| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuning Liu, Hong Xing, Alexis F Ernst, Canna Liu, Christian Maugee, Fumiaki Yokoi, Madepalli Lakshmana, Yuqing L. Hyperactivity of Purkinje cell and motor deficits in C9orf72 knockout mice. Molecular and cellular neurosciences. 2022-07-17. PMID:35843530. |
we found hyperactivity of purkinje cells in the c9orf72 knockout mouse accompanied by a significant increase of the large-conductance calcium-activated potassium channel (bk) protein in the cerebellum. |
2022-07-17 |
2023-08-14 |
mouse |
| Raffaella Alò, Gilda Fazzari, Merylin Zizza, Ennio Avolio, Anna Di Vito, Ilaria Olvito, Rosalinda Bruno, Marcello Canonaco, Rosa Maria Facciol. Emotional and Spontaneous Locomotor Behaviors Related to cerebellar Daidzein-dependent TrkB Expression Changes in Obese Hamsters. Cerebellum (London, England). 2022-07-06. PMID:35794426. |
in this condition, such a treatment widely led to an overall improvement of hfd-induced neurodegeneration damages, above all in the purkinje and granular layers of the cerebellum. |
2022-07-06 |
2023-08-14 |
Not clear |
| Steven Bellows, Joohi Jimenez-Shahe. Is essential tremor a disorder of GABA dysfunction? No. International review of neurobiology. vol 163. 2022-06-24. PMID:35750366. |
the gaba hypothesis states that disinhibition of deep cerebellar neurons due to reduced gabaergic input from purkinje cells results in increased pacemaker activity, leading to rhythmic output to the thalamo-cortical circuit and resulting in tremor. |
2022-06-24 |
2023-08-14 |
mouse |
| Phyllis L Faus. Is essential tremor a degenerative disorder or an electric disorder? Degenerative disorder. International review of neurobiology. vol 163. 2022-06-24. PMID:35750370. |
most of these pathological changes are centered on the purkinje cell and connected neuronal populations, which can result in partial loss of purkinje cells and circuitry reorganizations that would disturb cerebellar function. |
2022-06-24 |
2023-08-14 |
Not clear |
| Kazuyuki Miyamoto, Motoyasu Nakamura, Hirokazu Ohtaki, Keisuke Suzuki, Hiroki Yamaga, Kaoru Yanagisawa, Atsuo Maeda, Masaharu Yagi, Munetaka Hayashi, Kazuho Honda, Kenji Doh. Heatstroke-induced late-onset neurological deficits in mice caused by white matter demyelination, Purkinje cell degeneration, and synaptic impairment in the cerebellum. Scientific reports. vol 12. issue 1. 2022-06-22. PMID:35732789. |
late-onset motor impairment was suggested to be caused by cerebellar dysfunctions morphologically assessed by myelin staining of cerebellar white matter and immunostaining of purkinje cells with pre- and postsynaptic markers. |
2022-06-22 |
2023-08-14 |
mouse |
| Laura Cutando, Emma Puighermanal, Laia Castell, Pauline Tarot, Morgane Belle, Federica Bertaso, Margarita Arango-Lievano, Fabrice Ango, Marcelo Rubinstein, Albert Quintana, Alain Chédotal, Manuel Mameli, Emmanuel Valjen. Cerebellar dopamine D2 receptors regulate social behaviors. Nature neuroscience. 2022-06-17. PMID:35710984. |
by combining cell-type-specific transcriptomics, histological analyses, three-dimensional imaging and patch-clamp recordings, we demonstrate that cerebellar dopamine d2 receptors (d2rs) in mice are preferentially expressed in purkinje cells (pcs) and regulate synaptic efficacy onto pcs. |
2022-06-17 |
2023-08-14 |
mouse |
| Salvatore Botta, Alexei Chemiakine, Vincenzo A Gennarin. Dual antibody strategy for high-resolution imaging of murine Purkinje cells and their dendrites across multiple layers. STAR protocols. vol 3. issue 2. 2022-06-16. PMID:35707684. |
