| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C N Prudente, C A Pardo, J Xiao, J Hanfelt, E J Hess, M S Ledoux, H A Jinna. Neuropathology of cervical dystonia. Experimental neurology. vol 241. 2013-04-08. PMID:23195594. |
additionally, the cerebellum showed patchy loss of purkinje cells, areas of focal gliosis and torpedo bodies. |
2013-04-08 |
2023-08-12 |
Not clear |
| Alireza Mansouri, Weixian Min, Christina J Cole, Sheena A Josselyn, Jeffrey Theodore Henderson, Matthijs van Eede, R Mark Henkelman, Cameron Ackerley, Eyal Grunebaum, Chaim M Roifma. Cerebellar abnormalities in purine nucleoside phosphorylase deficient mice. Neurobiology of disease. vol 47. issue 2. 2013-04-03. PMID:22521465. |
the cerebellum of pnp-ko mice contained reduced purkinje cells (pc), which were irregular in shape and had degenerated dendrites. |
2013-04-03 |
2023-08-12 |
mouse |
| John E Greenle. Treatment of paraneoplastic cerebellar degeneration. Current treatment options in neurology. vol 15. issue 2. 2013-04-01. PMID:23315179. |
paraneoplastic cerebellar degeneration is an uncommon autoimmune disorder characterized clinically by progressive, ultimately incapacitating ataxia and pathologically by destruction of cerebellar purkinje cells, with variable loss of other cell populations. |
2013-04-01 |
2023-08-12 |
Not clear |
| John E Greenle. Treatment of paraneoplastic cerebellar degeneration. Current treatment options in neurology. vol 15. issue 2. 2013-04-01. PMID:23315179. |
the hallmark of paraneoplastic cerebellar degeneration is the presence of an immune response reactive with intracellular proteins of purkinje or other neurons or, less commonly, against neuronal surface antigens. |
2013-04-01 |
2023-08-12 |
Not clear |
| Adebimpe W Kasumu, Charlotte Hougaard, Frederik Rode, Thomas A Jacobsen, Jean Marc Sabatier, Birgitte L Eriksen, Dorte Strøbæk, Xia Liang, Polina Egorova, Dasha Vorontsova, Palle Christophersen, Lars Christian B Rønn, Ilya Bezprozvann. Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chemistry & biology. vol 19. issue 10. 2013-03-26. PMID:23102227. |
purkinje cells (pc) of the cerebellum fire irregularly and eventually die in sca2. |
2013-03-26 |
2023-08-12 |
mouse |
| L Silvestri, A Bria, L Sacconi, G Iannello, F S Pavon. Confocal light sheet microscopy: micron-scale neuroanatomy of the entire mouse brain. Optics express. vol 20. issue 18. 2013-03-22. PMID:23037106. |
we obtained a comprehensive map of purkinje cells in the cerebellum of l7-gfp transgenic mice. |
2013-03-22 |
2023-08-12 |
mouse |
| Pi-Xian Zhang, Fa-Ren Zhang, Jian-Jun Xie, Li-Hua Tao, Zhuo Lü, Xiu-E Xu, Jian Shen, Li-Yan Xu, En-Min L. Expression of NGAL and NGALR in human embryonic, fetal and normal adult tissues. Molecular medicine reports. vol 6. issue 4. 2013-03-14. PMID:22797813. |
results demonstrated that during the development of the nervous system, ngalr was prevalent in the neural tube and cerebrum, and ngal was only detected in the stellate cells of the cerebrum and the purkinje cells of the cerebellum. |
2013-03-14 |
2023-08-12 |
human |
| Marija M Petrinovic, Raphael Hourez, Elisabeth M Aloy, Gregoire Dewarrat, David Gall, Oliver Weinmann, Julien Gaudias, Lukas C Bachmann, Serge N Schiffmann, Kaspar E Vogt, Martin E Schwa. Neuronal Nogo-A negatively regulates dendritic morphology and synaptic transmission in the cerebellum. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 3. 2013-03-14. PMID:23277570. |
we addressed this question in the cerebellum, where nogo-a is transitorily highly expressed in the purkinje cells (pcs) during early postnatal development. |
2013-03-14 |
2023-08-12 |
mouse |
| Reema Roshan, Tanay Ghosh, Mugdha Gadgil, Beena Pilla. Regulation of BACE1 by miR-29a/b in a cellular model of Spinocerebellar Ataxia 17. RNA biology. vol 9. issue 6. 2013-03-06. PMID:22664922. |
this disease is characterized by intranuclear protein aggregates and selective loss of cerebellar neurons, including purkinje cells. |
2013-03-06 |
2023-08-12 |
Not clear |
| Robert A Nawrocki, Majid Shaalan, Sean E Shaheen, Nancy M Lorenzo. Monitoring performance degradation of cerebellar functions using computational neuroscience methods: implications on neurological diseases. PloS one. vol 7. issue 9. 2013-03-06. PMID:23029114. |
this paper presents computational modeling of cerebellar function in relation to neurodegeneration either affecting a specific cerebellar cell type, such as granule cells or purkinje cells, or more generally affecting cerebellar cells and the implications on effects in relation to performance degradation throughout the progression of cell death. |
2013-03-06 |
2023-08-12 |
human |
