| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jia Lu, Kian Chye Ng, Geoffrey Ling, Jian Wu, David Jia Fei Poon, Enci Mary Kan, Mui Hong Tan, Ya Jun Wu, Ping Li, Shabbir Moochhala, Eric Yap, Lionel Kim Hock Lee, Melissa Teo, Ing Berne Yeh, Darvi Michell Bufete Sergio, Frederic Chua, Srinivasan Dinesh Kumar, Eng-Ang Lin. Effect of blast exposure on the brain structure and cognition in Macaca fascicularis. Journal of neurotrauma. vol 29. issue 7. 2013-02-05. PMID:21639720. |
mri and histopathology revealed ultrastructural changes in the brain, notably in the purkinje neurons in the cerebellum and pyramidal neurons in the hippocampus, which were most vulnerable to the blast. |
2013-02-05 |
2023-08-12 |
monkey |
| Tung-Yi Huang, Lung-Sheng Lin, Keng-Chi Cho, Shean-Jen Chen, Yu-Min Kuo, Lung Yu, Fong-Sen Wu, Jih-Ing Chuang, Hsiun-Ing Chen, Chauying J Je. Chronic treadmill exercise in rats delicately alters the Purkinje cell structure to improve motor performance and toxin resistance in the cerebellum. Journal of applied physiology (Bethesda, Md. : 1985). vol 113. issue 6. 2013-02-05. PMID:22837167. |
purkinje cells in cerebellar slices were visualized by lucifer yellow labeling in single neurons and by calbindin immunostaining in groups of neurons. |
2013-02-05 |
2023-08-12 |
rat |
| N Unger, B Ueberberg, S Schulz, W Saeger, K Mann, S Petersen. Differential expression of somatostatin receptor subtype 1-5 proteins in numerous human normal tissues. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 120. issue 8. 2013-01-29. PMID:22976314. |
the cerebellum expressed sst5 in a certain cell type, representing presumably purkinje cells, while sst2a was stained in intercellular fibers. |
2013-01-29 |
2023-08-12 |
human |
| Naoaki Yamada, Satoshi Sasaki, Hiroyuki Ishii, Junko Sato, Takeshi Kanno, Yumi Wako, Minoru Tsuchitan. Dark cell change of the cerebellar Purkinje cells induced by terbutaline under transient disruption of the blood-brain barrier in adult rats: morphological evaluation. Journal of applied toxicology : JAT. vol 32. issue 10. 2013-01-24. PMID:21618259. |
this study aimed to establish a cerebellar degeneration animal model and to characterize the dark cell change of purkinje cells. |
2013-01-24 |
2023-08-12 |
rat |
| Naoaki Yamada, Satoshi Sasaki, Hiroyuki Ishii, Junko Sato, Takeshi Kanno, Yumi Wako, Minoru Tsuchitan. Dark cell change of the cerebellar Purkinje cells induced by terbutaline under transient disruption of the blood-brain barrier in adult rats: morphological evaluation. Journal of applied toxicology : JAT. vol 32. issue 10. 2013-01-24. PMID:21618259. |
dark-stained purkinje cells were observed in the entire cerebellum on day 3. |
2013-01-24 |
2023-08-12 |
rat |
| Georgia Mandolesi, Giorgio Grasselli, Alessandra Musella, Antonietta Gentile, Gabriele Musumeci, Helena Sepman, Nabila Haji, Diego Fresegna, Giorgio Bernardi, Diego Centonz. GABAergic signaling and connectivity on Purkinje cells are impaired in experimental autoimmune encephalomyelitis. Neurobiology of disease. vol 46. issue 2. 2013-01-24. PMID:22349452. |
although clinical and experimental studies have been conducted to understand the pathophysiology of cerebellar dysfunction in ms, no electrophysiological and morphological studies have investigated potential alterations of synaptic connections of cerebellar purkinje cells (pc). |
2013-01-24 |
2023-08-12 |
mouse |
