| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexander S Fanning, Amin Md Shakhawat, Jennifer L Raymon. Population calcium responses of Purkinje cells in the oculomotor cerebellum driven by nonvisual input. Journal of neurophysiology. vol 126. issue 4. 2021-11-17. PMID:34346783. |
the climbing fiber input to the cerebellum conveys instructive signals that can induce synaptic plasticity and learning by triggering complex spikes accompanied by large calcium transients in purkinje cells. |
2021-11-17 |
2023-08-13 |
mouse |
| Alexander S Fanning, Amin Md Shakhawat, Jennifer L Raymon. Population calcium responses of Purkinje cells in the oculomotor cerebellum driven by nonvisual input. Journal of neurophysiology. vol 126. issue 4. 2021-11-17. PMID:34346783. |
thus, population calcium responses of purkinje cells in the cerebellar flocculus to visual and nonvisual input are similar to what has been reported previously for complex spikes, suggesting that multimodal instructive signals control the synaptic plasticity supporting oculomotor learning. |
2021-11-17 |
2023-08-13 |
mouse |
| Ehsan Sedaghat-Nejad, Mohammad Amin Fakharian, Jay Pi, Paul Hage, Yoshiko Kojima, Robi Soetedjo, Shogo Ohmae, Javier F Medina, Reza Shadmeh. P-sort: an open-source software for cerebellar neurophysiology. Journal of neurophysiology. vol 126. issue 4. 2021-11-17. PMID:34432996. |
analysis of electrophysiological data from purkinje cells (p-cells) of the cerebellum presents unique challenges to spike sorting. |
2021-11-17 |
2023-08-13 |
mouse |
| Sharon R Stevens, Meike E van der Heijden, Yuki Ogawa, Tao Lin, Roy V Sillitoe, Matthew N Rasban. Ankyrin-R links Kv3.3 to the spectrin cytoskeleton and is required for Purkinje neuron survival. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2021-11-17. PMID:34785580. |
in the cerebellum, ankyrin-r (ankr) is highly enriched in purkinje neurons, granule cells, and in the cerebellar nuclei. |
2021-11-17 |
2023-08-13 |
mouse |
| Joana Duarte-Neves, Cláudia Cavadas, Luís Pereira de Almeid. Neuropeptide Y (NPY) intranasal delivery alleviates Machado-Joseph disease. Scientific reports. vol 11. issue 1. 2021-11-11. PMID:33558582. |
this was in line with a reduction of cerebellar pathology, evidenced by a preservation of cerebellar granular layer and of purkinje cells and reduction of mutant ataxin-3 aggregate numbers. |
2021-11-11 |
2023-08-13 |
mouse |
| Pronit Biswas, Whidul Hasan, Juli Jain, Rajesh Kumar Kori, Devasish Bose, Rajesh Singh Yada. Non-permitted food colorants induced neurotoxicity in cerebellum of rat brain. Drug and chemical toxicology. 2021-11-10. PMID:34753371. |
further, the histological study also revealed the loss of purkinje neurons in the cerebellum of the rat brain. |
2021-11-10 |
2023-08-13 |
rat |
| Stefanie S Bradley, Erika Howe, Craig D C Bailey, Matthew K Vickaryou. The Dendrite Arbor of Purkinje Cells Is Altered Following to Tail Regeneration in the Leopard Gecko. Integrative and comparative biology. vol 61. issue 2. 2021-11-09. PMID:34038505. |
purkinje cells of the cerebellum have a complex arborized arrangement of dendrites and are among the most distinctive cell types of the nervous system. |
2021-11-09 |
2023-08-13 |
Not clear |
| Sha Yin, Qinyuan Liao, Yida Wang, Qianwen Shi, Peng Xia, Ming Yi, Jing Huan. Ccdc134 deficiency impairs cerebellar development and motor coordination. Genes, brain, and behavior. vol 20. issue 7. 2021-11-09. PMID:34382738. |
here, we report that ccdc134 is highly expressed in purkinje cells (pcs) at all developmental stages and regulates mammalian cerebellar development in a cell type-specific manner. |
2021-11-09 |
2023-08-13 |
mouse |
| Donatella Farini, Daniela Marazziti, Maria Concetta Geloso, Claudio Sett. Transcriptome programs involved in the development and structure of the cerebellum. Cellular and molecular life sciences : CMLS. vol 78. issue 19-20. 2021-11-08. PMID:34406416. |
notably, the apparently simple neuronal organization of the cerebellum, in which purkinje cells represent the only output, hides an elevated functional diversity even within the same neuronal population. |
2021-11-08 |
2023-08-13 |
mouse |
| Ivonne Carolina Bolaños-Burgos, Ana María Bernal-Correa, Germán Arturo Bohórquez Mahecha, Ângela Maria Ribeiro, Christopher Kushmeric. Thiamine Deficiency Increases Intrinsic Excitability of Mouse Cerebellar Purkinje Cells. Cerebellum (London, England). vol 20. issue 2. 2021-11-05. PMID:33098550. |
thiamine deficiency is associated with cerebellar dysfunction; however, the consequences of thiamine deficiency on the electrophysiological properties of cerebellar purkinje cells are poorly understood. |
2021-11-05 |
2023-08-13 |
mouse |
| Ivonne Carolina Bolaños-Burgos, Ana María Bernal-Correa, Germán Arturo Bohórquez Mahecha, Ângela Maria Ribeiro, Christopher Kushmeric. Thiamine Deficiency Increases Intrinsic Excitability of Mouse Cerebellar Purkinje Cells. Cerebellum (London, England). vol 20. issue 2. 2021-11-05. PMID:33098550. |
