| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lin Zhao, Nan Cheng, Bo Sun, Shuzhen Wang, Anyuan Li, Zhixue Wang, Yuan Wang, Fanghua Q. Regulatory effects of Ningdong granule on microglia-mediated neuroinflammation in a rat model of Tourette's syndrome. Bioscience trends. vol 14. issue 4. 2021-07-05. PMID:32741856. |
idnp led to robust pathological changes and neurobehavioral complications, with activation of microglia in the striatum of rats with ts. |
2021-07-05 |
2023-08-13 |
rat |
| Lin Zhao, Nan Cheng, Bo Sun, Shuzhen Wang, Anyuan Li, Zhixue Wang, Yuan Wang, Fanghua Q. Regulatory effects of Ningdong granule on microglia-mediated neuroinflammation in a rat model of Tourette's syndrome. Bioscience trends. vol 14. issue 4. 2021-07-05. PMID:32741856. |
after activation by idnp, microglia strongly responded to this specific injury, and tnf-α, il-6, and mcp-1 were released in the striatum and/or serum of rats with ts. |
2021-07-05 |
2023-08-13 |
rat |
| Lin Zhao, Nan Cheng, Bo Sun, Shuzhen Wang, Anyuan Li, Zhixue Wang, Yuan Wang, Fanghua Q. Regulatory effects of Ningdong granule on microglia-mediated neuroinflammation in a rat model of Tourette's syndrome. Bioscience trends. vol 14. issue 4. 2021-07-05. PMID:32741856. |
interestingly, ndg inhibited the activation of microglia and decreased the abnormal expression of tnf-α, il-6, and mcp-1 in the striatum and/or serum of rats with ts, thus controlling tics. |
2021-07-05 |
2023-08-13 |
rat |
| Lin Zhao, Nan Cheng, Bo Sun, Shuzhen Wang, Anyuan Li, Zhixue Wang, Yuan Wang, Fanghua Q. Regulatory effects of Ningdong granule on microglia-mediated neuroinflammation in a rat model of Tourette's syndrome. Bioscience trends. vol 14. issue 4. 2021-07-05. PMID:32741856. |
in conclusion, microglia might play key roles in mediating neuroinflammatory responses in ts, triggering the release of tnf-α, il-6, and mcp-1.ndg inhibited tics in rats with ts, and this mechanism may be associated with a reduction in the increased number of activated microglia and a decrease in the expression of pro-inflammatory cytokines and chemokines in the striatum and/or serum. |
2021-07-05 |
2023-08-13 |
rat |
| Hongjie Chen, Jun Zho. Effects of Sodium Selenite on Oxidative Damage in the Liver, Kidney and Brain in a Selenite Cataract Rat Model. Biological trace element research. vol 197. issue 2. 2021-06-18. PMID:31832924. |
this damage was evidenced by mild gliocyte proliferation, significant disorder of neuronal arrangement with acidophilic changes in the hippocampus, and significant occurrence of focal microglia or lymphocytic infiltration in the corpus striatum after selenite injection for cataract simulation. |
2021-06-18 |
2023-08-13 |
human |
| Valeria G Parra-Paz, Ashanty Calderón-Sauri, Diego Granados-Patrón, Sergio G Cuevas-Carbonell, Daniel García-López, Alicia Dawn-Ojeda, Mirza Mut-Martín, Leticia Olivera-Castillo, Fernando J Álvarez-Cervera, Humberto Salgado, Javier Alamilla, María Del R García-Miss, Lizbeth Vásquez-Celaya, Irma I Aranda-González, José L Góngora-Alfar. Chronic feeding with 3% dried raw blueberries (V. corymbosum) reduces apomorphine-induced rotations and striatal dopaminergic loss in hemiparkinsonian rats. Food research international (Ottawa, Ont.). vol 140. 2021-05-27. PMID:33648289. |
striatal slices were immunostained for tyrosine hydroxylase (th) and the ionized calcium-binding protein-1 adapter (iba1) [immunoreactive area or microglia count in right striatum expressed as % of the left striatum]. |
2021-05-27 |
2023-08-13 |
rat |
| Jae-Hwan Jang, Mi-Jung Yeom, Sora Ahn, Ju-Young Oh, Suhwan Ji, Tae-Hong Kim, Hi-Joon Par. Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson's disease. Brain, behavior, and immunity. vol 89. 2021-04-27. PMID:32827699. |
