| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nobutaka Ohgami, Akira Iizuka, Hirokazu Hirai, Ichiro Yajima, Machiko Iida, Atsuyoshi Shimada, Toyonori Tsuzuki, Mayumi Jijiwa, Naoya Asai, Masahide Takahashi, Masashi Kat. Loss-of-function mutation of c-Ret causes cerebellar hypoplasia in mice with Hirschsprung disease and Down's syndrome. The Journal of biological chemistry. vol 296. 2021-09-09. PMID:33561442. |
despite the fact that c-ret has been shown to be associated with hscr-ds in humans and to be expressed in purkinje cells (pcs) in experimental animals, there is limited information about the role of activity of c-ret/c-ret kinase in cerebellar hypoplasia. |
2021-09-09 |
2023-08-13 |
mouse |
| Yu-Te Lin, Yong-Shiou Lin, Wen-Ling Cheng, Jui-Chih Chang, Yi-Chun Chao, Chin-San Liu, An-Chi We. Transcriptomic and Metabolic Network Analysis of Metabolic Reprogramming and IGF-1 Modulation in SCA3 Transgenic Mice. International journal of molecular sciences. vol 22. issue 15. 2021-09-08. PMID:34360740. |
growth hormone (gh) therapy has shown positive effects on the exercise behavior of mice with cerebellar atrophy, retains more purkinje cells, and exhibits less dna damage after gh intervention. |
2021-09-08 |
2023-08-13 |
mouse |
| Balamurugan Thirunavukkarasu, Kirti Gupta, Ridhi Sood, Neha Saharan, Azhar Navid, Chaithanya Reddy, Jitendra Kumar Sah. Neuropathological findings in a 17-month-old boy with kinky hair due to Menkes disease. Clinical neuropathology. vol 40. issue 5. 2021-09-07. PMID:34032205. |
cerebellum showed aberrant dendritic arborization, somal sprouts, and axonal torpedoes within the purkinje neurons. |
2021-09-07 |
2023-08-13 |
Not clear |
| Fumiaki Sugahara, Juan Pascual-Anaya, Shigehiro Kuraku, Shigeru Kuratani, Yasunori Murakam. Genetic Mechanism for the Cyclostome Cerebellar Neurons Reveals Early Evolution of the Vertebrate Cerebellum. Frontiers in cell and developmental biology. vol 9. 2021-09-07. PMID:34485287. |
two major cerebellar neuronal subtypes, granule cells (excitatory) and purkinje cells (inhibitory), are generated from the anterior rhombic lip and the ventricular zone, respectively. |
2021-09-07 |
2023-08-13 |
Not clear |
| Tingting Zhang, Tengyuan Liu, Bassem A Hassa. Induction of granule and Purkinje cells from primary cultured mouse cerebellar progenitors. STAR protocols. vol 2. issue 3. 2021-09-03. PMID:34467229. |
induction of granule and purkinje cells from primary cultured mouse cerebellar progenitors. |
2021-09-03 |
2023-08-13 |
mouse |
| Ravi Chopra, David D Bushart, John P Cooper, Dhananjay Yellajoshyula, Logan M Morrison, Haoran Huang, Hillary P Handler, Luke J Man, Warunee Dansithong, Daniel R Scoles, Stefan M Pulst, Harry T Orr, Vikram G Shakkotta. Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in spinocerebellar ataxia type 1. Human molecular genetics. vol 29. issue 19. 2021-08-30. PMID:32964235. |
atxn1[82q] purkinje neurons from the anterior cerebellum were found to degenerate earlier than those from the nodular zone, and this early degeneration was associated with selective dysregulation of ion channel transcripts and altered purkinje neuron spiking. |
2021-08-30 |
2023-08-13 |
Not clear |
| Astrid Buchberger, Lena Schepergerdes, Maren Flaßhoff, Conrad Kunick, Reinhard W Köste. A novel inhibitor rescues cerebellar defects in a zebrafish model of Down syndrome-associated kinase Dyrk1A overexpression. The Journal of biological chemistry. vol 297. issue 1. 2021-08-26. PMID:34090874. |
