| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Parminder J S Vig, Maripar E Lopez, Jinrong Wei, David R D'Souza, Sh Subramony, Jeffrey Henegar, Jonathan D Fratki. Glial S100B Positive Vacuoles In Purkinje Cells: Earliest Morphological Abnormality In SCA1 Transgenic Mice. Journal of neurological sciences (Turkish). vol 23. issue 3. 2020-09-29. PMID:18176630. |
the overexpression of mutant ataxin-1 in sca1 transgenic mice results in the formation of cytoplasmic vacuoles in purkinje neurons (pkn) of the cerebellum. |
2020-09-29 |
2023-08-12 |
mouse |
| Aravindhan Veerapandiyan, Stephanie Enner, Venkatraman Thulasi, Xue Min. A Rare Syndrome of Child neurology open. vol 4. 2020-09-29. PMID:28856174. |
a rare syndrome of the glutamate receptor, ionotropic, delta 2 gene codes for an ionotropic glutamate delta-2 receptor, which is selectively expressed in cerebellar purkinje cells, and facilitates cerebellar synapse organization and transmission. |
2020-09-29 |
2023-08-13 |
Not clear |
| Wen-Juan Fan, Ming-Chao Yan, Lai Wang, Yi-Zheng Sun, Jin-Bo Deng, Jie-Xin Den. Synaptic aging disrupts synaptic morphology and function in cerebellar Purkinje cells. Neural regeneration research. vol 13. issue 6. 2020-09-29. PMID:29926829. |
this study was designed to investigate the occurrence of synaptic aging in the cerebellum by observing the ultrastructural changes of dendritic spines and synapses in cerebellar purkinje cells of aging mice. |
2020-09-29 |
2023-08-13 |
mouse |
| Rafael Falcón-Moya, Pilar Losada-Ruiz, Talvinder S Sihra, Antonio Rodríguez-Moren. Cerebellar Kainate Receptor-Mediated Facilitation of Glutamate Release Requires Ca Frontiers in molecular neuroscience. vol 11. 2020-09-29. PMID:29928192. |
in cerebellar slices, ka (3 μm) increased the amplitude of evoked excitatory postsynaptic currents (eepscs) at synapses between axon terminals of parallel fibers (pf) and purkinje neurons. |
2020-09-29 |
2023-08-13 |
Not clear |
| Hengameh Dortaj, Maryam Yadegari, Mohammad Hosseini Sharif Abad, Abolghasem Abbasi Sarcheshmeh, Morteza Anvar. Stereological Method for Assessing the Effect of Vitamin C Administration on the Reduction of Acrylamide-induced Neurotoxicity. Basic and clinical neuroscience. vol 9. issue 1. 2020-09-29. PMID:29942437. |
the purpose of this study was to evaluate the effects of acr on development of cortical layer, white matter, and number of purkinje cells of the cerebellum in rat newborns. |
2020-09-29 |
2023-08-13 |
rat |
| Frederik Bartels, Harald Prüss, Carsten Fink. Anti-ARHGAP26 Autoantibodies Are Associated With Isolated Cognitive Impairment. Frontiers in neurology. vol 9. 2020-09-29. PMID:30158896. |
of neurology at charité-universitätsmedizin berlin identified 14 patients with arhgap26 autoantibodies on a cell-based assay, of which three patients had additional brain immunohistochemistry staining of cerebellar molecular layer and purkinje cells, who were therefore considered antibody-positive. |
2020-09-29 |
2023-08-13 |
Not clear |
| Rimante Minkeviciene, Iryna Hlushchenko, Anaïs Virenque, Lauri Lahti, Pushpa Khanal, Tuomas Rauramaa, Arto Koistinen, Ville Leinonen, Francesco M Noe, Pirta Hotulaine. MIM-Deficient Mice Exhibit Anatomical Changes in Dendritic Spines, Cortex Volume and Brain Ventricles, and Functional Changes in Motor Coordination and Learning. Frontiers in molecular neuroscience. vol 12. 2020-09-28. PMID:31803019. |
mim is an i-bar containing membrane curving protein, shown to be involved in dendritic spine initiation and dendritic branching in purkinje cells in the cerebellum. |
2020-09-28 |
2023-08-13 |
mouse |
| Naveed Aslam, Farah Alv. Simplified Model of PKCγ Signaling Dysregulation and Cytosol-to-Membrane Translocation Kinetics During Neurodegenerative Spinocerebellar Ataxia Type 14 (SCA14). Frontiers in neuroscience. vol 13. 2020-09-28. PMID:32082104. |
these symptoms are linked to the loss of purkinje cells (pcs), which leads to cerebellar neurodegeneration. |
2020-09-28 |
2023-08-13 |
Not clear |
| Valentina Cerrat. Cerebellar Astrocytes: Much More Than Passive Bystanders In Ataxia Pathophysiology. Journal of clinical medicine. vol 9. issue 3. 2020-09-28. PMID:32168822. |
it comprises several forms with a highly variegated etiology, mainly united by motor, balance, and speech impairments and, at the tissue level, by cerebellar atrophy and purkinje cells degeneration. |
2020-09-28 |
2023-08-13 |
Not clear |
| Francesca Binda, Carla Pernaci, Smita Saxen. Cerebellar Development and Circuit Maturation: A Common Framework for Spinocerebellar Ataxias. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32300292. |
in the cerebellum, purkinje cells (pcs) are the most vulnerable and their prominent loss in the late phase of the pathology is the main characteristic of these neurodegenerative diseases. |
2020-09-28 |
2023-08-13 |
Not clear |
