| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexander R Bottini, Richard A Gatti, Martin Wirenfeldt, Harry V Vinter. Heterotopic Purkinje cells in ataxia-telangiectasia. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 32. issue 1. 2012-05-17. PMID:21978196. |
using the anti-calbindin d-28k antibody to label purkinje cells in cerebellar tissue from five a-t patients and five age- and sex-matched controls, the study found calbindin-positive heterotopic purkinje cells in the molecular layer occurring at a significantly higher rate in a-t patients than in controls (p = 0.012). |
2012-05-17 |
2023-08-12 |
Not clear |
| Moritoshi Hirono, Fumihito Saitow, Moeko Kudo, Hidenori Suzuki, Yuchio Yanagawa, Masahisa Yamada, Soichi Nagao, Shiro Konishi, Kunihiko Obat. Cerebellar globular cells receive monoaminergic excitation and monosynaptic inhibition from Purkinje cells. PloS one. vol 7. issue 1. 2012-05-14. PMID:22235322. |
cerebellar globular cells receive monoaminergic excitation and monosynaptic inhibition from purkinje cells. |
2012-05-14 |
2023-08-12 |
mouse |
| Moritoshi Hirono, Fumihito Saitow, Moeko Kudo, Hidenori Suzuki, Yuchio Yanagawa, Masahisa Yamada, Soichi Nagao, Shiro Konishi, Kunihiko Obat. Cerebellar globular cells receive monoaminergic excitation and monosynaptic inhibition from Purkinje cells. PloS one. vol 7. issue 1. 2012-05-14. PMID:22235322. |
because globular cells project their axons long in the transversal direction, the neuronal circuit that includes interplay between purkinje cells and globular cells could regulate purkinje cell activity in different microzones under the influence of monoamines and mossy fiber inputs, suggesting that globular cells likely play a unique modulatory role in cerebellar motor control. |
2012-05-14 |
2023-08-12 |
mouse |
| Milena Laure-Kamionowska, Danuta Maślińsk. Cerebellar cortical neurons misplaced in the white matter due to disturbed migration during development of human brain. Folia neuropathologica. vol 49. issue 4. 2012-05-03. PMID:22212918. |
clusters of grey matter reflecting the cerebellar cortical pattern with well-defined molecular layer and altered granular and purkinje cells were most frequently observed. |
2012-05-03 |
2023-08-12 |
human |
| Soraya Ghafari, Danial Roshandel, Mohammad J Golalipou. Effect of intrauterine morphine sulfate exposure on cerebellar histomorphological changes in neonatal mice. Folia neuropathologica. vol 49. issue 4. 2012-05-03. PMID:22212923. |
this study was done to determine the neurotoxic effects of prenatal morphine exposure on the histo-morphological changes of cerebellar cortical layer and purkinje cells in mice neonates. |
2012-05-03 |
2023-08-12 |
mouse |
| Patricia Seja, Martijn Schonewille, Guillermo Spitzmaul, Aleksandra Badura, Ilse Klein, York Rudhard, William Wisden, Christian A Hübner, Chris I De Zeeuw, Thomas J Jentsc. Raising cytosolic Cl- in cerebellar granule cells affects their excitability and vestibulo-ocular learning. The EMBO journal. vol 31. issue 5. 2012-05-03. PMID:22252133. |
cerebellar cortical throughput involved in motor control comprises granule cells (gcs) and purkinje cells (pcs), both of which receive inhibitory gabaergic input from interneurons. |
2012-05-03 |
2023-08-12 |
Not clear |
| Yi Wang, Jiapeng Zhong, Wei Wei, Jian Gong, Jing Dong, Fei Yu, Yuan Wang, Jie Che. Developmental iodine deficiency and hypothyroidism impair neural development, upregulate caveolin-1, and downregulate synaptotagmin-1 in the rat cerebellum. Biological trace element research. vol 144. issue 1-3. 2012-04-27. PMID:21611807. |
