| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mégane Homa, Anne Loyens, Sabiha Eddarkaoui, Emilie Faivre, Vincent Deramecourt, Claude-Alain Maurage, Luc Buée, Vincent Huin, Bernard Sablonnièr. The TMEM240 Protein, Mutated in SCA21, Is Expressed in Purkinje Cells and Synaptic Terminals. Cerebellum (London, England). vol 19. issue 3. 2021-03-15. PMID:32002801. |
these data suggest that tmem240 may be involved in the organization of the cerebellar network, particularly in synaptic inputs converging on purkinje cells. |
2021-03-15 |
2023-08-13 |
mouse |
| Funmilayo Eniola Olopade, Omowumi Femi-Akinlosotu, Adejoke Joan Adekanmbi, Seun Ajani, Matthew Temitayo Shokunb. Neurobehavioural changes and morphological study of cerebellar purkinje cells in kaolin induced hydrocephalus. Anatomical science international. vol 96. issue 1. 2021-03-08. PMID:32789737. |
this study assesses the morphological changes in the purkinje cells in relation to cerebellar dysfunction observed in juvenile hydrocephalic rats. |
2021-03-08 |
2023-08-13 |
rat |
| Elizabeth P Lackey, Roy V Sillito. Eph/ephrin Function Contributes to the Patterning of Spinocerebellar Mossy Fibers Into Parasagittal Zones. Frontiers in systems neuroscience. vol 14. 2021-03-04. PMID:32116578. |
here, we used knockout mice to test whether eph/ephrin signaling controls purkinje cell-mossy fiber interactions during cerebellar circuit formation. |
2021-03-04 |
2023-08-13 |
mouse |
| V L Zamoyski, V V Grigoriev, A Yu Aksinenko, S O Bachuri. Modulation of Calcium-Activated Chloride Currents in Rat Neurons with New 2-Aminotiophene-3-Carboxylic Acid Derivatives. Doklady. Biochemistry and biophysics. vol 494. issue 1. 2021-03-03. PMID:33119821. |
using the patch-clamp method in the whole cell configuration, it was shown that new conjugates of 2-aminothiophene-3-carboxylic acid with adamantane derivatives exhibit the ability to modulate cacc activity in the single purkinje neurons of rat cerebellum. |
2021-03-03 |
2023-08-13 |
rat |
| Ryosuke Tsumagari, Kenta Maruo, Sho Kakizawa, Shuji Ueda, Minoru Yamanoue, Hiromitsu Saito, Noboru Suzuki, Yasuhito Shira. Precise Regulation of the Basal PKCγ Activity by DGKγ Is Crucial for Motor Coordination. International journal of molecular sciences. vol 21. issue 21. 2021-03-01. PMID:33114041. |
therefore, we first produced purkinje cell-specific dgkγ ko (tm1d) mice to investigate the specific function of dgkγ in purkinje cells and confirmed that tm1d mice showed cerebellar motor dysfunction in the rotarod and beam tests, and the basal pkcγ upregulation but not pkcα in the cerebellum of tm1d mice. |
2021-03-01 |
2023-08-13 |
mouse |
| Tayebeh Noori, Ahmad Reza Dehpour, Antoni Sureda, Sajad Fakhri, Eduardo Sobarzo-Sanchez, Mohammad Hosein Farzaei, Esra Küpeli Akkol, Zahra Khodarahmi, Seyede Zahra Hosseini, Seyede Darya Alavi, Samira Shirooi. The role of glycogen synthase kinase 3 beta in multiple sclerosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 132. 2021-02-25. PMID:33080467. |
gsk-3 occurs in mammals in two isoforms gsk-3α and gsk-3β, both of which are common in the brain, although gsk-3α is found particularly in the cerebral cortex, cerebellum, striated hippocampus and purkinje cells, while gsk-3β is found in all brain regions. |
2021-02-25 |
2023-08-13 |
Not clear |
| Mahdi Eskandarian Boroujeni, Tahmineh Peirouvi, Fatemeh Shaerzadeh, Abolhasan Ahmadiani, Mohammad Amin Abdollahifar, Abbas Aliaghae. Differential gene expression and stereological analyses of the cerebellum following methamphetamine exposure. Addiction biology. vol 25. issue 1. 2021-02-10. PMID:30714656. |
further, meth induced a significant reduction in volumes of cerebellar layers (molecular, granular, and purkinje) and a decrease in the white matter volume along with a rise in astrogliosis as well as increased locomotor activity. |
2021-02-10 |
2023-08-13 |
Not clear |
| Qin-Wei Wu, Josef P Kapfhamme. Modulation of Increased mGluR1 Signaling by RGS8 Protects Purkinje Cells From Dendritic Reduction and Could Be a Common Mechanism in Diverse Forms of Spinocerebellar Ataxia. Frontiers in cell and developmental biology. vol 8. 2021-02-10. PMID:33553137. |
we have studied the expression of rgs8 in the cerebellum in more detail and show that it is specifically expressed in mouse cerebellar purkinje cells. |
2021-02-10 |
2023-08-13 |
mouse |
| Mike Gilbert, R Chris Mial. How and Why the Cerebellum Recodes Input Signals: An Alternative to Machine Learning. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2021-02-09. PMID:33559532. |
mossy fiber input to the cerebellum is received by granule cells where it is thought to be recoded into internal signals received by purkinje cells, which alone carry the output of the cerebellar cortex. |
2021-02-09 |
2023-08-13 |
Not clear |
| Tiffany T Terry, Tao Cheng, Moe Mahjoub, Hui Zon. Mosaic Analysis with Double Markers reveals IGF1R function in granule cell progenitors during cerebellar development. Developmental biology. vol 465. issue 2. 2021-02-03. PMID:32697974. |