| Polina A Egorova, Aleksandra V Gavrilova, Ilya B Bezprozvann. Ataxic Symptoms in Huntington's Disease Transgenic Mouse Model Are Alleviated by Chlorzoxazone. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32317916. |
cerebellar purkinje cells (pcs) are responsible for the proper cerebellar pathways functioning and motor control. |
2020-09-28 |
2023-08-13 |
mouse |
| Jaime Moreira Pires, Maira Licia Foresti, Clivandir Severino Silva, Débora Bandeira Rêgo, Michele Longoni Calió, Amanda Cristina Mosini, Thabatta Karollynne Estevam Nakamura, Ana Teresa F Leslie, Luiz Eugênio Mell. Lipopolysaccharide-Induced Systemic Inflammation in the Neonatal Period Increases Microglial Density and Oxidative Stress in the Cerebellum of Adult Rats. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32581717. |
interestingly, purkinje cells ectopically positioned in the granular and molecular layers of the cerebellum were observed in animals of the lps group. |
2020-09-28 |
2023-08-13 |
human |
| Katherine J Robinson, Maxinne Watchon, Angela S Lair. Aberrant Cerebellar Circuitry in the Spinocerebellar Ataxias. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32765211. |
interestingly, aberrant function and degeneration of purkinje cells, the major output neuronal population present within the cerebellum, precedes abnormalities in other neuronal populations within many scas, suggesting that purkinje cells have increased vulnerability to cellular perturbations. |
2020-09-28 |
2023-08-13 |
Not clear |
| Chandrakanth Reddy Edamakanti, Puneet Opa. Purification of Prominin-1+ Stem Cells from Postnatal Mouse Cerebellum. Journal of visualized experiments : JoVE. issue 158. 2020-09-23. PMID:32338650. |
most cerebellar neurons arise from two embryonic stem niches: a rhombic lip niche, which generates all the cerebellar excitatory glutamatergic neurons, and a ventricular zone niche, which generates the inhibitory gabaergic purkinje cells, which are neurons that constitute the deep cerebellar nuclei and bergman glia. |
2020-09-23 |
2023-08-13 |
mouse |
| Lauren N Miterko, Joshua J White, Tao Lin, Amanda M Brown, Kevin J O'Donovan, Roy V Sillito. Persistent motor dysfunction despite homeostatic rescue of cerebellar morphogenesis in the Car8 waddles mutant mouse. Neural development. vol 14. issue 1. 2020-09-18. PMID:30867000. |
purkinje cells play a central role in establishing the cerebellar circuit. |
2020-09-18 |
2023-08-13 |
mouse |
| Thomas C Harmon, David L McLean, Indira M Rama. Integration of Swimming-Related Synaptic Excitation and Inhibition by olig2 The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 15. 2020-09-18. PMID:32139583. |
integration of swimming-related synaptic excitation and inhibition by olig2 the cerebellum influences motor control through purkinje target neurons, which transmit cerebellar output. |
2020-09-18 |
2023-08-13 |
zebrafish |
| Yusuke Sakai, Hidetoshi Kassai, Hisako Nakayama, Masahiro Fukaya, Tatsuya Maeda, Kazuki Nakao, Kouichi Hashimoto, Hiroyuki Sakagami, Masanobu Kano, Atsu Aib. Hyperactivation of mTORC1 disrupts cellular homeostasis in cerebellar Purkinje cells. Scientific reports. vol 9. issue 1. 2020-09-15. PMID:30808980. |
in the mouse cerebellum, purkinje cell-specific knockout of tsc1/2 has been implicated in autistic-like behaviors. |
2020-09-15 |
2023-08-13 |
mouse |
| Elan D Louis, Chloë A Kerridge, Debotri Chatterjee, Regina T Martuscello, Daniel Trujillo Diaz, Arnulf H Koeppen, Sheng-Han Kuo, Jean-Paul G Vonsattel, Peter A Sims, Phyllis L Faus. Contextualizing the pathology in the essential tremor cerebellar cortex: a patholog-omics approach. Acta neuropathologica. vol 138. issue 5. 2020-09-15. PMID:31317229. |
several morphological changes, centered in/around purkinje cells (pcs), have been identified in the cerebellum of essential tremor (et) patients. |
2020-09-15 |
2023-08-13 |
Not clear |
| Feng-Qi Hu, Fu-Rong Shang, Jing-Jing Liu, Hai Yua. Plasma exchange for treating anti-Yo-associated paraneoplastic cerebellar degeneration: Case report and literature review. Medicine. vol 99. issue 33. 2020-09-15. PMID:32872070. |
paraneoplastic cerebellar degeneration (pcd) is a rare neurodegenerative syndrome associated with antibodies targeting the purkinje cells of the cerebellum. |
2020-09-15 |
2023-08-13 |
Not clear |
| Maedeh Mahmoudi, Amir-Hossein Bayat, Mahdi Eskandarian Boroujeni, Mohammad Amin Abdollahifar, Vahid Ebrahimi, Samira Danyali, Mohammad Hassan Heidari, Abbas Aliaghae. Curcumin protects purkinje neurons, ameliorates motor function and reduces cerebellar atrophy in rat model of cerebellar ataxia induced by 3-AP. Journal of chemical neuroanatomy. vol 102. 2020-09-14. PMID:31669431. |
curcumin protects purkinje neurons, ameliorates motor function and reduces cerebellar atrophy in rat model of cerebellar ataxia induced by 3-ap. |
2020-09-14 |
2023-08-13 |
rat |