| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dennis Y Chuang, Jiankun Cui, Agnes Simonyi, Victoria A Engel, Shanyan Chen, Kevin L Fritsche, Andrew L Thomas, Wendy L Applequist, William R Folk, Dennis B Lubahn, Albert Y Sun, Grace Y Sun, Zezong G. Dietary Sutherlandia and elderberry mitigate cerebral ischemia-induced neuronal damage and attenuate p47phox and phospho-ERK1/2 expression in microglial cells. ASN neuro. vol 6. issue 6. 2015-06-12. PMID:25324465. |
immunohistochemical staining for ionized calcium-binding adapter molecule-1 demonstrated pronounced activation of microglia in the hippocampus and striatum in the ischemic brains 3 days after i/r, and microglial activation was significantly reduced in animals fed supplemented diets. |
2015-06-12 |
2023-08-13 |
mouse |
| Patricia Rivera, Laura Bindila, Antoni Pastor, Margarita Pérez-Martín, Francisco J Pavón, Antonia Serrano, Rafael de la Torre, Beat Lutz, Fernando Rodríguez de Fonseca, Juan Suáre. Pharmacological blockade of the fatty acid amide hydrolase (FAAH) alters neural proliferation, apoptosis and gliosis in the rat hippocampus, hypothalamus and striatum in a negative energy context. Frontiers in cellular neuroscience. vol 9. 2015-04-14. PMID:25870539. |
cell proliferation (phospho-h3(+) or brdu(+) cells) of the main adult neurogenic zones as well as apoptosis (cleaved caspase-3(+)), astroglia (gfap(+)), and microglia (iba1(+) cells) were analyzed in the hippocampus, hypothalamus and striatum of rats intraperitoneally treated with urb597 (0.3 mg/kg/day) at one dose/4-days resting or 5 doses (1 dose/day). |
2015-04-14 |
2023-08-13 |
rat |
| b' Susanna Amadio, Chiara Parisi, Cinzia Montilli, Alberto Savio Carrubba, Savina Apolloni, Cinzia Volont\\xc3\\xa. P2Y(12) receptor on the verge of a neuroinflammatory breakdown. Mediators of inflammation. vol 2014. 2015-04-08. PMID:25180027.' |
by comparative analysis, we have established here that p2y12 receptor immunolabelled by antibodies against c-terminus or second intracellular loop, is, respectively, distributed and modulated under neuroinflammatory conditions on ramified microglia or myelinated fibers, in primary organotypic cerebellar cultures, tissue slices from rat striatum and cerebellum, spinal cord sections from symptomatic/end stage sod1-g93a als mice, and finally autoptic cortical tissue from progressive ms donors. |
2015-04-08 |
2023-08-13 |
mouse |
| Robert W Regenhardt, Adam P Mecca, Fiona Desland, Phillip F Ritucci-Chinni, Jacob A Ludin, David Greenstein, Cristina Banuelos, Jennifer L Bizon, Mary K Reinhard, Colin Sumner. Centrally administered angiotensin-(1-7) increases the survival of stroke-prone spontaneously hypertensive rats. Experimental physiology. vol 99. issue 2. 2014-11-03. PMID:24142453. |
this ang-(1-7) treatment also decreased the number of haemorrhages in the striatum, improved neurological status (reduced lethargy), decreased the number of microglia in the striatum and tended to increase neuron survival at the same site. |
2014-11-03 |
2023-08-12 |
rat |
| Alessia Melani, Francesca Corti, Lucrezia Cellai, Maria Giuliana Vannucchi, Felicita Pedat. Low doses of the selective adenosine A2A receptor agonist CGS21680 are protective in a rat model of transient cerebral ischemia. Brain research. vol 1551. 2014-10-15. PMID:24457041. |
an overexpression of a2a adenosine receptors occurs at central level on neurons and microglia of ischemic striatum and cortex after focal ischemia. |
2014-10-15 |
2023-08-12 |
rat |
| Peter Ferrazzano, Vishal Chanana, Kutluay Uluc, Emin Fidan, Erinc Akture, Douglas B Kintner, Pelin Cengiz, Dandan Su. Age-dependent microglial activation in immature brains after hypoxia- ischemia. CNS & neurological disorders drug targets. vol 12. issue 3. 2014-07-11. PMID:23469850. |
p9 brains demonstrated a 2-3 fold greater increase in microglia counts than p30 brains in each region (hippocampus, cortex, and striatum) during day 1-17 post-hi. |
2014-07-11 |
2023-08-12 |
mouse |
