| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julia Saifetiarova, Manzoor A Bha. Ablation of cytoskeletal scaffolding proteins, Band 4.1B and Whirlin, leads to cerebellar purkinje axon pathology and motor dysfunction. Journal of neuroscience research. vol 97. issue 3. 2020-07-01. PMID:30447021. |
the primary output neurons from the cerebellum are the purkinje neurons that transmit inhibitory responses to deep cerebellar nuclei through their myelinated axons. |
2020-07-01 |
2023-08-13 |
Not clear |
| Julia Saifetiarova, Manzoor A Bha. Ablation of cytoskeletal scaffolding proteins, Band 4.1B and Whirlin, leads to cerebellar purkinje axon pathology and motor dysfunction. Journal of neuroscience research. vol 97. issue 3. 2020-07-01. PMID:30447021. |
altered morphological organization and electrical properties of the purkinje axons lead to detrimental changes in locomotor activity often leading to cerebellar ataxias. |
2020-07-01 |
2023-08-13 |
Not clear |
| Kazuhiko Yamaguchi, Masao It. Assessment of Long-term Depression Induction in Adult Cerebellar Slices. Journal of visualized experiments : JoVE. issue 152. 2020-06-30. PMID:31680672. |
for cerebellar motor learning, long-term depression (ltd) of synaptic transmissions from parallel fibers (pf) to purkinje cells (pc) is considered the basis for motor learning, and deficiencies of both ltd and motor learning are observed in various gene-manipulated animals. |
2020-06-30 |
2023-08-13 |
mouse |
| Lidia Yshii, Béatrice Pignolet, Emilie Mauré, Mandy Pierau, Monika Brunner-Weinzierl, Oliver Hartley, Jan Bauer, Roland Libla. IFN-γ is a therapeutic target in paraneoplastic cerebellar degeneration. JCI insight. vol 4. issue 7. 2020-06-29. PMID:30944244. |
in an animal model, in which a neo-self-antigen was expressed in both purkinje neurons and implanted breast tumor cells, immune checkpoint blockade led to complete tumor control at the expense of cerebellum infiltration by t cells and purkinje neuron loss, thereby mimicking pcd. |
2020-06-29 |
2023-08-13 |
mouse |
| Urko Del Castillo, Megan M Gnazzo, Christopher G Sorensen Turpin, Ken C Q Nguyen, Emily Semaya, Yuwan Lam, Matthew A de Cruz, Joshua N Bembenek, David H Hall, Blake Riggs, Vladimir I Gelfand, Ahna R Sko. Conserved role for Ataxin-2 in mediating endoplasmic reticulum dynamics. Traffic (Copenhagen, Denmark). vol 20. issue 6. 2020-06-25. PMID:30989774. |
sca2 is characterized by shrunken dendritic arbors and torpedo-like axons within the purkinje neurons of the cerebellum. |
2020-06-25 |
2023-08-13 |
caenorhabditis_elegans |
| Peng Li, Huanhuan Gu, Jin Xu, Zhaohuan Zhang, Fei Li, Meiyan Feng, Qing Tian, Chenyong Shang, Jianhua Zhuan. Purkinje cells of vestibulocerebellum play an important role in acute vestibular migraine. Journal of integrative neuroscience. vol 18. issue 4. 2020-06-22. PMID:31912699. |
purkinje cells are the only source of cerebellar output and it innervates inhibitory action. |
2020-06-22 |
2023-08-13 |
human |
| Sumitra Pati, Lishann M Ingram, Min K Sun, John J Wagner, Brian S Cumming. Localization and expression of CTP: Phosphocholine cytidylyltransferase in rat brain following cocaine exposure. Journal of chemical neuroanatomy. vol 96. 2020-06-15. PMID:30366030. |
in contrast, cctβ expression was detected in the purkinje cells of the cerebellum with decreases in expression following cocaine exposure. |
2020-06-15 |
2023-08-13 |
rat |
| An Hotterbeekx, Martin Lammens, Richard Idro, Pamela R Akun, Robert Lukande, Geoffrey Akena, Avindra Nath, Joneé Taylor, Francis Olwa, Samir Kumar-Singh, Robert Colebunder. Neuroinflammation and Not Tauopathy Is a Predominant Pathological Signature of Nodding Syndrome. Journal of neuropathology and experimental neurology. vol 78. issue 11. 2020-06-15. PMID:31553445. |
