| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Raquel Martín-Ibáñez, Empar Crespo, Miriam Esgleas, Noelia Urban, Bei Wang, Ronald Waclaw, Katia Georgopoulos, Salvador Martínez, Kenneth Campbell, Carlos Vicario-Abejón, Jordi Alberch, Susan Chan, Philippe Kastner, John L Rubenstein, Josep M Canal. Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons. Stem cells and development. vol 21. issue 12. 2012-12-11. PMID:22142223. |
moreover, helios is also expressed by purkinje neurons during postnatal cerebellar development. |
2012-12-11 |
2023-08-12 |
Not clear |
| Donna Gruol, Mario Manto, Duane Haine. Ca2+ signaling in cerebellar Purkinje neurons--editorial. Cerebellum (London, England). vol 11. issue 3. 2012-12-11. PMID:22806980. |
recent years have seen major developments in terms of understanding the roles of ca(2+) signals in the cerebellar circuitry, especially for purkinje neurons and granule cells. |
2012-12-11 |
2023-08-12 |
Not clear |
| Donna Gruol, Mario Manto, Duane Haine. Ca2+ signaling in cerebellar Purkinje neurons--editorial. Cerebellum (London, England). vol 11. issue 3. 2012-12-11. PMID:22806980. |
the unique morphology of purkinje neurons serves as a platform to unravel the secrets of ca(2+) homeostasis in cerebellar microcircuits. |
2012-12-11 |
2023-08-12 |
Not clear |
| K Kollmann, M Damme, S Markmann, W Morelle, M Schweizer, I Hermans-Borgmeyer, A K Röchert, S Pohl, T Lübke, J-C Michalski, R Käkelä, S U Walkley, T Braulk. Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice. Brain : a journal of neurology. vol 135. issue Pt 9. 2012-12-05. PMID:22961545. |
prominent astrogliosis and the accumulation of organelles and storage material in focally swollen axons were observed in the cerebellum and were accompanied by a loss of purkinje cells. |
2012-12-05 |
2023-08-12 |
mouse |
| Sonia Canterini, Adriana Bosco, Valentina Carletti, Andrea Fuso, Armando Curci, Franco Mangia, Maria Teresa Fiorenz. Subcellular TSC22D4 localization in cerebellum granule neurons of the mouse depends on development and differentiation. Cerebellum (London, England). vol 11. issue 1. 2012-12-04. PMID:20878296. |
we have now studied tsc22d4 cytoplasmic/nuclear localization in cgns and purkinje cells: (1) during cgn differentiation/maturation in vivo, (2) during cgn differentiation in vitro, and (3) by in vitro culturing ex vivo cerebellum slices under conditions favoring/inhibiting cgn/purkinje cell differentiation. |
2012-12-04 |
2023-08-12 |
mouse |
| Masayoshi Mishina, Takeshi Uemura, Misato Yasumura, Tomoyuki Yoshid. Molecular mechanism of parallel fiber-Purkinje cell synapse formation. Frontiers in neural circuits. vol 6. 2012-11-29. PMID:23189042. |
the cerebellum receives two excitatory afferents, the climbing fiber (cf) and the mossy fiber-parallel fiber (pf) pathway, both converging onto purkinje cells (pcs) that are the sole neurons sending outputs from the cerebellar cortex. |
2012-11-29 |
2023-08-12 |
mouse |
| Hong Goo Chae, Sung Ji Ahn, Yun Hwa Hong, Won Seok Chang, Jun Kim, Sang Jeong Ki. Transient receptor potential canonical channels regulate the induction of cerebellar long-term depression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 37. 2012-11-28. PMID:22973014. |
in the cerebellum, synaptic strength at the synapses between parallel fibers and purkinje cells is best known to be modulated via metabotropic glutamate receptor 1 (mglur1)-dependent cerebellar long-term depression (ltd). |
2012-11-28 |
2023-08-12 |
rat |
| Janet K Kern, David A Geier, Tapan Audhya, Paul G King, Lisa K Sykes, Mark R Geie. Evidence of parallels between mercury intoxication and the brain pathology in autism. Acta neurobiologiae experimentalis. vol 72. issue 2. 2012-11-27. PMID:22810216. |