overexpression of human dyrk1a in postmitotic cerebellar purkinje neurons resulted in a structural misorganization of the purkinje cells in cerebellar hemispheres and a compaction of this cell population. |
2021-08-26 |
2023-08-13 |
human |
| Astrid Buchberger, Lena Schepergerdes, Maren Flaßhoff, Conrad Kunick, Reinhard W Köste. A novel inhibitor rescues cerebellar defects in a zebrafish model of Down syndrome-associated kinase Dyrk1A overexpression. The Journal of biological chemistry. vol 297. issue 1. 2021-08-26. PMID:34090874. |
this impaired purkinje cell organization was progressive, leading to an age-dependent dispersal of purkinje neurons throughout the cerebellar molecular layer with larval swim deficits resulting in miscoordination of swimming and reduced exploratory behavior in aged adults. |
2021-08-26 |
2023-08-13 |
human |
| Jian-Wei Zhu, Wei-Qiang Jia, Hui Zhou, Yi-Fei Li, Ming-Ming Zou, Zhao-Tao Wang, Bing-Shan Wu, Ru-Xiang X. Deficiency of TRIM32 Impairs Motor Function and Purkinje Cells in Mid-Aged Mice. Frontiers in aging neuroscience. vol 13. 2021-08-24. PMID:34421574. |
purkinje cells (pcs), the sole output neurons of the cerebellar cortex, play essential roles in cerebellar motor function. |
2021-08-24 |
2023-08-13 |
mouse |
| Rui Tu, Chanchan Zhang, Ling Feng, Huiqun Wang, Wenjuan Wang, Ping L. Impact of selenium on cerebellar injury and mRNA expression in offspring of rat exposed to methylmercury. Ecotoxicology and environmental safety. vol 223. 2021-08-23. PMID:34365210. |
in the mehg-exposed group, a large number of purkinje cells showed pathological changes and mitochondria were significantly swollen; co-exposure with se significantly improved the structure and organization of the cerebellum. |
2021-08-23 |
2023-08-13 |
rat |
| Tara Barron, Jun Hee Ki. Preterm Birth Impedes Structural and Functional Development of Cerebellar Purkinje Cells in the Developing Baboon Cerebellum. Brain sciences. vol 10. issue 12. 2021-08-21. PMID:33255158. |
preterm birth impedes structural and functional development of cerebellar purkinje cells in the developing baboon cerebellum. |
2021-08-21 |
2023-08-13 |
human |
| Tara Barron, Jun Hee Ki. Preterm Birth Impedes Structural and Functional Development of Cerebellar Purkinje Cells in the Developing Baboon Cerebellum. Brain sciences. vol 10. issue 12. 2021-08-21. PMID:33255158. |
the fetal development of purkinje cells, the primary output cells of the cerebellar cortex, is crucial for the structure and function of the cerebellum. |
2021-08-21 |
2023-08-13 |
human |
| Tara Barron, Jun Hee Ki. Preterm Birth Impedes Structural and Functional Development of Cerebellar Purkinje Cells in the Developing Baboon Cerebellum. Brain sciences. vol 10. issue 12. 2021-08-21. PMID:33255158. |
however, morphological and electrophysiological features in purkinje cells at different gestational ages, and the effects of neonatal intensive care unit (nicu) experience on cerebellar development are unexplored. |
2021-08-21 |
2023-08-13 |
human |
| Tara Barron, Jun Hee Ki. Preterm Birth Impedes Structural and Functional Development of Cerebellar Purkinje Cells in the Developing Baboon Cerebellum. Brain sciences. vol 10. issue 12. 2021-08-21. PMID:33255158. |
utilizing the non-human primate baboon cerebellum, we investigated purkinje cell development during the last trimester of pregnancy and the effect of nicu experience following premature birth on developmental features of purkinje cells. |