| Shogo Haraguchi, Sakurako Hara, Takayoshi Ubuka, Masatoshi Mita, Kazuyoshi Tsutsu. Possible role of pineal allopregnanolone in Purkinje cell survival. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 51. 2013-02-28. PMID:23213208. |
pinealectomy (px) decreased allo concentration in the cerebellum and induced apoptosis of purkinje cells, whereas administration of allo to px quail chicks prevented apoptosis of purkinje cells. |
2013-02-28 |
2023-08-12 |
Not clear |
| Paul J Mathews, Ka Hung Lee, Zechun Peng, Carolyn R Houser, Thomas S Oti. Effects of climbing fiber driven inhibition on Purkinje neuron spiking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 50. 2013-02-27. PMID:23238715. |
together, our findings suggest that such inhibition may bind together groups of purkinje neurons to provide instructive signals to downstream sites in the cerebellar circuit. |
2013-02-27 |
2023-08-12 |
rat |
| Shaun D McCullough, Xiaojiang Xu, Sharon Y R Dent, Stefan Bekiranov, Robert G Roeder, Patrick A Gran. Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 52. 2013-02-21. PMID:23236151. |
here we describe the development and use of a human astrocyte cell culture model to identify reelin, a factor intimately involved in the development and maintenance of purkinje cells and the cerebellum as a whole, as an atxn7 target gene. |
2013-02-21 |
2023-08-12 |
human |
| Satsuki Noma, Wakana Ohya-Shimada, Masaaki Kanai, Keiji Ueda, Toshikazu Nakamura, Hiroshi Funakosh. Overexpression of HGF attenuates the degeneration of Purkinje cells and Bergmann glia in a knockin mouse model of spinocerebellar ataxia type 7. Neuroscience research. vol 73. issue 2. 2013-02-19. PMID:22426494. |
the purkinje cellular degeneration and reduced expression of glutamate transporters in the cerebellum of sca7-ki mice were largely attenuated in the sca7-ki/hgf-tg mice. |
2013-02-19 |
2023-08-12 |
mouse |
| Jun Nishiyama, Yukari Hayashi, Toshihiro Nomura, Eriko Miura, Wataru Kakegawa, Michisuke Yuzak. Selective and regulated gene expression in murine Purkinje cells by in utero electroporation. The European journal of neuroscience. vol 36. issue 7. 2013-02-18. PMID:22775058. |
cerebellar purkinje cells, which convey the only output from the cerebellar cortex, play an essential role in cerebellar functions, such as motor coordination and motor learning. |
2013-02-18 |
2023-08-12 |
mouse |
| Jun Nishiyama, Yukari Hayashi, Toshihiro Nomura, Eriko Miura, Wataru Kakegawa, Michisuke Yuzak. Selective and regulated gene expression in murine Purkinje cells by in utero electroporation. The European journal of neuroscience. vol 36. issue 7. 2013-02-18. PMID:22775058. |
to understand how purkinje cells develop and function in the mature cerebellum, an efficient method for molecularly perturbing them is needed. |
2013-02-18 |
2023-08-12 |
mouse |
| Jeesun Kim, Paul K Y Won. Targeting p38 mitogen-activated protein kinase signaling restores subventricular zone neural stem cells and corrects neuromotor deficits in Atm knockout mouse. Stem cells translational medicine. vol 1. issue 7. 2013-02-13. PMID:23197859. |
in a-t patients, necropsy has revealed atrophy of cerebellar cortical layers along with purkinje and granular cell loss. |
2013-02-13 |
2023-08-12 |
mouse |
| Jeesun Kim, Paul K Y Won. Targeting p38 mitogen-activated protein kinase signaling restores subventricular zone neural stem cells and corrects neuromotor deficits in Atm knockout mouse. Stem cells translational medicine. vol 1. issue 7. 2013-02-13. PMID:23197859. |
in addition, treated atm(-/-) mice exhibited more purkinje cells in the cerebellum. |
2013-02-13 |
2023-08-12 |
mouse |
| Loai Alzghoul, Marco Bortolato, Foteini Delis, Panayotis K Thanos, Ryan D Darling, Sean C Godar, Junlin Zhang, Samuel Grant, Gene-Jack Wang, Kimberly L Simpson, Kevin Chen, Nora D Volkow, Rick C S Lin, Jean C Shi. Altered cerebellar organization and function in monoamine oxidase A hypomorphic mice. Neuropharmacology. vol 63. issue 7. 2013-02-12. PMID:22971542. |
histological and immunohistochemical analyses using calbindin-d-28k (cb) expression of purkinje cells revealed abnormal cerebellar foliation with vermal hypoplasia and decreased in purkinje cell count and their dendritic density in mao-a(neo) mice compared to wt. |
2013-02-12 |
2023-08-12 |
mouse |
| Sung-min Park, Esra Tara, Kamran Khodakha. Efficient generation of reciprocal signals by inhibition. Journal of neurophysiology. vol 107. issue 9. 2013-02-11. PMID:22298833. |
here we show in acutely prepared cerebellar slices that the input-output relationship of these laterally positioned purkinje cells is linear and reciprocal to the first set. |
2013-02-11 |
2023-08-12 |
Not clear |