| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John H Freeman, Adam B Steinmet. Neural circuitry and plasticity mechanisms underlying delay eyeblink conditioning. Learning & memory (Cold Spring Harbor, N.Y.). vol 18. issue 10. 2012-01-27. PMID:21969489. |
evidence favors a two-site plasticity model within the cerebellum with long-term depression of parallel fiber synapses on purkinje cells and long-term potentiation of mossy fiber synapses on neurons in the anterior interpositus nucleus. |
2012-01-27 |
2023-08-12 |
Not clear |
| Liborio Rampello, Barbara Casolla, Luigi Rampello, Marco Pignatelli, Giuseppe Battaglia, Roberto Gradini, Francesco Orzi, Ferdinando Nicolett. The conditioned eyeblink reflex: a potential tool for the detection of cerebellar dysfunction in multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England). vol 17. issue 10. 2012-01-23. PMID:21613334. |
a tone) relies entirely on the functional integrity of a cerebellar motor circuitry that involves the contingent activation of purkinje cells by parallel and climbing fibres. |
2012-01-23 |
2023-08-12 |
mouse |
| Egidio D'Angel. Neural circuits of the cerebellum: hypothesis for function. Journal of integrative neuroscience. vol 10. issue 3. 2012-01-19. PMID:21960306. |
it is suggested that the cerebellum can, in this way, operate the realignment of temporally incongruent signals, allowing their binding and pattern recognition in purkinje cells. |
2012-01-19 |
2023-08-12 |
Not clear |
| Petter Strømme, Kostantin Dobrenis, Roy V Sillitoe, Maria Gulinello, Nafeeza F Ali, Cristin Davidson, Matthew C Micsenyi, Gloria Stephney, Linda Ellevog, Arne Klungland, Steven U Walkle. X-linked Angelman-like syndrome caused by Slc9a6 knockout in mice exhibits evidence of endosomal-lysosomal dysfunction. Brain : a journal of neurology. vol 134. issue Pt 11. 2012-01-18. PMID:21964919. |
neuroaxonal dystrophy similar to that observed in lysosomal disease was observed in the cerebellum and was accompanied by a marked and progressive loss of purkinje cells, particularly in those lacking the expression of zebrin ii. |
2012-01-18 |
2023-08-12 |
mouse |
| Gene J Blatt, S Hossein Fatem. Alterations in GABAergic biomarkers in the autism brain: research findings and clinical implications. Anatomical record (Hoboken, N.J. : 2007). vol 294. issue 10. 2012-01-17. PMID:21901839. |
the key synthesizing enzymes for gaba, glutamic acid decarboxylase type 65 and 67 (gad65 and gad67), are decreased in the cerebellum and closer examination of mrna levels revealed that it is largely due to decreases in purkinje cells and a subpopulation of larger dentate neurons as measured by in situ hybridization studies. |
2012-01-17 |
2023-08-12 |
Not clear |
| Tom J H Ruigro. Ins and outs of cerebellar modules. Cerebellum (London, England). vol 10. issue 3. 2012-01-13. PMID:20232190. |
in this concept, a cerebellar module is defined as the conglomerate of one or multiple and non-adjacent, parasagittally arranged zones of purkinje cells, their specific projection to a well-defined region of the cerebellar nuclei, and the climbing fiber input to these zones by a well-defined region of the inferior olivary complex. |
2012-01-13 |
2023-08-12 |
rat |
| Nadia L Cerminara, Richard App. Behavioural significance of cerebellar modules. Cerebellum (London, England). vol 10. issue 3. 2012-01-13. PMID:20838949. |
in turn, purkinje cells within each zone project to specific regions of the cerebellar and vestibular nuclei. |
2012-01-13 |
2023-08-12 |
Not clear |
| Jakob Jankowski, Andreas Miething, Karl Schilling, John Oberdick, Stephan Baade. Cell death as a regulator of cerebellar histogenesis and compartmentation. Cerebellum (London, England). vol 10. issue 3. 2012-01-13. PMID:20941559. |
to support this hypothesis, we provide new data obtained from a cerebellar mutant with prolonged expression of engrailed-2 specifically in cerebellar purkinje cells which shows increased local physiological cell death and concomitant changes in the pattern of afferent innervation. |
2012-01-13 |
2023-08-12 |
Not clear |
| Izumi Sugihar. Compartmentalization of the deep cerebellar nuclei based on afferent projections and aldolase C expression. Cerebellum (London, England). vol 10. issue 3. 2012-01-13. PMID:20981512. |
the distribution of aldolase c (zebrin ii)-positive and -negative purkinje cells (pcs) can be used to define about 20 longitudinally extended compartments in the cerebellar cortex of the rat, which may correspond to certain aspects of cerebellar functional localization. |
2012-01-13 |
2023-08-12 |
rat |
