| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ah Reum Hong, Jae Geun Jang, Young Cheul Chung, So-Yoon Won, Byung Kwan Ji. Interleukin 13 on Microglia is Neurotoxic in Lipopolysaccharide-injected Striatum Experimental neurobiology. vol 31. issue 1. 2022-03-08. PMID:35256543. |
interleukin 13 on microglia is neurotoxic in lipopolysaccharide-injected striatum to explore the potential function of interleukin-13 (il-13), lipopolysaccharide (lps) or pbs as a control was unilaterally microinjected into striatum of rat brain. |
2022-03-08 |
2023-08-13 |
rat |
| Olga Bakina, Helmut Kettenmann, Christiane Nolt. Microglia form satellites with different neuronal subtypes in the adult murine central nervous system. Journal of neuroscience research. 2022-02-25. PMID:35213755. |
we quantified satellite microglia associated with gabaergic and glutamatergic neurons in the somatosensory cortex, striatum, and thalamus; with dopaminergic and serotonergic neurons in the basal forebrain and raphe nucleus, respectively; and with cerebellar purkinje cell neurons. |
2022-02-25 |
2023-08-13 |
mouse |
| Si Han Li, Tash-Lynn L Colson, Khaled S Abd-Elrahman, Stephen S G Ferguso. Metabotropic Glutamate Receptor 5 Antagonism Reduces Pathology and Differentially Improves Symptoms in Male and Female Heterozygous zQ175 Huntington's Mice. Frontiers in molecular neuroscience. vol 15. 2022-02-21. PMID:35185467. |
however, ctep reduced the number of huntingtin aggregates, improved neuronal survival and decreased microglia activation in the striatum of both male and female zq175 mice. |
2022-02-21 |
2023-08-13 |
mouse |
| Yuejun Wang, Li Li, Yuting Wu, Shouping Zhang, Qianqian Ju, Yinuo Yang, Yan Jin, Hui Shi, Cheng Su. CD44 deficiency represses neuroinflammation and rescues dopaminergic neurons in a mouse model of Parkinson's disease. Pharmacological research. 2022-02-19. PMID:35182746. |
in pd model mice, cd44 knockout improved behavioral defects, prevented th loss in the snpc and striatum, and blocked activation of microglia and astrocytes. |
2022-02-19 |
2023-08-13 |
mouse |
| Osamu Nakagawasai, Kohei Takahashi, Yuki Miura, Wataru Nemoto, Yutaro Obara, Koichi Tan-N. ERK5 inhibitor BIX02189 attenuates methamphetamine-induced hyperactivity by modulating microglial activation in the striatum. Journal of pharmacological sciences. vol 148. issue 3. 2022-02-18. PMID:35177212. |
we revealed that mice treated with meth showed hyperactivity, and increased p-erk5 and iba1 (a microglia marker) levels in the striatum. |
2022-02-18 |
2023-08-13 |
mouse |
| Osamu Nakagawasai, Kohei Takahashi, Yuki Miura, Wataru Nemoto, Yutaro Obara, Koichi Tan-N. ERK5 inhibitor BIX02189 attenuates methamphetamine-induced hyperactivity by modulating microglial activation in the striatum. Journal of pharmacological sciences. vol 148. issue 3. 2022-02-18. PMID:35177212. |
the results suggest that meth-induced hyperactivity is associated with the activation of microglia via p-erk5 in the striatum. |
2022-02-18 |
2023-08-13 |
mouse |
| Ayumi E Pottenger, Mitchell J Bartlett, Scott J Sherman, Torsten Falk, Helena W Morriso. Evaluation of microglia in a rodent model of Parkinson's disease primed with L-DOPA after sub-anesthetic ketamine treatment. Neuroscience letters. vol 765. 2021-12-03. PMID:34536508. |
we further extended our prior work by showing that while ketamine treatment did lead to an increase of striatal interleukin-6 in dyskinetic rats, indicating a modulation of an inflammatory response, it did not change microglia number or morphology in the dyskinetic striatum. |
2021-12-03 |
2023-08-13 |
rat |
| Kaidong Wang, Baofu Zhang, Tian Tian, Bingyang Zhang, Ge Shi, Chunhui Zhang, Guoliang Li, Min Huan. Taurine protects dopaminergic neurons in paraquat-induced Parkinson's disease mouse model through PI3K/Akt signaling pathways. Amino acids. 2021-11-27. PMID:34837554. |
