| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian Zhao, Yan Hao, Xiaoqian Yang, Jie Mao, Fengjie Tian, Yi Gao, Xiaolin Tian, Xiaoyan Yan, Yulan Qi. Mitigation of maternal fecal microbiota transplantation on neurobehavioral deficits of offspring rats prenatally exposed to arsenic: Role of microbiota-gut-brain axis. Journal of hazardous materials. vol 457. 2023-06-12. PMID:37307732. |
in prenatal as-challenged offspring after maternal fmt treatment, remarkably, suppressed expression of inflammatory cytokines in tissues (colon, serum, and striatum) were observed along with reversed mrna and protein expression of tight junction related molecules in intestinal barrier and blood-brain barrier (bbb); further, expression of serum lipopolysaccharide (lps), toll-like receptor 4 (tlr4), myeloid differentiation factor 88 (myd88) and nuclear transcription factor-κb (nf-κb) in colonic and striatal tissues were repressed with activation of astrocytes and microglia inhibited. |
2023-06-12 |
2023-08-14 |
rat |
| Chen-Meng Qiao, Wei Quan, Yu Zhou, Gu-Yu Niu, Hui Hong, Jian Wu, Li-Ping Zhao, Ting Li, Chun Cui, Wei-Jiang Zhao, Yan-Qin She. Orally Induced High Serum Level of Trimethylamine N-oxide Worsened Glial Reaction and Neuroinflammation on MPTP-Induced Acute Parkinson's Disease Model Mice. Molecular neurobiology. 2023-06-02. PMID:37266763. |
moreover, high serum tmao significantly increased activation of microglia and astrocytes both in striatum and in substantia nigra. |
2023-06-02 |
2023-08-14 |
mouse |
| Cláudia Saraiva, Jéssica Lopes-Nunes, Marta Esteves, Tiago Santos, Ana Vale, Ana Clara Cristóvão, Raquel Ferreira, Liliana Bernardin. CtBP Neuroprotective Role in Toxin-Based Parkinson's Disease Models: From Expression Pattern to Dopaminergic Survival. Molecular neurobiology. 2023-04-15. PMID:37060501. |
herein, we showed that ctbp1 and ctbp2 are expressed in neurons, dopaminergic neurons, astrocytes, and microglia in the substantia nigra (sn) and striatum of adult mice. |
2023-04-15 |
2023-08-14 |
mouse |
| Naveen Nagarajan, Mario R Capecch. Optogenetic stimulation of mouse Hoxb8 microglia in specific regions of the brain induces anxiety, grooming, or both. Molecular psychiatry. 2023-04-10. PMID:37037872. |
optogenetic stimulation of hoxb8 microglia within the dorsomedial striatum (dms) or the medial prefrontal cortex (mpfc) induces grooming, whereas stimulation of hoxb8 microglia in the basolateral amygdala (bla) or central amygdala (cea) produces elevated anxiety. |
2023-04-10 |
2023-08-14 |
mouse |
| Minhee Jang, Jong Hee Choi, Dae Sik Jang, Ik-Hyun Ch. Micrandilactone C, a Nortriterpenoid Isolated from Roots of Cells. vol 12. issue 5. 2023-03-11. PMID:36899922. |
mc also inhibited the activation of the signal transducer and activator of transcription 3 (stat3) in the striatum and microglia after 3-npa treatment. |
2023-03-11 |
2023-08-14 |
Not clear |
| Jogen Atone, Karen Wagner, Shinichiro Koike, Jun Yang, Sung Hee Hwang, Bruce D Hammoc. Inhibition of Soluble Epoxide Hydrolase Reduces Paraquat Neurotoxicity in Rodents. Environmental toxicology and pharmacology. 2023-01-22. PMID:36682504. |
thus, this study attempts to observe changes in inflammatory and endoplasmic reticulum stress markers in mouse striatum following chronic paraquat administration to determine whether inhibiting soluble epoxide hydrolase mitigates paraquat-induced neurotoxicity and whether it can reduce tlr4-mediated inflammation in primary astrocytes and microglia. |
2023-01-22 |
2023-08-14 |
mouse |
| Rafael Teixeira Ribeiro, Andrey Vinícios Soares Carvalho, Rafael Palavro, Luz Elena Durán-Carabali, Ângela Beatris Zemniaçak, Alexandre Umpierrez Amaral, Carlos Alexandre Netto, Moacir Wajne. L-2-Hydroxyglutaric Acid Administration to Neonatal Rats Elicits Marked Neurochemical Alterations and Long-Term Neurobehavioral Disabilities Mediated by Oxidative Stress. Neurotoxicity research. 2022-12-29. PMID:36580261. |