despite being among the largest neurons in the mammalian brain, purkinje cells are difficult to visualize and trace via immunofluorescence because their dendritic arbors extend through several cerebellar layers. |
2022-06-16 |
2023-08-14 |
mouse |
| Bérénice Coutant, Jimena Laura Frontera, Elodie Perrin, Adèle Combes, Thibault Tarpin, Fabien Menardy, Caroline Mailhes-Hamon, Sylvie Perez, Bertrand Degos, Laurent Venance, Clément Léna, Daniela Pop. Cerebellar stimulation prevents Levodopa-induced dyskinesia in mice and normalizes activity in a motor network. Nature communications. vol 13. issue 1. 2022-06-10. PMID:35680891. |
here, in order to determine how cerebellar stimulation induces lid alleviation, we performed daily short trains of optogenetic stimulations of purkinje cells (pc) in freely moving lid mice. |
2022-06-10 |
2023-08-14 |
mouse |
| Amir Raoofi, Ali Delbari, Davood Nasiry, Rahim Golmohammadi, Sara Sadat Javadinia, Reza Sadrzadeh, Mohammad-Shafi Mojadadi, Auob Rustamzadeh, Amin Mousavi Khaneghah, Vahid Ebrahimi, Mohammad Jafar Rezai. Caffeine modulates apoptosis, oxidative stress, and inflammation damage induced by tramadol in cerebellum of male rats. Journal of chemical neuroanatomy. 2022-06-06. PMID:35660069. |
stereological evaluations were performed to determine the total volume of granular and molecular layers and white matter of cerebellum tissue and numerical density of the purkinje cells. |
2022-06-06 |
2023-08-14 |
rat |
| Kristin Mayoral-Palarz, Andreia Neves-Carvalho, Sara Duarte-Silva, Daniela Monteiro-Fernandes, Patrícia Maciel, Kamran Khodakha. Cerebellar neuronal dysfunction accompanies early motor symptoms in spinocerebellar ataxia type 3. Disease models & mechanisms. 2022-06-06. PMID:35660856. |
the abnormal cerebellar output, however, was accompanied with non-progressive abnormal activity of their upstream synaptic inputs, the purkinje cells. |
2022-06-06 |
2023-08-14 |
mouse |
| Andrea Pirone, Chiara Magliaro, Carlo Cantile, Carla Lenzi, Alessandra Coli, Vincenzo Miragliott. Comparative and quantitative morphology of the pig and wild boar cerebellum for identifying possible effects of domestication. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 2022-06-01. PMID:35644466. |
despite the morphological data alone are not sufficient to draw any final conclusions, our findings on purkinje cells may represent good indicators of a reduction of the pig cerebellum motor and cognitive functions during the process wild boar-to-pig domestication. |
2022-06-01 |
2023-08-13 |
human |
| Maxime Veleanu, Beetsi Urrieta-Chávez, Séverine M Sigoillot, Maëla A Paul, Alessia Usardi, Keerthana Iyer, Marine Delagrange, Joseph P Doyle, Nathaniel Heintz, Carine Bécamel, Fekrije Selim. Modified climbing fiber/Purkinje cell synaptic connectivity in the cerebellum of the neonatal phencyclidine model of schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 21. 2022-05-19. PMID:35588456. |
in this model, we found specific long-term synaptic changes in purkinje cells and transient gene expression changes in the cerebellum. |
2022-05-19 |
2023-08-13 |
human |
| Wanchen Wang, Ryo Shiraishi, Daisuke Kawauch. Sonic Hedgehog Signaling in Cerebellar Development and Cancer. Frontiers in cell and developmental biology. vol 10. 2022-05-16. PMID:35573667. |
in the cerebellum, shh secreted by purkinje cells is a potent mitogen for granule cell progenitors, which are the most abundant cell type in the mature brain. |
2022-05-16 |
2023-08-13 |
Not clear |
