| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel Manrique-Castano, Maryam Sardari, Tayana Silva de Carvalho, Thorsten R Doeppner, Aurel Popa-Wagner, Christoph Kleinschnitz, Andrew Chan, Dirk M Herman. Deactivation of ATP-Binding Cassette Transporters ABCB1 and ABCC1 Does Not Influence Post-ischemic Neurological Deficits, Secondary Neurodegeneration and Neurogenesis, but Induces Subtle Microglial Morphological Changes. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31572128. |
iba1 immunohistochemistry revealed no changes of the overall density of activated microglia in the ischemic striatum of abc transporter inhibitor treated mice, but subtle changes of microglial morphology, that is, reduced microglial cell volume by abcb1 deactivation after 14 and 28 days and reduced microglial ramification by abcb1, abcc1 and combined abcb1 and abcc1 deactivation after 56 days. |
2020-10-01 |
2023-08-13 |
mouse |
| Anya Kim, Esther García-García, Marco Straccia, Andrea Comella-Bolla, Andrés Miguez, Mercè Masana, Jordi Alberch, Josep M Canals, Manuel J Rodrígue. Reduced Fractalkine Levels Lead to Striatal Synaptic Plasticity Deficits in Huntington's Disease. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32625064. |
automated cell morphology analysis showed a non-inflammatory ramified microglia in the striatum of r6/1 mice. |
2020-09-28 |
2023-08-13 |
mouse |
| Chih-Hsin Lin, Pei-Cih Wei, Chiung-Mei Chen, Yu-Ting Huang, Jia-Lan Lin, Yen-Shi Lo, Jia-Li Lin, Chung-Yin Lin, Yih-Ru Wu, Kuo-Hsuan Chang, Guey-Jen Lee-Che. Lactulose and Melibiose Attenuate MPTP-Induced Parkinson's Disease in Mice by Inhibition of Oxidative Stress, Reduction of Neuroinflammation and Up-Regulation of Autophagy. Frontiers in aging neuroscience. vol 12. 2020-09-28. PMID:32848705. |
lactulose and melibiose significantly rescued motor deficits, increased dopamine in the striatum, reduced microglia and astrocyte reactivity as well as decreased levels of 4-hne. |
2020-09-28 |
2023-08-13 |
mouse |
| Martin Bona, Natalia Hvizdosova, Jana Jachova, Petra Bonova, Darina Kluchov. Response of distant regions affected by diaschisis commissuralis in one of the most common models of transient focal ischemia in rats. Journal of chemical neuroanatomy. vol 101. 2020-09-22. PMID:31415804. |
total microglia also started to fall, the earliest in the contra-penumbra region of the striatum (day 1), followed by the contra-core of the striatum and both cortex regions at the seventh day. |
2020-09-22 |
2023-08-13 |
rat |
| Ariana Q Farrand, Kristi L Helke, Luis Aponte-Cofresí, Monika B Gooz, Rebecca A Gregory, Vanessa K Hinson, Heather A Boge. Effects of vagus nerve stimulation are mediated in part by TrkB in a parkinson's disease model. Behavioural brain research. vol 373. 2020-09-14. PMID:31301412. |
following the final vns session, rats were euthanized, and left striatum, bilateral substantia nigra and locus coeruleus were sectioned for immunohistochemical detection of neurons, α-synuclein, astrocytes, and microglia. |
2020-09-14 |
2023-08-13 |
rat |
| Jianzhong Zhang, Dongwei Zhou, Zuopeng Zhang, Xinhui Qu, Kunwang Bao, Guohui Lu, Jian Dua. miR-let-7a suppresses α-Synuclein-induced microglia inflammation through targeting STAT3 in Parkinson's disease. Biochemical and biophysical research communications. vol 519. issue 4. 2020-06-22. PMID:31547989. |
lastly, mir-let-7a overexpression via injection of mir-7 mimics into mouse striatum suppressed microglia activation and reduced pro-inflammatory cytokine production, which were accompanied by relieved movement disorder and improved spatial memory deficits in α-syn-induced pd mice. |
2020-06-22 |
2023-08-13 |
mouse |
| Steven Vetel, Sophie Sérrière, Johnny Vercouillie, Jackie Vergote, Gabrielle Chicheri, Jean-Bernard Deloye, Frédéric Dollé, Sylvie Bodard, Claire Tronel, Lydie Nadal-Desbarats, Antoine Lefèvre, Patrick Emond, Sylvie Chalo. Extensive exploration of a novel rat model of Parkinson's disease using partial 6-hydroxydopamine lesion of dopaminergic neurons suggests new therapeutic approaches. Synapse (New York, N.Y.). vol 73. issue 3. 2020-04-22. PMID:30368914. |
