| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weipang Chang, Andrea Pedroni, Victoria Hohendorf, Stefania Giacomello, Masahiko Hibi, Reinhard W Köster, Konstantinos Ampatzi. Functionally distinct Purkinje cell types show temporal precision in encoding locomotion. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 29. 2020-09-14. PMID:32632015. |
purkinje cells, the principal neurons of cerebellar computations, are believed to comprise a uniform neuronal population of cells, each with similar functional properties. |
2020-09-14 |
2023-08-13 |
zebrafish |
| Madhavi Joshi, Amee Krishnakuma. Hypoglycemia causes dysregulation of Neuregulin 1, ErbB receptors, Ki67 in cerebellum and brainstem during diabetes: Implications in motor function. Behavioural brain research. vol 372. 2020-09-10. PMID:31195035. |
cellular alteration of purkinje neurons in the cerebellum and presence of axonal spheroids in the brainstem are suggestive of impairment to neural circuits involved in motor function. |
2020-09-10 |
2023-08-13 |
Not clear |
| Klara Szigeti-Buck, Laura Manuelidi. Prokaryotic SPHINX replication sequences are conserved in mammalian brain and participate in neurodegeneration. Journal of cellular biochemistry. vol 120. issue 10. 2020-09-09. PMID:31231867. |
vacuolar loss of cerebellar synaptic complexes, thinning of the internal granule cell layer, and fibrillar spx accumulations within purkinje neurons were prominent in scjd gp brains. |
2020-09-09 |
2023-08-13 |
mouse |
| D Panja, C A Vedeler, M Schuber. Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity. Neuropathology and applied neurobiology. vol 45. issue 2. 2020-09-01. PMID:29679372. |
paraneoplastic cerebellar degeneration (pcd), characterized by progressive purkinje neurone degeneration following paraneoplastic yo antibody internalization and binding to cerebellar degeneration-related protein cdr2 and cdr2l, has been linked to intracellular calcium homeostasis imbalance due to calbindin d |
2020-09-01 |
2023-08-13 |
Not clear |
| Saaki Tamura, Yukiko Yasuoka, Hiromi Miura, Gou Takahashi, Masahiro Sato, Masato Ohtsuk. Thy1 promoter activity in the Rosa26 locus in mice: lessons from Dre-rox conditional expression system. Experimental animals. vol 69. issue 3. 2020-08-31. PMID:32051391. |
the thy1 promoter targeted to the rosa26 locus appeared active in virtually all purkinje cells in the cerebellum and hippocampus. |
2020-08-31 |
2023-08-13 |
mouse |
| Wolfgang Wagner, Kristina Lippmann, Frank F Heisler, Kira V Gromova, Franco L Lombino, Mona K Roesler, Yvonne Pechmann, Sönke Hornig, Michaela Schweizer, Simona Polo, Jürgen R Schwarz, Jens Eilers, Matthias Kneusse. Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression. Cell reports. vol 28. issue 1. 2020-08-27. PMID:31269433. |
together, these data suggest that myosin vi directly promotes clathrin-mediated endocytosis of ampa receptors in purkinje cells to mediate cerebellar long-term depression. |
2020-08-27 |
2023-08-13 |
Not clear |
| Rebeca Mejias, Shu-Ling Chiu, Mei Han, Rebecca Rose, Ana Gil-Infante, Yifan Zhao, Richard L Huganir, Tao Wan. Purkinje cell-specific Grip1/2 knockout mice show increased repetitive self-grooming and enhanced mGluR5 signaling in cerebellum. Neurobiology of disease. vol 132. 2020-08-06. PMID:31476380. |
purkinje cell-specific grip1/2 knockout mice show increased repetitive self-grooming and enhanced mglur5 signaling in cerebellum. |
2020-08-06 |
2023-08-13 |
mouse |
| Óscar López-Pérez, Alicia Otero, Hicham Filali, David Sanz-Rubio, Janne M Toivonen, Pilar Zaragoza, Juan J Badiola, Rosa Bolea, Inmaculada Martín-Burrie. Dysregulation of autophagy in the central nervous system of sheep naturally infected with classical scrapie. Scientific reports. vol 9. issue 1. 2020-08-05. PMID:30760781. |
however, the increment of lc3 proteins and the mild expression of p62 in basal ganglia and cerebellum, primarily in purkinje cells, suggests that autophagy machinery is still intact in less affected areas. |
2020-08-05 |
2023-08-13 |
Not clear |
| Chinky Chatur, Ankit Balani, Rammohan Vadapalli, Mallapragada Gopalakrishna Murth. Isolated Unilateral Cerebellar Hemispheric Dysplasia: A Rare Entity. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 46. issue 6. 2020-08-04. PMID:31352912. |
genes expressed in migration and maintenance of the purkinje cells and/or in the generation and migration of granular cells when mutated will disrupt cerebellar migration and foliation and thus cause cerebellar malformation.3-5 cerebellum is known to be a centre for motor learning, coordination, and higher cognitive functions. |
2020-08-04 |
2023-08-13 |
Not clear |
| Naveen Sendhilnathan, Mulugeta Semework, Michael E Goldberg, Anna E Ipat. Neural Correlates of Reinforcement Learning in Mid-lateral Cerebellum. Neuron. vol 106. issue 1. 2020-07-28. PMID:32001108. |
here, we investigated the activity of purkinje cells (p-cells) in the mid-lateral cerebellum as the monkey learned to associate one arbitrary symbol with the movement of the left hand and another with the movement of the right hand. |
2020-07-28 |
2023-08-13 |
monkey |