thus, the data obtained in the present study indicate that increased excitability of purkinje cells may represent a leading indicator of cerebellar dysfunction caused by lack of thiamine. |
2021-11-05 |
2023-08-13 |
mouse |
| Qin-Wei Wu, Josef P Kapfhamme. Serine/threonine kinase 17b (STK17B) signalling regulates Purkinje cell dendritic development and is altered in multiple spinocerebellar ataxias. The European journal of neuroscience. vol 54. issue 7. 2021-11-01. PMID:34536317. |
we present evidence that stk17b is strongly expressed in mouse cerebellar purkinje cells starting in the early postnatal period and remaining highly expressed throughout adult stages and that stk17b is a target of pkc phosphorylation in the cerebellum. |
2021-11-01 |
2023-08-13 |
mouse |
| Friedrich Schinzel, Hannah Seyfer, Lena Ebbers, Hans Gerd Nothwan. The Lbx1 lineage differentially contributes to inhibitory cell types of the dorsal cochlear nucleus, a cerebellum-like structure, and the cerebellum. The Journal of comparative neurology. vol 529. issue 11. 2021-10-29. PMID:33786818. |
in contrast, in the cerebellum, stellate cells and golgi cells were part of the lbx1 lineage and purkinje cells were not. |
2021-10-29 |
2023-08-13 |
mouse |
| Raghavendra Y Nagaraja, David M Sherry, Jennifer L Fessler, Megan A Stiles, Feng Li, Karanpreet Multani, Albert Orock, Mohiuddin Ahmad, Richard S Brush, Robert E Anderson, Martin-Paul Agbaga, Ferenc Deá. W246G Mutant ELOVL4 Impairs Synaptic Plasticity in Parallel and Climbing Fibers and Causes Motor Defects in a Rat Model of SCA34. Molecular neurobiology. vol 58. issue 10. 2021-10-27. PMID:34227061. |
to understand the mechanism of these motor deficits, we performed electrophysiological studies using cerebellar slices from rats homozygous for w246g mutant elovl4 and found marked reduction of long-term potentiation at parallel fiber synapses and long-term depression at climbing fiber synapses onto purkinje cells. |
2021-10-27 |
2023-08-13 |
rat |
| Ramesh Iyer, Clara Franzini-Armstron. The location of InsP3 receptors in Purkinje cells of murine cerebellum does not supports a direct interaction in the transfer of calcium ions between ER and mitochondria. European journal of translational myology. vol 31. issue 3. 2021-10-26. PMID:34498451. |
the location of insp3 receptors in purkinje cells of murine cerebellum does not supports a direct interaction in the transfer of calcium ions between er and mitochondria. |
2021-10-26 |
2023-08-13 |
Not clear |
| Yusra Mansour, Alyson Burchell, Randy J Kulesz. Central Auditory and Vestibular Dysfunction Are Key Features of Autism Spectrum Disorder. Frontiers in integrative neuroscience. vol 15. 2021-10-22. PMID:34658804. |
further, the cerebellum was one of the first brain structures implicated in asd and studies have revealed loss of purkinje cells and the presence of ectopic neurons. |
2021-10-22 |
2023-08-13 |
human |
| Hideki Miwa, Ken Kobayashi, Shinobu Hirai, Mitsuhiko Yamada, Masahiko Watanabe, Haruo Okado, Yuchio Yanagaw. GAD67-mediated GABA Synthesis and Signaling Impinges on Directing Basket Cell Axonal Projections Toward Purkinje Cells in the Cerebellum. Cerebellum (London, England). 2021-10-22. PMID:34676525. |
gad67-mediated gaba synthesis and signaling impinges on directing basket cell axonal projections toward purkinje cells in the cerebellum. |
2021-10-22 |
2023-08-13 |
mouse |
| Alessia Erika Russo, Simona Scalone, Giulia Costanza Leonardi, Aurora Scalisi, Giorgio Giorda, Roberto Sori. Paraneoplastic cerebellar degeneration associated with ovarian cancer. Oncology letters. vol 5. issue 2. 2021-10-21. PMID:23420048. |
paraneoplastic cerebellar degeneration (pcd) is a rare neurological disorder characterized by a widespread loss of purkinje cells associated with a progressive pancerebellar dysfunction. |
2021-10-21 |
2023-08-12 |
Not clear |
| Ravi Chopra, Vikram G Shakkotta. Translating cerebellar Purkinje neuron physiology to progress in dominantly inherited ataxia. Future neurology. vol 9. issue 2. 2021-10-21. PMID:25221437. |
the cerebellum is an important structure for accurate control and timing of movement, and purkinje neurons in the cerebellar cortex are key players in cerebellar motor control. |
2021-10-21 |
2023-08-13 |
mouse |
| Ayush Mandwal, Javier G Orlandi, Christoph Simon, Jörn Davidse. A biochemical mechanism for time-encoding memory formation within individual synapses of Purkinje cells. PloS one. vol 16. issue 5. 2021-10-21. PMID:33961660. |
within the classical eye-blink conditioning, purkinje cells within the cerebellum are known to suppress their tonic firing rates for a well defined time period in response to the conditional stimulus after training. |
2021-10-21 |
2023-08-13 |
Not clear |