in addition, we observed strong microglia activation in both the striatum and sn ipsilateral to the lesion, highlighting that this moderate degeneration of da neurons was associated with a marked neuroinflammation. |
2020-04-22 |
2023-08-13 |
rat |
| Stéphanie Pain, Jackie Vergote, Zuhal Gulhan, Sylvie Bodard, Sylvie Chalon, Afsaneh Gaillar. Inflammatory process in Parkinson disease: neuroprotection by neuropeptide Y. Fundamental & clinical pharmacology. vol 33. issue 5. 2020-04-07. PMID:30866091. |
in an animal experimental model of pd, the present study shows that npy inhibited the activation of microglia evaluated by the binding of the translocator protein (tspo) ligand [3h]pk11195 in striatum and substantia nigra of 6-ohda rats. |
2020-04-07 |
2023-08-13 |
rat |
| Georgia Mandolesi, Silvia Bullitta, Diego Fresegna, Francesca De Vito, Francesca Romana Rizzo, Alessandra Musella, Livia Guadalupi, Valentina Vanni, Mario Stampanoni Bassi, Fabio Buttari, Maria Teresa Viscomi, Diego Centonze, Antonietta Gentil. Voluntary running wheel attenuates motor deterioration and brain damage in cuprizone-induced demyelination. Neurobiology of disease. vol 129. 2020-03-24. PMID:31100354. |
moreover, exercise induced an early protection against axonal damage and the loss of the myelin associated proteins, myelin basic protein (mbp) and 2',3'-cyclic-nucleotide 3'-phosphodiesterase (cnpase), in the striatum and the corpus callosum, in coincidence of a strongly attenuated microglia activation in both brain areas. |
2020-03-24 |
2023-08-13 |
mouse |
| Joshua K Hakimian, Tien S Dong, Jorge A Barahona, Venu Lagishetty, Suchi Tiwari, Darien Azani, Matthew Barrera, Suhjin Lee, Amie L Severino, Nitish Mittal, Catherine M Cahill, Jonathan P Jacobs, Wendy M Walwy. Dietary Supplementation with Omega-3 Polyunsaturated Fatty Acids Reduces Opioid-Seeking Behaviors and Alters the Gut Microbiome. Nutrients. vol 11. issue 8. 2020-02-03. PMID:31416242. |
lastly, we examined the activation state of microglia in the striatum and found that n-3 pufa supplementation reduced the basal activation state of microglia. |
2020-02-03 |
2023-08-13 |
human |
| Patricia Rivera, Daniel Silva-Peña, Eduardo Blanco, Antonio Vargas, Sergio Arrabal, Antonia Serrano, Francisco Javier Pavón, Laura Bindila, Beat Lutz, Fernando Rodríguez de Fonseca, Juan Suáre. Oleoylethanolamide restores alcohol-induced inhibition of neuronal proliferation and microglial activity in striatum. Neuropharmacology. vol 146. 2020-01-23. PMID:30496754. |
oea also decreased astrocyte-related vimentin immunoreactivity and increased microglial cell population (iba-1, inos) in the striatum. |
2020-01-23 |
2023-08-13 |
rat |
| b' Lei Liu, Mary K Vollmer, Abdullah S Ahmad, Victoria M Fernandez, Hocheol Kim, Sylvain Dor\\xc3\\xa. Pretreatment with Korean red ginseng or dimethyl fumarate attenuates reactive gliosis and confers sustained neuroprotection against cerebral hypoxic-ischemic damage by an Nrf2-dependent mechanism. Free radical biology & medicine. vol 131. 2020-01-21. PMID:30458277.' |
in both ischemic striatum and cortex, the dynamic pattern of attenuated reactive gliosis in astrocytes and microglia, including affected astrocytic dysfunction in glutamate metabolism and water homeostasis, correlated well with the nrf2-dependent neuroprotection by ginseng or dmf. |
2020-01-21 |
2023-08-13 |
mouse |
| Xiaoning Han, Qian Li, Xi Lan, Leena El-Mufti, Honglei Ren, Jian Wan. Microglial Depletion with Clodronate Liposomes Increases Proinflammatory Cytokine Levels, Induces Astrocyte Activation, and Damages Blood Vessel Integrity. Molecular neurobiology. vol 56. issue 9. 2020-01-09. PMID:30734229. |
in this study, injecting 1 μl of clodronate liposomes (7 μg/μl) into the striatum of mice caused ablation of microglia at 1 day that persisted for 3 days. |
2020-01-09 |
2023-08-13 |
mouse |