we also determined immunohistochemical landmarks of neuronal viability (neun), astrogliosis (s100b and gfap), microglia activation (iba1), and myelination (mbp and cnpase) in the cerebral cortex and striatum following l-2-hg administration. |
2022-12-29 |
2023-08-14 |
rat |
| Bina Lee, Ingabire Ines, Jihyun Je, Eun Jung Park, Hyemin Seong, Min Gi Jo, Hwajin Kim, Seon-Hee Kim, Seong Jae Kim, Hye Jung Kim, Minkyeong Kim, Sang Won Park, Seung Pil Yu. Effect of Renal Ischemia Reperfusion on Brain Neuroinflammation. Biomedicines. vol 10. issue 11. 2022-11-26. PMID:36428560. |
in the situation of kidney ischemia reperfusion (ir)-induced aki, activation of microglia and astrocytes were observed in the striatum, ventral midbrain, hippocampus, and cortex. |
2022-11-26 |
2023-08-14 |
Not clear |
| Yukihiro Okada, Nobutake Hosoi, Yasunori Matsuzaki, Yuuki Fukai, Akito Hiraga, Junichi Nakai, Keisuke Nitta, Yoichiro Shinohara, Ayumu Konno, Hirokazu Hira. Development of microglia-targeting adeno-associated viral vectors as tools to study microglial behavior in vivo. Communications biology. vol 5. issue 1. 2022-11-12. PMID:36369525. |
the 1.7-kb genomic sequence upstream of the start codon in exon 1 of the iba1 (aif1) gene, functions as microglia preferential promoter in the striatum and cerebellum. |
2022-11-12 |
2023-08-14 |
mouse |
| Reem Abdel-Haq, Johannes C M Schlachetzki, Joseph C Boktor, Thaisa M Cantu-Jungles, Taren Thron, Mengying Zhang, John W Bostick, Tahmineh Khazaei, Sujatha Chilakala, Livia H Morais, Greg Humphrey, Ali Keshavarzian, Jonathan E Katz, Matthew Thomson, Rob Knight, Viviana Gradinaru, Bruce R Haymaker, Christopher K Glass, Sarkis K Mazmania. A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice. eLife. vol 11. 2022-11-08. PMID:36346385. |
single-cell rna-seq analysis of microglia from the substantia nigra and striatum uncovers increased pro-inflammatory signaling and reduced homeostatic responses in aso mice compared to wild-type counterparts on standard diets. |
2022-11-08 |
2023-08-14 |
mouse |
| Zahra Nazari, Khadijeh Bahrehbar, Mohammad Jafar Golalipou. Effect of MDMA exposure during pregnancy on cell apoptosis, astroglia, and microglia activity in rat offspring striatum. Iranian journal of basic medical sciences. vol 25. issue 9. 2022-10-17. PMID:36246062. |
effect of mdma exposure during pregnancy on cell apoptosis, astroglia, and microglia activity in rat offspring striatum. |
2022-10-17 |
2023-08-14 |
rat |
| Rui-Chen Xu, Wen-Teng Miao, Jing-Yi Xu, Wen-Xin Xu, Ming-Ran Liu, Song-Tao Ding, Yu-Xin Jian, Yi-Han Lei, Ning Yan, Han-Deng Li. Neuroprotective Effects of Sodium Butyrate and Monomethyl Fumarate Treatment through GPR109A Modulation and Intestinal Barrier Restoration on PD Mice. Nutrients. vol 14. issue 19. 2022-10-14. PMID:36235813. |
according to our results, mptp-induced defected motor function, decreased dopamine and 5-hydroxytryptamine levels in the striatum, decreased tyrosine hydroxylase-positive neurons and increased activated microglia in the sn, and systemic inflammation were ameliorated by nab or mmf treatment. |
2022-10-14 |
2023-08-14 |
mouse |
| Meghna Bains, Jaspreet Kaur, Ansab Akhtar, Anurag Kuhad, Sangeeta Pilkhwal Sa. Anti-inflammatory effects of ellagic acid and vanillic acid against quinolinic acid-induced rat model of Huntington's disease by targeting IKK-NF-κB pathway. European journal of pharmacology. 2022-10-09. PMID:36209926. |
hd striatum has increased conversion of kynurenine to quinolinic acid (qa) which activates nmda receptors leading to activation of microglia and increased levels of nuclear factor kappa b (nf-κb) leading to elevated transcription of inducible nitric oxide synthase (inos) and various cytokines causing neuronal death via neuroinflammation, oxidative stress, mitochondrial dysfunction and apoptosis. |