| Kunal K Ghosh, Laurie D Burns, Eric D Cocker, Axel Nimmerjahn, Yaniv Ziv, Abbas El Gamal, Mark J Schnitze. Miniaturized integration of a fluorescence microscope. Nature methods. vol 8. issue 10. 2011-12-23. PMID:21909102. |
this capability allowed concurrent tracking of ca2+ spiking in >200 purkinje neurons across nine cerebellar microzones. |
2011-12-23 |
2023-08-12 |
mouse |
| J Benavides, K Willoughby, C Underwood, B Newman, G Mitchell, H Cart. Encephalitis and neuronal necrosis in a 3-month-old suckled beef calf. Veterinary pathology. vol 48. issue 5. 2011-12-20. PMID:21273383. |
histologic examination of the brain showed neuronal chromatolysis and necrosis in the hind brain and loss of purkinje cells in the cerebellum, accompanied by mild nonsuppurative encephalitis in the hind brain with a striking lack of inflammation in the cerebellar layers. |
2011-12-20 |
2023-08-12 |
Not clear |
| Daniela Necchi, Selene Lomoio, Elda Scherin. Dysfunction of the ubiquitin-proteasome system in the cerebellum of aging Ts65Dn mice. Experimental neurology. vol 232. issue 2. 2011-12-20. PMID:21867700. |
in the cerebellum of adult-aging ts65dn mice, a murine model of down syndrome, purkinje cells undergo degeneration. |
2011-12-20 |
2023-08-12 |
mouse |
| Justyna R Sarna, Richard Hawke. Patterned Purkinje cell loss in the ataxic sticky mouse. The European journal of neuroscience. vol 34. issue 1. 2011-12-19. PMID:21645134. |
in addition, zebrin ii/aldolase c expression in the sticky cerebellum is profoundly downregulated, whereas the heat-shock protein 25 is both ectopically expressed in some scattered purkinje cells and downregulated in other purkinje cells in which it is normally expressed constitutively. |
2011-12-19 |
2023-08-12 |
mouse |
| Wolfgang Wagner, Seumas McCroskery, John A Hamme. An efficient method for the long-term and specific expression of exogenous cDNAs in cultured Purkinje neurons. Journal of neuroscience methods. vol 200. issue 2. 2011-12-15. PMID:21708190. |
we present a simple and efficient method for expressing cdnas in purkinje neurons (pns) present in heterogeneous mouse cerebellar cultures. |
2011-12-15 |
2023-08-12 |
mouse |
| Tatiana Hurtado de Mendoza, Carlos G Perez-Garcia, Todd T Kroll, Nien H Hoong, Dennis D M O'Leary, Inder M Verm. Antiapoptotic protein Lifeguard is required for survival and maintenance of Purkinje and granular cells. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 41. 2011-12-13. PMID:21957071. |
these data demonstrate that lfg is required for proper development and survival of granular and purkinje cells and suggest lfg may play a role in cerebellar disorders. |
2011-12-13 |
2023-08-12 |
mouse |
| You-Kang Chang, Ming-Hsiang Chen, Yi-Hung Chiang, Yu-Fan Chen, Wei-Hsien Ma, Chian-You Tseng, Bin-Wen Soong, Jennifer H Ho, Oscar K Le. Mesenchymal stem cell transplantation ameliorates motor function deterioration of spinocerebellar ataxia by rescuing cerebellar Purkinje cells. Journal of biomedical science. vol 18. 2011-12-12. PMID:21824437. |
spinocerebellar ataxia (sca) refers to a disease entity in which polyglutamine aggregates are over-produced in purkinje cells (pcs) of the cerebellum as well as other neurons in the central nervous system, and the formation of intracellular polyglutamine aggregates result in the loss of neurons as well as deterioration of motor functions. |
2011-12-12 |
2023-08-12 |
human |
| Marios Hadjivassilio. Immune-mediated acquired ataxias. Handbook of clinical neurology. vol 103. 2011-12-06. PMID:21827889. |
the cerebellum, and in particular the purkinje cells within it, appear to be a frequent immunological target in the context of some systemic diseases. |
2011-12-06 |
2023-08-12 |
Not clear |
| Marios Hadjivassilio. Immune-mediated acquired ataxias. Handbook of clinical neurology. vol 103. 2011-12-06. PMID:21827889. |
this observation may relate to the fact that the cerebellum is one of the largest, oldest, and most structurally conserved structures in the vertebrate nervous system and/or that purkinje cells possess good and multiple antigenic targets. |
2011-12-06 |
2023-08-12 |
Not clear |
| Marios Hadjivassilio. Immune-mediated acquired ataxias. Handbook of clinical neurology. vol 103. 2011-12-06. PMID:21827889. |
the pathophysiology leading to cerebellar damage, loss of purkinje cells, and the development of ataxia remains speculative, but existing clues are discussed in detail. |
2011-12-06 |
2023-08-12 |
Not clear |
| Mario Mant. Toxic agents causing cerebellar ataxias. Handbook of clinical neurology. vol 103. 2011-12-06. PMID:21827890. |
the cerebellum is particularly vulnerable to intoxication and poisoning, especially so the cerebellar cortex and purkinje neurons. |
2011-12-06 |
2023-08-12 |
Not clear |