| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bin Li, Longfei Du, Shusheng Wu, Yuye Yi. Protective effects of taurine on heat Stress-Induced cognitive impairment through Npas4 and Lcn2. International immunopharmacology. vol 143. issue Pt 1. 2024-10-15. PMID:39405930. |
the results revealed that taurine ameliorated cognitive deficits following hs in mice and mitigated hs-induced astrocyte and microglia activation as well as blood-brain barrier (bbb) damage in the hippocampus. |
2024-10-15 |
2024-10-18 |
mouse |
| Yu Chen, Cheng Long, Li Yan. Isolation and Whole-Cell Patch-Clamp Recording of Hippocampal Microglia from Adult Mice. Journal of visualized experiments : JoVE. issue 211. 2024-10-14. PMID:39400194. |
isolation and whole-cell patch-clamp recording of hippocampal microglia from adult mice. |
2024-10-14 |
2024-10-16 |
mouse |
| Yu Chen, Cheng Long, Li Yan. Isolation and Whole-Cell Patch-Clamp Recording of Hippocampal Microglia from Adult Mice. Journal of visualized experiments : JoVE. issue 211. 2024-10-14. PMID:39400194. |
this study introduces an easy-to-follow protocol for isolating hippocampal microglia from adult mice and performing whole-cell patch-clamp recordings on the isolated cells. |
2024-10-14 |
2024-10-16 |
mouse |
| Yu Chen, Cheng Long, Li Yan. Isolation and Whole-Cell Patch-Clamp Recording of Hippocampal Microglia from Adult Mice. Journal of visualized experiments : JoVE. issue 211. 2024-10-14. PMID:39400194. |
briefly, the brain was removed from a mouse after decapitation, the hippocampus was dissected bilaterally, and microglia were isolated using an adult mouse brain dissociation kit. |
2024-10-14 |
2024-10-16 |
mouse |
| Mark B Stoessel, Rianne D Stowell, Rebecca L Lowery, Linh Le, Andy N Vu, Brendan S Whitelaw, Ania K Majewsk. The effects of P2Y12 loss on microglial gene expression, dynamics, and injury response in the cerebellum and cerebral cortex. bioRxiv : the preprint server for biology. 2024-10-10. PMID:39386439. |
cerebellar microglia, in particular, exhibit transcriptional, epigenetic, and functional profiles that set them apart from their better studied cortical and hippocampal counterparts. |
2024-10-10 |
2024-10-12 |
Not clear |
| Soojin Park, Soomi Cho, Kyung Min Kim, Min Kyung Chu, Chul Hoon Kim, Kyoung Hoon Jeong, Won-Joo Ki. Honokiol-induced SIRT3 upregulation protects hippocampal neurons by suppressing inflammatory processes in pilocarpine-induced status epilepticus. Neurochemistry international. 2024-10-03. PMID:39362498. |
post-treatment with hnk after se onset increased sirt3 expression, which mitigated glial activation, including reactive astrocytes and activated microglia, in the hippocampus following pcse. |
2024-10-03 |
2024-10-07 |
Not clear |
| Cheng-Gang Li, Lu-Shan Xu, Liang Sun, Yu-Hao Xu, Xiang Cao, Chen-Chen Zhao, Sheng-Nan Xia, Qing-Xiu Zhang, Yun X. Xiangshao Granules Ameliorate Post-Stroke Depression by Inhibiting Activation of Microglia and IDO1 Expression in Hippocampus and Prefrontal Cortex. Chinese journal of integrative medicine. 2024-10-02. PMID:39356429. |
xiangshao granules ameliorate post-stroke depression by inhibiting activation of microglia and ido1 expression in hippocampus and prefrontal cortex. |
2024-10-02 |
2024-10-04 |
Not clear |
| Ethan J Goodman, Damon J DiSabato, John F Sheridan, Jonathan P Godbou. Novel microglial transcriptional signatures promote social and cognitive deficits following repeated social defeat. Communications biology. vol 7. issue 1. 2024-09-29. PMID:39341879. |
using single-cell (sc)rnaseq, we identify novel, to the best of our knowledge, stress-associated microglia in the hippocampus defined by rna profiles of cytokine/chemokine signaling, cellular stress, and phagocytosis. |