these findings may implicate decreases in the number of purkinje cells and the alterations in the levels of caveolin-1 and synaptotagmin-1 in the impairments of cerebellar development induced by developmental iodine deficiency and hypothyroidism. |
2012-04-27 |
2023-08-12 |
rat |
| P Heman, C Barcia, A Gómez, C M Ros, F Ros-Bernal, J E Yuste, V de Pablos, E Fernandez-Villalba, M R Toledo-Cárdenas, M T Herrer. Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys. Histology and histopathology. vol 27. issue 1. 2012-04-27. PMID:22127600. |
in our study, we observed a persistent activation of purkinje cells in the cerebellum of chronic parkinsonian macaques, characterized by the expression of c-fos, which correlated with dopaminergic degeneration. |
2012-04-27 |
2023-08-12 |
monkey |
| Charmaine Nelson, Maike D Glitsc. Lack of kinase regulation of canonical transient receptor potential 3 (TRPC3) channel-dependent currents in cerebellar Purkinje cells. The Journal of biological chemistry. vol 287. issue 9. 2012-04-25. PMID:22207762. |
ltd induction requires protein kinase c (pkc) and protein kinase g (pkg) activation, and although pkc phosphorylation targets are well established, virtually nothing is known about pkg targets in ltd. because trpc3 channels are inhibited after phosphorylation by pkc and pkg in expression systems, we examined whether native trpc3 channels in purkinje cells are a target for pkg or pkc, thereby contributing to cerebellar ltd. we find that in purkinje cells, activation of trpc3-dependent currents is not inhibited by conventional pkc or pkg to any significant extent and that inhibition of these kinases does not significantly impact on trpc3-mediated currents either. |
2012-04-25 |
2023-08-12 |
Not clear |
| Kingsley Ibhazehiebo, Toshiharu Iwasaki, Takayuki Okano-Uchida, Noriaki Shimokawa, Yasuki Ishizaki, Noriyuki Koibuch. Suppression of thyroid hormone receptor-mediated transcription and disruption of thyroid hormone-induced cerebellar morphogenesis by the polybrominated biphenyl mixture, BP-6. Neurotoxicology. vol 32. issue 4. 2012-04-23. PMID:21396401. |
in primary rat cerebellar culture, bp-6 significantly suppressed th-induced dendrite arborization of purkinje cells, and in reaggregate rat granule cell culture, impaired th-induced neurite extension of granule cells. |
2012-04-23 |
2023-08-12 |
rat |
| Eriko Fujita, Yuko Tanabe, Mariko Y Momoi, Takashi Momo. Cntnap2 expression in the cerebellum of Foxp2(R552H) mice, with a mutation related to speech-language disorder. Neuroscience letters. vol 506. issue 2. 2012-04-19. PMID:22133810. |
here we show that cntnap2 mrna levels significantly increased in the cerebellum of foxp2(r552h) ki pups, although the cerebellar population of foxp2-positive purkinje cells was very small. |
2012-04-19 |
2023-08-12 |
mouse |
| Marylka Uusisaari, Erik De Schutte. The mysterious microcircuitry of the cerebellar nuclei. The Journal of physiology. vol 589. issue Pt 14. 2012-04-16. PMID:21521761. |
however, activity in purkinje neurons, either as single cells or populations, does not directly mediate the cerebellar effects on the motor effector systems. |
2012-04-16 |
2023-08-12 |
Not clear |
| Kazuhiro Mitsumura, Nobutake Hosoi, Nobuhiko Furuya, Hirokazu Hira. Disruption of metabotropic glutamate receptor signalling is a major defect at cerebellar parallel fibre-Purkinje cell synapses in staggerer mutant mice. The Journal of physiology. vol 589. issue Pt 13. 2012-04-13. PMID:21558162. |