| Harry Clifford, Anna Dulneva, Chris P Ponting, Wilfried Haerty, Esther B E Becke. A gene expression signature in developing Purkinje cells predicts autism and intellectual disability co-morbidity status. Scientific reports. vol 9. issue 1. 2020-07-27. PMID:30679692. |
to gain insight into the genetic and molecular mechanisms that might link the cerebellum to asd, we analysed the transcriptome dynamics of a developing cell population highly enriched for purkinje cells of the mouse cerebellum across multiple timepoints. |
2020-07-27 |
2023-08-13 |
mouse |
| Udaiyappan Janakiraman, Jie Yu, Aubin Moutal, Dhanalakshmi Chinnasamy, Lisa Boinon, Shelby N Batchelor, Annaduri Anandhan, Rajesh Khanna, Mark A Nelso. TAF1-gene editing alters the morphology and function of the cerebellum and cerebral cortex. Neurobiology of disease. vol 132. 2020-07-27. PMID:31344492. |
abnormal motor symptoms in taf1-edited rats were associated with irregular cerebellar output caused by changes in the intrinsic activity of the purkinje cells due to loss of pre-synaptic cav3.1. |
2020-07-27 |
2023-08-13 |
mouse |
| Nesli-Ece Sen, Júlia Canet-Pons, Melanie V Halbach, Aleksandar Arsovic, Ulrich Pilatus, Woon-Hyung Chae, Zeynep-Ece Kaya, Kay Seidel, Ewa Rollmann, Michel Mittelbronn, David Meierhofer, Chris I De Zeeuw, Laurens W J Bosman, Suzana Gispert, Georg Auburge. Generation of an Atxn2-CAG100 knock-in mouse reveals N-acetylaspartate production deficit due to early Nat8l dysregulation. Neurobiology of disease. vol 132. 2020-07-27. PMID:31376479. |
spinocerebellar ataxia type 2 (sca2) is an autosomal dominant neurodegenerative disorder caused by cag-expansion mutations in the atxn2 gene, mainly affecting motor neurons in the spinal cord and purkinje neurons in the cerebellum. |
2020-07-27 |
2023-08-13 |
mouse |
| Afrida Rahman, Janet Weber, Edward Labin, Cary Lai, Anne L Priet. Developmental expression of Neuregulin-3 in the rat central nervous system. The Journal of comparative neurology. vol 527. issue 4. 2020-07-24. PMID:30328115. |
in the cerebellum, nrg3 was found in both purkinje cells and granule neurons. |
2020-07-24 |
2023-08-13 |
rat |
| Orçun Orkan Özcan, Xiaolu Wang, Francesca Binda, Kevin Dorgans, Chris I De Zeeuw, Zhenyu Gao, Ad Aertsen, Arvind Kumar, Philippe Isop. Differential Coding Strategies in Glutamatergic and GABAergic Neurons in the Medial Cerebellar Nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 1. 2020-07-20. PMID:31694963. |
here, we investigate the influence of the cerebellar cortical output, the purkinje cells, on identified cerebellar nuclei neurons |
2020-07-20 |
2023-08-13 |
Not clear |
| Samuel S McAfee, Yu Liu, Roy V Sillitoe, Detlef H Hec. Cerebellar Lobulus Simplex and Crus I Differentially Represent Phase and Phase Difference of Prefrontal Cortical and Hippocampal Oscillations. Cell reports. vol 27. issue 8. 2020-07-16. PMID:31116979. |
purkinje cells in cerebellar ls and crus i differentially represented specific phases and phase differences of mpfc and dca1 lfp oscillations in a frequency-specific manner, suggesting a site- and frequency-specific cerebellar representation of temporal aspects of neuronal oscillations in non-motor cerebral cortical areas. |
2020-07-16 |
2023-08-13 |
Not clear |
| Chiheng Ju, Laurens W J Bosman, Tycho M Hoogland, Arthiha Velauthapillai, Pavithra Murugesan, Pascal Warnaar, Romano M van Genderen, Mario Negrello, Chris I De Zeeu. Neurons of the inferior olive respond to broad classes of sensory input while subject to homeostatic control. The Journal of physiology. vol 597. issue 9. 2020-07-14. PMID:30908629. |
purkinje cells in the cerebellum integrate input from sensory organs with that from premotor centres. |
2020-07-14 |
2023-08-13 |
human |
| Ioannis Mavroudis, Foivos Petridis, Dimitrios Kazis, Samuel N Njau, Vasiliki Costa, Stavros J Baloyanni. Purkinje Cells Pathology in Alzheimer's Disease. American journal of Alzheimer's disease and other dementias. vol 34. issue 7-8. 2020-07-10. PMID:31256608. |
in present study, we aim to investigate the morphological changes in the purkinje cells in different cerebellar regions in ad and to correlate them with the underlying ad pathology. |
2020-07-10 |
2023-08-13 |
Not clear |
| Ioannis Mavroudis, Foivos Petridis, Dimitrios Kazis, Samuel N Njau, Vasiliki Costa, Stavros J Baloyanni. Purkinje Cells Pathology in Alzheimer's Disease. American journal of Alzheimer's disease and other dementias. vol 34. issue 7-8. 2020-07-10. PMID:31256608. |
the present study gives new insights into the cerebellar pathology in ad and confirms that purkinje cells pathology is a key finding in ad brains and that ad is characterized by regional-specific atrophy picked in the anterior cerebellar lobe. |
2020-07-10 |
2023-08-13 |
Not clear |
| David Díaz, Carlos Del Pilar, José Carretero, José Ramón Alonso, Eduardo Weruag. Daily bone marrow cell transplantations for the management of fast neurodegenerative processes. Journal of tissue engineering and regenerative medicine. vol 13. issue 9. 2020-07-08. PMID:31272136. |
so far, this phenomenon has only been identified in purkinje cells, whose death is the cause of different diseases like cerebellar ataxias. |
2020-07-08 |
2023-08-13 |
mouse |