| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Debora Cutuli, Paola De Bartolo, Paola Caporali, Daniela Laricchiuta, Francesca Foti, Maurizio Ronci, Claudia Rossi, Cristina Neri, Gianfranco Spalletta, Carlo Caltagirone, Stefano Farioli-Vecchioli, Laura Petrosin. n-3 polyunsaturated fatty acids supplementation enhances hippocampal functionality in aged mice. Frontiers in aging neuroscience. vol 6. 2014-09-09. PMID:25202271. |
in fact, n-3 pufa supplementation increased hippocampal neurogenesis and dendritic arborization of newborn neurons, volume, neuronal density and microglial cell number, while it decreased apoptosis, astrocytosis and lipofuscin accumulation in the hippocampus. |
2014-09-09 |
2023-08-13 |
mouse |
| Stephanie L Aungst, Shruti V Kabadi, Scott M Thompson, Bogdan A Stoica, Alan I Fade. Repeated mild traumatic brain injury causes chronic neuroinflammation, changes in hippocampal synaptic plasticity, and associated cognitive deficits. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 34. issue 7. 2014-09-02. PMID:24756076. |
repeated mtbi caused substantial neuronal cell loss and significantly increased numbers of activated microglia in both ipsilateral and contralateral hippocampus on post-injury day (pid) 28. |
2014-09-02 |
2023-08-13 |
rat |
| C A McPherson, B A Merrick, G J Harr. In vivo molecular markers for pro-inflammatory cytokine M1 stage and resident microglia in trimethyltin-induced hippocampal injury. Neurotoxicity research. vol 25. issue 1. 2014-08-28. PMID:24002884. |
in vivo molecular markers for pro-inflammatory cytokine m1 stage and resident microglia in trimethyltin-induced hippocampal injury. |
2014-08-28 |
2023-08-12 |
mouse |
| Fen He, Jun-Tao Zou, Qiong-Fang Zhou, Dao-Li Niu, Wei-Hua Ji. Glatiramer acetate reverses cognitive deficits from cranial-irradiated rat by inducing hippocampal neurogenesis. Journal of neuroimmunology. vol 271. issue 1-2. 2014-08-18. PMID:24713401. |
the numbers of iba-i-positive microglia, brdu(+)/dcx(+) cells and brdu(+)/neun(+) cells in hippocampus increased, which are accompanied with increased ifn-γ and decreased il-6, il-4. |
2014-08-18 |
2023-08-13 |
rat |
| Ukpong B Eyo, Sam A Miner, Katelin E Ahlers, Long-Jun Wu, Michael E Daile. P2X7 receptor activation regulates microglial cell death during oxygen-glucose deprivation. Neuropharmacology. vol 73. 2014-08-13. PMID:23770338. |
to validate and extend these in vitro findings, we assessed parenchymal microglia in freshly isolated hippocampal tissue slices from gfp-reporter mice (cx3cr1(gfp/+)). |
2014-08-13 |
2023-08-12 |
mouse |
| Robert Nisticò, Francesco Mori, Marco Feligioni, Ferdinando Nicoletti, Diego Centonz. Synaptic plasticity in multiple sclerosis and in experimental autoimmune encephalomyelitis. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 369. issue 1633. 2014-08-11. PMID:24298163. |
evidence obtained from a mouse model of ms, the experimental autoimmune encephalomyelitis (eae), suggests that in the hippocampus of eae mice long-term potentiation (ltp) is favoured over long-term depression in response to repetitive synaptic activation, through a mechanism dependent on enhanced il-1β released from infiltrating lymphocytes or activated microglia. |
2014-08-11 |
2023-08-12 |
mouse |
| Gregory P Marshall, Loic P Deleyrolle, Brent A Reynolds, Dennis A Steindler, Eric D Laywel. Microglia from neurogenic and non-neurogenic regions display differential proliferative potential and neuroblast support. Frontiers in cellular neuroscience. vol 8. 2014-07-31. PMID:25076873. |
microglia isolated from the neurogenic subependymal zone (sez) and hippocampus (hc) are capable of massive in vitro population expansion that is not possible with microglia isolated from non-neurogenic regions. |
2014-07-31 |
2023-08-13 |
