| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Raphael Hourez, Laurent Servais, David Orduz, David Gall, Isabelle Millard, Alban de Kerchove d'Exaerde, Guy Cheron, Harry T Orr, Massimo Pandolfo, Serge N Schiffman. Aminopyridines correct early dysfunction and delay neurodegeneration in a mouse model of spinocerebellar ataxia type 1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 33. 2011-10-13. PMID:21849540. |
chronic treatment with 3,4-diaminopyridine is associated with increased cerebellar levels of bdnf, suggesting that partial protection against atrophy of purkinje cells is possibly provided by an increased production of growth factors secondary to the reincrease in electrical activity. |
2011-10-13 |
2023-08-12 |
mouse |
| Hiroshi Doi, Kunihiro Yoshida, Takao Yasuda, Mitsunori Fukuda, Yoko Fukuda, Hiroshi Morita, Shu-ichi Ikeda, Rumiko Kato, Yoshinori Tsurusaki, Noriko Miyake, Hirotomo Saitsu, Haruya Sakai, Satoko Miyatake, Masaaki Shiina, Nobuyuki Nukina, Shigeru Koyano, Shoji Tsuji, Yoshiyuki Kuroiwa, Naomichi Matsumot. Exome sequencing reveals a homozygous SYT14 mutation in adult-onset, autosomal-recessive spinocerebellar ataxia with psychomotor retardation. American journal of human genetics. vol 89. issue 2. 2011-10-10. PMID:21835308. |
an immunohistochemical analysis clearly showed that syt14 is specifically localized to purkinje cells of the cerebellum in humans and mice. |
2011-10-10 |
2023-08-12 |
mouse |
| T van der Vaart, G M van Woerden, Y Elgersma, C I de Zeeuw, M Schonewill. Motor deficits in neurofibromatosis type 1 mice: the role of the cerebellum. Genes, brain, and behavior. vol 10. issue 4. 2011-10-07. PMID:21352477. |
cerebellar purkinje cells, the sole output neurons of the cerebellar cortex, are gabaergic neurons and express neurofibromin at high levels, suggesting an important role for the cerebellum in the observed motor deficits in nf1. |
2011-10-07 |
2023-08-12 |
mouse |
| Minyoung Shin, Setareh H Moghadam, Chris Sekirnjak, Martha W Bagnall, Kristine E Kolkman, Richard Jacobs, Michael Faulstich, Sascha du La. Multiple types of cerebellar target neurons and their circuitry in the vestibulo-ocular reflex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 30. 2011-10-07. PMID:21795530. |
here we examined the cell types and microcircuits through which purkinje cells influence an oculomotor behavior controlled by the cerebellum, the horizontal vestibulo-ocular reflex, which involves only two eye muscles. |
2011-10-07 |
2023-08-12 |
mouse |
| Minyoung Shin, Setareh H Moghadam, Chris Sekirnjak, Martha W Bagnall, Kristine E Kolkman, Richard Jacobs, Michael Faulstich, Sascha du La. Multiple types of cerebellar target neurons and their circuitry in the vestibulo-ocular reflex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 30. 2011-10-07. PMID:21795530. |
these results indicate that the cerebellum regulates a simple reflex behavior via at least five different cell types that are postsynaptic to purkinje cells. |
2011-10-07 |
2023-08-12 |
mouse |
| Megumi Kaneko, Kazuhiko Yamaguchi, Mototsugu Eiraku, Motohiko Sato, Norio Takata, Yoshimoto Kiyohara, Masayoshi Mishina, Hajime Hirase, Tsutomu Hashikawa, Mineko Kengak. Remodeling of monoplanar Purkinje cell dendrites during cerebellar circuit formation. PloS one. vol 6. issue 5. 2011-10-05. PMID:21655286. |
our results suggest that the monoplanar arborization of purkinje cells is coupled with functional development of the cerebellar circuitry. |
2011-10-05 |
2023-08-12 |