| Eriko Fujita, Yuko Tanabe, Beat A Imhof, Mariko Y Momoi, Takashi Momo. A complex of synaptic adhesion molecule CADM1, a molecule related to autism spectrum disorder, with MUPP1 in the cerebellum. Journal of neurochemistry. vol 123. issue 5. 2013-01-10. PMID:22994563. |
cadm1 colocalized with mupp1 and gabbr2 on the dendrites of purkinje cells in the molecular layers of the developing cerebellum and on the dendrites of hippocampal neurons cultured in vitro. |
2013-01-10 |
2023-08-12 |
mouse |
| Masakazu Fukunaga, Yasuko Yamamoto, Misaki Kawasoe, Yuko Arioka, Yuki Murakami, Masato Hoshi, Kuniaki Sait. Studies on tissue and cellular distribution of indoleamine 2,3-dioxygenase 2: the absence of IDO1 upregulates IDO2 expression in the epididymis. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 60. issue 11. 2013-01-07. PMID:22895526. |
immunohistochemical analysis revealed that ido2 protein was exclusively expressed on the hepatocytes, interlobular bile ducts, neuronal cells of the cerebrum cortex, purkinje cells of the cerebellum cortex, lamina epithelialis, proximal convoluted tubule, and the collecting tubule of the kidney. |
2013-01-07 |
2023-08-12 |
mouse |
| Yukio Yamamoto, Dongwon Lee, Yoonhee Kim, Bokyoung Lee, Changwoo Seo, Hiroshi Kawasaki, Shinya Kuroda, Keiko Tanaka-Yamamot. Raf kinase inhibitory protein is required for cerebellar long-term synaptic depression by mediating PKC-dependent MAPK activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 41. 2013-01-03. PMID:23055494. |
when this rkip mutant was introduced into purkinje cells of mouse cerebellar slices through patch-clamp electrodes, ltd was blocked, while wild-type (wt) rkip had no effect on ltd. physiological epistasis experiments demonstrated that rkip works downstream of pkc and upstream of mapk during ltd induction. |
2013-01-03 |
2023-08-12 |
mouse |
| Alessandro Didonna, Joshua Sussman, Federico Benetti, Giuseppe Legnam. The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells. Prion. vol 6. issue 3. 2013-01-02. PMID:22561161. |
whereas prp (c) is highly expressed in the central nervous system (cns), dpl is detected mostly in testes and its ectopic expression in the cns leads to ataxia as well as purkinje and granule cell degeneration in the cerebellum. |
2013-01-02 |
2023-08-12 |
mouse |
| Kerry M Brown, Izumi Sugihara, Yoshikazu Shinoda, Giorgio A Ascol. Digital morphometry of rat cerebellar climbing fibers reveals distinct branch and bouton types. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 42. 2013-01-02. PMID:23077053. |
cerebellar climbing fibers (cfs) provide powerful excitatory input to purkinje cells (pcs), which represent the sole output of the cerebellar cortex. |
2013-01-02 |
2023-08-12 |
rat |
| Eriola Hoxha, Enrica Boda, Francesca Montarolo, Roberta Parolisi, Filippo Tempi. Excitability and synaptic alterations in the cerebellum of APP/PS1 mice. PloS one. vol 7. issue 4. 2012-12-28. PMID:22511962. |
aim of this study was to investigate the alterations of intrinsic membrane properties and of synaptic inputs in purkinje cells (pcs) of the cerebellum, where only soluble aβ is present. |
2012-12-28 |
2023-08-12 |
mouse |
| Yoshihisa Takiyam. Sacsinopathies: sacsin-related ataxia. Cerebellum (London, England). vol 6. issue 4. 2012-12-27. PMID:17853117. |
the principal neuropathology comprises atrophy of the upper vermis and the loss of purkinje cells in the cerebellum. |
2012-12-27 |
2023-08-12 |
Not clear |
| Abigail L Person, Indira M Rama. Synchrony and neural coding in cerebellar circuits. Frontiers in neural circuits. vol 6. 2012-12-19. PMID:23248585. |
