| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Taisuke Miyazaki, Miwako Yamasaki, Kenji F Tanaka, Masahiko Watanab. Compartmentalized Input-Output Organization of Lugaro Cells in the Cerebellar Cortex. Neuroscience. vol 462. 2021-05-14. PMID:32470477. |
purkinje cells (pcs) are principal cerebellar neurons, and several classes of interneurons modulate their activity. |
2021-05-14 |
2023-08-13 |
mouse |
| Heeyoun Park, Yukio Yamamoto, Keiko Tanaka-Yamamot. Refinement of Cerebellar Network Organization by Extracellular Signaling During Development. Neuroscience. vol 462. 2021-05-14. PMID:32502568. |
the cerebellum forms regular neural network structures consisting of a few major types of neurons, such as purkinje cells, granule cells, and molecular layer interneurons, and receives two major inputs from climbing fibers and mossy fibers. |
2021-05-14 |
2023-08-13 |
Not clear |
| Meike E van der Heijden, Roy V Sillito. Interactions Between Purkinje Cells and Granule Cells Coordinate the Development of Functional Cerebellar Circuits. Neuroscience. vol 462. 2021-05-14. PMID:32554107. |
interactions between purkinje cells and granule cells coordinate the development of functional cerebellar circuits. |
2021-05-14 |
2023-08-13 |
Not clear |
| Meike E van der Heijden, Roy V Sillito. Interactions Between Purkinje Cells and Granule Cells Coordinate the Development of Functional Cerebellar Circuits. Neuroscience. vol 462. 2021-05-14. PMID:32554107. |
purkinje cells are central to all cerebellar circuits, they are the first cerebellar cortical neurons to be born, and based on their cellular and molecular signaling, they are considered the master regulators of cerebellar development. |
2021-05-14 |
2023-08-13 |
Not clear |
| Soichi Naga. Ocular Reflex Adaptation as an Experimental Model of Cerebellar Learning -- In Memory of Masao Ito -. Neuroscience. vol 462. 2021-05-14. PMID:32710914. |
he suggested that cerebellar flocculus (fl) purkinje cells (pcs), which directly inhibit the vestibular nuclear neurons driving extraocular muscle motor neurons, adaptively control the horizontal vestibulo-ocular reflex (hvor) through the modification of mossy and parallel fiber-mediated vestibular responsiveness by visual climbing fiber (cf) inputs. |
2021-05-14 |
2023-08-13 |
Not clear |
| Mayu Takahashi, Yoshikazu Shinod. Neural Circuits of Inputs and Outputs of the Cerebellar Cortex and Nuclei. Neuroscience. vol 462. 2021-05-14. PMID:32768619. |
his pioneering contributions to cerebellar physiology began with his discovery of inhibition and disinhibition of target neurons by cerebellar purkinje cells, and his discovery of the presence of long-term depression in parallel fiber-purkinje cell synapses. |
2021-05-14 |
2023-08-13 |
Not clear |
| Mayu Takahashi, Yoshikazu Shinod. Neural Circuits of Inputs and Outputs of the Cerebellar Cortex and Nuclei. Neuroscience. vol 462. 2021-05-14. PMID:32768619. |
purkinje cells formed the nodal point of masao ito's landmark model of motor control by the cerebellum. |
2021-05-14 |
2023-08-13 |
Not clear |
| Stephen G Lisberge. The Rules of Cerebellar Learning: Around the Ito Hypothesis. Neuroscience. vol 462. 2021-05-14. PMID:32866603. |
(3) recurrent feedback from purkinje cells to the inferior olive, through interneurons in the cerebellar nucleus, limits the magnitude of fast, early learning in the cerebellar cortex. |
2021-05-14 |
2023-08-13 |
monkey |
| Michael Longley, John Ballard, Maria Andres-Alonso, Rebecca Constance Varatharajah, Hadleigh Cuthbert, Christopher H Ye. A Patterned Architecture of Monoaminergic Afferents in the Cerebellar Cortex: Noradrenergic and Serotonergic Fibre Distributions within Lobules and Parasagittal Zones. Neuroscience. vol 462. 2021-05-14. PMID:32949672. |
the geometry of the glutamatergic mossy-parallel fibre and climbing fibre inputs to cerebellar cortical purkinje cells has powerfully influenced thinking about cerebellar functions. |
2021-05-14 |
2023-08-13 |
rat |
| Mohammadhosein Akhlaghpasand, Mahdi Tizro, Amir Raoofi, Arman Zeinaddini Meymand, Mohammaderfan Farhadieh, Fariba Khodagholi, Aysan Khatmi, Reza Soltani, Yadolah Hoseini, Ali Jahanian, Mahdi Eskandarian Boroujeni, Abbas Aliaghae. Grafted human chorionic stem cells restore motor function and preclude cerebellar neurodegeneration in rat model of cerebellar ataxia. Metabolic brain disease. vol 35. issue 4. 2021-05-11. PMID:32062747. |
the findings revealed that grafting of hcscs in 3-ap model of ataxia decreased the expression levels of several inflammatory, autophagic and apoptotic genes and provoked the up-regulation of vegf in the cerebellar region, prevented the degeneration of purkinje cells caused by 3-ap toxicity and ameliorated motor coordination and muscle function. |
2021-05-11 |
2023-08-13 |
human |
