| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaohong Wang, Tetsuya Imura, Michael V Sofroniew, Shinji Fushik. Loss of adenomatous polyposis coli in Bergmann glia disrupts their unique architecture and leads to cell nonautonomous neurodegeneration of cerebellar Purkinje neurons. Glia. vol 59. issue 6. 2012-03-26. PMID:21381115. |
these results demonstrate that loss of apc selectively disrupts the bergmann glial scaffold in late postnatal development and leads to cerebellar degeneration with loss of purkinje neurons in adults, providing another potential mechanism for region-specific non-cell autonomous neurodegeneration. |
2012-03-26 |
2023-08-12 |
mouse |
| Rebecca Boehme, Victor N Uebele, John J Renger, Christine Pedroaren. Rebound excitation triggered by synaptic inhibition in cerebellar nuclear neurons is suppressed by selective T-type calcium channel block. Journal of neurophysiology. vol 106. issue 5. 2012-03-26. PMID:21849607. |
here, this issue was investigated in the deep cerebellar nuclear neurons (dcns), which receive the output of the cerebellar cortex conveyed exclusively by the inhibitory purkinje cells and are also known to display rebound excitation. |
2012-03-26 |
2023-08-12 |
Not clear |
| Ying Huang, Ho Ko, Zelda H Cheung, Ken K L Yung, Tai Yao, Jian-Jun Wang, Alexei Morozov, Ya Ke, Nancy Y Ip, Wing-Ho Yun. Dual actions of brain-derived neurotrophic factor on GABAergic transmission in cerebellar Purkinje neurons. Experimental neurology. vol 233. issue 2. 2012-03-26. PMID:22178325. |
here we show dual effects of bdnf on gabaergic synaptic transmission in purkinje neurons in rat cerebellar slices. |
2012-03-26 |
2023-08-12 |
rat |
| Mitsuo Kawato, Shinya Kuroda, Nicolas Schweighofe. Cerebellar supervised learning revisited: biophysical modeling and degrees-of-freedom control. Current opinion in neurobiology. vol 21. issue 5. 2012-03-20. PMID:21665461. |
especially, for cerebellar supervised learning, the triangle closed-loop circuit consisting of purkinje cells, the inferior olive nucleus, and the cerebellar nucleus is proposed as a circuit to optimally control synchronous firing and degrees-of-freedom in learning. |
2012-03-20 |
2023-08-12 |
Not clear |
| Kjeld Andersen, Birgitte Bo Andersen, Bente Pakkenber. Stereological quantification of the cerebellum in patients with Alzheimer's disease. Neurobiology of aging. vol 33. issue 1. 2012-03-13. PMID:20728248. |
the cerebellum was divided into 5 regions and the purkinje and granule cell number and density, cortical volume, molecular and granular layer volume and thickness, white matter volume, surface area, and the purkinje cell gradient were stereologically estimated. |
2012-03-13 |
2023-08-12 |
human |
| Richard M Bliss, Velvet Lee Finckbone, Jacquelyn Trice, Howard Strahlendorf, Jean Strahlendor. Tumor necrosis factor-α (TNF-α) augments AMPA-induced Purkinje neuron toxicity. Brain research. vol 1386. 2012-03-12. PMID:21276434. |
in a postnatal rat cerebellar slice model, we found that tnf-α exacerbated ampa-induced excitotoxicity in purkinje neurons in a dose-dependent manner beyond the toxicity caused by ampa alone. |
2012-03-12 |
2023-08-12 |
rat |
| Taisuke Miyazaki, Miwako Yamasaki, Kouichi Hashimoto, Maya Yamazaki, Manabu Abe, Hiroshi Usui, Masanobu Kano, Kenji Sakimura, Masahiko Watanab. Cav2.1 in cerebellar Purkinje cells regulates competitive excitatory synaptic wiring, cell survival, and cerebellar biochemical compartmentalization. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 4. 2012-03-12. PMID:22279216. |
cav2.1 in cerebellar purkinje cells regulates competitive excitatory synaptic wiring, cell survival, and cerebellar biochemical compartmentalization. |
2012-03-12 |
2023-08-12 |
mouse |
| Yongqi Rong, Peng Wei, Jennifer Parris, Hong Guo, Roberto Pattarini, Kristen Correia, Leyi Li, Sheila V Kusnoor, Ariel Y Deutch, James I Morga. Comparison of Cbln1 and Cbln2 functions using transgenic and knockout mice. Journal of neurochemistry. vol 120. issue 4. 2012-03-08. PMID:22117778. |
here, we show that cbln1 and cbln2 have similar binding activities to β-neurexins and grid2 and the targeted ectopic expression of cbln2 to purkinje cells in transgenic mice rescues the cerebellar deficits in cbln1-null animals: suggesting that the two proteins have redundant function mediated by their common receptor binding properties. |
2012-03-08 |
2023-08-12 |
mouse |
| Abigail L Person, Indira M Rama. Purkinje neuron synchrony elicits time-locked spiking in the cerebellar nuclei. Nature. vol 481. issue 7382. 2012-03-02. PMID:22198670. |
one indication of how these synapses transmit information is that populations of purkinje neurons synchronize their spikes during cerebellar behaviours. |
2012-03-02 |
2023-08-12 |
mouse |
| Abigail L Person, Indira M Rama. Purkinje neuron synchrony elicits time-locked spiking in the cerebellar nuclei. Nature. vol 481. issue 7382. 2012-03-02. PMID:22198670. |
thus, cerebellar nuclear neurons can preferentially relay the spike timing of synchronized purkinje cells to downstream premotor areas. |
2012-03-02 |
2023-08-12 |
mouse |
