| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gerrit Cornelis Beekhof, Catarina Osório, Joshua J White, Scott van Zoomeren, Hannah van der Stok, Bilian Xiong, Ingo Hms Nettersheim, Willem Ashwin Mak, Marit Runge, Francesca Romana Fiocchi, Henk-Jan Boele, Freek E Hoebeek, Martijn Schonewill. Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors. eLife. vol 10. 2021-10-21. PMID:33973524. |
distinct populations of purkinje cells (pcs) with unique molecular and connectivity features are at the core of the modular organization of the cerebellum. |
2021-10-21 |
2023-08-13 |
mouse |
| Anton M Jetten, Joung Hyuck Jo. Retinoid-related Orphan Receptors (RORs): Roles in Cellular Differentiation and Development. Advances in developmental biology (Amsterdam, Netherlands). vol 16. 2021-10-20. PMID:18418469. |
roralpha plays a key role in the development of the cerebellum particularly in the regulation of the maturation and survival of purkinje cells. |
2021-10-20 |
2023-08-12 |
mouse |
| Meike E van der Heijden, Elizabeth P Lackey, Ross Perez, Fatma S Ișleyen, Amanda M Brown, Sarah G Donofrio, Tao Lin, Huda Y Zoghbi, Roy V Sillito. Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons. eLife. vol 10. 2021-10-19. PMID:34542409. |
we generated mutant mice that lack the majority of excitatory cerebellar neurons and tracked the structural and functional consequences on purkinje cells. |
2021-10-19 |
2023-08-13 |
mouse |
| John S Stahl, Aaron Ketting-Olivier, Prasad A Tendolkar, Tenesha L Conno. Impact of Purkinje Cell Simple Spike Synchrony on Signal Transmission from Flocculus. Cerebellum (London, England). 2021-10-19. PMID:34665396. |
purkinje cells (pcs) in the cerebellar flocculus carry rate-coded information that ultimately drives eye movement. |
2021-10-19 |
2023-08-13 |
mouse |
| Chihiro Nakamoto, Kohtarou Konno, Taisuke Miyazaki, Ena Nakatsukasa, Rie Natsume, Manabu Abe, Meiko Kawamura, Yugo Fukazawa, Ryuichi Shigemoto, Miwako Yamasaki, Kenji Sakimura, Masahiko Watanab. Expression mapping, quantification, and complex formation of GluD1 and GluD2 glutamate receptors in adult mouse brain. The Journal of comparative neurology. vol 528. issue 6. 2021-10-18. PMID:31625608. |
in the cerebellum, glud2 is exclusively expressed in purkinje cells, where it regulates synapse formation and regeneration, synaptic plasticity, and motor learning. |
2021-10-18 |
2023-08-13 |
mouse |
| Joshua J White, Laurens W J Bosman, Francois G C Blot, Catarina Osório, Bram W Kuppens, Wilhelmina H J J Krijnen, Charlotte Andriessen, Chris I De Zeeuw, Dick Jaarsma, Martijn Schonewill. Region-specific preservation of Purkinje cell morphology and motor behavior in the ATXN1[82Q] mouse model of spinocerebellar ataxia 1. Brain pathology (Zurich, Switzerland). vol 31. issue 5. 2021-10-13. PMID:33724582. |
additionally, we found that purkinje cells in other cerebellar lobules that typically express aldoc, not only display severe pathology but also show loss of aldoc expression. |
2021-10-13 |
2023-08-13 |
mouse |
| Stijn Stroobants, Rudi D'Hooge, Markus Damm. Aged Tmem106b knockout mice display gait deficits in coincidence with Purkinje cell loss and only limited signs of non-motor dysfunction. Brain pathology (Zurich, Switzerland). vol 31. issue 2. 2021-10-12. PMID:33016371. |
histologically, we observed late-onset loss of purkinje cells followed by reactive gliosis in the cerebellum, which likely contributed to progressive decline in motor function and gait defects in particular. |
2021-10-12 |
2023-08-13 |
mouse |
| Anshul Srivastava, Serguei Liachenko, Sumit Sarkar, Merle Paule, Natalya Sadovova, Joseph P Hani. Global Neurotoxicity: Quantitative Analysis of Rat Brain Toxicity Following Exposure to Trimethyltin. International journal of toxicology. vol 40. issue 4. 2021-10-11. PMID:33878910. |
trimethyltin toxicity was greatest in the hippocampus, olfactory area, cerebellum, pons, mammillary nucleus, inferior and superior colliculus, hypoglossal nucleus, thalamus, and cerebellar purkinje cells. |
2021-10-11 |
2023-08-13 |
rat |
| Reza Shadmeh. Population coding in the cerebellum: a machine learning perspective. Journal of neurophysiology. vol 124. issue 6. 2021-09-29. PMID:33112717. |
the cere resembles a feedforward, three-layer network of neurons in which the "hidden layer" consists of purkinje cells (p-cells) and the output layer consists of deep cerebellar nucleus (dcn) neurons. |
2021-09-29 |
2023-08-13 |
Not clear |
| Shimaa M Abou-Zeid, Basma A Elkhadrawey, Anis Anis, Huda O AbuBakr, Badr E El-Bialy, Hesham S Elsabbagh, Nermeen B El-Bora. Neuroprotective effect of sesamol against aluminum nanoparticle-induced toxicity in rats. Environmental science and pollution research international. vol 28. issue 38. 2021-09-29. PMID:34037932. |