| Saša Peter, Bastiaan H A Urbanus, Remco V Klaassen, Bin Wu, Henk-Jan Boele, Sameha Azizi, Johan A Slotman, Adriaan B Houtsmuller, Martijn Schonewille, Freek E Hoebeek, Sabine Spijker, August B Smit, Chris I De Zeeu. AMPAR Auxiliary Protein SHISA6 Facilitates Purkinje Cell Synaptic Excitability and Procedural Memory Formation. Cell reports. vol 31. issue 2. 2021-04-27. PMID:32294428. |
our data indicate that purkinje cells require shisa6-dependent modification of ampar function in order to facilitate cerebellar, procedural memory formation. |
2021-04-27 |
2023-08-13 |
Not clear |
| Shiori Kamiya, Kazuhiko Sawad. Immunohistochemical characterization of postnatal changes in cerebellar cortical cytoarchitectures in ferrets. Anatomical record (Hoboken, N.J. : 2007). vol 304. issue 2. 2021-04-14. PMID:32396712. |
relatively slow development or maturation of the ferret cerebellum was revealed by the timing of the monolayer alignment and morphological maturation of purkinje cells. |
2021-04-14 |
2023-08-13 |
Not clear |
| Xueqing Zhang, Masakazu Ibi, Ryu Haga, Kazumi Iwata, Misaki Matsumoto, Nozomi Asaoka, Junjie Liu, Masato Katsuyama, Chihiro Yabe-Nishimur. NOX1/NADPH oxidase affects the development of autism-like behaviors in a maternal immune activation model. Biochemical and biophysical research communications. vol 534. 2021-04-13. PMID:33310189. |
taken together, these results suggested that nox1/nadph oxidase plays an essential role in some behavioral phenotypes observed in asd, possibly by promoting the loss of purkinje cells in the cerebellum. |
2021-04-13 |
2023-08-13 |
mouse |
| Yosef Shilo. The cerebellar degeneration in ataxia-telangiectasia: A case for genome instability. DNA repair. vol 95. 2021-04-12. PMID:32871349. |
it is the ensuing deterioration and eventual loss of cerebellar purkinje cells, which are very vulnerable to atm absence due to a unique combination of physiological features, which kindles the cerebellar decay in a-t. |
2021-04-12 |
2023-08-13 |
Not clear |
| Tsubasa Itoh, Miki Takeuchi, Marina Sakagami, Kazuhide Asakawa, Kenta Sumiyama, Koichi Kawakami, Takashi Shimizu, Masahiko Hib. Gsx2 is required for specification of neurons in the inferior olivary nuclei from Ptf1a-expressing neural progenitors in zebrafish. Development (Cambridge, England). vol 147. issue 19. 2021-04-09. PMID:32928905. |
neurons in the inferior olivary nuclei (io neurons) send climbing fibers to purkinje cells to elicit functions of the cerebellum. |
2021-04-09 |
2023-08-13 |
zebrafish |
| Liansheng Chang, Shahid Hussain Soomro, Hongfeng Zhang, Hui F. Ankfy1 Is Involved in the Maintenance of Cerebellar Purkinje Cells. Frontiers in cellular neuroscience. vol 15. 2021-04-03. PMID:33796010. |
purkinje cells are critical for the function of cerebellum. |
2021-04-03 |
2023-08-13 |
mouse |
| Liansheng Chang, Shahid Hussain Soomro, Hongfeng Zhang, Hui F. Ankfy1 Is Involved in the Maintenance of Cerebellar Purkinje Cells. Frontiers in cellular neuroscience. vol 15. 2021-04-03. PMID:33796010. |
further investigation demonstrated that the cerebellum of the mutant mouse has lost most of its purkinje cells, while other cerebellar cells remained largely normal. |
2021-04-03 |
2023-08-13 |
mouse |
| Ola Mohammed Youssef, Amira Ibrahim Morsy, Mona A El-Shahat, Amany M Shams, Samira Lotfy Abd-Elhad. The neuroprotective effect of simvastatin on the cerebellum of experimentally-induced diabetic rats through klotho upregulation: An immunohistochemical study. Journal of chemical neuroanatomy. vol 108. 2021-04-02. PMID:32479899. |
klotho is an anti-aging protein expressed in purkinje cells of the cerebellum. |
2021-04-02 |
2023-08-13 |
rat |
| Lidia Yshii, Chloé Bost, Roland Libla. Immunological Bases of Paraneoplastic Cerebellar Degeneration and Therapeutic Implications. Frontiers in immunology. vol 11. 2021-03-29. PMID:32655545. |
in pcd, the deleterious adaptive immune response targets self-antigens aberrantly expressed by tumor cells, mostly gynecological cancers, and physiologically expressed by the purkinje neurons of the cerebellum. |
2021-03-29 |
2023-08-13 |
Not clear |
| David J Herzfeld, Nathan J Hall, Marios Tringides, Stephen G Lisberge. Principles of operation of a cerebellar learning circuit. eLife. vol 9. 2021-03-16. PMID:32352914. |
the four principles are: (1) early, fast, acquisition driven by climbing fiber inputs to the cerebellar cortex, with poor retention; (2) learned responses of purkinje cells guide transfer of learning from the cerebellar cortex to the deep cerebellar nucleus, with excellent retention; (3) functionally different neural signals are subject to learning in the cerebellar cortex versus the deep cerebellar nuclei; and (4) negative feedback from the cerebellum to the inferior olive reduces the magnitude of the teaching signal in climbing fibers and limits learning. |
2021-03-16 |
2023-08-13 |
human |