| Zhihui Liu, Man Jiang, Kif Liakath-Ali, Alessandra Sclip, Jaewon Ko, Roger Shen Zhang, Thomas C Südho. Deletion of Calsyntenin-3, an atypical cadherin, suppresses inhibitory synapses but increases excitatory parallel-fiber synapses in cerebellum. eLife. vol 11. 2022-05-05. PMID:35420982. |
here, we show that, surprisingly, acute crispr-mediated deletion of calsyntenin-3 in mouse cerebellum in vivo causes a large decrease in inhibitory synapse, but a robust increase in excitatory parallel-fiber synapses in purkinje cells. |
2022-05-05 |
2023-08-16 |
mouse |
| Zhihui Liu, Man Jiang, Kif Liakath-Ali, Alessandra Sclip, Jaewon Ko, Roger Shen Zhang, Thomas C Südho. Deletion of Calsyntenin-3, an atypical cadherin, suppresses inhibitory synapses but increases excitatory parallel-fiber synapses in cerebellum. eLife. vol 11. 2022-05-05. PMID:35420982. |
sparse selective deletion of calsyntenin-3 only in purkinje cells recapitulated the synaptic phenotype, indicating that calsyntenin-3 acts by a cell-autonomous postsynaptic mechanism in cerebellum. |
2022-05-05 |
2023-08-16 |
mouse |
| Ester Antón-Galindo, Elisa Dalla Vecchia, Javier G Orlandi, Gustavo Castro, Emilio J Gualda, Andrew M J Young, Marc Guasch-Piqueras, Concepció Arenas, Carlos Herrera-Úbeda, Jordi Garcia-Fernàndez, Fernando Aguado, Pablo Loza-Alvarez, Bru Cormand, William H J Norton, Noèlia Fernàndez-Castill. Deficiency of the ywhaz gene, involved in neurodevelopmental disorders, alters brain activity and behaviour in zebrafish. Molecular psychiatry. 2022-05-02. PMID:35501409. |
we observed that ywhaz expression was pan-neuronal during developmental stages and restricted to purkinje cells in the adult cerebellum, cells that are described to be reduced in number and size in autistic patients. |
2022-05-02 |
2023-08-13 |
mouse |
| Omid A Zobeiri, Kathleen E Culle. Distinct representations of body and head motion are dynamically encoded by Purkinje cell populations in the macaque cerebellum. eLife. vol 11. 2022-04-25. PMID:35467528. |
the anterior vermis of the cerebellum is thought to play a key role in this transformation, yet how its purkinje cells integrate these inputs or what information they dynamically encode during self-motion remains unknown. |
2022-04-25 |
2023-08-13 |
monkey |
| Omid A Zobeiri, Kathleen E Culle. Distinct representations of body and head motion are dynamically encoded by Purkinje cell populations in the macaque cerebellum. eLife. vol 11. 2022-04-25. PMID:35467528. |
we propose that the observed heterogeneity in purkinje cells underlies the cerebellum's capacity to compute the dynamic representation of body motion required to ensure accurate postural control and perceptual stability in our daily lives. |
2022-04-25 |
2023-08-13 |
monkey |
| Ayla Arslan, Niyazi Acer, Hakan Kesici, Mehmet Fatih Sonmez, Tolga Ertekin, Murat Gultekin, Ulvi Dagdelen, Omer Galip Saracogl. Stereological Study on the Effect of Carnosine on of Purkinje Cells in the Cerebellum of Rats Exposed to 900 MHz Electromagnetic Field. Turkish neurosurgery. 2022-04-13. PMID:35416258. |
stereological study on the effect of carnosine on of purkinje cells in the cerebellum of rats exposed to 900 mhz electromagnetic field. |
2022-04-13 |
2023-08-13 |
rat |
| Ayla Arslan, Niyazi Acer, Hakan Kesici, Mehmet Fatih Sonmez, Tolga Ertekin, Murat Gultekin, Ulvi Dagdelen, Omer Galip Saracogl. Stereological Study on the Effect of Carnosine on of Purkinje Cells in the Cerebellum of Rats Exposed to 900 MHz Electromagnetic Field. Turkish neurosurgery. 2022-04-13. PMID:35416258. |
aim: electromagnetic fields have been known to reduce the number of purkinje neurons in the cerebellum, whereas carnosine has been known to protect them. |
2022-04-13 |
2023-08-13 |
rat |