| Giovanni Cirillo, Mario Cirillo, Fivos Panetsos, Assunta Virtuoso, Michele Pap. Selective Vulnerability of Basal Ganglia: Insights into the Mechanisms of Bilateral Striatal Necrosis. Journal of neuropathology and experimental neurology. vol 78. issue 2. 2019-11-29. PMID:30605553. |
immunohistochemistry of rat brain sections after single intraperitoneal administration (60 mg/kg) of the mitochondrial toxin 3-nitropropionic acid (3-np) revealed (i) selective bilateral striatal necrotic/cavitary lesions, (ii) degeneration of striatal medium spiny neurons, (iii) evidence of synaptic and transcriptional dysfunction, and (iv) reactive gliosis (activated microglia and astrocytes) in the striatum. |
2019-11-29 |
2023-08-13 |
rat |
| Lu Yang, Fang Niu, Honghong Yao, Ke Liao, Xufeng Chen, Yeonhee Kook, Rong Ma, Guoku Hu, Shilpa Buc. Exosomal miR-9 Released from HIV Tat Stimulated Astrocytes Mediates Microglial Migration. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 13. issue 3. 2019-10-02. PMID:29497921. |
in vivo studies wherein the mir-9 precursor-transduced microglia were transplanted into the striatum of mice, followed by assessing their migration in response to a stimulus administered distally, further validated the role of mir-9 in mediating microglial migration. |
2019-10-02 |
2023-08-13 |
mouse |
| Anastasia Noël, Libin Zhou, Bénédicte Foveau, P Jesper Sjöström, Andréa C LeBlan. Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6. Cell death and differentiation. vol 25. issue 7. 2019-09-16. PMID:29352267. |
microglia and astrocytes were increased in the hippocampal stratum lacunosum molecular and in the cortex, but not in the striatum. |
2019-09-16 |
2023-08-13 |
mouse |
| Yuan Chao Xue, Chelsea M Ruller, Gabriel Fung, Yasir Mohamud, Haoyu Deng, Huitao Liu, Jingchun Zhang, Ralph Feuer, Honglin Lu. Enteroviral Infection Leads to Transactive Response DNA-Binding Protein 43 Pathology in Vivo. The American journal of pathology. vol 188. issue 12. 2019-08-20. PMID:30273599. |
histologic and immunohistochemical analysis of brain tissues demonstrated sustained inflammation (microglia and astrogliosis) and lesions in multiple regions of the brain (hippocampus, cerebral cortex, striatum, olfactory bulb, and putamen) in parallel with virus detection as early as 2 days for up to 90 days after infection. |
2019-08-20 |
2023-08-13 |
mouse |
| Bianca Seminotti, Ângela Zanatta, Rafael Teixeira Ribeiro, Mateus Struecker da Rosa, Angela T S Wyse, Guilhian Leipnitz, Moacir Wajne. Disruption of Brain Redox Homeostasis, Microglia Activation and Neuronal Damage Induced by Intracerebroventricular Administration of S-Adenosylmethionine to Developing Rats. Molecular neurobiology. vol 56. issue 4. 2019-08-06. PMID:30058022. |
therefore, we investigated the effects of intracerebroventricular administration of adomet on redox homeostasis, microglia activation, synaptophysin levels, and tau phosphorylation in cerebral cortex and striatum of young rats. |
2019-08-06 |
2023-08-13 |
rat |
| Sumit Sarkar, Edward Lu, James Raymick, Joseph Hanig, Qiang G. ERK/MAP Kinase Activation is Evident in Activated Microglia of the Striatum and Substantia Nigra in an Acute and Chronically-Induced Mouse Model of Parkinson's Disease. Current neurovascular research. vol 15. issue 4. 2019-07-30. PMID:30468126. |
erk/map kinase activation is evident in activated microglia of the striatum and substantia nigra in an acute and chronically-induced mouse model of parkinson's disease. |
2019-07-30 |
2023-08-13 |
mouse |
| Lodewijk J A Toonen, João Casaca-Carreira, Maria Pellisé-Tintoré, Hailiang Mei, Yasin Temel, Ali Jahanshahi, Willeke M C van Roon-Mo. Intracerebroventricular Administration of a 2'-O-Methyl Phosphorothioate Antisense Oligonucleotide Results in Activation of the Innate Immune System in Mouse Brain. Nucleic acid therapeutics. vol 28. issue 2. 2019-07-05. PMID:29565739. |
histological analysis confirmed activation of microglia and astrocytes in striatum. |
2019-07-05 |
2023-08-13 |
mouse |