acupuncture also restored the overexpression of microglia and astrocyte as well as conversion of bax and bcl-2 expression in both the striatum and the substantia nigra, indicating that inflammatory responses and apoptosis were blocked by acupuncture. |
2021-04-27 |
2023-08-13 |
mouse |
| Huifangjie Li, William C Knight, Pengfei Yang, Yingqiu Guo, Joel S Perlmutter, John C Morris, Randall J Bateman, Tammie L S Benzinger, Jinbin X. Microglia Implicated in Tauopathy in the Striatum of Neurodegenerative Disease Patients from Genotype to Phenotype. International journal of molecular sciences. vol 21. issue 17. 2021-04-09. PMID:32842621. |
microglia implicated in tauopathy in the striatum of neurodegenerative disease patients from genotype to phenotype. |
2021-04-09 |
2023-08-13 |
Not clear |
| Huifangjie Li, William C Knight, Pengfei Yang, Yingqiu Guo, Joel S Perlmutter, John C Morris, Randall J Bateman, Tammie L S Benzinger, Jinbin X. Microglia Implicated in Tauopathy in the Striatum of Neurodegenerative Disease Patients from Genotype to Phenotype. International journal of molecular sciences. vol 21. issue 17. 2021-04-09. PMID:32842621. |
we observed possible microglia dystrophy in the striatum of neurodegenerative brains. |
2021-04-09 |
2023-08-13 |
Not clear |
| Laura Boi, Augusta Pisanu, Maria Francesca Palmas, Giuliana Fusco, Ezio Carboni, Maria Antonietta Casu, Valentina Satta, Maria Scherma, Elzbieta Janda, Ignazia Mocci, Giovanna Mulas, Anna Ena, Saturnino Spiga, Paola Fadda, Alfonso De Simone, Anna R Cart. Modeling Parkinson's Disease Neuropathology and Symptoms by Intranigral Inoculation of Preformed Human α-Synuclein Oligomers. International journal of molecular sciences. vol 21. issue 22. 2021-04-05. PMID:33198335. |
h-αsynos triggered p129-αsyn deposition in snpc neurons and microglia and spread to the striatum. |
2021-04-05 |
2023-08-13 |
human |
| Md Saidur Rahman, Jianbo Yang, Yan Luan, Zhengguo Qiu, Jianshui Zhang, Haixia Lu, Xinlin Chen, Yong Li. Attenuation of Acute Intracerebral Hemorrhage-Induced Microglial Activation and Neuronal Death Mediated by the Blockade of Metabotropic Glutamate Receptor 5 In Vivo. Neurochemical research. vol 45. issue 5. 2021-01-29. PMID:32140955. |
mglur5 was highly localized in reactive microglia in the peri-hematomal cortex and striatum on days 3 and 7 post-ich. |
2021-01-29 |
2023-08-13 |
mouse |
| Wen-Wen Liu, Shi-Zhuang Wei, Guo-Dong Huang, Lu-Bing Liu, Chao Gu, Yun Shen, Xian-Hui Wang, Shu-Ting Xia, An-Mu Xie, Li-Fang Hu, Fen Wang, Chun-Feng Li. BMAL1 regulation of microglia-mediated neuroinflammation in MPTP-induced Parkinson's disease mouse model. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 5. 2021-01-22. PMID:32246801. |
we here showed that inactivation of brain and muscle arnt-like 1 (bmal1) in 1-methyl-4-phenyl-1,2,4,5-tetrahydropyridine (mptp)-treated mice resulted in obvious motor functional deficit, loss of dopaminergic neurons (dans) in the substantia nigra pars compacta (snpc), decrease of dopamine (da) transmitter, and increased activation of microglia and astrocytes in the striatum. |
2021-01-22 |
2023-08-13 |
mouse |
| Hemraj B Dodiya, Christopher B Forsyth, Robin M Voigt, Phillip A Engen, Jinal Patel, Maliha Shaikh, Stefan J Green, Ankur Naqib, Avik Roy, Jeffrey H Kordower, Kalipada Pahan, Kathleen M Shannon, Ali Keshavarzia. Chronic stress-induced gut dysfunction exacerbates Parkinson's disease phenotype and pathology in a rotenone-induced mouse model of Parkinson's disease. Neurobiology of disease. vol 135. 2021-01-15. PMID:30579705. |
in addition, rs promoted a number of rotenone-induced effects in the brain including: 1) reduced number of resting microglia and a higher number of dystrophic/phagocytic microglia as well as (fj-c+) dying cells in the substantia nigra (sn), 2) increased lipopolysaccharide (lps) reactivity in the sn, and 3) reduced dopamine (da) and da metabolites (dopac, hva) in the striatum compared to control mice. |
2021-01-15 |