this review finds evidence of many parallels between the two, including: (1) microtubule degeneration, specifically large, long-range axon degeneration with subsequent abortive axonal sprouting (short, thin axons); (2) dentritic overgrowth; (3) neuroinflammation; (4) microglial/astrocytic activation; (5) brain immune response activation; (6) elevated glial fibrillary acidic protein; (7) oxidative stress and lipid peroxidation; (8) decreased reduced glutathione levels and elevated oxidized glutathione; (9) mitochondrial dysfunction; (10) disruption in calcium homeostasis and signaling; (11) inhibition of glutamic acid decarboxylase (gad) activity; (12) disruption of gabaergic and glutamatergic homeostasis; (13) inhibition of igf-1 and methionine synthase activity; (14) impairment in methylation; (15) vascular endothelial cell dysfunction and pathological changes of the blood vessels; (16) decreased cerebral/cerebellar blood flow; (17) increased amyloid precursor protein; (18) loss of granule and purkinje neurons in the cerebellum; (19) increased pro-inflammatory cytokine levels in the brain (tnf-α, ifn-γ, il-1β, il-8); and (20) aberrant nuclear factor kappa-light-chain-enhancer of activated b cells (nf-kappab). |
2012-11-27 |
2023-08-12 |
Not clear |
| Naofumi Uesaka, Takayasu Mikuni, Kouichi Hashimoto, Hirokazu Hirai, Kenji Sakimura, Masanobu Kan. Organotypic coculture preparation for the study of developmental synapse elimination in mammalian brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 34. 2012-11-19. PMID:22915109. |
we verified that climbing fibers (cfs), the axons of inferior olivary neurons, formed functional synapses onto purkinje cells (pcs) in the cerebellum of cocultures. |
2012-11-19 |
2023-08-12 |
mouse |
| Jimena Gonzalez-Joekes, Bernard G Schreur. Anatomical characterization of a rabbit cerebellar eyeblink premotor pathway using pseudorabies and identification of a local modulatory network in anterior interpositus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 36. 2012-11-16. PMID:22956838. |
labeled fourth-order purkinje cells were found in ipsilateral cerebellar cortex in cerebellar lobule hvi and in lobule i. |
2012-11-16 |
2023-08-12 |
rabbit |
| Guilherme Baldo, Fabiana Quoos Mayer, Barbara Martinelli, Anna Dilda, Fabiola Meyer, Katherine P Ponder, Roberto Giugliani, Ursula Matt. Evidence of a progressive motor dysfunction in Mucopolysaccharidosis type I mice. Behavioural brain research. vol 233. issue 1. 2012-11-05. PMID:22580166. |
histological examination of 8-month old mice cortex and cerebellum revealed storage of gags in purkinje cells and neuroinflammation, evidenced by gfap immunostaining. |
2012-11-05 |
2023-08-12 |
mouse |
| Marco dal Maschio, Diego Ghezzi, Guillaume Bony, Alessandro Alabastri, Gabriele Deidda, Marco Brondi, Sebastian Sulis Sato, Remo Proietti Zaccaria, Enzo Di Fabrizio, Gian Michele Ratto, Laura Cancedd. High-performance and site-directed in utero electroporation by a triple-electrode probe. Nature communications. vol 3. 2012-11-02. PMID:22805567. |
by improvement in the efficiency of the electrical field distribution, demonstrated here by a mathematical simulation, the multi-electrode configuration also extends the developmental timeframe for reliable in utero electroporation, allowing for the first time specific transfection of purkinje cells in the rat cerebellum. |
2012-11-02 |
2023-08-12 |
rat |
| Masahiko Hibi, Takashi Shimiz. Development of the cerebellum and cerebellar neural circuits. Developmental neurobiology. vol 72. issue 3. 2012-10-16. PMID:21309081. |