our study showed that pd mice with tau intervention recovered motor and non-motor functions to some extent, and the number of dopaminergic (dac) neurons in the substantia nigra and the level of dopamine (da) secretion in the striatum were also significantly increased compared with the pq-dyed group, and the protein content of pi3k and pdk-1 and the phosphorylation level of akt were reduced in parallel with the reduction in the expression of microglia and related inflammatory factors. |
2021-11-27 |
2023-08-13 |
mouse |
| Miho Shukuri, Miyu Uchino, Takafumi Sakamaki, Satoru Onoe, Rie Hosoi, Kenichiro Todoroki, Yasushi Arano, Toshihiro Sakai, Hiromichi Akizawa, Osamu Inou. Ex vivo imaging and analysis of ROS generation correlated with microglial activation in rat model with acute neuroinflammation induced by intrastriatal injection of LPS. Biochemical and biophysical research communications. vol 584. 2021-11-24. PMID:34781201. |
the inhibition of microglial activation by minocycline remarkably reduced ros levels in the lps-injected striatum, which indicated that the increased ros generation caused by lps was induced by activated microglia. |
2021-11-24 |
2023-08-13 |
rat |
| Yan Cheng, Woong-Ki Kim, Laurie L Wellman, Larry D Sanford, Ming-Lei Gu. Short-Term Sleep Fragmentation Dysregulates Autophagy in a Brain Region-Specific Manner. Life (Basel, Switzerland). vol 11. issue 10. 2021-10-26. PMID:34685469. |
additionally, 5 days of sf activated microglia in the striatum but not in the hippocampus or frontal cortex. |
2021-10-26 |
2023-08-13 |
mouse |
| Thuy Thi Lai, Yun Joong Kim, Phuong Thi Nguyen, Young Ho Koh, Tinh Thi Nguyen, Hyeo-Il Ma, Young Eun Ki. Temporal Evolution of Inflammation and Neurodegeneration With Alpha-Synuclein Propagation in Parkinson's Disease Mouse Model. Frontiers in integrative neuroscience. vol 15. 2021-10-23. PMID:34675786. |
in the pff-injected striatum, inflammatory response cells, including microglia and astrocytes, were activated at the earliest stage and reduced with time, and the phosphorylated form of αsyn accumulation increased behind it. |
2021-10-23 |
2023-08-13 |
mouse |
| Ernest T Chivero, Susmita Sil, Seema Singh, Annadurai Thangaraj, Lila Gordon, Grace B Evah-Nzoughe, Natasha Ferguson, Shannon Callen, Shilpa Buc. Protective Role of Lactobacillus rhamnosus Probiotic in Reversing Cocaine-Induced Oxidative Stress, Glial Activation and Locomotion in Mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2021-10-10. PMID:34628571. |
in cocaine administered mice, there was increased activation of both microglia and astrocytes in the striatum and cortex of the brain as shown by enhanced expression of cd11b and gfap, respectively. |
2021-10-10 |
2023-08-13 |
mouse |
| Zhe Zhong, Weijie Chen, Huan Gao, Ningning Che, Min Xu, Lanqing Yang, Yingfang Zhang, Min Y. Fecal Microbiota Transplantation Exerts a Protective Role in MPTP-Induced Parkinson's Disease via the TLR4/PI3K/AKT/NF-κB Pathway Stimulated by α-Synuclein. Neurochemical research. vol 46. issue 11. 2021-10-04. PMID:34347266. |
additionally, fmt decreased the expression of α-syn, as well as inhibited the activation of microglia in the sn, and blocked the tlr4/pi3k/akt/nf-κb signaling in the sn and striatum. |
2021-10-04 |
2023-08-13 |
mouse |
| Taewoo Kim, Jeha Jeon, Jin-Sun Park, Yeongwon Park, Jooeui Kim, Haneul Noh, Hee-Sun Kim, Hyemyung Se. Matrix Metalloproteinase-8 Inhibitor Ameliorates Inflammatory Responses and Behavioral Deficits in LRRK2 G2019S Parkinson's Disease Model Mice. Biomolecules & therapeutics. vol 29. issue 5. 2021-09-14. PMID:34045367. |
we observed a significant increase of ionized calcium- binding adapter molecule 1 (iba1)-positive activated microglia in the striatum of lrrk2 g2019s mice compared to normal control mice, indicating enhanced neuro-inflammatory responses. |