| Gisa Ellrichmann, Christiane Reick, Carsten Saft, Ralf A Linke. The role of the immune system in Huntington's disease. Clinical & developmental immunology. vol 2013. 2014-02-17. PMID:23956761. |
activation of microglia with expression of proinflammatory cytokines, impaired migration of macrophages, and deposition of complement factors in the striatum indicate an activation of the innate immune system. |
2014-02-17 |
2023-08-12 |
mouse |
| Antonietta Gentile, Silvia Rossi, Valeria Studer, Caterina Motta, Valentina De Chiara, Alessandra Musella, Helena Sepman, Diego Fresegna, Gabriele Musumeci, Giorgio Grasselli, Nabila Haji, Sagit Weiss, Liat Hayardeny, Georgia Mandolesi, Diego Centonz. Glatiramer acetate protects against inflammatory synaptopathy in experimental autoimmune encephalomyelitis. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 8. issue 3. 2014-02-11. PMID:23370991. |
single neuron electrophysiological recordings and immunofluorescence analysis of microglia activation were performed in the striatum of eae mice, treated or not with ga, at different stages of the disease. |
2014-02-11 |
2023-08-12 |
mouse |
| Marcio Lazzarini, Sabine Martin, Mišo Mitkovski, Rita Raisman Vozari, Walter Stühmer, Elaine Del Be. Doxycycline restrains glia and confers neuroprotection in a 6-OHDA Parkinson model. Glia. vol 61. issue 7. 2014-02-10. PMID:23595698. |
this protective effect was associated with: (1) a reduction of microglia in normal mice as a result of doxycycline administration per se; (2) a decrease in the astrocyte and microglia response to the neurotoxin 6-ohda in the globus pallidus and substantia nigra compacta, and (3) the astrocyte reaction in the striatum. |
2014-02-10 |
2023-08-12 |
mouse |
| Charles B Breckenridge, Nicholas C Sturgess, Mark Butt, Jeffrey C Wolf, Dan Zadory, Melissa Beck, James M Mathews, Merrill O Tisdel, Daniel Minnema, Kim Z Travis, Andrew R Cook, Philip A Botham, Lewis L Smit. Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effects of paraquat in the substantia nigra pars compacta and striatum of male C57BL/6J mice. Neurotoxicology. vol 37. 2014-02-05. PMID:23523781. |
mptp activated microglia and astrocytes within 4 h of the last dose, reaching a peak within 48 h. the microglial response ended by 96 h in the snpc, but the astrocytic response continued through 168 h in the striatum. |
2014-02-05 |
2023-08-12 |
mouse |
| Malin Åkerblom, Rohit Sachdeva, Luis Quintino, Erika Elgstrand Wettergren, Katie Z Chapman, Giuseppe Manfre, Olle Lindvall, Cecilia Lundberg, Johan Jakobsso. Visualization and genetic modification of resident brain microglia using lentiviral vectors regulated by microRNA-9. Nature communications. vol 4. 2013-11-26. PMID:23612311. |
we use this approach to visualize and isolate activated resident microglia without affecting circulating and infiltrating monocytes or macrophages in an excitotoxic lesion model in rat striatum. |
2013-11-26 |
2023-08-12 |
mouse |
| Mariana Astiz, Yolanda Diz-Chaves, Luis M Garcia-Segur. Sub-chronic exposure to the insecticide dimethoate induces a proinflammatory status and enhances the neuroinflammatory response to bacterial lypopolysaccharide in the hippocampus and striatum of male mice. Toxicology and applied pharmacology. vol 272. issue 2. 2013-11-26. PMID:23891859. |
in this study, we have assessed in c57bl/6 adult male mice, whether sub-chronic (5weeks) intoxication with a low dose of dimethoate (1.4mg/kg) affects the expression of inflammatory molecules and the reactivity of microglia in the hippocampus and striatum under basal conditions and after an immune challenge caused by the systemic administration of lipopolysaccharide. |
2013-11-26 |
2023-08-12 |
mouse |
| Mariana Astiz, Yolanda Diz-Chaves, Luis M Garcia-Segur. Sub-chronic exposure to the insecticide dimethoate induces a proinflammatory status and enhances the neuroinflammatory response to bacterial lypopolysaccharide in the hippocampus and striatum of male mice. Toxicology and applied pharmacology. vol 272. issue 2. 2013-11-26. PMID:23891859. |