in the mammalian and teleost cerebellum,purkinje and granule cells serve, respectively, as the major gabaergic and glutamatergic neurons. |
2012-10-16 |
2023-08-12 |
zebrafish |
| M P Moisan, J R Seckl, L P Brett, C Monder, A K Agarwal, P C White, C R Edward. 11Beta-Hydroxysteroid Dehydrogenase Messenger Ribonucleic Acid Expression, Bioactivity and Immunoreactivity in Rat Cerebellum. Journal of neuroendocrinology. vol 2. issue 6. 2012-10-02. PMID:19215429. |
11beta-ohsd messenger ribonucleic acid was expressed in cerebellum and was localized in purkinje and granule cells. |
2012-10-02 |
2023-08-12 |
rat |
| J F Ewing, M D Maine. In situ hybridization and immunohistochemical localization of heme oxygenase-2 mRNA and protein in normal rat brain: Differential distribution of isozyme 1 and 2. Molecular and cellular neurosciences. vol 3. issue 6. 2012-10-02. PMID:19912899. |
impressive levels of ho-2 transcripts and immunoreactive protein were observed in purkinje cells of cerebellum, red nucleus, superior and inferior colliculus, nucleus of the trapezoid body, cochlear neurons, and facial nucleus of brain stem. |
2012-10-02 |
2023-08-12 |
rat |
| Bimla Nehru, Shailender Singh Kanwa. Modulation by N-acetylcysteine of lead-induced alterations in rat brain: reduced glutathione levels and morphology. Toxicology mechanisms and methods. vol 17. issue 5. 2012-10-02. PMID:20020952. |
histological analysis of the different brain regions also revealed a marked deterioration in the organization of the pyramidal cellular layer of the cerebrum and the purkinje's cellular layer of the cerebellum. |
2012-10-02 |
2023-08-12 |
rat |
| N Matsokis, T Valcan. [(3)H]GABA binding in the cerebellum of the reeler murine mutant. Neurochemistry international. vol 7. issue 1. 2012-10-02. PMID:20492896. |
the decreased affinity of the na(+)-independent gaba binding and the increased affinity of the na(+)-dependent binding, evidenced only in cerebellar tissue, were interpreted to indicate, respectively, hypo- and hypersensitivity of the postsynaptic and presynaptic elements of cerebellar gabaergic synapses, induced by the depressed excitatory granule cell input and/or the increased mossy fiber contact with the ectopic purkinje cells. |
2012-10-02 |
2023-08-12 |
mouse |
| P Mailly, A B Younès-Chennouft, S Bo. The monoclonal antibodies Elec-39, HNK-1 and NC-1 recognize common structures in the nervous system and muscles of vertebrates. Neurochemistry international. vol 15. issue 4. 2012-10-02. PMID:20504528. |
in the cortex and cerebellum, they label the surface of neural processes and terminals apposed to large multipolar neurons and purkinje cells, as well as membranous material contained in inclusions dispersed in the cytoplasm of these neurons. |
2012-10-02 |
2023-08-12 |
rat |
| S N Schiffmann, J J Vanderhaeghe. Immunocytochemical detection of GABAergic nerve cells in the human striatum and cerebellum using a gamma-aminobutyric acid antiserum. Neurochemistry international. vol 17. issue 1. 2012-10-02. PMID:20504608. |
in the cerebellum, purkinje, stellate, golgi and basket cells are gaba-immunoreactive. |
2012-10-02 |
2023-08-12 |
human |
| J A Batch, G A Werther, A Hogg, F A Mendelsohn, C Scott, B J Oldfiel. Localization of Insulin-Like Growth Factor-II Receptors in Rat Brain by in vitro Autoradiography and Immunohistochemistry. Journal of neuroendocrinology. vol 4. issue 4. 2012-10-02. PMID:21554634. |
using the immunohistochemical technique igf-ii receptors were localized to specific neuronal groups such as the mitral cells of the olfactory bulb, purkinje cells of the cerebellum and neurons in the red nucleus. |
2012-10-02 |
2023-08-12 |
human |