| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wael B Elkholy, Marwa A Al-Ghola. Role of medical ozone in attenuating age-related changes in the rat cerebellum. Microscopy (Oxford, England). 2019-11-20. PMID:29635467. |
age-related changes in the cerebellum were in the form of a significant reduction in the number of purkinje cells (pcs), which appeared shrunken with a darkly stained cytoplasm and vacuolated spaces in all layers. |
2019-11-20 |
2023-08-13 |
rat |
| Cecilie Totland, Torbjørn Kråkenes, Kibret Mazengia, Mette Haugen, Christian Vedele. Expression of the onconeural protein CDR1 in cerebellum and ovarian cancer. Oncotarget. vol 9. issue 35. 2019-11-20. PMID:29844866. |
cdr1 was strongly expressed in the cytosol and dendrites of purkinje cells and in interneurons of the molecular layer in cerebellum. |
2019-11-20 |
2023-08-13 |
Not clear |
| Yun Seok Jeon, Soo Young Lee, Jiwon Lee, Nam Su Gil, Young Jin Lim, Yong Chul Kim, Sang Chul Le. Effect of vasopressin on survival of Purkinje neurons in rat cerebellar slices after an in vitro simulated ischemia. Korean journal of anesthesiology. vol 56. issue 2. 2019-11-20. PMID:30625719. |
effect of vasopressin on survival of purkinje neurons in rat cerebellar slices after an in vitro simulated ischemia. |
2019-11-20 |
2023-08-13 |
rat |
| Julian Cheron, Guy Chero. Beta-gamma burst stimulations of the inferior olive induce high-frequency oscillations in the deep cerebellar nuclei. The European journal of neuroscience. vol 48. issue 8. 2019-11-14. PMID:29460990. |
as the inhibition of the deep cerebellar nuclei is related to inhibitory inputs from purkinje cells, we speculate that the oscillation represents the unmasking of the synchronous activation of another subtype of deep cerebellar neuronal subtype, devoid of gaba receptors and under the direct control of the climbing fibres from the inferior olive. |
2019-11-14 |
2023-08-13 |
mouse |
| Hermina Nedelescu, Mohamed Abdelhack, Arwel T Pritchar. Regional differences in Purkinje cell morphology in the cerebellar vermis of male mice. Journal of neuroscience research. vol 96. issue 9. 2019-11-11. PMID:29319237. |
in the cerebellum, analyses of purkinje cells (pcs), which are functionally critical as they provide the sole output of the cerebellar cortex, have suggested that the cerebellar cortex is not uniform in structure as traditionally assumed. |
2019-11-11 |
2023-08-13 |
mouse |
| Caroline Fecher, Laura Trovò, Stephan A Müller, Nicolas Snaidero, Jennifer Wettmarshausen, Sylvia Heink, Oskar Ortiz, Ingrid Wagner, Ralf Kühn, Jana Hartmann, Rosa Maria Karl, Arthur Konnerth, Thomas Korn, Wolfgang Wurst, Doron Merkler, Stefan F Lichtenthaler, Fabiana Perocchi, Thomas Misgel. Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity. Nature neuroscience. vol 22. issue 10. 2019-11-05. PMID:31501572. |
we determined the mitochondrial proteome of the three major cerebellar cell types (purkinje cells, granule cells and astrocytes) and identified hundreds of mitochondrial proteins that are differentially regulated. |
2019-11-05 |
2023-08-13 |
mouse |
| Moritoshi Hirono, Satoshi Watanabe, Fuyuki Karube, Fumino Fujiyama, Shigenori Kawahara, Soichi Nagao, Yuchio Yanagawa, Hiroaki Misono. Perineuronal Nets in the Deep Cerebellar Nuclei Regulate GABAergic Transmission and Delay Eyeblink Conditioning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 27. 2019-10-25. PMID:29858484. |