lipopolysaccharide caused a significant increase in the mrna levels of il1β, tnfα, il6 and interferon-γ-inducible protein 10, and a significant increase in the proportion of microglia with reactive phenotype in the hippocampus and the striatum. |
2013-11-26 |
2023-08-12 |
mouse |
| Sang-Hun Bae, Tae-Ho Kong, Hyun-Seob Lee, Kyung-Sul Kim, Kwan Soo Hong, Michael Chopp, Myung-Seo Kang, Jisook Moo. Long-lasting paracrine effects of human cord blood cells on damaged neocortex in an animal model of cerebral palsy. Cell transplantation. vol 21. issue 11. 2013-11-01. PMID:22524897. |
hucbcs increased microglia temporarily in the periventricular striatum in the early phase of disease, protected mature neurons in the neocortex from injury, paved the way for the near-normalization of brain damage in the subventricular zone (svz), and, in consequence, significantly improved performance in a battery of behavioral tests compared to the vehicle-treated group. |
2013-11-01 |
2023-08-12 |
human |
| Bailin Wu, Bo Song, Haiqing Yang, Boyuan Huang, Bo Chi, Yansu Guo, Huaijun Li. Central nervous system damage due to acute paraquat poisoning: an experimental study with rat model. Neurotoxicology. vol 35. 2013-09-10. PMID:23261591. |
in substantia nigra (sn) and striatum we found obvious microglia (labeled by iba-1) activation within one week. |
2013-09-10 |
2023-08-12 |
rat |
| Mohamed Salama, Basem Helmy, Mohamed El-Gamal, Amr Reda, Amr Ellaithy, Dina Tantawy, Mie Mohamed, Aya El-Gamal, Hussein Sheashaa, Mohamed Sob. Role of L-thyroxin in counteracting rotenone induced neurotoxicity in rats. Environmental toxicology and pharmacology. vol 35. issue 2. 2013-09-06. PMID:23357603. |
photomicrographs for coronal sections of the substantia nigra and striatum were taken and analyzed using image j software to evaluate cell count in snpc and striatal fibers density and number of microglia in the nigrostriatal system. |
2013-09-06 |
2023-08-12 |
rat |
| Vanesa Sanchez-Guajardo, Ambra Annibali, Poul Henning Jensen, Marina Romero-Ramo. α-Synuclein vaccination prevents the accumulation of parkinson disease-like pathologic inclusions in striatum in association with regulatory T cell recruitment in a rat model. Journal of neuropathology and experimental neurology. vol 72. issue 7. 2013-09-03. PMID:23771222. |
this resulted in a high-titer anti-α-syn antibody response on α-syn overexpression; the accumulation of cd4-positive, mhc ii-positive ramified microglia in the substantia nigra; long-lasting infiltration of cd4-positive, foxp3-positive cells throughout the nigrostriatal system; and fewer pathologic aggregates in the striatum versus control animals that had received a mock vaccine. |
2013-09-03 |
2023-08-12 |
human |
| Ahmed Sharaf, Kerstin Krieglstein, Björn Spitta. Distribution of microglia in the postnatal murine nigrostriatal system. Cell and tissue research. vol 351. issue 3. 2013-08-07. PMID:23250575. |
we clearly show that the microglia numbers in the sn and in the striatum dramatically increase from p0 to p15 and significantly decrease in both areas in 18-month-old and 24-month-old animals. |
2013-08-07 |
2023-08-12 |
mouse |
| Danielle M Friend, Kristen A Keef. Glial reactivity in resistance to methamphetamine-induced neurotoxicity. Journal of neurochemistry. vol 125. issue 4. 2013-07-01. PMID:23414433. |
neurotoxic regimens of methamphetamine (meth) result in reactive microglia and astrocytes in striatum. |
2013-07-01 |
2023-08-12 |
rat |
| Francisco J Ortega, Jukka Jolkkonen, Nicole Mahy, Manuel J Rodrígue. Glibenclamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 33. issue 3. 2013-04-19. PMID:23149556. |
in vivo glibenclamide was associated with increased migration of doublecortin-positive cells in the striatum toward the ischemic lesion 72 hours after mcao, and reactive microglia expressed sulfonylurea receptor 1 (sur1) and kir6.2 in the medial striatum. |
2013-04-19 |
2023-08-12 |
rat |