| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Trace L Stay, Jean Laurens, Roy V Sillitoe, Dora E Angelak. Genetically eliminating Purkinje neuron GABAergic neurotransmission increases their response gain to vestibular motion. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 8. 2019-05-01. PMID:30723151. |
purkinje neurons in the caudal cerebellar vermis combine semicircular canal and otolith signals to segregate linear and gravitational acceleration, evidence for how the cerebellum creates internal models of body motion. |
2019-05-01 |
2023-08-13 |
mouse |
| Jennifer Rakotomamonjy, Abdel Mouman Ghoumar. Brain-Derived Neurotrophic Factor Is Required for the Neuroprotective Effect of Mifepristone on Immature Purkinje Cells in Cerebellar Slice Culture. International journal of molecular sciences. vol 20. issue 2. 2019-04-26. PMID:30642045. |
brain-derived neurotrophic factor is required for the neuroprotective effect of mifepristone on immature purkinje cells in cerebellar slice culture. |
2019-04-26 |
2023-08-13 |
mouse |
| Jennifer Rakotomamonjy, Abdel Mouman Ghoumar. Brain-Derived Neurotrophic Factor Is Required for the Neuroprotective Effect of Mifepristone on Immature Purkinje Cells in Cerebellar Slice Culture. International journal of molecular sciences. vol 20. issue 2. 2019-04-26. PMID:30642045. |
endogenous γ-aminobutyric acid (gaba)-dependent activity induces death of developing purkinje neurons in mouse organotypic cerebellar cultures and the synthetic steroid mifepristone blocks this effect. |
2019-04-26 |
2023-08-13 |
mouse |
| Jakub Trzesniewski, Sandrine Altmann, Levy Jäger, Josef P Kapfhamme. Reduced Purkinje cell size is compatible with near normal morphology and function of the cerebellar cortex in a mouse model of spinocerebellar ataxia. Experimental neurology. vol 311. 2019-04-10. PMID:30312605. |
there was no overt degeneration of purkinje cells in vivo and the cerebellum appeared morphologically normal with the exception of lobule 7 where abnormal purkinje cells were present. |
2019-04-10 |
2023-08-13 |
mouse |
| Jakub Trzesniewski, Sandrine Altmann, Levy Jäger, Josef P Kapfhamme. Reduced Purkinje cell size is compatible with near normal morphology and function of the cerebellar cortex in a mouse model of spinocerebellar ataxia. Experimental neurology. vol 311. 2019-04-10. PMID:30312605. |
despite this reduction in dendritic tree size, climbing fiber innervation of purkinje cells as visualized by immunostaining for the vesicular glutamate transporter 2 (vglut2) appeared normal in most parts of the cerebellum. |
2019-04-10 |
2023-08-13 |
mouse |
| Jakub Trzesniewski, Sandrine Altmann, Levy Jäger, Josef P Kapfhamme. Reduced Purkinje cell size is compatible with near normal morphology and function of the cerebellar cortex in a mouse model of spinocerebellar ataxia. Experimental neurology. vol 311. 2019-04-10. PMID:30312605. |
around cerebellar lobule 7 there was high transgene expression from the l7 promotor and purkinje cells showed abnormal morphologies. |
2019-04-10 |
2023-08-13 |
mouse |
| Zhicheng Yang, Jun L. Influence of temperature on cerebellar metabolite levels. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. vol 34. issue 3. 2019-03-29. PMID:28540835. |
the cerebellum is extremely sensitive to heat-induced injury because of the abundance of purkinje cells. |
2019-03-29 |
2023-08-13 |
Not clear |