here, we investigated the contribution of pnns to gabaergic transmission from cerebellar purkinje cells (pcs) to large glutamatergic neurons in the deep cerebellar nuclei (dcn) in male mice by recording ipscs from cerebellar slices, in which pnns were depleted with chondroitinase abc (chabc). |
2019-10-25 |
2023-08-13 |
mouse |
| Mona G Amer, Rehab A Kara. Morphological and Biochemical Features of Cerebellar Cortex After Exposure to Zinc Oxide Nanoparticles: Possible Protective Role of Curcumin. Anatomical record (Hoboken, N.J. : 2007). vol 301. issue 8. 2019-10-24. PMID:29575794. |
histopathological degeneration of purkinje and granular cells together with loss of nissl substance, astrocyte gliosis, and affection of cerebellar blood brain barrier were detected. |
2019-10-24 |
2023-08-13 |
rat |
| Mona G Amer, Rehab A Kara. Morphological and Biochemical Features of Cerebellar Cortex After Exposure to Zinc Oxide Nanoparticles: Possible Protective Role of Curcumin. Anatomical record (Hoboken, N.J. : 2007). vol 301. issue 8. 2019-10-24. PMID:29575794. |
moreover, an apoptotic marker (caspase-3) was significantly expressed in purkinje and granular layers together with elevated gene expression of p53 and cox-2 in cerebellar tissue of znonps intoxicated group. |
2019-10-24 |
2023-08-13 |
rat |
| Hyun Geun Shim, Sung-Soo Jang, Seung Ha Kim, Eun Mi Hwang, Joo Ok Min, Hye Yun Kim, Yoo Sung Kim, Changhyeon Ryu, Geehoon Chung, YoungSoo Kim, Bo-Eun Yoon, Sang Jeong Ki. TNF-α increases the intrinsic excitability of cerebellar Purkinje cells through elevating glutamate release in Bergmann Glia. Scientific reports. vol 8. issue 1. 2019-10-21. PMID:30072733. |
here, we suggest that tumor necrosis factor α (tnf-α), a key inflammatory cytokine, alters the neural activity of the cerebellar purkinje cells (pcs) by facilitating gliotransmission in the juvenile male rat cerebellum. |
2019-10-21 |
2023-08-13 |
human |
| Matthias Luz, Philip C Allen, John Bringas, Chris Boiko, Diane E Stockinger, Kristen J Nikula, Owen Lewis, Max Woolley, H Christian Fibiger, Krystof Bankiewicz, Erich Moh. Intermittent convection-enhanced delivery of GDNF into rhesus monkey putamen: absence of local or cerebellar toxicity. Archives of toxicology. vol 92. issue 7. 2019-10-07. PMID:29785638. |
it was hypothesized that continuous leakage of gdnf into the cerebrospinal fluid compartment during the infusions led to down-regulation of gdnf receptors on purkinje cells, and that subsequent acute withdrawal of gdnf then mediated the observed cerebellar lesions. |
2019-10-07 |
2023-08-13 |
monkey |
| Andras Salamon, Rita Torok, Evelin Sumegi, Fanni Boros, Zsofia Gabriella Pesei, Mate Fort Molnar, Gabor Veres, Denes Zadori, Laszlo Vecsei, Peter Kliveny. The effect of physical stimuli on the expression level of key elements in mitochondrial biogenesis. Neuroscience letters. vol 698. 2019-10-07. PMID:30611892. |
the cause of the prominent cerebellar elevation of pgc-, and sirtuin isoforms could be an increase in synaptic plasticity between purkinje cells, which facilitates better motor coordination and more precise movement integration. |
2019-10-07 |
2023-08-13 |
mouse |
| Cristina V Dieni, Jacqueline A Sullivan, Mario Faralli, Samuele Contemori, Andrea Biscarini, Vito E Pettorossi, Roberto Panich. 17 beta-estradiol synthesis modulates cerebellar dependent motor memory formation in adult male rats. Neurobiology of learning and memory. vol 155. 2019-09-23. PMID:30125696. |
moreover, aromatase expression in the cerebellum of adult rodents is maintained at very low levels and localized to purkinje cells. |
