| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Philipp Euler, Bernd Friedrich, Ruhtraut Ziegler, Alexandre Kuhn, Katrin S Lindenberg, Cornelius Weiller, Birgit Zucke. Gene expression analysis on a single cell level in Purkinje cells of Huntington's disease transgenic mice. Neuroscience letters. vol 517. issue 1. 2012-09-06. PMID:22712074. |
cerebellar neurodegeneration of purkinje cells (pcs) in huntington’s disease (hd) brain was described in the 1980s. |
2012-09-06 |
2023-08-12 |
mouse |
| Samrawit A Gebre, Stacey L Reeber, Roy V Sillito. Parasagittal compartmentation of cerebellar mossy fibers as revealed by the patterned expression of vesicular glutamate transporters VGLUT1 and VGLUT2. Brain structure & function. vol 217. issue 2. 2012-09-04. PMID:21814870. |
in the cerebellum, mossy fibers terminate in bands that are topographically aligned with stripes of purkinje cells. |
2012-09-04 |
2023-08-12 |
mouse |
| Mitsuhiro Hashimoto, Masahiko Hib. Development and evolution of cerebellar neural circuits. Development, growth & differentiation. vol 54. issue 3. 2012-09-04. PMID:22524607. |
granule and purkinje cells receive input from outside of the cerebellum from mossy and climbing fibers. |
2012-09-04 |
2023-08-12 |
mouse |
| Ying Cao, Selva K Maran, Mukesh Dhamala, Dieter Jaeger, Detlef H Hec. Behavior-related pauses in simple-spike activity of mouse Purkinje cells are linked to spike rate modulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 25. 2012-08-30. PMID:22723707. |
purkinje cells (pcs) in the mammalian cerebellum express high-frequency spontaneous activity with average spike rates between 30 and 200 hz. |
2012-08-30 |
2023-08-12 |
mouse |
| Ratnakar Tripathi, Rajnikant Mishr. Aging-associated modulation in the expression of Pax6 in mouse brain. Cellular and molecular neurobiology. vol 32. issue 2. 2012-08-29. PMID:21901510. |
pax6 positive cells were significantly lower in dentate gyrus, ca1, ca2, and ca3 regions of hippocampus, in mitral cell (mice), and internal plexiform (inpl) layers of olfactory lobe, and in granular cell (grla), and purkinje's cell (puce) layers of cerebellum from p0 to old age. |
2012-08-29 |
2023-08-12 |
mouse |
| Holly A Shill, Charles H Adler, Thomas G Beac. Pathology in essential tremor. Parkinsonism & related disorders. vol 18 Suppl 1. 2012-08-27. PMID:22166412. |
the main findings include a reduction in cerebellar purkinje cells, other pathological changes of cerebellar degeneration and restricted lewy bodies in the locus ceruleus. |
2012-08-27 |
2023-08-12 |
Not clear |
| Shigeko Takeuchi, Chiaki Masuda, Hisae Maebayashi, Ikuo Tooyam. Immunohistochemical Mapping of TRK-Fused Gene Products in the Rat Brainstem. Acta histochemica et cytochemica. vol 45. issue 1. 2012-08-23. PMID:22489105. |
purkinje cells in the cerebellum and motor neurons in the spinal anterior horn were also positive for tfg. |
2012-08-23 |
2023-08-12 |
human |
| Kazuyoshi Tsutsui, Kazuyoshi Ukena, Hirotaka Sakamoto, Shin-Ichiro Okuyama, Shogo Haraguch. Biosynthesis, mode of action, and functional significance of neurosteroids in the purkinje cell. Frontiers in endocrinology. vol 2. 2012-08-23. PMID:22654818. |
3α,5α-tetrahydroprogesterone (allopregnanolone), a progesterone metabolite, is also synthesized in the cerebellum and considered to act as a survival factor of purkinje cells in the neonate. |
2012-08-23 |
2023-08-12 |
Not clear |
| T Sandhya, J Sowjanya, B Veeres. Bacopa monniera (L.) Wettst ameliorates behavioral alterations and oxidative markers in sodium valproate induced autism in rats. Neurochemical research. vol 37. issue 5. 2012-08-20. PMID:22322665. |
induction of autism significantly affected normal behavior, increased oxidative stress and serotonin level, altered histoarchitecture of cerebellum (decreased number of purkinje cells, neuronal degeneration and chromatolysis) when compared with normal control group. |
2012-08-20 |
2023-08-12 |
rat |
| Marta Florio, Ketty Leto, Luca Muzio, Andrea Tinterri, Aurora Badaloni, Laura Croci, Paola Zordan, Valeria Barili, Ilaria Albieri, François Guillemot, Ferdinando Rossi, G Giacomo Consale. Neurogenin 2 regulates progenitor cell-cycle progression and Purkinje cell dendritogenesis in cerebellar development. Development (Cambridge, England). vol 139. issue 13. 2012-08-15. PMID:22669821. |
by serving as the sole output of the cerebellar cortex, integrating a myriad of afferent stimuli, purkinje cells (pcs) constitute the principal neuron in cerebellar circuits. |
2012-08-15 |
2023-08-12 |
mouse |
| Jun-Ichi Goto, Katsuhiko Mikoshib. Inositol 1,4,5-trisphosphate receptor-mediated calcium release in Purkinje cells: from molecular mechanism to behavior. Cerebellum (London, England). vol 10. issue 4. 2012-08-13. PMID:21701896. |
receptor stimulation, such as through mglur1, activates the g(q)-plc pathway, which leads to ip(3)-induced calcium release and subsequent cellular responses, including cerebellar long-term depression in purkinje cells. |
2012-08-13 |
2023-08-12 |