during cerebellar development, granule cell progenitors (gcps) proliferate exponentially for a fixed period, promoted by paracrine mitogenic factor sonic hedgehog (shh) secreted from purkinje cells (pcs). |
2021-02-03 |
2023-08-13 |
mouse |
| Alexander S Brown, Pratap Meera, Gabe Quinones, Jessica Magri, Thomas S Otis, Stefan M Pulst, Anthony E Or. Receptor protein tyrosine phosphatases control Purkinje neuron firing. Cell cycle (Georgetown, Tex.). vol 19. issue 2. 2021-01-29. PMID:31876231. |
spinocerebellar ataxias (sca) are a genetically heterogeneous family of cerebellar neurodegenerative diseases characterized by abnormal firing of purkinje neurons and degeneration. |
2021-01-29 |
2023-08-13 |
Not clear |
| Jeong-Kyu Han, Sun-Ho Kwon, Yong Gyu Kim, Jaeyong Choi, Jong-Il Kim, Yong-Seok Lee, Sang-Kyu Ye, Sang Jeong Ki. Ablation of STAT3 in Purkinje cells reorganizes cerebellar synaptic plasticity in long-term fear memory network. eLife. vol 10. 2021-01-22. PMID:33459594. |
ablation of stat3 in purkinje cells reorganizes cerebellar synaptic plasticity in long-term fear memory network. |
2021-01-22 |
2023-08-13 |
Not clear |
| Kazuyoshi Tsutsui, Shogo Haraguch. Neuroprotective actions of cerebellar and pineal allopregnanolone on Purkinje cells. FASEB bioAdvances. vol 2. issue 3. 2021-01-10. PMID:32161904. |
neuroprotective actions of cerebellar and pineal allopregnanolone on purkinje cells. |
2021-01-10 |
2023-08-13 |
Not clear |
| Kazuyoshi Tsutsui, Shogo Haraguch. Neuroprotective actions of cerebellar and pineal allopregnanolone on Purkinje cells. FASEB bioAdvances. vol 2. issue 3. 2021-01-10. PMID:32161904. |
this review summarizes the discovery of cerebellar and pineal allopregnanolone and its neuroprotective action on purkinje cells. |
2021-01-10 |
2023-08-13 |
Not clear |
| Hongling Zhu, Laura E Meissner, Colleen Byrnes, Galina Tuymetova, Cynthia J Tifft, Richard L Proi. The Complement Regulator Susd4 Influences Nervous-System Function and Neuronal Morphology in Mice. iScience. vol 23. issue 3. 2021-01-10. PMID:32179479. |
susd4 ko brain had abnormal "hairy" basket cells surrounding purkinje neurons within the cerebellum and significantly reduced dendritic spine density in hippocampal pyramidal neurons. |
2021-01-10 |
2023-08-13 |
mouse |
| Zhilai Yang, Na Chen, Rongjing Ge, Hao Qian, Jin-Hui Wan. Functional compatibility between Purkinje cell axon branches and their target neurons in the cerebellum. Oncotarget. vol 8. issue 42. 2021-01-09. PMID:29069799. |
we have examined this hypothesis by using electrophysiological method in the cerebellum, in which the main axon of purkinje cell projected to deep nucleus cells and the recurrent axons innervated the adjacent purkinje cells. |
2021-01-09 |
2023-08-13 |
Not clear |
| Douglas J Bakkum, Marie Engelene J Obien, Milos Radivojevic, David Jäckel, Urs Frey, Hirokazu Takahashi, Andreas Hierleman. The Axon Initial Segment is the Dominant Contributor to the Neuron's Extracellular Electrical Potential Landscape. Advanced biosystems. vol 3. issue 2. 2021-01-09. PMID:30882024. |
however, by recording voltages of single neurons in dissociated rat cortical cultures and purkinje cells in acute mouse cerebellar slices through hundreds of densely packed electrodes, it is found, instead, that the axon initial segment dominates the measured eap landscape, and, surprisingly, the soma only contributes to a minor extent. |
2021-01-09 |
2023-08-13 |
mouse |
| Niamh X Cawley, Anna T Lyons, Daniel Abebe, Christopher A Wassif, Forbes D Porte. Evaluation of the Potential Role of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Niemann-Pick Disease, Type C1. International journal of molecular sciences. vol 21. issue 7. 2021-01-07. PMID:32244519. |
in the cerebellum this causes neurodegeneration of the purkinje neurons that die in an anterior-to-posterior and time-dependent manner. |
2021-01-07 |
2023-08-13 |
Not clear |
| Christine M Pedroaren. A Slow Short-Term Depression at Purkinje to Deep Cerebellar Nuclear Neuron Synapses Supports Gain-Control and Linear Encoding over Second-Long Time Windows. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 31. 2020-12-31. PMID:32554551. |
a slow short-term depression at purkinje to deep cerebellar nuclear neuron synapses supports gain-control and linear encoding over second-long time windows. |
2020-12-31 |
2023-08-13 |
mouse |
| Bridget R Boyle, Sierra E Melli, Ruth S Altreche, Zachary M Padron, Fawad A K Yousufzai, Sarah Kim, Mariella D Vasquez, Dawn M Carone, Benjamin R Carone, Ileana Sot. NPC1 deficiency impairs cerebellar postnatal development of microglia and climbing fiber refinement in a mouse model of Niemann-Pick disease type C. Development (Cambridge, England). vol 147. issue 21. 2020-12-23. PMID:32611604. |
degeneration of cerebellar purkinje cells occurs at an earlier stage and to a greater extent in npc; therefore, we analyzed the effect of npc1 deficiency on microglia and on climbing fiber synaptic refinement during cerebellar postnatal development using the |
2020-12-23 |
2023-08-13 |
mouse |