2019-09-23 |
2023-08-13 |
rat |
| Thomas Klockgether, Caterina Mariotti, Henry L Paulso. Spinocerebellar ataxia. Nature reviews. Disease primers. vol 5. issue 1. 2019-09-16. PMID:30975995. |
most sca mutations cause prominent damage to cerebellar purkinje neurons with consecutive cerebellar atrophy, although purkinje neurons are only mildly affected in some scas. |
2019-09-16 |
2023-08-13 |
Not clear |
| Nahed A Omar, Ali H Abu-Almaaty, Yasmin M Abd El-Aziz, Ahmed M Abdeen, Fatma El Zahraa Ammar Mohamed, Mohamed M M Hashem, Seddik Hamma. Impacts of Egyptian propolis extract on rat cerebellum intoxicated by aluminum silicate: histopathological studies. Environmental science and pollution research international. vol 26. issue 21. 2019-09-13. PMID:31144179. |
further, histopathological examination showed that als-exposed rats revealed abnormal purkinje cells with irregular size and shrank shape, evidence of pre-necrotic stage in the form of nuclear pyknosis, and condensed and frequent darkly stained cells in cerebellar layers. |
2019-09-13 |
2023-08-13 |
human |
| Chandrakanth Reddy Edamakanti, Jeehaeh Do, Alessandro Didonna, Marco Martina, Puneet Opa. Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1. The Journal of clinical investigation. vol 128. issue 6. 2019-09-10. PMID:29533923. |
mutant atxn1 thus alters the neural circuitry of the developing cerebellum, setting the stage for the later vulnerability of purkinje cells to sca1. |
2019-09-10 |
2023-08-13 |
mouse |
| Abbas Aliaghaei, Mahdi Eskandarian Boroujeni, Houssein Ahmadi, Amir-Hossein Bayat, Mostafa Rezaei Tavirani, Mohammad Amin Abdollahifar, Mohammad H Pooyafar, Vahid Mansour. Dental pulp stem cell transplantation ameliorates motor function and prevents cerebellar atrophy in rat model of cerebellar ataxia. Cell and tissue research. vol 376. issue 2. 2019-08-30. PMID:30635776. |
the findings showed that transplantation of dpscs in a 3-ap model of ataxia ameliorated motor coordination and muscle activity, increased cerebellar volumes of molecular and granular layers plus white matter, reduced the levels of inflammatory cytokines and thwarted the degeneration of purkinje cells against 3-ap toxicity. |
2019-08-30 |
2023-08-13 |
human |
| Sandhya Prakash Kamath, Albert I Che. Myocyte Enhancer Factor 2c Regulates Dendritic Complexity and Connectivity of Cerebellar Purkinje Cells. Molecular neurobiology. vol 56. issue 6. 2019-08-29. PMID:30276662. |
although perturbations in the cerebellum, notably purkinje cells, have been linked to these neurological disorders, the underlying mechanisms remain poorly understood. |
2019-08-29 |
2023-08-13 |
Not clear |
| R Mohammadi, M H Heidari, Y Sadeghi, M A Abdollahifar, A Aghae. Evaluation of the spatial arrangement of Purkinje cells in ataxic rat's cerebellum after Sertoli cells transplantation. Folia morphologica. vol 77. issue 2. 2019-08-13. PMID:29064552. |
evaluation of the spatial arrangement of purkinje cells in ataxic rat's cerebellum after sertoli cells transplantation. |
2019-08-13 |
2023-08-13 |
rat |
| R Mohammadi, M H Heidari, Y Sadeghi, M A Abdollahifar, A Aghae. Evaluation of the spatial arrangement of Purkinje cells in ataxic rat's cerebellum after Sertoli cells transplantation. Folia morphologica. vol 77. issue 2. 2019-08-13. PMID:29064552. |
purkinje cells (pcs) pathology is important in cerebellar disorders like ataxia. |
2019-08-13 |
2023-08-13 |
rat |