| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vipan K Parihar, Bharathi Hattiangady, Bing Shuai, Ashok K Shett. Mood and memory deficits in a model of Gulf War illness are linked with reduced neurogenesis, partial neuron loss, and mild inflammation in the hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 12. 2014-06-03. PMID:23807240. |
furthermore, these behavioral impairments were associated with reduced hippocampal volume and multiple cellular alterations such as chronic reductions in neural stem cell activity and neurogenesis, partial loss of principal neurons, and mild inflammation comprising sporadic occurrence of activated microglia and significant hypertrophy of astrocytes. |
2014-06-03 |
2023-08-12 |
Not clear |
| Graham L Collingridge, Stephane Peinea. Strippers reveal their depressing secrets: removing AMPA receptors. Neuron. vol 82. issue 1. 2014-06-02. PMID:24698263. |
(2014) describe a novel form of long-term depression of ampa receptor-mediated synaptic transmission in the hippocampus involving the activation of microglia. |
2014-06-02 |
2023-08-13 |
Not clear |
| J J Rodríguez, H N Noristani, T Hilditch, M Olabarria, C Y Yeh, J Witton, A Verkhratsk. Increased densities of resting and activated microglia in the dentate gyrus follow senile plaque formation in the CA1 subfield of the hippocampus in the triple transgenic model of Alzheimer's disease. Neuroscience letters. vol 552. 2014-05-15. PMID:23827221. |
increased densities of resting and activated microglia in the dentate gyrus follow senile plaque formation in the ca1 subfield of the hippocampus in the triple transgenic model of alzheimer's disease. |
2014-05-15 |
2023-08-12 |
mouse |
| J J Rodríguez, H N Noristani, T Hilditch, M Olabarria, C Y Yeh, J Witton, A Verkhratsk. Increased densities of resting and activated microglia in the dentate gyrus follow senile plaque formation in the CA1 subfield of the hippocampus in the triple transgenic model of Alzheimer's disease. Neuroscience letters. vol 552. 2014-05-15. PMID:23827221. |
although post-mortem studies suggest later involvement of the dg into the ad progression, changes in microglia have not been studied in this subfield of the hippocampus. |
2014-05-15 |
2023-08-12 |
mouse |
| Ana M García-Cabrero, Rosa Guerrero-López, Beatriz G Giráldez, María Llorens-Martín, Jesús Avila, José M Serratosa, Marina P Sánche. Hyperexcitability and epileptic seizures in a model of frontotemporal dementia. Neurobiology of disease. vol 58. 2014-04-23. PMID:23774255. |
astrocytosis and activated microglia are prominent in the hippocampus and other brain regions of young ftdp-17 mice where the human mutant tau transgene is expressed, before the appearance of hyperphosphorylated tau aggregates in these structures. |
2014-04-23 |
2023-08-12 |
mouse |
| Gergely Silasi, Frederick Colbourn. Unilateral brain hypothermia as a method to examine efficacy and mechanisms of neuroprotection against global ischemia. Therapeutic hypothermia and temperature management. vol 1. issue 2. 2014-04-11. PMID:24716998. |
near-complete injury and a strong microglia response occurred in the left (normothermic) hippocampus as occurred in both hippocampi of the untreated group. |
2014-04-11 |
2023-08-13 |
rat |
| Paola Forabosco, Adaikalavan Ramasamy, Daniah Trabzuni, Robert Walker, Colin Smith, Jose Bras, Adam P Levine, John Hardy, Jennifer M Pocock, Rita Guerreiro, Michael E Weale, Mina Ryte. Insights into TREM2 biology by network analysis of human brain gene expression data. Neurobiology of aging. vol 34. issue 12. 2014-04-02. PMID:23855984. |
using network analysis, we detect a highly preserved trem2-containing module in human brain, show that it relates to microglia, and demonstrate that trem2 is a hub gene in 5 brain regions, including the hippocampus, suggesting that it can drive module function. |
2014-04-02 |
2023-08-12 |
human |
| Monica R P Elmore, Michael D Burton, Matthew S Conrad, Jennifer L Rytych, William G Van Alstine, Rodney W Johnso. Respiratory viral infection in neonatal piglets causes marked microglia activation in the hippocampus and deficits in spatial learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 6. 2014-04-01. PMID:24501353. |
respiratory viral infection in neonatal piglets causes marked microglia activation in the hippocampus and deficits in spatial learning. |
2014-04-01 |
2023-08-12 |
human |
| Monica R P Elmore, Michael D Burton, Matthew S Conrad, Jennifer L Rytych, William G Van Alstine, Rodney W Johnso. Respiratory viral infection in neonatal piglets causes marked microglia activation in the hippocampus and deficits in spatial learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 6. 2014-04-01. PMID:24501353. |
using a piglet model, the present study showed that inoculation on postnatal day 7 with the porcine reproductive and respiratory syndrome virus (prrsv) caused microglial activation within the hippocampus with 82% and 43% of isolated microglia being mhc ii(+) 13 and 20 d after inoculation, respectively. |
2014-04-01 |
2023-08-12 |
human |