mouse |
| Kouichi Hashimoto, Mika Tsujita, Taisuke Miyazaki, Kazuo Kitamura, Maya Yamazaki, Hee-Sup Shin, Masahiko Watanabe, Kenji Sakimura, Masanobu Kan. Postsynaptic P/Q-type Ca2+ channel in Purkinje cell mediates synaptic competition and elimination in developing cerebellum. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 24. 2011-09-29. PMID:21628556. |
at birth, purkinje cells (pcs) in the cerebellum are innervated by multiple climbing fibers (cfs) with similar synaptic strengths. |
2011-09-29 |
2023-08-12 |
mouse |
| Keiko Matsuda, Michisuke Yuzak. Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions. The European journal of neuroscience. vol 33. issue 8. 2011-09-16. PMID:21410790. |
precerebellin) is a unique bidirectional synaptic organizer that plays an essential role in the formation and maintenance of excitatory synapses between granule cells and purkinje cells in the mouse cerebellum. |
2011-09-16 |
2023-08-12 |
mouse |
| Kwan Young Lee, Jin Seong Kim, Se Hoon Kim, Hyung Seo Park, Young-Gil Jeong, Nam-Seob Lee, Dong Kwan Ki. Altered Purkinje cell responses and calmodulin expression in the spontaneously ataxic mouse, Pogo. The European journal of neuroscience. vol 33. issue 8. 2011-09-16. PMID:21410792. |
ataxia is often associated with altered cerebellar motor control, a process in which purkinje cells (pcs) play a principal role. |
2011-09-16 |
2023-08-12 |
mouse |
| Maria Johanna Dizon, Kamran Khodakha. The role of interneurons in shaping Purkinje cell responses in the cerebellar cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 29. 2011-09-16. PMID:21775592. |
the well established anatomy of the cerebellar cortex has led to suggestions that cerebellar molecular layer interneurons laterally inhibit purkinje cells. |
2011-09-16 |
2023-08-12 |
rat |
| Maria Johanna Dizon, Kamran Khodakha. The role of interneurons in shaping Purkinje cell responses in the cerebellar cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 29. 2011-09-16. PMID:21775592. |
in support of the anatomical predictions, on-beam excitation and off-beam inhibition of purkinje cells have been shown to occur when the surface of the cerebellum is electrically excited. |
2011-09-16 |
2023-08-12 |
rat |
| Antonio R Martins, Cesar A B Zanella, Fabiola C R Zucchi, Thaís C D Dombroski, Edmar T Costa, Liliane M Guethe, Alina O Oliveira, Ana L F Donatti, Luciano Neder, Leila Chimelli, Gilberto De Nucci, Paulo Lee-Ho, Ferid Mura. Immunolocalization of nitric oxide synthase isoforms in human archival and rat tissues, and cultured cells. Journal of neuroscience methods. vol 198. issue 1. 2011-08-26. PMID:21420432. |
neuronal nos antigenicity in human archival and rat nervous tissue sections was microwave-retrieved in 50 mm tris-hcl buffer, ph 9.5, for 20 min at 900 w. neuronal nos was expressed in stellate, basket, purkinje and granule cells in human and rat cerebellum. |
2011-08-26 |
2023-08-12 |
human |
| E Lampo, W Van den Broeck, N Willemarck, M Van Poucke, C R Casteleyn, W De Spiegelaere, A Van Zeveren, L J Peelma. Distribution of the Shadoo protein in the ovine brain assessed by immunohistochemistry. Research in veterinary science. vol 90. issue 3. 2011-08-24. PMID:20667569. |
the strongest staining level was found in the cerebellum (especially in the purkinje cells) and in the pons, but cerebrum, hippocampus, pituitary gland, medulla oblongata, thalamus and hypothalamus were also immunopositive. |
2011-08-24 |
2023-08-12 |
Not clear |