2022-10-09 |
2023-08-14 |
rat |
| Genmeng Yang, Juan Li, Chi-Kwan Leung, Baoyu Shen, Chan Wang, Yue Xu, Shucheng Lin, Shuwei Zhang, Yi Tan, Huijie Zhang, Xiaofeng Zeng, Shijun Hong, Lihua L. Methamphetamine and HIV-1 Tat proteins synergistically induce microglial autophagy via activation of the Nrf2/NQO1/HO-1 signal pathway. Neuropharmacology. 2022-09-26. PMID:36162528. |
meth and hiv-1tat protein combination significantly increase the autophagy-related proteins (lc3-ii, beclin-1, atg5, and atg7) expression in microglia and striatum of c57bl/6j mice. |
2022-09-26 |
2023-08-14 |
mouse |
| Kelly Barko, Micah Shelton, Xiangning Xue, Yvette Afriyie-Agyemang, Stephanie Puig, Zachary Freyberg, George C Tseng, Ryan W Logan, Marianne L Sene. Brain region- and sex-specific transcriptional profiles of microglia. Frontiers in psychiatry. vol 13. 2022-09-12. PMID:36090351. |
transcripts more highly expressed in pfc isolated microglia were enriched for synapse-related pathways while microglia isolated from the striatum were enriched for pathways related to microtubule polymerization. |
2022-09-12 |
2023-08-14 |
mouse |
| Kelly Barko, Micah Shelton, Xiangning Xue, Yvette Afriyie-Agyemang, Stephanie Puig, Zachary Freyberg, George C Tseng, Ryan W Logan, Marianne L Sene. Brain region- and sex-specific transcriptional profiles of microglia. Frontiers in psychiatry. vol 13. 2022-09-12. PMID:36090351. |
we also found evidence for a gradient of expression of microglia-specific transcripts across the rostral-to-caudal axes of the brain, with microglia extracted from the striatum exhibiting a transcriptional profile intermediate between that of the pfc and midbrain. |
2022-09-12 |
2023-08-14 |
mouse |
| Liping Zhou, Xingzhe Wang, Xueyao Wang, Jing An, Xin Zheng, Deqiang Han, Zhiguo Che. Neuroprotective effects of human umbilical cord mesenchymal stromal cells in PD mice via centrally and peripherally suppressing NLRP3 inflammasome-mediated inflammatory responses. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076517. |
the mptp-induced activation of microglia and increase in tumor necrosis factor-α and interleukin-1β mrna expression in the striatum were also attenuated by hmscs. |
2022-09-09 |
2023-08-14 |
mouse |
| Chan Rim, Hyun-Sun Park, Min-Jung You, Bohyun Yang, Hui-Ju Kim, Soyoung Sung, Min-Soo Kwo. Microglia involvement in sex-dependent behaviors and schizophrenia occurrence in offspring with maternal dexamethasone exposure. Schizophrenia (Heidelberg, Germany). vol 8. issue 1. 2022-09-08. PMID:36075925. |
microglia in the medial prefrontal cortex (mpfc) and the striatum (str) of 10 w males prenatally treated with dexamethasone (10 w pn-dex-m) showed hyper-ramified morphology and dramatically reduced spine density in mpfc. |
2022-09-08 |
2023-08-14 |
mouse |
| Soheil Kazemi Roodsari, Yan Cheng, Kirstin M Reed, Laurie L Wellman, Larry D Sanford, Woong-Ki Kim, Ming-Lei Gu. Sleep Disturbance Alters Cocaine-Induced Locomotor Activity: Involvement of Striatal Neuroimmune and Dopamine Signaling. Biomedicines. vol 10. issue 5. 2022-05-28. PMID:35625897. |
meanwhile, sf modulated the effects of cocaine on neuroimmune signaling in the striatum and in ex vivo isolated microglia. |
2022-05-28 |
2023-08-13 |
mouse |
| Grace T Akingbade, Omamuyovwi M Ijomone, Aminu Imam, Michael Aschner, Moyosore S Aja. D-Ribose- L-Cysteine attenuates manganese-induced cognitive and motor deficit, oxidative damage, and reactive microglia activation. Environmental toxicology and pharmacology. 2022-05-05. PMID:35513219. |
mn caused a significant decrease in weight, memory and motor activities, increased lactate dehydrogenase level, overexpression of iba1 reflecting microglia activation, and distortion of the neuronal cytoarchitecture of the striatum and motor cortex, respectively. |
2022-05-05 |
2023-08-13 |
rat |