Not clear |
| Yi Wang, Huijuan He, Dan Li, Wenjing Zhu, Kaiming Duan, Yuan Le, Yan Liao, Yangwen O. The role of the TLR4 signaling pathway in cognitive deficits following surgery in aged rats. Molecular medicine reports. vol 7. issue 4. 2014-07-25. PMID:23426570. |
shortly after surgery, aged rats demonstrated significant deficits in memory and learning, accompanied by the activation of microglia, marked upregulation of tlr4 on microglia in the hippocampus, as well as an increased expression of two downstream factors [myeloid differentiation factor 88 (myd88) and tir-domain-containing adapter-inducing interferon-β (trif)] and pro-inflammatory cytokines [including tumor necrosis factor α (tnf-α) and interleukin 1β (il-1β)]. |
2014-07-25 |
2023-08-12 |
rat |
| Takeshi Kanaumi, Ivan Milenkovic, Homa Adle-Biassette, Eleonora Aronica, Gabor G Kovac. Non-neuronal cell responses differ between normal and Down syndrome developing brains. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 31. issue 8. 2014-07-23. PMID:24113258. |
we evaluated immunoreactivity for cd68 (macrophage), hla-dr (microglia), olig2 and tppp/p25 (oligodendroglia), and gfap (astroglia) in the germinal matrix (gm), temporal lobe white matter (tewm) and hippocampus from 14 weeks of gestations to newborn in 28 ds patients and 30 age-matched controls. |
2014-07-23 |
2023-08-12 |
Not clear |
| Jeong-Ho Song, Ju-Won Lee, Beomsoo Shim, Chang-Yeol Lee, Sooyong Choi, Chulhun Kang, Nak-Won Sohn, Jung-Won Shi. Glycyrrhizin alleviates neuroinflammation and memory deficit induced by systemic lipopolysaccharide treatment in mice. Molecules (Basel, Switzerland). vol 18. issue 12. 2014-07-18. PMID:24352029. |
in the hippocampal tissue, grz significantly reduced the up-regulated iba1 protein expression and the average cell size of iba1-expressing microglia induced by lps. |
2014-07-18 |
2023-08-12 |
mouse |
| Inelia Morales, José M Jiménez, Marcela Mancilla, Ricardo B Maccion. Tau oligomers and fibrils induce activation of microglial cells. Journal of Alzheimer's disease : JAD. vol 37. issue 4. 2014-07-13. PMID:23948931. |
furthermore, conditioned media of stimulated microglia cells were exposed to hippocampal neurons generating altered patterns in these cells, including shortening of neuritic processes and cytoskeleton reorganization. |
2014-07-13 |
2023-08-12 |
Not clear |
| Peter Ferrazzano, Vishal Chanana, Kutluay Uluc, Emin Fidan, Erinc Akture, Douglas B Kintner, Pelin Cengiz, Dandan Su. Age-dependent microglial activation in immature brains after hypoxia- ischemia. CNS & neurological disorders drug targets. vol 12. issue 3. 2014-07-11. PMID:23469850. |
p9 brains demonstrated a 2-3 fold greater increase in microglia counts than p30 brains in each region (hippocampus, cortex, and striatum) during day 1-17 post-hi. |
2014-07-11 |
2023-08-12 |
mouse |
| Rachel A Kohman, Tushar K Bhattacharya, Elzbieta Wojcik, Justin S Rhode. Exercise reduces activation of microglia isolated from hippocampus and brain of aged mice. Journal of neuroinflammation. vol 10. 2014-06-25. PMID:24044641. |
exercise reduces activation of microglia isolated from hippocampus and brain of aged mice. |
2014-06-25 |
2023-08-12 |
mouse |
| Rachel A Kohman, Tushar K Bhattacharya, Elzbieta Wojcik, Justin S Rhode. Exercise reduces activation of microglia isolated from hippocampus and brain of aged mice. Journal of neuroinflammation. vol 10. 2014-06-25. PMID:24044641. |
therefore, we evaluated changes in basal microglia activation in cells isolated from the hippocampus and remaining brain following running-wheel access. |
2014-06-25 |
2023-08-12 |
mouse |