the cerebellum showed atrophy and loss of purkinje cells with hyperplasia of the bergmann glia. |
2020-06-15 |
2023-08-13 |
human |
| Fabien Menardy, Andrés Pablo Varani, Adèle Combes, Clément Léna, Daniela Pop. Functional Alteration of Cerebello-Cerebral Coupling in an Experimental Mouse Model of Parkinson's Disease. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 4. 2020-06-02. PMID:30715237. |
this increase may result from reduced inhibitory purkinje cells inputs, since a population of slow and irregular purkinje cells was observed in the cerebellar hemispheres of lesioned animals. |
2020-06-02 |
2023-08-13 |
mouse |
| Daniel Majoral, Ajmal Zemmar, Raul Vicent. A model for time interval learning in the Purkinje cell. PLoS computational biology. vol 16. issue 2. 2020-05-27. PMID:32040505. |
recent experimental findings indicate that purkinje cells in the cerebellum represent time intervals by mechanisms other than conventional synaptic weights. |
2020-05-27 |
2023-08-13 |
Not clear |
| Chunlei Wang, Yi-Hsuan Pan, Yue Wang, Gene Blatt, Xiao-Bing Yua. Segregated expressions of autism risk genes Cdh11 and Cdh9 in autism-relevant regions of developing cerebellum. Molecular brain. vol 12. issue 1. 2020-05-26. PMID:31046797. |
during the first postnatal week, both cdh9 and cdh11 were expressed at high levels in segregated sub-populations of purkinje cells in the cerebellum, and the expression of both genes was declined as development proceeded. |
2020-05-26 |
2023-08-13 |
human |
| Takayuki Nimura, Tsubasa Itoh, Hanako Hagio, Takuto Hayashi, Vincenzo Di Donato, Miki Takeuchi, Takeaki Itoh, Fuduki Inoguchi, Yoshikatsu Sato, Naoyuki Yamamoto, Yu Katsuyama, Filippo Del Bene, Takashi Shimizu, Masahiko Hib. Role of Reelin in cell positioning in the cerebellum and the cerebellum-like structure in zebrafish. Developmental biology. vol 455. issue 2. 2020-05-14. PMID:31323192. |
the cerebellum and the cerebellum-like structure in the mesencephalic tectum in zebrafish contain multiple cell types, including principal cells (i.e., purkinje cells and type i neurons) and granule cells, that form neural circuits in which the principal cells receive and integrate inputs from granule cells and other neurons. |
2020-05-14 |
2023-08-13 |
zebrafish |
| Takayuki Nimura, Tsubasa Itoh, Hanako Hagio, Takuto Hayashi, Vincenzo Di Donato, Miki Takeuchi, Takeaki Itoh, Fuduki Inoguchi, Yoshikatsu Sato, Naoyuki Yamamoto, Yu Katsuyama, Filippo Del Bene, Takashi Shimizu, Masahiko Hib. Role of Reelin in cell positioning in the cerebellum and the cerebellum-like structure in zebrafish. Developmental biology. vol 455. issue 2. 2020-05-14. PMID:31323192. |
here we found that zebrafish with mutations in reelin or in the reelin-signaling molecules vldlr or dab1a exhibited ectopic purkinje cells, eurydendroid cells (projection neurons), and bergmann glial cells in the cerebellum, and ectopic type i neurons in the tectum. |
2020-05-14 |
2023-08-13 |
zebrafish |
| Takayuki Nimura, Tsubasa Itoh, Hanako Hagio, Takuto Hayashi, Vincenzo Di Donato, Miki Takeuchi, Takeaki Itoh, Fuduki Inoguchi, Yoshikatsu Sato, Naoyuki Yamamoto, Yu Katsuyama, Filippo Del Bene, Takashi Shimizu, Masahiko Hib. Role of Reelin in cell positioning in the cerebellum and the cerebellum-like structure in zebrafish. Developmental biology. vol 455. issue 2. 2020-05-14. PMID:31323192. |