| Annarita Patrizi, Laura Viltono, Elena Frola, Kirsten Harvey, Robert J Harvey, Marco Sassoè-Pognett. Selective localization of collybistin at a subset of inhibitory synapses in brain circuits. The Journal of comparative neurology. vol 520. issue 1. 2012-02-29. PMID:21681748. |
surprisingly, we found that collybistin is expressed only transiently in purkinje cells, suggesting that in these cerebellar neurons collybistin plays a selective role during the initial assembly of postsynaptic specializations. |
2012-02-29 |
2023-08-12 |
mouse |
| S M Hearst, L R Walker, Q Shao, M Lopez, D Raucher, P J S Vi. The design and delivery of a thermally responsive peptide to inhibit S100B-mediated neurodegeneration. Neuroscience. vol 197. 2012-02-27. PMID:21958864. |
sca1 is a trinucleotide repeat disorder in which the expanded polyglutamine mutation in the protein ataxin-1 primarily targets purkinje cells of the cerebellum. |
2012-02-27 |
2023-08-12 |
mouse |
| Sonja Janmaat, Yvette Akwa, Mohamed Doulazmi, Joëlle Bakouche, Vanessa Gautheron, Philippe Liere, Bernard Eychenne, Antoine Pianos, Paul Luiten, Ton Groothuis, Etienne-Emile Baulieu, Jean Mariani, Rachel M Sherrard, Florence Frédéri. Age-related Purkinje cell death is steroid dependent: RORα haplo-insufficiency impairs plasma and cerebellar steroids and Purkinje cell survival. Age (Dordrecht, Netherlands). vol 33. issue 4. 2012-02-21. PMID:21222044. |
finally, cerebellar neurosteroids did not decrease with age in either genotype or gender; but were profoundly reduced by 3 months in male rora(+/sg) cerebella, which may contribute to the fragility of their purkinje neurons. |
2012-02-21 |
2023-08-12 |
mouse |
| W Wittmann, I S McLenna. The male bias in the number of Purkinje cells and the size of the murine cerebellum may require Müllerian inhibiting substance/anti-Müllerian hormone. Journal of neuroendocrinology. vol 23. issue 9. 2012-02-17. PMID:21732997. |
the male bias in the number of purkinje cells and the size of the murine cerebellum may require müllerian inhibiting substance/anti-müllerian hormone. |
2012-02-17 |
2023-08-12 |
mouse |
| W Wittmann, I S McLenna. The male bias in the number of Purkinje cells and the size of the murine cerebellum may require Müllerian inhibiting substance/anti-Müllerian hormone. Journal of neuroendocrinology. vol 23. issue 9. 2012-02-17. PMID:21732997. |
there is a male bias in the size of the cerebellum, with males, on average, having more purkinje cells than females. |
2012-02-17 |
2023-08-12 |
mouse |
| W Wittmann, I S McLenna. The male bias in the number of Purkinje cells and the size of the murine cerebellum may require Müllerian inhibiting substance/anti-Müllerian hormone. Journal of neuroendocrinology. vol 23. issue 9. 2012-02-17. PMID:21732997. |
consistent with this, in the present study, we report that purkinje cells and other cerebella neurones express receptors for mis, and that mis(-/-) male mice have female-like numbers of purkinje cells and a female-like size to other parts of their cerebellum. |
2012-02-17 |
2023-08-12 |
mouse |
| T Puthussery, J Gayet-Primo, W R Taylo. Carbonic anhydrase-related protein VIII is expressed in rod bipolar cells and alters signaling at the rod bipolar to AII-amacrine cell synapse in the mammalian retina. The European journal of neuroscience. vol 34. issue 9. 2012-02-17. PMID:22004450. |
mutation of the gene encoding carbonic anhydrase-related protein viii (caviii) results in motor coordination deficits in mice and humans, due to loss of this protein in purkinje cells of the cerebellum. |
2012-02-17 |
2023-08-12 |
mouse |
| Yoojin Seo, Se-Ran Yang, Min Ki Jee, Eun Kyung Joo, Kyung-Hwan Roh, Min-Soo Seo, Tae Hee Han, So Yeong Lee, Pan Dong Ryu, Ji-Won Jung, Kwang-Won Seo, Soo-Kyung Kang, Kyung-Sun Kan. Human umbilical cord blood-derived mesenchymal stem cells protect against neuronal cell death and ameliorate motor deficits in Niemann Pick type C1 mice. Cell transplantation. vol 20. issue 7. 2012-02-14. PMID:21176403. |
in addition, we observed that hucb-mscs reduced purkinje neuronal loss by suppression of inflammatory and apoptotic signaling in the cerebellum as shown by immunohistochemistry. |
2012-02-14 |
2023-08-12 |
mouse |
| C Jacquelin, C Strazielle, R Lalond. Neurologic function during developmental and adult stages in Dab1(scm) (scrambler) mutant mice. Behavioural brain research. vol 226. issue 1. 2012-02-09. PMID:21945093. |
cerebellar cortical layers and efferent deep nuclei of dab1(scm) mice appeared hypometabolic relative to non-ataxic mice despite normal metabolism in both regular and ectopic purkinje cells. |
2012-02-09 |
2023-08-12 |
mouse |
| Masahiko Tanaka, Minami Asaoka, Yuchio Yanagawa, Naohide Hirashim. Long-term gene-silencing effects of siRNA introduced by single-cell electroporation into postmitotic CNS neurons. Neurochemical research. vol 36. issue 8. 2012-02-01. PMID:21509509. |
to explore how long the gene-silencing effects of sirna introduced into postmitotic neurons continue, we transferred sirna against gfp into gfp-expressing purkinje and golgi cells in cerebellar cell cultures by single-cell electroporation. |
2012-02-01 |
2023-08-12 |
Not clear |