| Motohide Furuya, Tsuyoshi Miyaoka, Toshiko Tsumori, Kristian Liaury, Sadayuki Hashioka, Rei Wake, Keiko Tsuchie, Michiyo Fukushima, Satoko Ezoe, Jun Horiguch. Yokukansan promotes hippocampal neurogenesis associated with the suppression of activated microglia in Gunn rat. Journal of neuroinflammation. vol 10. 2014-06-25. PMID:24305622. |
yokukansan promotes hippocampal neurogenesis associated with the suppression of activated microglia in gunn rat. |
2014-06-25 |
2023-08-12 |
rat |
| Gaurav Singhal, Emily J Jaehne, Frances Corrigan, Bernhard T Baun. Cellular and molecular mechanisms of immunomodulation in the brain through environmental enrichment. Frontiers in cellular neuroscience. vol 8. 2014-06-24. PMID:24772064. |
physical exercise (pe), a form of ee, elicits anti-inflammatory and neuromodulatory effects through interaction with several immune pathways including interleukin (il)-6 secretion from muscle fibers, reduced expression of toll-like receptors on monocytes and macrophages, reduced secretion of adipokines, modulation of hippocampal t cells, priming of microglia, and upregulation of mitogen-activated protein kinase phosphatase-1 in central nervous system. |
2014-06-24 |
2023-08-13 |
Not clear |
| Satoshi Okuyama, Kana Yamamoto, Hirotomo Mori, Nobuki Toyoda, Morio Yoshimura, Yoshiaki Amakura, Takashi Yoshida, Kuniaki Sugawara, Masahiko Sudo, Mitsunari Nakajima, Yoshiko Furukaw. Auraptene in the Peels of Citrus kawachiensis (Kawachi Bankan) Ameliorates Lipopolysaccharide-Induced Inflammation in the Mouse Brain. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-06-23. PMID:24955102. |
when this dried peel powder was orally preadministered at the dose of 1.2 or 2.4 g/kg/day for 7 days into lipopolysaccharide- (lps-) injected mice, an animal model of systemic inflammation, it suppressed (1) lps-induced loss of body weight and abnormal behavior in the open field, (2) lps-induced activation of microglia and astrocytes in the hippocampus, and (3) lps-induced expression of cyclooxygenase (cox)-2, which were coexpressed in astrocytes of these mice. |
2014-06-23 |
2023-08-13 |
mouse |
| K S Dhami, M A Churchward, G B Baker, K G Tod. Fluoxetine and citalopram decrease microglial release of glutamate and D-serine to promote cortical neuronal viability following ischemic insult. Molecular and cellular neurosciences. vol 56. 2014-06-20. PMID:23876875. |
antidepressants have been shown to promote midbrain and hippocampal neuronal survival following an ischemic insult and this survival is mediated through the anti-inflammatory effects on microglia, but the effects on cortical neuronal survival after this insult have yet to be investigated. |
2014-06-20 |
2023-08-12 |
Not clear |
| Thereza Quirico-Santos, Angélica Nascimento Mello, Aline Casimiro Gomes, Lian Pontes de Carvalho, Jorge Marcondes de Souza, Soniza Alves-Leo. Increased metalloprotease activity in the epileptogenic lesion--Lobectomy reduces metalloprotease activity and urokinase-type uPAR circulating levels. Brain research. vol 1538. 2014-06-20. PMID:24095794. |
surgical fragments (n=4) from epileptogenic focus (ef) e perilesion area (pl), and control hippocampus from autopsy (n=5) were processed for glial protein (gfap), activated microglia (ib4) immunohistochemistry, and metalloprotease activity (mmp-2, -9). |
2014-06-20 |
2023-08-12 |
Not clear |
| Vipan K Parihar, Bharathi Hattiangady, Bing Shuai, Ashok K Shett. Mood and memory deficits in a model of Gulf War illness are linked with reduced neurogenesis, partial neuron loss, and mild inflammation in the hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 12. 2014-06-03. PMID:23807240. |
we investigated the effect of 4 weeks of exposure to gulf war illness-related (gwir) chemicals in the absence or presence of mild stress on mood and cognitive function, dentate gyrus neurogenesis, and neurons, microglia, and astrocytes in the hippocampus. |
2014-06-03 |
2023-08-12 |
Not clear |