| Rm Gracien, M Kordulla, U Zieman. Paraneoplastic cerebellar degeneration mimicking development of secondary progressive multiple sclerosis in a patient with relapsing-remitting multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England). vol 17. issue 4. 2011-08-15. PMID:21148018. |
paraneoplastic cerebellar degeneration (pcd) is a rare non-metastatic complication of cancer mediated by t lymphocytes and auto-antibodies directed against purkinje cells of the cerebellum. |
2011-08-15 |
2023-08-12 |
Not clear |
| Michaela Metz, Martin Gassmann, Bernd Fakler, Nicole Schaeren-Wiemers, Bernhard Bettle. Distribution of the auxiliary GABAB receptor subunits KCTD8, 12, 12b, and 16 in the mouse brain. The Journal of comparative neurology. vol 519. issue 8. 2011-08-10. PMID:21452234. |
in contrast, granule, purkinje, and golgi cells in the cerebellum selectively express one kctd at a time. |
2011-08-10 |
2023-08-12 |
mouse |
| Cynthia J M Kane, Kevin D Phelan, Lihong Han, Renea R Smith, Jin Xie, James C Douglas, Paul D Dre. Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-γ agonists. Brain, behavior, and immunity. vol 25 Suppl 1. 2011-08-08. PMID:21376806. |
rodent models of fasd have previously demonstrated that both purkinje cells and granule cells, which are the two major types of neurons in the cerebellum, are highly susceptible to the toxic effects of ethanol. |
2011-08-08 |
2023-08-12 |
mouse |
| C L Dalgard, Q Zhou, T G Lundell, M L Dought. Altered gene expression in the emerging cerebellar primordium of Neurog1-/- mice. Brain research. vol 1388. 2011-08-08. PMID:21382351. |
expression of the basic helix-loop-helix (bhlh) transcription factor neurogenin1 (neurog1) coincides with the emergence of the cerebellum and neurog1-expressing progenitors are fated to become purkinje cells and later interneurons. |
2011-08-08 |
2023-08-12 |
mouse |
| Martin B Gill, Akihiko S Kato, Matthew F Roberts, Hong Yu, He Wang, Susumu Tomita, David S Bred. Cornichon-2 modulates AMPA receptor-transmembrane AMPA receptor regulatory protein assembly to dictate gating and pharmacology. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 18. 2011-08-05. PMID:21543622. |
in the cerebellum, however, cnih-2 expressed in purkinje neurons does not reach the neuronal surface. |
2011-08-05 |
2023-08-12 |
mouse |
| Erdem Tüzün, Erdem Yaka, Luigi Zuliani, Sema Içöz, Bariş Baklan, Omer Birişik, Pinar Kurd, Gülşen Akman-Demir, Angela Vincent, Gülden Akda. Steroid-responsive recurrent limbic encephalitis associated with small cell lung cancer and neuropil antibodies. Acta neurologica Belgica. vol 111. issue 2. 2011-08-03. PMID:21748934. |
however, the patient's serum and cerebrospinal fluid igg, obtained during both exacerbations, immunolabeled cytoplasm and dendrites of purkinje cells, cerebellar and hippocampal molecular layers, basal ganglia, thalamus, and the surface of cultured hippocampal neurons, in a manner distinct from previously identified neuropil antibodies associated with sclc. |
2011-08-03 |
2023-08-12 |
Not clear |
| Hai-Xia Lu, Hannah Levis, Yong Liu, Terry Parke. Organotypic slices culture model for cerebellar ataxia: potential use to study Purkinje cell induction from neural stem cells. Brain research bulletin. vol 84. issue 2. 2011-07-22. PMID:21145378. |
analysis indicated that cerebellar cytoarchitecture was well preserved and purkinje cells survived for over three weeks with fewer purkinje cells in slices cultured from penitrem a treated neonates compared to controls. |
2011-07-22 |
2023-08-12 |
rat |