuchi, Naoyuki Yamamoto, Masahiko Hib. Morphological analysis of the cerebellum and its efferent system in a basal actinopterygian fish, Polypterus senegalus. The Journal of comparative neurology. 2021-11-24. PMID:34729771. |
in amniotes, cerebellar efferent neurons form clusters, deep cerebellar nuclei, lie deep in the cerebellum, and receive synaptic inputs from purkinje cells but not granule cells. |
2021-11-24 |
2023-08-13 |
Not clear |
| Takanori Ikenaga, Rinko Shimomai, Hanako Hagio, Satoru Kimura, Kazumasa Matsumoto, Dai-Ichiro Kato, Kentaro Uesugi, Akihisa Takeuchi, Naoyuki Yamamoto, Masahiko Hib. Morphological analysis of the cerebellum and its efferent system in a basal actinopterygian fish, Polypterus senegalus. The Journal of comparative neurology. 2021-11-24. PMID:34729771. |
however, in the cerebellum of teleosts, the efferent neurons, called eurydendroid cells, lie near the cell bodies of purkinje cells and receive inputs both from axons of purkinje cells and granule cell parallel fibers. |
2021-11-24 |
2023-08-13 |
Not clear |
| Takanori Ikenaga, Rinko Shimomai, Hanako Hagio, Satoru Kimura, Kazumasa Matsumoto, Dai-Ichiro Kato, Kentaro Uesugi, Akihisa Takeuchi, Naoyuki Yamamoto, Masahiko Hib. Morphological analysis of the cerebellum and its efferent system in a basal actinopterygian fish, Polypterus senegalus. The Journal of comparative neurology. 2021-11-24. PMID:34729771. |
we found that the cell bodies of purkinje cells are not aligned in a layer; incoming climbing fibers terminate mainly on the basal portion of purkinje cells, revealing that the polypterus cerebellum has unique features among vertebrate cerebella. |
2021-11-24 |
2023-08-13 |
Not clear |
| Jérome Carriot, Isabelle Mackrous, Kathleen E Culle. Challenges to the Vestibular System in Space: How the Brain Responds and Adapts to Microgravity. Frontiers in neural circuits. vol 15. 2021-11-23. PMID:34803615. |
space-based experiments have shown that altered gravity causes structural and functional changes at multiple stages of vestibular processing, spanning from the hair cells of its sensory organs to the purkinje cells of the vestibular cerebellum. |
2021-11-23 |
2023-08-13 |
human |
| Miki Hieda, Taizo Matsumoto, Mari Isobe, Sadamu Kurono, Kaneko Yuka, Satoshi Kametaka, Jing-Ya Wang, Ya-Hui Chi, Kenji Kameda, Hiroshi Kimura, Nariaki Matsuura, Shuji Matsuur. The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal. Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33686165. |
further, sun1-knockout mice, which show impaired cerebellar development and cerebellar ataxia, presented altered golgi morphology in purkinje cells. |
2021-11-22 |
2023-08-13 |
mouse |
| Anna Niewiadomska-Cimicka, Frédéric Doussau, Jean-Baptiste Perot, Michel J Roux, Celine Keime, Antoine Hache, Françoise Piguet, Ariana Novati, Chantal Weber, Binnaz Yalcin, Hamid Meziane, Marie-France Champy, Erwan Grandgirard, Alice Karam, Nadia Messaddeq, Aurélie Eisenmann, Emmanuel Brouillet, Hoa Huu Phuc Nguyen, Julien Flament, Philippe Isope, Yvon Trottie. SCA7 Mouse Cerebellar Pathology Reveals Preferential Downregulation of Key Purkinje Cell-Identity Genes and Shared Disease Signature with SCA1 and SCA2. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 22. 2021-11-19. PMID:33888607. |
sca7 mouse cerebellar pathology reveals preferential downregulation of key purkinje cell-identity genes and shared disease signature with sca1 and sca2. |
2021-11-19 |
2023-08-13 |
mouse |
| Shannon Thomson, Karen A Waters, Rita Machaalan. The Unfolded Protein Response in the Human Infant Brain and Dysregulation Seen in Sudden Infant Death Syndrome (SIDS). Molecular neurobiology. vol 58. issue 5. 2021-11-18. PMID:33417217. |
infants who were bed-sharing had higher pperk in the dorsal raphe nuclei of the pons and the purkinje cells of the cerebellum. |
2021-11-18 |
2023-08-13 |
human |
| Alexander S Fanning, Amin Md Shakhawat, Jennifer L Raymon. Population calcium responses of Purkinje cells in the oculomotor cerebellum driven by nonvisual input. Journal of neurophysiology. vol 126. issue 4. 2021-11-17. PMID:34346783. |
population calcium responses of purkinje cells in the oculomotor cerebellum driven by nonvisual input. |
2021-11-17 |
2023-08-13 |
mouse |