| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael D Weber, Matthew G Frank, Kevin J Tracey, Linda R Watkins, Steven F Maie. Stress induces the danger-associated molecular pattern HMGB-1 in the hippocampus of male Sprague Dawley rats: a priming stimulus of microglia and the NLRP3 inflammasome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 1. 2015-03-20. PMID:25568124. |
exposure to 100 inescapable tail shocks (iss) increased hmgb-1 and nlrp3 protein in the hippocampus and led isolated microglia to release hmgb-1 ex vivo. |
2015-03-20 |
2023-08-13 |
rat |
| Michael D Weber, Matthew G Frank, Kevin J Tracey, Linda R Watkins, Steven F Maie. Stress induces the danger-associated molecular pattern HMGB-1 in the hippocampus of male Sprague Dawley rats: a priming stimulus of microglia and the NLRP3 inflammasome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 1. 2015-03-20. PMID:25568124. |
hippocampal microglia were isolated 24 h later and stimulated with lps ex vivo to probe for stress-induced sensitization of proinflammatory responses. |
2015-03-20 |
2023-08-13 |
rat |
| Dong-Sung Lee, Gil-Saeng Jeon. Arylbenzofuran isolated from Dalbergia odorifera suppresses lipopolysaccharide-induced mouse BV2 microglial cell activation, which protects mouse hippocampal HT22 cells death from neuroinflammation-mediated toxicity. European journal of pharmacology. vol 728. 2015-03-02. PMID:24485892. |
arylbenzofuran isolated from dalbergia odorifera suppresses lipopolysaccharide-induced mouse bv2 microglial cell activation, which protects mouse hippocampal ht22 cells death from neuroinflammation-mediated toxicity. |
2015-03-02 |
2023-08-12 |
mouse |
| Giulia Ronchi, Vitaly Ryu, Michele Fornaro, Krzysztof Czaj. Hippocampal plasticity after a vagus nerve injury in the rat. Neural regeneration research. vol 7. issue 14. 2015-02-27. PMID:25722695. |
both the capsaicin- and the vagotomy-induced damage to the vagus nerve decreased microglia activation in the hippocampus at 15 days after the injury. |
2015-02-27 |
2023-08-13 |
rat |
| Simon M L Paine, Alex R Willsher, Sarah L Nicholson, Neil J Sebire, Thomas S Jacque. Characterization of a population of neural progenitor cells in the infant hippocampus. Neuropathology and applied neurobiology. vol 40. issue 5. 2015-02-26. PMID:23742713. |
prompted by the observations that a sensitive immunohistochemical marker of microglia used in diagnostic practice does not typically stain these cells and that the hippocampus is a site of postnatal neurogenesis, we hypothesized that this transient population of cells were not microglia but neural progenitors. |
2015-02-26 |
2023-08-12 |
Not clear |
| Peter L P Smith, Henrik Hagberg, Andrew S Naylor, Carina Mallar. Neonatal peripheral immune challenge activates microglia and inhibits neurogenesis in the developing murine hippocampus. Developmental neuroscience. vol 36. issue 2. 2015-02-23. PMID:24642725. |
neonatal peripheral immune challenge activates microglia and inhibits neurogenesis in the developing murine hippocampus. |
2015-02-23 |
2023-08-12 |
Not clear |
| Hiroko Nomaru, Kunihiko Sakumi, Atsuhisa Katogi, Yoshinori N Ohnishi, Kosuke Kajitani, Daisuke Tsuchimoto, Eric J Nestler, Yusaku Nakabepp. Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia. Glia. vol 62. issue 8. 2015-02-04. PMID:24771617. |
in this study, we found that microglia express equivalent levels of fosb and Δfosb mrnas to hippocampal neurons and, using microarray analysis, we identified six microglial genes whose expression is dependent on fosb products. |
2015-02-04 |
2023-08-13 |
mouse |
| Robert Nunan, Harri Sivasathiaseelan, Damla Khan, Malik Zaben, William Gra. Microglial VPAC1R mediates a novel mechanism of neuroimmune-modulation of hippocampal precursor cells via IL-4 release. Glia. vol 62. issue 8. 2015-02-04. PMID:24801739. |
here, we show that depleting microglia from hippocampal cultures reduces nspc survival and proliferation. |
2015-02-04 |
2023-08-13 |
Not clear |
| Robert Nunan, Harri Sivasathiaseelan, Damla Khan, Malik Zaben, William Gra. Microglial VPAC1R mediates a novel mechanism of neuroimmune-modulation of hippocampal precursor cells via IL-4 release. Glia. vol 62. issue 8. 2015-02-04. PMID:24801739. |
furthermore, addition of purified hippocampal microglia, or their conditioned media, is trophic and proliferative to nspcs. |
2015-02-04 |
2023-08-13 |
Not clear |
| Peter Toth, Zsuzsanna Tucsek, Stefano Tarantini, Danuta Sosnowska, Tripti Gautam, Matthew Mitschelen, Akos Koller, William E Sonntag, Anna Csiszar, Zoltan Ungvar. IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 34. issue 12. 2015-02-04. PMID:25248835. |
likely downstream consequences of cerebrovascular autoregulatory dysfunction in hypertensive igf-1-deficient mice included exacerbated disruption of the blood-brain barrier and neuroinflammation (microglia activation and upregulation of proinflammatory cytokines and chemokines), which were associated with impaired hippocampal cognitive function. |
2015-02-04 |
2023-08-13 |
mouse |
