| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong-Wei Wang, Jing-Tong Zhao, Bing-Xue Li, Shan-Shan Su, Yan-Hua Bing, Chun-Ping Chu, Wei-Ming Wang, Yu-Zi Li, De-Lai Qi. Corticotrophin-Releasing Factor Modulates Cerebellar Purkinje Cells Simple Spike Activity Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30034323. |
corticotrophin-releasing factor modulates cerebellar purkinje cells simple spike activity corticotropin-releasing factor (crf) is a major neuromodulator that modulates cerebellar neuronal activity via crf receptors during stress responses. |
2020-10-01 |
2023-08-13 |
mouse |
| Masashi Watanave, Yasunori Matsuzaki, Yasuyo Nakajima, Atsushi Ozawa, Masanobu Yamada, Hirokazu Hira. Contribution of Thyrotropin-Releasing Hormone to Cerebellar Long-Term Depression and Motor Learning. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30618637. |
these results suggest that trh is involved in cerebellar ltd presumably by upregulating the basal cgmp level in purkinje cells, and, consequently, in motor learning. |
2020-10-01 |
2023-08-13 |
mouse |
| Ruanna Wang, Jiahui Tan, Junxiu Guo, Yuhan Zheng, Qing Han, Kwok-Fai So, Jiandong Yu, Li Zhan. Aberrant Development and Synaptic Transmission of Cerebellar Cortex in a VPA Induced Mouse Autism Model. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30622458. |
on acute cerebellar slices, suppressed synaptic transmission of the purkinje cells were reported in the vpa-treated mice. |
2020-10-01 |
2023-08-13 |
mouse |
| Sriram Narayanan, Vatsala Thirumala. Contributions of the Cerebellum for Predictive and Instructional Control of Movement. Current opinion in physiology. vol 8. 2020-10-01. PMID:30944888. |
we review these studies focusing on the three major cerebellar cell types, namely: granule cells, purkinje neurons and the cells of the deep cerebellar nuclei. |
2020-10-01 |
2023-08-13 |
Not clear |
| Lingling An, Yuanhong Tang, Quan Wang, Qingqi Pei, Ran Wei, Huiyuan Duan, Jian K Li. Coding Capacity of Purkinje Cells With Different Schemes of Morphological Reduction. Frontiers in computational neuroscience. vol 13. 2020-10-01. PMID:31156415. |
here, using 10 individual purkinje cells of the cerebellum from three species of guinea-pig, mouse and rat, we consider four types of reduction methods and study their effects on the coding capacity of purkinje cells in terms of firing rate, timing coding, spiking pattern, and modulated firing under different stimulation protocols. |
2020-10-01 |
2023-08-13 |
mouse |
| Yunliang Zang, Erik De Schutte. Climbing Fibers Provide Graded Error Signals in Cerebellar Learning. Frontiers in systems neuroscience. vol 13. 2020-10-01. PMID:31572132. |
previous data seemed to demonstrate that climbing fibers are inefficient instructors, because they were thought to carry "binary" error signals to individual purkinje cells, which significantly constrains the efficiency of cerebellar learning in several regards. |
2020-10-01 |
2023-08-13 |
Not clear |
| Francesca Prestori, Lisa Mapelli, Egidio D'Angel. Diverse Neuron Properties and Complex Network Dynamics in the Cerebellar Cortical Inhibitory Circuit. Frontiers in molecular neuroscience. vol 12. 2020-10-01. PMID:31787879. |
in the last 50 years, the prevailing view on the functional role of cerebellar cortical inhibitory circuits was that excitatory and inhibitory inputs sum spatially and temporally in order to determine the motor output through purkinje cells (pcs). |
2020-10-01 |
2023-08-13 |
Not clear |
| Cheng-Kun Deng, Zhi-Hao Mu, Yi-He Miao, Yi-Dan Liu, Lei Zhou, Yong-Jie Huang, Fan Zhang, Yao-Yi Wang, Zhi-Hong Yang, Zhong-Yi Qian, Xie Wang, Jia-Zhi Guo, Mei-Yan Zhang, Xin-Yu Liao, Qi Wan, Di Lu, Ying-Ying Zo. Gastrodin Ameliorates Motor Learning Deficits Through Preserving Cerebellar Long-Term Depression Pathways in Diabetic Rats. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31824244. |
the cellular degeneration and the apoptosis of purkinje cells were evident in the cerebellum of diabetic rats. |
2020-10-01 |
2023-08-13 |
rat |
| Kim M Gruver, Alanna J Wat. Optimizing Optogenetic Activation of Purkinje Cell Axons to Investigate the Purkinje Cell - DCN Synapse. Frontiers in synaptic neuroscience. vol 11. 2020-10-01. PMID:31824291. |
in the cerebellum, purkinje cells serve as the sole output of the cerebellar cortex where they synapse on neurons in the deep cerebellar nuclei (dcn). |
2020-10-01 |
2023-08-13 |
Not clear |
| Kim M Gruver, Alanna J Wat. Optimizing Optogenetic Activation of Purkinje Cell Axons to Investigate the Purkinje Cell - DCN Synapse. Frontiers in synaptic neuroscience. vol 11. 2020-10-01. PMID:31824291. |
using optical stimulation of channelrhodopsin-2 (chr2)-expressing purkinje cells combined with patch-clamp recordings of purkinje cells and dcn neurons in acute cerebellar slices, we determine the photostimulation parameters required to elicit single time-locked action potentials from purkinje cell axons. |
