| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stefano Di Donato, Caterina Mariotti, Franco Taron. Spinocerebellar ataxia type 1. Handbook of clinical neurology. vol 103. 2011-12-06. PMID:21827903. |
its diagnostic pathological feature is olivopontocerebellar atrophy and degeneration predominantly affects the purkinje cells and the dentate nuclei of the cerebellum. |
2011-12-06 |
2023-08-12 |
Not clear |
| Baiping Wang, Wilbur Harrison, Paul A Overbeek, Hui Zhen. Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development. Development (Cambridge, England). vol 138. issue 20. 2011-11-28. PMID:21937600. |
correct development of the cerebellum requires coordinated sonic hedgehog (shh) signaling from purkinje to granule cells. |
2011-11-28 |
2023-08-12 |
mouse |
| Baiping Wang, Wilbur Harrison, Paul A Overbeek, Hui Zhen. Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development. Development (Cambridge, England). vol 138. issue 20. 2011-11-28. PMID:21937600. |
our study identifies an essential function for skor2 as a novel transcriptional regulator in purkinje cells that acts upstream of shh during cerebellum development. |
2011-11-28 |
2023-08-12 |
mouse |
| Seung-Hyuk Chung, Marco Calafiore, Jennifer M Plane, David E Pleasure, Wenbin Den. Apoptosis inducing factor deficiency causes reduced mitofusion 1 expression and patterned Purkinje cell degeneration. Neurobiology of disease. vol 41. issue 2. 2011-11-22. PMID:20974255. |
using immunoblotting and flow cytometry analysis with harlequin mutant mice that have a proviral insertion in the aif gene, we first revealed that mitofusion 1 (mfn1), a key mitochondrial fusion protein, is significantly diminished in purkinje cells of the harlequin cerebellum. |
2011-11-22 |
2023-08-12 |
mouse |
| Seung-Hyuk Chung, Marco Calafiore, Jennifer M Plane, David E Pleasure, Wenbin Den. Apoptosis inducing factor deficiency causes reduced mitofusion 1 expression and patterned Purkinje cell degeneration. Neurobiology of disease. vol 41. issue 2. 2011-11-22. PMID:20974255. |
using immunohistochemistry with zebrin ii, the most studied compartmentalization marker in the cerebellum, we found that zebrin ii-negative purkinje cells first started to degenerate at 7 months of age. |
2011-11-22 |
2023-08-12 |
mouse |
| Seung-Hyuk Chung, Marco Calafiore, Jennifer M Plane, David E Pleasure, Wenbin Den. Apoptosis inducing factor deficiency causes reduced mitofusion 1 expression and patterned Purkinje cell degeneration. Neurobiology of disease. vol 41. issue 2. 2011-11-22. PMID:20974255. |
subsequently, most of the purkinje cells disappeared in the harlequin cerebellum. |
2011-11-22 |
2023-08-12 |
mouse |
| Seung-Hyuk Chung, Marco Calafiore, Jennifer M Plane, David E Pleasure, Wenbin Den. Apoptosis inducing factor deficiency causes reduced mitofusion 1 expression and patterned Purkinje cell degeneration. Neurobiology of disease. vol 41. issue 2. 2011-11-22. PMID:20974255. |
the surviving purkinje cells were concentrated in cerebellar lobules ix and x, where these cells were positive for heat shock protein 25 and resistant to degeneration. |
2011-11-22 |
2023-08-12 |
mouse |
| Kazunori Namba, Izumi Sugihara, Mitsuhiro Hashimot. Close correlation between the birth date of Purkinje cells and the longitudinal compartmentalization of the mouse adult cerebellum. The Journal of comparative neurology. vol 519. issue 13. 2011-11-15. PMID:21456012. |
close correlation between the birth date of purkinje cells and the longitudinal compartmentalization of the mouse adult cerebellum. |
2011-11-15 |
2023-08-12 |
mouse |
| Kazunori Namba, Izumi Sugihara, Mitsuhiro Hashimot. Close correlation between the birth date of Purkinje cells and the longitudinal compartmentalization of the mouse adult cerebellum. The Journal of comparative neurology. vol 519. issue 13. 2011-11-15. PMID:21456012. |
these compartments in the adult cerebellum are closely correlated with the striped expression of zebrin ii (aldolase c), a late-onset marker of purkinje cells. |
2011-11-15 |
2023-08-12 |
mouse |
| Kazunori Namba, Izumi Sugihara, Mitsuhiro Hashimot. Close correlation between the birth date of Purkinje cells and the longitudinal compartmentalization of the mouse adult cerebellum. The Journal of comparative neurology. vol 519. issue 13. 2011-11-15. PMID:21456012. |
to examine this issue, we labeled purkinje cells (pcs) born at embryonic day (e) 10.5, e11.5, and e12.5 by using an adenoviral vector and traced their fated positions in the adult cerebellum. |
2011-11-15 |
2023-08-12 |
mouse |
| Luis Velázquez-Pérez, Roberto Rodríguez-Labrada, Julio Cesar García-Rodríguez, Luis Enrique Almaguer-Mederos, Tania Cruz-Mariño, José Miguel Laffita-Mes. A comprehensive review of spinocerebellar ataxia type 2 in Cuba. Cerebellum (London, England). vol 10. issue 2. 2011-11-10. PMID:21399888. |