2021-08-21 |
2023-08-13 |
human |
| Tara Barron, Jun Hee Ki. Preterm Birth Impedes Structural and Functional Development of Cerebellar Purkinje Cells in the Developing Baboon Cerebellum. Brain sciences. vol 10. issue 12. 2021-08-21. PMID:33255158. |
immunostaining and whole-cell patch clamp recordings of purkinje cells in the baboon cerebellum at different gestational ages revealed that molecular layer width, driven by purkinje dendrite extension, drastically increased and refinement of action potential waveform properties occurred throughout the last trimester of pregnancy. |
2021-08-21 |
2023-08-13 |
human |
| Pellegrino Lippiello, Eriola Hoxha, Filippo Tempia, Maria Concetta Miniac. GIRK1-Mediated Inwardly Rectifying Potassium Current Is a Candidate Mechanism Behind Purkinje Cell Excitability, Plasticity, and Neuromodulation. Cerebellum (London, England). vol 19. issue 6. 2021-08-19. PMID:32617840. |
using patch-clamp recordings in mice cerebellar slices, we examined the properties of the girk currents in purkinje cells (pcs) and investigated the effects of a selective agonist of girk1-containing channels, ml297 (ml), on pc firing and synaptic plasticity. |
2021-08-19 |
2023-08-13 |
mouse |
| Margherita De Silva, Javad Sadeghinezhad, Jens R Nyengaard, Mahdi Aghabalazadeh Asl, Ava Saeidi, Nadia De Sordi, Roberto Chiocchetti, Annamaria Grandi. Design-based stereological study of the guinea-pig (Cavia porcellus) cerebellum. Journal of anatomy. vol 239. issue 2. 2021-08-18. PMID:33763861. |
cerebellar total volume, gray and white matter volume fractions, molecular and granular layers volume fractions, cerebellar surface area, purkinje cellular and nuclear volumes, and the purkinje cell total count were stereologically estimated. |
2021-08-18 |
2023-08-13 |
human |
| Margherita De Silva, Javad Sadeghinezhad, Jens R Nyengaard, Mahdi Aghabalazadeh Asl, Ava Saeidi, Nadia De Sordi, Roberto Chiocchetti, Annamaria Grandi. Design-based stereological study of the guinea-pig (Cavia porcellus) cerebellum. Journal of anatomy. vol 239. issue 2. 2021-08-18. PMID:33763861. |
the cerebellar surface area was estimated through the use of test lines; purkinje cellular and nuclear volumes were analysed using the nucleator technique, whereas the purkinje cell total count was obtained by means of the optical disector technique. |
2021-08-18 |
2023-08-13 |
human |
| Mohamed A Elsaey, Kazuhiko Namikawa, Reinhard W Köste. Genetic Modeling of the Neurodegenerative Disease Spinocerebellar Ataxia Type 1 in Zebrafish. International journal of molecular sciences. vol 22. issue 14. 2021-08-17. PMID:34298970. |
dominant spinocerebellar ataxias (scas) are progredient neurodegenerative diseases commonly affecting the survival of purkinje cells (pcs) in the human cerebellum. |
2021-08-17 |
2023-08-13 |
human |
| Hanan E L Mokhtar, Mohey A E Hulail, Samar Mortada Mahmoud, Doaa Mohammed Youse. Impact of cisplatin administration on cerebellar cortical structure and locomotor activity of infantile and juvenile albino rats: the role of oxidative stress. Anatomical science international. 2021-08-13. PMID:34386931. |
histopathologically, cispt sowed deleterious changes within cerebellar cortical layers in the form of vacuolations, decreased thickness, and hemorrhage (in pd17), while purkinje cells exhibited profound degenerative changes in the form of swelling, disrupted arrangement, distortion, and nuclear shrinkage. |
2021-08-13 |
2023-08-13 |
rat |