2023-08-13 |
mouse |
| Min Guo, Jian Wang, Yanxin Zhao, Yiwei Feng, Sida Han, Qiang Dong, Mei Cui, Kim Tie. Microglial exosomes facilitate α-synuclein transmission in Parkinson's disease. Brain : a journal of neurology. vol 143. issue 5. 2020-12-14. PMID:32355963. |
the in vivo significance of these exosomes was demonstrated by stereotaxic injection of exosomes isolated from α-synuclein preformed fibrils treated microglia into the mouse striatum. |
2020-12-14 |
2023-08-13 |
mouse |
| Dharani Manickavasagam, Li Lin, Moses O Oyewum. Nose-to-brain co-delivery of repurposed simvastatin and BDNF synergistically attenuates LPS-induced neuroinflammation. Nanomedicine : nanotechnology, biology, and medicine. vol 23. 2020-11-11. PMID:31655202. |
we found out that the efficiency of the combination drug-loaded polymersomes to suppress microglia activation in brain regions followed the order: frontal cortex > striatum > hippocampus. |
2020-11-11 |
2023-08-13 |
Not clear |
| Francesca Siani, Rosaria Greco, Giovanna Levandis, Cristina Ghezzi, Francesca Daviddi, Chiara Demartini, Elisabetta Vegeto, Marie-Thérèse Fuzzati-Armentero, Fabio Blandin. Influence of Estrogen Modulation on Glia Activation in a Murine Model of Parkinson's Disease. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28620274. |
animals were sacrificed at different time points following 6-ohda injection and brain sections containing striatum and substantia nigra pars compacta (snc) underwent immunohistochemistry for tyrosine hydroxylase (th) (dopaminergic marker), immunofluorescence for iba1 and gfap (markers of microglia and astrocyte activation, respectively) and triple immunoflorescent to identify polarization of microglia toward the cytotoxic m1 (dapi/iba1/tnfα) or cytoprotective m2 (dapi/iba1/cd206) phenotype. |
2020-10-01 |
2023-08-13 |
mouse |
| Zhu-Man Lv, Rong-Jian Zhao, Xiao-Song Zhi, Ying Huang, Jia-Yin Chen, Ning-Ning Song, Chang-Jun Su, Yu-Qiang Din. Expression of DCX and Transcription Factor Profiling in Photothrombosis-Induced Focal Ischemia in Mice. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30524246. |
we found that astrocytes and microglia increased in early post-ischemic stage, followed by a 1-week late-onset of doublecortin (dcx) expression in the striatum. |
2020-10-01 |
2023-08-13 |
mouse |
| Jong Hee Choi, Minhee Jang, Joon-Il Lee, Won-Seok Chung, Ik-Hyun Ch. Neuroprotective Effects of a Traditional Multi-Herbal Medicine Kyung-Ok-Ko in an Animal Model of Parkinson's Disease: Inhibition of MAPKs and NF-κB Pathways and Activation of Keap1-Nrf2 Pathway. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30618742. |
these positive effects of kok were related to inhibition of loss of tyrosine hydroxylase-positive neurons, reduction of mitosox activity, increased apoptotic cells, microglia activation, and upregulation of inflammatory factors [interleukin (il)-1β, il-6, cyclooxygenase-2, and inducible nitric oxide], and reduced blood-brain barrier (bbb) disruption in the substantia nigra pars compacta (snpc) and/or striatum after mptp intoxication. |
2020-10-01 |
2023-08-13 |
mouse |
| Eugenia Falomir-Lockhart, Franco Juan Cruz Dolcetti, Luis Miguel García-Segura, Claudia Beatriz Hereñú, Maria Jose Bellin. IGF1 Gene Therapy Modifies Microglia in the Striatum of Senile Rats. Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:30890930. |
igf1 gene therapy modifies microglia in the striatum of senile rats. |
2020-10-01 |
2023-08-13 |
rat |
| Walace Gomes-Lea. Why microglia kill neurons after neural disorders? The friendly fire hypothesis. Neural regeneration research. vol 14. issue 9. 2020-10-01. PMID:31089039. |
we have previously shown that following experimental middle cerebral artery occlusion in the rat brain, microglia seem to support and impair adult neurogenesis in the same ischemic striatum. |
2020-10-01 |
2023-08-13 |
rat |