| Jing Cai, Da Jing, Ming Shi, Yang Liu, Tian Lin, Zhen Xie, Yi Zhu, Haibo Zhao, Xiaodan Shi, Fang Du, Gang Zha. Epigallocatechin gallate (EGCG) attenuates infrasound-induced neuronal impairment by inhibiting microglia-mediated inflammation. The Journal of nutritional biochemistry. vol 25. issue 7. 2015-01-27. PMID:24746834. |
we showed that, after 1-, 2- or 5-day exposure of rats to 16 hz, 130 db infrasound (2 h/day), egcg significantly inhibited infrasound-induced microglial activation in rat hippocampal region, evidenced by reduced expressions of iba-1 (a marker for microglia) and proinflammatory cytokines (il-1β, il-6, il-18 and tnf-α). |
2015-01-27 |
2023-08-13 |
rat |
| Antiño R Allen, Kirsten Eilertson, Sourabh Sharma, Jennifer Baure, Barrett Allen, David Leu, Susanna Rosi, Jacob Raber, Ting-Ting Huang, John R Fik. Delayed administration of alpha-difluoromethylornithine prevents hippocampus-dependent cognitive impairment after single and combined injury in mice. Radiation research. vol 182. issue 5. 2015-01-26. PMID:25375198. |
after cognitive testing, animals were euthanized and their brains snap frozen for immunohistochemical assessment of neuroinflammation (activated microglia) and neurogenesis in the hippocampal dentate gyrus. |
2015-01-26 |
2023-08-13 |
mouse |
| T Kreisel, M G Frank, T Licht, R Reshef, O Ben-Menachem-Zidon, M V Baratta, S F Maier, R Yirmiy. Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis. Molecular psychiatry. vol 19. issue 6. 2015-01-09. PMID:24342992. |
we report that following an initial period (2-3 days) of stress-induced microglial proliferation and activation, some microglia underwent apoptosis, leading to reductions in their numbers within the hippocampus, but not in other brain regions, following 5 weeks of cus exposure. |
2015-01-09 |
2023-08-12 |
mouse |
| Zhao Yang, Tianzhi Zhao, Yongjie Zou, John H Zhang, Hua Fen. Curcumin inhibits microglia inflammation and confers neuroprotection in intracerebral hemorrhage. Immunology letters. vol 160. issue 1. 2015-01-06. PMID:24680995. |
in addition, curcumin protected hippocampal ht22 cells from indirect toxicity mediated by ich-treated microglia cells. |
2015-01-06 |
2023-08-12 |
Not clear |
| Kae M Pusic, Aya D Pusic, Jordan Kemme, Richard P Krai. Spreading depression requires microglia and is decreased by their M2a polarization from environmental enrichment. Glia. vol 62. issue 7. 2015-01-02. PMID:24723305. |
selective ablation of microglia from rat hippocampal slice cultures confirmed that microglia are essential for initiation of sd. |
2015-01-02 |
2023-08-13 |
rat |
| Marcus Boehme, Madlen Guenther, Anna Stahr, Marie Liebmann, Nadine Jaenisch, Otto W Witte, Christiane Frah. Impact of indomethacin on neuroinflammation and hippocampal neurogenesis in aged mice. Neuroscience letters. vol 572. 2014-12-23. PMID:24796813. |
during hippocampal aging, the transcript expression of pro-inflammatory cytokines (tnfα, il-1α, il-1β), the chemokine mip-1α, and markers for activated astrocytes (gfap, lcn2, but not vim and serpina3n) and microglia (iba1, f4/80, cd68, cd86) significantly increased. |
2014-12-23 |
2023-08-13 |
mouse |
| Junfang Wu, Zaorui Zhao, Boris Sabirzhanov, Bogdan A Stoica, Alok Kumar, Tao Luo, Jacob Skovira, Alan I Fade. Spinal cord injury causes brain inflammation associated with cognitive and affective changes: role of cell cycle pathways. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 33. 2014-12-16. PMID:25122899. |
sci caused chronic microglial activation in the hippocampus and cerebral cortex, where microglia with hypertrophic morphologies and m1 phenotype predominated. |
2014-12-16 |
2023-08-13 |
mouse |
| Jee Y Lee, Hyung E Lee, So R Kang, Hye Y Choi, Jong H Ryu, Tae Y Yun. Fluoxetine inhibits transient global ischemia-induced hippocampal neuronal death and memory impairment by preventing blood-brain barrier disruption. Neuropharmacology. vol 79. 2014-12-03. PMID:24316161. |
in addition, the activation of microglia and astrocyte in hippocampal regions was significantly attenuated by fluoxetine. |
2014-12-03 |
2023-08-12 |
Not clear |
| Sha Sha, Xiao-Na Xing, Yun-Peng Ca. Active immunotherapy facilitates Aβ plaque removal following through microglial activation without obvious T cells infiltrating the CNS. Journal of neuroimmunology. vol 274. issue 1-2. 2014-11-11. PMID:25087756. |
immunohistochemical and immunofluorescence showed there was significantly less plaque deposition accomplied with less microglia activation as detected both in the frontal cortex and hippocampus. |
2014-11-11 |
2023-08-13 |
mouse |
| Xiaoxia Zhu, Juyeon Park, Julianne Golinski, Jianhua Qiu, Jugta Khuman, Christopher C H Lee, Eng H Lo, Alexei Degterev, Michael J Whale. Role of Akt and mammalian target of rapamycin in functional outcome after concussive brain injury in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 34. issue 9. 2014-10-31. PMID:24938400. |
in a mouse closed head injury (chi) concussion traumatic brain injury (tbi) model, phosphorylation of akt (p-akt), mtor (p-mtor), and s6rp (p-s6rp) was increased by 24 hours in cortical and hippocampal brain homogenates (p<0.05 versus sham for each), and p-s6rp was robustly induced in iba-1+ microglia and glial fibrillary acidic protein-positive (gfap+) astrocytes. |
2014-10-31 |
2023-08-13 |
mouse |