2020-10-01 |
2023-08-13 |
Not clear |
| Haihong Yang, Chaojuan Yang, Qian Zhu, Mengping Wei, Ying Li, Juanxian Cheng, Fengjiao Liu, Yan Wu, Jiyan Zhang, Chen Zhang, Haitao W. Rack1 Controls Parallel Fiber-Purkinje Cell Synaptogenesis and Synaptic Transmission. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31920545. |
purkinje cells (pcs) in the cerebellum receive two excitatory afferents including granule cells-derived parallel fiber (pf) and the climbing fiber. |
2020-10-01 |
2023-08-13 |
mouse |
| Fabrizio Pontarelli, Dimitry Ofengeim, R Suzanne Zukin, Elizabeth A Jona. Mouse Transient Global Ischemia Two-Vessel Occlusion Model. Bio-protocol. vol 2. issue 18. 2020-09-30. PMID:27446974. |
transient global ischemia in rodents induces delayed death of hippocampal ca1 neurons, as well as in some hilar neurons of the dentate gyrus, medium aspiny neurons of the striatum, pyramidal neurons in neocortical layers ii, v and vi, and purkinje neurons of the cerebellum. |
2020-09-30 |
2023-08-13 |
mouse |
| Maggie M K Wong, Lauren M Watson, Esther B E Becke. Recent advances in modelling of cerebellar ataxia using induced pluripotent stem cells. Journal of neurology & neuromedicine. vol 2. issue 7. 2020-09-30. PMID:28825058. |
the cerebellar ataxias are a group of incurable brain disorders that are caused primarily by the progressive dysfunction and degeneration of cerebellar purkinje cells. |
2020-09-30 |
2023-08-13 |
human |
| Keisuke Nitta, Yasunori Matsuzaki, Ayumu Konno, Hirokazu Hira. Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates. Molecular therapy. Methods & clinical development. vol 6. 2020-09-30. PMID:28828391. |
cerebellar purkinje cells play a pivotal role in cerebellar functions. |
2020-09-30 |
2023-08-13 |
mouse |
| Mohamed F Ibrahim, Emmet M Power, Kay Potapov, Ruth M Empso. Motor and Cerebellar Architectural Abnormalities during the Early Progression of Ataxia in a Mouse Model of SCA1 and How Early Prevention Leads to a Better Outcome Later in Life. Frontiers in cellular neuroscience. vol 11. 2020-09-30. PMID:28979190. |
exposing developing cerebellar purkinje neurons (pns) to mutant ataxin1 (atxn1) in 82q spinocerebellar ataxia type 1 (sca1) mice disrupts motor behavior and cerebellar climbing fiber (cf) architecture from as early as 4 weeks of age. |
2020-09-30 |
2023-08-13 |
mouse |
| Gabriel Olaiya Omotoso, Ismail Temitayo Gbadamosi, Olayemi Joseph Olajide, Shakirat Opeyemi Dada-Habeeb, Tolulope Timothy Arogundade, Emmanuel Olusola Yawso. Moringa oleifera phytochemicals protect the brain against experimental nicotine-induced neurobehavioral disturbances and cerebellar degeneration. Pathophysiology : the official journal of the International Society for Pathophysiology. vol 25. issue 1. 2020-09-30. PMID:29307662. |
the purkinje cells of the cerebellum of animals in this group were degenerated. |
2020-09-30 |
2023-08-13 |
rat |
| Bernard Cohen, Sergei B Yakushin, Catherine Ch. Hypothesis: The Vestibular and Cerebellar Basis of the Mal de Debarquement Syndrome. Frontiers in neurology. vol 9. 2020-09-30. PMID:29459843. |
(2) the groups of vo neurons are driven by signals that originate in purkinje cells in the cerebellar nodulus. |
2020-09-30 |
2023-08-13 |
Not clear |
| Viet T Nguyen-Minh, Khoa Tran-Anh, Yuanjun Luo, Izumi Sugihar. Electrophysiological Excitability and Parallel Fiber Synaptic Properties of Zebrin-Positive and -Negative Purkinje Cells in Lobule VIII of the Mouse Cerebellar Slice. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30670950. |
electrophysiological excitability and parallel fiber synaptic properties of zebrin-positive and -negative purkinje cells in lobule viii of the mouse cerebellar slice. |
2020-09-30 |
2023-08-13 |
mouse |
| Yasmin Yarden-Rabinowitz, Yosef Yaro. Delayed Complex Spike Response Evoked by Conditioned Stimulus Encodes Movement Onset Time and Is Determined by Intrinsic Inferior Olive Properties. Frontiers in systems neuroscience. vol 13. 2020-09-30. PMID:31649513. |
we then provide original data recorded from purkinje and cerebellar nuclei neurons, demonstrating that delayed complex spike activity is an intrinsic property of the cerebellar circuit. |
2020-09-30 |
2023-08-13 |
Not clear |
| David E Buchholz, Thomas S Carroll, Arif Kocabas, Xiaodong Zhu, Hourinaz Behesti, Phyllis L Faust, Lauren Stalbow, Yin Fang, Mary E Hatte. Novel genetic features of human and mouse Purkinje cell differentiation defined by comparative transcriptomics. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 26. 2020-09-30. PMID:32546527. |
to analyze human purkinje cell (pc) differentiation, we optimized a protocol to generate human pluripotent stem cell-derived purkinje cells (hpsc-pcs) that formed synapses when cultured with mouse cerebellar glia and granule cells and fired large calcium currents, measured with the genetically encoded calcium indicator jrgeco1a. |
2020-09-30 |
2023-08-13 |
mouse |