the cerebellum showed loss of purkinje cells, and the cerebrum showed perivascular edema, neuronal degeneration, necrosis, and neuronal apoptosis. |
2021-09-29 |
2023-08-13 |
rat |
| Andrew C Robinson, Nin Bajaj, Marios Hadjivassiliou, James Minshull, Aiza Mahmood, Federico Roncarol. Neuropathology of a case of fragile X-associated tremor ataxia syndrome without tremor. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 40. issue 6. 2021-09-27. PMID:32830366. |
the molecular, purkinje's cell, and granule cell layers of the cerebellar folia demonstrated mild gliosis, and cerebellar white matter was mildly affected. |
2021-09-27 |
2023-08-13 |
human |
| Polina A Egorova, Aleksandra V Gavrilova, Ilya B Bezprozvann. In vivo analysis of the spontaneous firing of cerebellar Purkinje cells in awake transgenic mice that model spinocerebellar ataxia type 2. Cell calcium. vol 93. 2021-09-24. PMID:33248384. |
cerebellar purkinje cells (pcs) fire spontaneously in a tonic mode, although the precision of this pacemaking activity is disturbed in many abnormal conditions involving cerebellar atrophy, such as many spinocerebellar ataxias (scas). |
2021-09-24 |
2023-08-13 |
mouse |
| Aaron Sathyanesan, Panagiotis Kratimenos, Vittorio Gall. Disruption of neonatal Purkinje cell function underlies injury-related learning deficits. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 11. 2021-09-23. PMID:33688045. |
chemogenetic inhibition of neonatal purkinje cells is sufficient to phenocopy the effects of perinatal cerebellar injury. |
2021-09-23 |
2023-08-13 |
Not clear |
| Cheryl Brandenburg, Lindsey A Smith, Michaela B C Kilander, Morgan S Bridi, Yu-Chih Lin, Shiyong Huang, Gene J Blat. Parvalbumin subtypes of cerebellar Purkinje cells contribute to differential intrinsic firing properties. Molecular and cellular neurosciences. vol 115. 2021-09-23. PMID:34197921. |
purkinje cells (pcs) are central to cerebellar information coding and appreciation for the diversity of their firing patterns and molecular profiles is growing. |
2021-09-23 |
2023-08-13 |
Not clear |
| Felipe Cunha, Cristian Gutiérrez-Ibáñez, Kelsey Racicot, Douglas R Wylie, Andrew N Iwaniu. A quantitative analysis of cerebellar anatomy in birds. Brain structure & function. vol 226. issue 8. 2021-09-20. PMID:34357439. |
however, the rate at which neuron numbers increased with cerebellum size varied across purkinje cells, granule cells, and cerebellar nuclei neurons. |
2021-09-20 |
2023-08-13 |
Not clear |
| Felipe Cunha, Cristian Gutiérrez-Ibáñez, Kelsey Racicot, Douglas R Wylie, Andrew N Iwaniu. A quantitative analysis of cerebellar anatomy in birds. Brain structure & function. vol 226. issue 8. 2021-09-20. PMID:34357439. |
our estimate of cerebellar folding, the midsagittal foliation index, was a poor predictor of surface area and number of purkinje cells, but surface area was the best predictor of purkinje cell numbers. |
2021-09-20 |
2023-08-13 |
Not clear |
| Megan L Shipman, Sharath C Madasu, Anthony D Morielli, John T Gree. Intracerebellar infusion of an mGluR1/5 agonist enhances eyeblink conditioning. Behavioral neuroscience. vol 135. issue 3. 2021-09-17. PMID:33630615. |
cerebellar metabotropic glutamate receptor 1 (mglur1) expressed by purkinje cells may play an important role in learning-related cerebellar plasticity. |
2021-09-17 |
2023-08-13 |
mouse |
| Pauline Bohne, Damian Boden-El Mourabit, Mareike Josten, Melanie D Mar. Cognitive deficits in episodic ataxia type 2 mouse models. Human molecular genetics. vol 30. issue 19. 2021-09-17. PMID:34077522. |
to determine if the cerebellum is contributing to these cognitive deficits, we examined two different ea2 mouse models for cognition impairments where cacna1a was removed specifically from cerebellar purkinje or granule cells postnatally. |
2021-09-17 |
2023-08-13 |
mouse |
| Liyuan Guo, Haitao Ren, Siyuan Fan, Hongzhi Guan, Jing Wan. Autoantibody against the Rab6A/Rab6B in primary autoimmune cerebellar ataxia associated with Sjogren's syndrome: A case report. Journal of neuroimmunology. vol 359. 2021-09-14. PMID:34332492. |
tissue-based indirect immunofluorescence assay (tba) of the patient's serum and cerebrospinal fluid (csf) revealed igg antibody to purkinje cells and the granular layer of the rat cerebellum. |
2021-09-14 |
2023-08-13 |
rat |
| Javad Sadeghinezhad, Mahdi Aghabalazadeh Asl, Ava Saeidi, Margherita De Silv. Morphometrical study of the cat cerebellum using unbiased design-based stereology. Anatomia, histologia, embryologia. vol 49. issue 6. 2021-09-13. PMID:32524671. |
cerebellar surface area was estimated using test lines, and purkinje cellular and nuclear volumes were analysed using the nucleator technique. |
2021-09-13 |
2023-08-13 |
cat |