staggerer mutant mice have functional loss of a transcription factor, retinoid-related orphan receptor α (rorα), which is abundantly expressed in purkinje cells (pcs) of the cerebellum.homozygous staggerer (sg/sg)mice show cerebellar hypoplasia and congenital ataxia. |
2012-04-13 |
2023-08-12 |
mouse |
| Enyuan Shang, Qingping Cui, Xiangyuan Wang, Cheryl Beseler, David A Greenberg, Debra J Wolgemut. The bromodomain-containing gene BRD2 is regulated at transcription, splicing, and translation levels. Journal of cellular biochemistry. vol 112. issue 10. 2012-04-12. PMID:21608014. |
in situ hybridization and immunohistochemical studies showed that although brd2 mrna is expressed in both the hippocampus and cerebellum, brd2 protein only can be detected in the cerebellar purkinje cells and not in hippocampal cells. |
2012-04-12 |
2023-08-12 |
mouse |
| Safa Al-Sarraj, Andrew King, Claire Troakes, Bradley Smith, Satomi Maekawa, Istvan Bodi, Boris Rogelj, Ammar Al-Chalabi, Tibor Hortobágyi, Christopher E Sha. p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS. Acta neuropathologica. vol 122. issue 6. 2012-04-10. PMID:22101323. |
p62 positive ncis were also abundant in the cerebellar granular and molecular layers in all cases and in purkinje cells in 12/14 cases but they were only positive for p-tdp-43 in the granular layer of one case. |
2012-04-10 |
2023-08-12 |
Not clear |
| R Michelle Reith, Sharon Way, James McKenna, Katherine Haines, Michael J Gambell. Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration. Neurobiology of disease. vol 43. issue 1. 2012-04-09. PMID:21419848. |
to investigate the effects of tsc on the cerebellum, we created a mouse model in which the tsc2 gene was selectively deleted from purkinje cells starting at postnatal day 6 (p6). |
2012-04-09 |
2023-08-12 |
mouse |
| Tatiana Hurtado de Mendoza, Bartosz Balana, Paul A Slesinger, Inder M Verm. Organotypic cerebellar cultures: apoptotic challenges and detection. Journal of visualized experiments : JoVE. issue 51. 2012-04-06. PMID:21633327. |
in the case of the cerebellum it is even more advantageous because it allows the study of purkinje cells, extremely difficult to obtain as dissociated primary culture. |
2012-04-06 |
2023-08-12 |
mouse |
| Lars Schack Kruse, Morten Møller, Christina Kruus. Distribution of PDE8A in the nervous system of the Sprague-Dawley rat. Journal of chemical neuroanatomy. vol 42. issue 3. 2012-04-02. PMID:21821118. |
in cerebellum pde8a immunoreactivity was located not only in the purkinje cells, but also in the granular cells as well as the parallel fibres in the molecular layer. |
2012-04-02 |
2023-08-12 |
rat |
| Sabrina Paratore, Maria Teresa Ciotti, Magali Basille, David Vaudry, Antonietta Gentile, Rosalba Parenti, Pietro Calissano, Sebastiano Cavallar. Gastric inhibitory polypeptide and its receptor are expressed in the central nervous system and support neuronal survival. Central nervous system agents in medicinal chemistry. vol 11. issue 3. 2012-03-29. PMID:21919873. |
widespread expression of gip and gipr was found in adult rat brain, whereas during postnatal cerebellum development, they were highly expressed in the external and internal granule layer, and in purkinje cells. |
2012-03-29 |
2023-08-12 |
rat |
| Xiaohong Wang, Tetsuya Imura, Michael V Sofroniew, Shinji Fushik. Loss of adenomatous polyposis coli in Bergmann glia disrupts their unique architecture and leads to cell nonautonomous neurodegeneration of cerebellar Purkinje neurons. Glia. vol 59. issue 6. 2012-03-26. PMID:21381115. |
purkinje neurons were normal in appearance and number at p21, but there was significant loss of purkinje neurons and cerebellar atrophy by middle age. |
2012-03-26 |
2023-08-12 |
mouse |