our findings suggest that in zebrafish, (1) reelin is transported from the granule cell soma to the superficial layer by axonal transport; (2) reelin controls the migration of neurons and glial cells from the ventricular zone; and (3) purkinje cells and type i neurons attract afferent axons during the formation of the cerebellum and the cerebellum-like structure. |
2020-05-14 |
2023-08-13 |
zebrafish |
| Zhaohui Yang, Alexandra L Joyne. YAP1 is involved in replenishment of granule cell precursors following injury to the neonatal cerebellum. Developmental biology. vol 455. issue 2. 2020-05-14. PMID:31376393. |
although yap1 plays only a minor role during normal development in differentiation of neps or gcps, the size of the cerebellum, and in particular the internal granule cell layer produced by gcps, is significantly reduced in yap1 mutants after irradiation, and the organization of purkinje cells and bergmann glial fibers is disrupted. |
2020-05-14 |
2023-08-13 |
mouse |
| Nashwa Fathy Gamal El-Tahawy, Sara Mohamed Naguib Abdel Hafez, Maggie M Ramzy, Nagwa M Zenhom, Heba A Abdel-Hami. Effect of experimentally induced hypertension on cerebellum of postmenopausal rat. Journal of cellular physiology. vol 234. issue 8. 2020-05-12. PMID:30536406. |
however, in ovx-h-group, oxidative stress, inflammation, and cerebellar damage were exacerbated and cerebellar estrogen was reduced associated with reduction in gl thickness and decreased purkinje cells number. |
2020-05-12 |
2023-08-13 |
rat |
| Ian L McWilliams, Jennifer L Kielczewski, Derek D C Ireland, Jacob S Sykes, Aaron P Lewkowicz, Krishnamurthy Konduru, Biying C Xu, Chi-Chao Chan, Rachel R Caspi, Mohanraj Manangeeswaran, Daniela Verthely. Pseudovirus rVSVΔG-ZEBOV-GP Infects Neurons in Retina and CNS, Causing Apoptosis and Neurodegeneration in Neonatal Mice. Cell reports. vol 26. issue 7. 2020-04-21. PMID:30759384. |
in the cerebellum, rvsvΔg-zebov-gp infects neurons in the granular and purkinje layers, resulting in progressive foci of apoptosis and neurodegeneration. |
2020-04-21 |
2023-08-13 |
mouse |
| Niamh X Cawley, Caitlin Sojka, Antony Cougnoux, Anna T Lyons, Elena-Raluca Nicoli, Christopher A Wassif, Forbes D Porte. Abnormal LAMP1 glycosylation may play a role in Niemann-Pick disease, type C pathology. PloS one. vol 15. issue 1. 2020-04-16. PMID:31999726. |
a hallmark of niemann-pick disease, type c (npc) is the progressive degeneration of purkinje neurons in the cerebellum caused by the accumulation of free cholesterol and glycosphingolipids in the lysosome. |
2020-04-16 |
2023-08-13 |
mouse |
| Laura D Knogler, Andreas M Kist, Ruben Portugue. Motor context dominates output from purkinje cell functional regions during reflexive visuomotor behaviours. eLife. vol 8. 2020-04-10. PMID:30681408. |
our findings reveal how sensorimotor information is encoded by individual purkinje cells and organized into behavioral modules across the entire cerebellum. |
2020-04-10 |
2023-08-13 |
zebrafish |
| Chieh-Sen Chuang, Jui-Chih Chang, Bing-Wen Soong, Sheng-Fei Chuang, Ta-Tsung Lin, Wen-Ling Cheng, Harry T Orr, Chin-San Li. Treadmill training increases the motor activity and neuron survival of the cerebellum in a mouse model of spinocerebellar ataxia type 1. The Kaohsiung journal of medical sciences. vol 35. issue 11. 2020-04-06. PMID:31271500. |
moreover, the cerebellar pathology revealed preserved purkinje neurons stained by carbindin with an increase of the neuronal per arnt sim domain protein 4, a key regulation in the structural and functional plasticity of neurons, in the excised sca1 mice relative to the controls. |
2020-04-06 |
2023-08-13 |
mouse |