| Yasuhiro Arai, Yuji Iwasaki, Toshihiro Suzuki, Shuuhei Ide, Makiko Kag. Elimination of amyloid precursor protein in senile plaques in the brain of a patient with Alzheimer-type dementia and Down syndrome. Brain & development. vol 41. issue 1. 2019-03-25. PMID:30086988. |
on microscopy, very few gamma-aminobutyric acid-ergic (gabaergic) neurons, in the form of small granular cells, in the cortex and purkinje cells in the cerebellum were visible. |
2019-03-25 |
2023-08-13 |
Not clear |
| Laura Lossi, Claudia Castagna, Adalberto Merigh. Caspase-3 Mediated Cell Death in the Normal Development of the Mammalian Cerebellum. International journal of molecular sciences. vol 19. issue 12. 2019-03-25. PMID:30545052. |
among the different types of neurons and glia in cerebellum, there is ample evidence for an intervention of caspase-3 in the regulation of nond of the post-mitotic cerebellar granule cells (cgcs) and purkinje neurons, as a consequence of failure to establish proper synaptic contacts with target (secondary cell death). |
2019-03-25 |
2023-08-13 |
mouse |
| Gustavo A Higuera, Grazia Iaffaldano, Meiwand Bedar, Guy Shpak, Robin Broersen, Shashini T Munshi, Catherine Dupont, Joost Gribnau, Femke M S de Vrij, Steven A Kushner, Chris I De Zeeu. An expandable embryonic stem cell-derived Purkinje neuron progenitor population that exhibits in vivo maturation in the adult mouse cerebellum. Scientific reports. vol 7. issue 1. 2019-03-21. PMID:28821816. |
many forms of ataxia result from degeneration of cerebellar purkinje cells, but thus far it has not been possible to efficiently generate purkinje neuron (pn) progenitors from human or mouse pluripotent stem cells, let alone to develop a methodology for in vivo transplantation in the adult cerebellum. |
2019-03-21 |
2023-08-13 |
mouse |
| Gustavo A Higuera, Grazia Iaffaldano, Meiwand Bedar, Guy Shpak, Robin Broersen, Shashini T Munshi, Catherine Dupont, Joost Gribnau, Femke M S de Vrij, Steven A Kushner, Chris I De Zeeu. An expandable embryonic stem cell-derived Purkinje neuron progenitor population that exhibits in vivo maturation in the adult mouse cerebellum. Scientific reports. vol 7. issue 1. 2019-03-21. PMID:28821816. |
when transplanted into the adult cerebellum of either wild-type mice or a strain lacking purkinje cells (l7cre-ercc1 knockout), gfp-labeled progenitors differentiated in vivo to establish a population of calbindin-positive cells in the molecular layer with dendritic trees typical of mature pns. |
2019-03-21 |
2023-08-13 |
mouse |
| Sami A Algaidi, Magda A Eldomiaty, Yasser M Elbastwisy, Shaima M Almasry, Maha K Desouky, Ahmed M Elnagga. Effect of voluntary running on expression of myokines in brains of rats with depression. International journal of immunopathology and pharmacology. vol 33. 2019-03-21. PMID:30834799. |
bdnf was expressed in neurons in dg, mpfc and granular and purkinje cells in cerebellum. |
2019-03-21 |
2023-08-13 |
rat |
| Takahiro Seki, Masahiro Sato, Ayumu Konno, Hirokazu Hirai, Yuki Kurauchi, Akinori Hisatsune, Hiroshi Katsuk. d-Cysteine promotes dendritic development in primary cultured cerebellar Purkinje cells via hydrogen sulfide production. Molecular and cellular neurosciences. vol 93. 2019-03-20. PMID:30342995. |
however, it remains unknown if d-cysteine affects cerebellar purkinje cells (pcs), which are important for cerebellar functions and are frequently degenerated in sca patients. |
2019-03-20 |
2023-08-13 |
Not clear |