sca2 is caused by the abnormal expansion of cytosine-adenine-guanine triplet repeats in the encoding region of the atxn2 gene and therefore the expression of toxic polyglutamine expansions in the ataxin 2 protein, which cause progressive neuronal death of purkinje cells in the cerebellum and several pontine, mesencephalic, and thalamic neurons among other cells. |
2011-11-10 |
2023-08-12 |
human |
| Liutao Du, Refik Kayali, Carmen Bertoni, Francesca Fike, Hailiang Hu, Patrick L Iversen, Richard A Gatt. Arginine-rich cell-penetrating peptide dramatically enhances AMO-mediated ATM aberrant splicing correction and enables delivery to brain and cerebellum. Human molecular genetics. vol 20. issue 16. 2011-11-10. PMID:21576124. |
furthermore, multiple injections significantly increased uptake in all areas of the brain, notably in cerebellum and purkinje cells, and showed no apparent signs of toxicity. |
2011-11-10 |
2023-08-12 |
mouse |
| Zéev R Abrams, Xiang Zhan. Signals and circuits in the purkinje neuron. Frontiers in neural circuits. vol 5. 2011-11-10. PMID:21980311. |
purkinje neurons (pn) in the cerebellum have over 100,000 inputs organized in an orthogonal geometry, and a single output channel. |
2011-11-10 |
2023-08-12 |
Not clear |
| Bhupinder Bawa, Louise C Abbot. Alterations in intracellular calcium ion concentrations in cerebellar granule cells of the CACNA1A mutant mouse, leaner, during postnatal development. Neurotoxicity research. vol 19. issue 1. 2011-11-08. PMID:20043243. |
intracellular ca²+ ([ca²+](i)) concentrations in leaner and tottering mouse purkinje cells have been described, but [ca²+](i) concentrations have not been reported for granule cells, the largest neuronal population of the cerebellum. |
2011-11-08 |
2023-08-12 |
mouse |
| Robert L Rodnitzk. Cerebellar pathology and essential tremor: did Dr. Purkinje leave any fingerprints? Parkinsonism & related disorders. vol 17. issue 6. 2011-10-24. PMID:21600831. |
cerebellar pathology and essential tremor: did dr. purkinje leave any fingerprints? |
2011-10-24 |
2023-08-12 |
Not clear |
| Min Li, Silvia Armelloni, Masami Ikehata, Alessandro Corbelli, Marzia Pesaresi, Novella Calvaresi, Laura Giardino, Deborah Mattinzoli, Francesca Nisticò, Serena Andreoni, Aldamaria Puliti, Roberto Ravazzolo, Gianluigi Forloni, Piergiorgio Messa, Maria Pia Rastald. Nephrin expression in adult rodent central nervous system and its interaction with glutamate receptors. The Journal of pathology. vol 225. issue 1. 2011-10-24. PMID:21630272. |
our results show that, besides a number of locations already found in embryos and newborns, endogenous nephrin in adult rodent cns extends to the pons and corpus callosum and is expressed by granule cells and purkinje cells of the cerebellum, with a characteristic alternating expression pattern. |
2011-10-24 |
2023-08-12 |
Not clear |
| Mario Prsa, Peter Thie. The role of the cerebellum in saccadic adaptation as a window into neural mechanisms of motor learning. The European journal of neuroscience. vol 33. issue 11. 2011-10-18. PMID:21645105. |
we focus our discussion on the plastic changes that are observed in the firing properties of purkinje cells during the acquisition of the wanted motor response and describe how the altered activity of these neurons modifies the dynamics of the cerebellar microcircuitry. |
2011-10-18 |
2023-08-12 |
Not clear |
| D A Velázquez-Zamora, M Martínez-Degollado, I González-Burgo. Morphological development of dendritic spines on rat cerebellar Purkinje cells. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 29. issue 5. 2011-10-17. PMID:21549828. |
hence, the changes found suggest that the development of motor control may be closely linked to the distinct developmental patterns of dendritic spines on purkinje cells, which has important implications for future studies of cerebellar dysfunctions. |
2011-10-17 |
2023-08-12 |
rat |
| Jean M Abel, Diane M Witt, Emilie F Rissma. Sex differences in the cerebellum and frontal cortex: roles of estrogen receptor alpha and sex chromosome genes. Neuroendocrinology. vol 93. issue 4. 2011-10-13. PMID:21325792. |
a robust sex difference was found in calb in the frontal cortex (fc) and cerebellum (cb; specifically in purkinje cells); mrna and protein were higher in females than in males. |
2011-10-13 |
2023-08-12 |
mouse |
| Ming-Wai Poon, Wan-Hong Tsang, Mary Miu-Yee Waye, Sun-On Cha. Distribution of Kiaa0319-like immunoreactivity in the adult mouse brain--a novel protein encoded by the putative dyslexia susceptibility gene KIAA0319-like. Histology and histopathology. vol 26. issue 8. 2011-10-13. PMID:21692029. |
in the cerebellum, the protein was observed in the molecular layer and a fraction of purkinje neurons. |
2011-10-13 |
2023-08-12 |
mouse |