possible answers come from accumulating evidence that subsets of purkinje cells synchronize their firing during behaviors that require the cerebellum. |
2012-12-19 |
2023-08-12 |
Not clear |
| Abigail L Person, Indira M Rama. Synchrony and neural coding in cerebellar circuits. Frontiers in neural circuits. vol 6. 2012-12-19. PMID:23248585. |
consistent with models predicting that coherent activity of inhibitory networks has the capacity to dictate firing patterns of target neurons, recent experimental work supports the idea that inhibitory synchrony may regulate the response of cerebellar nuclear cells to purkinje inputs, owing to the interplay between unusually fast inhibitory synaptic responses and high rates of intrinsic activity. |
2012-12-19 |
2023-08-12 |
Not clear |
| Abigail L Person, Indira M Rama. Synchrony and neural coding in cerebellar circuits. Frontiers in neural circuits. vol 6. 2012-12-19. PMID:23248585. |
data from multiple laboratories lead to a working hypothesis that synchronous inhibitory input from purkinje cells can set the timing and rate of action potentials produced by cerebellar nuclear cells, thereby relaying information out of the cerebellum. |
2012-12-19 |
2023-08-12 |
Not clear |
| Abigail L Person, Indira M Rama. Synchrony and neural coding in cerebellar circuits. Frontiers in neural circuits. vol 6. 2012-12-19. PMID:23248585. |
if so, then changing spatiotemporal patterns of purkinje activity would allow different subsets of inhibitory neurons to control cerebellar output at different times. |
2012-12-19 |
2023-08-12 |
Not clear |
| Velina Guergueltcheva, Dimitar N Azmanov, Dora Angelicheva, Katherine R Smith, Teodora Chamova, Laura Florez, Michael Bynevelt, Thai Nguyen, Sylvia Cherninkova, Veneta Bojinova, Ara Kaprelyan, Lyudmila Angelova, Bharti Morar, David Chandler, Radka Kaneva, Melanie Bahlo, Ivailo Tournev, Luba Kalaydjiev. Autosomal-recessive congenital cerebellar ataxia is caused by mutations in metabotropic glutamate receptor 1. American journal of human genetics. vol 91. issue 3. 2012-12-17. PMID:22901947. |
the mutated gene, grm1, encodes metabotropic glutamate receptor mglur1, which is highly expressed in cerebellar purkinje cells and plays an important role in cerebellar development and synaptic plasticity. |
2012-12-17 |
2023-08-12 |
human |
| Afef Troudi, Hanen Bouaziz, Nejla Soudani, Ibtissem Ben Amara, Tahia Boudawara, Hanen Touzani, Badiaa Lyoussi, Najiba Zegha. Neurotoxicity and oxidative stress induced by gibberellic acid in rats during late pregnancy and early postnatal periods: biochemical and histological changes. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 64. issue 6. 2012-12-14. PMID:21216576. |
the biochemical parameters were correlated histologically with an abnormal development of the external granular layer and a loss of purkinje cells in the cerebellum of ga(3)-treated suckling rats. |
2012-12-14 |
2023-08-12 |
rat |
| Adebimpe Kasumu, Ilya Bezprozvann. Deranged calcium signaling in Purkinje cells and pathogenesis in spinocerebellar ataxia 2 (SCA2) and other ataxias. Cerebellum (London, England). vol 11. issue 3. 2012-12-11. PMID:20480274. |
emerging research suggests that a fundamental cellular signaling pathway is disrupted by a majority of these mutated genes, which could explain the characteristic death of purkinje cells, cerebellar atrophy, and ataxia that occur in many scas. |
2012-12-11 |
2023-08-12 |
Not clear |