2021-09-14 |
2023-08-13 |
mouse |
| Kaori Masai, Keita Kuroda, Nami Isooka, Ryo Kikuoka, Shinki Murakami, Sunao Kamimai, Dengli Wang, Keyue Liu, Ikuko Miyazaki, Masahiro Nishibori, Masato Asanum. Neuroprotective Effects of Anti-high Mobility Group Box-1 Monoclonal Antibody Against Methamphetamine-Induced Dopaminergic Neurotoxicity. Neurotoxicity research. vol 39. issue 5. 2021-09-10. PMID:34417986. |
meth injections induced hyperthermia, an increase in plasma hmgb1 concentration, degeneration of dopaminergic nerve terminals, accumulation of microglia, and extracellular release of neuronal hmgb1 in the striatum. |
2021-09-10 |
2023-08-13 |
mouse |
| Ying Hou, Depeng Yang, Xianshi Wang, Huiyang Wang, Haotian Zhang, Pengwei Wang, Yinglu Liu, Xiaoyun Gao, Jingyu Yang, Chunfu W. Pseudoginsenoside-F11 promotes functional recovery after transient cerebral ischemia by regulating the microglia/macrophage polarization in rats. International immunopharmacology. vol 99. 2021-09-08. PMID:34246061. |
in vivo data showed that oral administration of pf11 (12 mg/kg) significantly attenuated cognitive deficits and sensorimotor dysfunction, infarct volume and brain edema in transient middle cerebral artery occlusion (tmcao)-treated rats, as well as reduced the loss of neurons and the over-activation of microglia in penumbra of ipsilateral striatum and cortex. |
2021-09-08 |
2023-08-13 |
rat |
| Michela Matteoli, Davide Pozz. Feeling depressed? Keep calm, and watch microglia. Immunity. vol 54. issue 2. 2021-08-31. PMID:33567256. |
show that the activation of microglia in the striatum triggers an il-6-mediated autocrine loop and the release of prostaglandins, which in turn induce a negative affective state via the stimulation of medium spiny neurons. |
2021-08-31 |
2023-08-13 |
Not clear |
| Rosane Bossle Bernardi, Ana Cláudia Tedesco Zanchi, Nilsa Regina Damaceno-Rodrigues, Mariana Matera Veras, Paulo Hilário Nascimento Saldiva, Helena Maria Tannhauser Barros, Cláudia Ramos Rhode. The impact of chronic exposure to air pollution over oxidative stress parameters and brain histology. Environmental science and pollution research international. vol 28. issue 34. 2021-08-26. PMID:33890219. |
the number of neurons or microglia in the striatum did not differ between fa and pa. on the other hand, neurons and microglia cell numbers were significantly higher in the cortex of the fa-pa group. |
2021-08-26 |
2023-08-13 |
rat |
| James Morgan, Mariana Alves, Giorgia Conte, Aida Menéndez-Méndez, Laura de Diego-Garcia, Gioacchino de Leo, Edward Beamer, Jonathon Smith, Annette Nicke, Tobias Enge. Characterization of the Expression of the ATP-Gated P2X7 Receptor Following Status Epilepticus and during Epilepsy Using a P2X7-EGFP Reporter Mouse. Neuroscience bulletin. vol 36. issue 11. 2021-07-28. PMID:32895896. |
the results showed increased p2x7-egfp expression after status epilepticus induced by intra-amygdala kainic acid and during epilepsy in different brain regions including the hippocampus, cortex, striatum, thalamus and cerebellum, and this was most evident in microglia and oligodendrocytes. |
2021-07-28 |
2023-08-13 |
mouse |
| Svetlana Altamentova, Prakasham Rumajogee, James Hong, Stephanie R Beldick, Sei Joon Park, Albert Yee, Michael G Fehling. Methylprednisolone Reduces Persistent Post-ischemic Inflammation in a Rat Hypoxia-Ischemia Model of Perinatal Stroke. Translational stroke research. vol 11. issue 5. 2021-07-19. PMID:32140998. |
administration of mpss resulted in reduced structural damage (corpus callosum, cortex, hippocampus, striatum), gliosis and reactive microglia and partial restoration of the oligodendrocyte population. |
2021-07-19 |
2023-08-13 |
human |