| Valentina Grande, Francesca Ornaghi, Liliana Comerio, Elena Restelli, Antonio Masone, Alessandro Corbelli, Daniele Tolomeo, Vanessa Capone, Jeffrey M Axten, Nicholas J Laping, Fabio Fiordaliso, Michele Sallese, Roberto Chies. PERK inhibition delays neurodegeneration and improves motor function in a mouse model of Marinesco-Sjögren syndrome. Human molecular genetics. vol 27. issue 14. 2019-03-12. PMID:29718201. |
woozy mice carrying a spontaneous sil1 mutation recapitulate key pathological features of mss, including cerebellar atrophy with degeneration of purkinje cells and progressive myopathy. |
2019-03-12 |
2023-08-13 |
mouse |
| D R Varman, M B Soria-Ortíz, A Martínez-Torres, D Reyes-Har. GABAρ3 expression in lobule X of the cerebellum is reduced in the valproate model of autism. Neuroscience letters. vol 687. 2019-03-07. PMID:30261230. |
several studies have shown that dysfunction of the cerebellum is a hallmark of asd, and postmortem studies in humans reported a reduced density of purkinje cells (pcs) together with an abnormal expression of gaba |
2019-03-07 |
2023-08-13 |
Not clear |
| Stephanie De Munter, Dorien Bamps, Ana Rita Malheiro, Ritesh Kumar Baboota, Pedro Brites, Myriam Bae. Autonomous Purkinje cell axonal dystrophy causes ataxia in peroxisomal multifunctional protein-2 deficiency. Brain pathology (Zurich, Switzerland). vol 28. issue 5. 2019-03-05. PMID:29341299. |
in order to investigate whether peroxisomal β-oxidation is essential within purkinje cells, the sole output neurons of the cerebellum, we generated and characterized a mouse model with purkinje cell selective deletion of the mfp2 gene. |
2019-03-05 |
2023-08-13 |
mouse |
| Stephanie De Munter, Dorien Bamps, Ana Rita Malheiro, Ritesh Kumar Baboota, Pedro Brites, Myriam Bae. Autonomous Purkinje cell axonal dystrophy causes ataxia in peroxisomal multifunctional protein-2 deficiency. Brain pathology (Zurich, Switzerland). vol 28. issue 5. 2019-03-05. PMID:29341299. |
we show that selective loss of mfp2 from mature cerebellar purkinje neurons causes a late-onset motor phenotype and progressive purkinje cell degeneration, thereby mimicking ataxia and cerebellar deterioration in patients with mild hsd17b4 mutations. |
2019-03-05 |
2023-08-13 |
mouse |
| Emily Bowie, Ryan Norris, Kathryn V Anderson, Sarah C Goet. Spinocerebellar ataxia type 11-associated alleles of Ttbk2 dominantly interfere with ciliogenesis and cilium stability. PLoS genetics. vol 14. issue 12. 2019-03-04. PMID:30532139. |
spinocerebellar ataxia type 11 (sca11) is a rare, dominantly inherited human ataxia characterized by atrophy of purkinje neurons in the cerebellum. |
2019-03-04 |
2023-08-13 |
human |
| Naofumi Uesaka, Masanobu Kan. Presynaptic Mechanisms Mediating Retrograde Semaphorin Signals for Climbing Fiber Synapse Elimination During Postnatal Cerebellar Development. Cerebellum (London, England). vol 17. issue 1. 2019-02-28. PMID:28965326. |
purkinje cells (pcs) in the neonatal cerebellum are innervated by multiple climbing fibers (cfs). |
2019-02-28 |
2023-08-13 |
Not clear |
| Marília M Wallauer, Fernanda Huf, Lucas S Tortorelli, Francine L Rahmeier, Fabiano B Carvalho, Rosalva T Meurer, Marilda da Cruz Fernande. Morphological changes in the cerebellum as a result of ethanol treatment and cigarette smoke exposure: A study on astrogliosis, apoptosis and Purkinje cells. Neuroscience letters. vol 672. 2019-02-18. PMID:29477594. |
morphological changes in the cerebellum as a result of ethanol treatment and cigarette smoke exposure: a study on astrogliosis, apoptosis and purkinje cells. |
2019-02-18 |
2023-08-13 |
human |