Not clear |
| Jun-Ichi Goto, Katsuhiko Mikoshib. Inositol 1,4,5-trisphosphate receptor-mediated calcium release in Purkinje cells: from molecular mechanism to behavior. Cerebellum (London, England). vol 10. issue 4. 2012-08-13. PMID:21701896. |
the ip(3) receptor plays a central role in calcium signaling in purkinje cells, affecting a wide variety of cellular functions, including development, plasticity, maintenance of synaptic functions, and cerebellar motor control. |
2012-08-13 |
2023-08-12 |
Not clear |
| Johannes Luthman, Freek E Hoebeek, Reinoud Maex, Neil Davey, Rod Adams, Chris I De Zeeuw, Volker Steube. STD-dependent and independent encoding of input irregularity as spike rate in a computational model of a cerebellar nucleus neuron. Cerebellum (London, England). vol 10. issue 4. 2012-08-13. PMID:21761198. |
neurons in the cerebellar nuclei (cn) receive inhibitory inputs from purkinje cells in the cerebellar cortex and provide the major output from the cerebellum, but their computational function is not well understood. |
2012-08-13 |
2023-08-12 |
mouse |
| Yusuke Kageyama, Zhongyan Zhang, Ricardo Roda, Masahiro Fukaya, Junko Wakabayashi, Nobunao Wakabayashi, Thomas W Kensler, P Hemachandra Reddy, Miho Iijima, Hiromi Sesak. Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage. The Journal of cell biology. vol 197. issue 4. 2012-08-10. PMID:22564413. |
when mouse drp1 was deleted in postmitotic purkinje cells in the cerebellum, mitochondrial tubules elongated due to excess fusion, became large spheres due to oxidative damage, accumulated ubiquitin and mitophagy markers, and lost respiratory function, leading to neurodegeneration. |
2012-08-10 |
2023-08-12 |
mouse |
| Letten F Saugsta. Further evidence that infantile autism is a chronic psychosis distinguished by a deficient delayed response function affecting the connections between hippocampus and singulum in its center, the SMA and the inhibitory Purkinje cells in cerebellum. Nutrition and health. vol 21. issue 1. 2012-08-02. PMID:22544774. |
further evidence that infantile autism is a chronic psychosis distinguished by a deficient delayed response function affecting the connections between hippocampus and singulum in its center, the sma and the inhibitory purkinje cells in cerebellum. |
2012-08-02 |
2023-08-12 |
Not clear |
| Letten F Saugsta. Further evidence that infantile autism is a chronic psychosis distinguished by a deficient delayed response function affecting the connections between hippocampus and singulum in its center, the SMA and the inhibitory Purkinje cells in cerebellum. Nutrition and health. vol 21. issue 1. 2012-08-02. PMID:22544774. |
one single adversity, deficient "brain food", seemingly retards growth sufficiently to cause excess pruning with absent activity in inhibitory purkinje cells in cerebellum, the sma and a deficient, lacking delayed response function. |
2012-08-02 |
2023-08-12 |
Not clear |
| Fushun Wang, Qiwu Xu, Weishan Wang, Takahiro Takano, Maiken Nedergaar. Bergmann glia modulate cerebellar Purkinje cell bistability via Ca2+-dependent K+ uptake. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 20. 2012-07-27. PMID:22547829. |
the decline in extracellular k(+) evoked by agonist-induced ca(2+) in bergmann glia transiently increased spike activity of purkinje cells in cerebellar slices as well as in live anesthetized mice. |
2012-07-27 |
2023-08-12 |
mouse |
| Song Lu, Lin-Yu Lu, Meng-Fei Liu, Qiu-Ju Yuan, Mai-Har Sham, Xin-Yuan Guan, Jian-Dong Huan. Cerebellar defects in Pdss2 conditional knockout mice during embryonic development and in adulthood. Neurobiology of disease. vol 45. issue 1. 2012-07-23. PMID:21871565. |
during cerebellum development, pdss2 knockout results in severe cerebellum hypoplasia by impairing cell migration and eliciting ectopic apoptosis, whereas pdss2 knockout in purkinje cells at postnatal stages leads to the development of cerebellar ataxia. |
2012-07-23 |
2023-08-12 |
mouse |
| M Yu, K Ma, P L Faust, L S Honig, E Cortés, J-P G Vonsattel, E D Loui. Increased number of Purkinje cell dendritic swellings in essential tremor. European journal of neurology. vol 19. issue 4. 2012-07-20. PMID:22136494. |
growing clinical and neuro-imaging evidence implicates cerebellar dysfunction in the pathogenesis of et and emerging postmortem studies have identified structural changes in the cerebellum, particularly in purkinje cells. |
2012-07-20 |
2023-08-12 |
Not clear |
| Valérie Baubet, Chaomei Xiang, Aliah Molczan, Laura Roccograndi, Svetlana Melamed, Nadia Dahman. Rp58 is essential for the growth and patterning of the cerebellum and for glutamatergic and GABAergic neuron development. Development (Cambridge, England). vol 139. issue 11. 2012-07-20. PMID:22513377. |
here we show that neural-specific deletion of the btb/poz zinc-finger transcription factor-encoding gene rp58 (znf238, zfp238) causes severe cerebellar hypoplasia and developmental failure of purkinje neurons, bergmann glia and granule neurons. |
2012-07-20 |
2023-08-12 |
mouse |