| Monica R P Elmore, Michael D Burton, Matthew S Conrad, Jennifer L Rytych, William G Van Alstine, Rodney W Johnso. Respiratory viral infection in neonatal piglets causes marked microglia activation in the hippocampus and deficits in spatial learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 6. 2014-04-01. PMID:24501353. |
in control piglets, <5% of microglia isolated from the hippocampus were mhc ii(+). |
2014-04-01 |
2023-08-12 |
human |
| Monica R P Elmore, Michael D Burton, Matthew S Conrad, Jennifer L Rytych, William G Van Alstine, Rodney W Johnso. Respiratory viral infection in neonatal piglets causes marked microglia activation in the hippocampus and deficits in spatial learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 6. 2014-04-01. PMID:24501353. |
overall, these data demonstrate that viral respiratory infection is associated with a marked increase in activated microglia in the hippocampus, neuroinflammation, and impaired performance in a spatial cognitive task. |
2014-04-01 |
2023-08-12 |
human |
| Isabelle Bardou, Holly M Brothers, Roxanne M Kaercher, Sarah C Hopp, Gary L Wen. Differential effects of duration and age on the consequences of neuroinflammation in the hippocampus. Neurobiology of aging. vol 34. issue 10. 2014-03-25. PMID:23639208. |
the duration of the lipopolysaccharide infusion, compared with the age of the rat, had the greatest effect on (1) spatial working memory; (2) the density and distribution of activated microglia within the hippocampus; and (3) the cytokine protein and gene expression profiles within the hippocampus. |
2014-03-25 |
2023-08-12 |
human |
| Carmelina Gemma, Adam D Bachstette. The role of microglia in adult hippocampal neurogenesis. Frontiers in cellular neuroscience. vol 7. 2014-03-25. PMID:24319411. |
the role of microglia in adult hippocampal neurogenesis. |
2014-03-25 |
2023-08-12 |
Not clear |
| Carmelina Gemma, Adam D Bachstette. The role of microglia in adult hippocampal neurogenesis. Frontiers in cellular neuroscience. vol 7. 2014-03-25. PMID:24319411. |
from cells being "silent" in the healthy brain, microglia have emerged to be actively involved in several brain physiological functions including adult hippocampal neurogenesis, and cognitive and behavioral function. |
2014-03-25 |
2023-08-12 |
Not clear |
| Carmelina Gemma, Adam D Bachstette. The role of microglia in adult hippocampal neurogenesis. Frontiers in cellular neuroscience. vol 7. 2014-03-25. PMID:24319411. |
in light of recent discoveries revealing a role of microglia as important effectors of neuronal circuit reorganization, considerable attention has been focused on how microglia and hippocampal neurogenesis could be an interdependent phenomenon. |
2014-03-25 |
2023-08-12 |
Not clear |
| Carmelina Gemma, Adam D Bachstette. The role of microglia in adult hippocampal neurogenesis. Frontiers in cellular neuroscience. vol 7. 2014-03-25. PMID:24319411. |
in this review the role of microglia in the adult hippocampal neurogenesis under physiological condition is discussed. |
2014-03-25 |
2023-08-12 |
Not clear |
| Isabel Lastres-Becker, Nadia G Innamorato, Tomasz Jaworski, Alberto Rábano, Sebastian Kügler, Fred Van Leuven, Antonio Cuadrad. Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis. Brain : a journal of neurology. vol 137. issue Pt 1. 2014-03-11. PMID:24277722. |
here, we show that hippocampal ht22 cells expressing human tau(p301l) mutant protein produce fractalkine, which in microglia activates akt, inhibits glycogen synthase kinase-3β and upregulates the transcription factor nrf2/nfe2l2 and its target genes including heme oxygenase 1. |
2014-03-11 |
2023-08-12 |
mouse |
| Isabel Lastres-Becker, Nadia G Innamorato, Tomasz Jaworski, Alberto Rábano, Sebastian Kügler, Fred Van Leuven, Antonio Cuadrad. Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis. Brain : a journal of neurology. vol 137. issue Pt 1. 2014-03-11. PMID:24277722. |
the hippocampus of patients with alzheimer's disease also exhibits increased expression of fractalkine in tau-injured neurons that recruit microglia. |
2014-03-11 |
2023-08-12 |
mouse |
| Derek A Costello, Marina A Lync. Toll-like receptor 3 activation modulates hippocampal network excitability, via glial production of interferon-β. Hippocampus. vol 23. issue 8. 2014-03-05. PMID:23554175. |
we provide evidence for the production of ifnβ from microglia and astrocytes, and using mice deficient in the type i ifn receptor α 1 (ifnar1), demonstrate that its subsequent activation is likely to underlie the tlr3-mediated modulation of hippocampal excitability. |
2014-03-05 |
2023-08-12 |
mouse |
| Jung-Won Shin, Young-Jin Cheong, Yong-Mo Koo, Sooyong Kim, Chung-Ku Noh, Young-Ha Son, Chulhun Kang, Nak-Won Soh. α-Asarone Ameliorates Memory Deficit in Lipopolysaccharide-Treated Mice via Suppression of Pro-Inflammatory Cytokines and Microglial Activation. Biomolecules & therapeutics. vol 22. issue 1. 2014-03-05. PMID:24596617. |
α-asarone did not reduce the number of iba1-expressing microglia on immunohistochemistry but the average cell size and percentage areas of iba1-expressing microglia in the hippocampus were significantly decreased by 30 mg/kg of α-asarone treatment. |
2014-03-05 |
2023-08-12 |
mouse |