2024-09-29 |
2024-10-01 |
mouse |
| Ethan J Goodman, Damon J DiSabato, John F Sheridan, Jonathan P Godbou. Novel microglial transcriptional signatures promote social and cognitive deficits following repeated social defeat. Communications biology. vol 7. issue 1. 2024-09-29. PMID:39341879. |
collectively, these stress-associated microglia influence transcriptional profiles in the hippocampus related to social and cognitive deficits. |
2024-09-29 |
2024-10-01 |
mouse |
| Xing Li, Erkai He, Guangquan Chen, Xinde Cao, Ling Zhao, Xiaoyun Xu, Zhuozhong Fu, Hao Qi. Intergenerational neurotoxicity of polystyrene nanoplastics in offspring mice is mediated by dysfunctional microbe-gut-brain axis. Environment international. vol 192. 2024-09-25. PMID:39321539. |
maternal psnps exposure significantly increased brain tnf-α level and microglia by 1.43 and 1.48 folds respectively, compared to control, accompanied by nuclear pyknosis and cell vacuolization in cortex and hippocampus. |
2024-09-25 |
2024-09-28 |
mouse |
| Sarah Steffens, Hilla Mäkinen, Tarja Stenberg, Henna-Kaisa Wigre. Microglial morphology aligns with vigilance stage-specific neuronal oscillations in a brain region-dependent manner. Glia. 2024-09-20. PMID:39301843. |
using iba1 immunostaining to identify microglia, we quantified morphological changes in microglia at different timepoints in multiple brain regions (cortex, hippocampus, basal forebrain, hindbrain, and cerebellum) in b6 male mice using semi-automated 3d structural analysis. |
2024-09-20 |
2024-09-22 |
mouse |
| Olawande Bamisi, Adesua Olukayode Oluwalabani, Tolulope Timothy Arogundade, Olayemi Joseph Olajid. Neuroinflammation and oxidative redox imbalance drive memory dysfunction in adolescent rats prenatally exposed to Datura Stramonium. Neurotoxicology and teratology. 2024-09-20. PMID:39303770. |
immunohistochemical labelling of gfap and iba-1 revealed increased expression of reactive astrocytes and microglia respectively, while the accompanying tnfα upregulation in both the hippocampus (dentate gyrus) and pfc causally linked intrauterine d. stramonium exposure with neuroinflammatory responses postnatally. |
2024-09-20 |
2024-09-23 |
rat |
| Qiu-Xia Xiao, Lu-Lu Xue, Ya-Xin Tan, Li-Ren Huangfu, Li Chen, Chen-Yang Zhai, Rui-Fang Ma, Mohammed Al-Hawwas, Hong-Su Zhou, Ting-Hua Wang, Xin-Fu Zhou, Liu-Lin Xion. p75ECD-Fc reverses neonatal hypoxic-ischemic encephalopathy-induced neurological deficits and inhibits apoptosis associated with Nestin. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 179. 2024-09-15. PMID:39278187. |
additionally, in vivo immunostaining showed that p75ecd-fc administration enhanced neuronal survival and regeneration, and reduced astrocytosis and microglia activation in the cortex and hippocampus of nhie rats. |
2024-09-15 |
2024-09-18 |
human |
| Sean X Naughton, Eun-Jeong Yang, Umar Iqbal, Kyle Trageser, Daniel Charytonowicz, Sibilla Masieri, Molly Estill, Henry Wu, Urdhva Raval, Weiting Lyu, Qing-Li Wu, Li Shen, James Simon, Robert Sebra, Giulio Maria Pasinett. Permethrin exposure primes neuroinflammatory stress response to drive depression-like behavior through microglial activation in a mouse model of Gulf War Illness. Journal of neuroinflammation. vol 21. issue 1. 2024-09-14. PMID:39272155. |
this behavioral change coincided with distinct alterations in the microglia phenotype, indicating microglial activation in the hippocampus. |
2024-09-14 |
2024-09-16 |
mouse |
| Sean X Naughton, Eun-Jeong Yang, Umar Iqbal, Kyle Trageser, Daniel Charytonowicz, Sibilla Masieri, Molly Estill, Henry Wu, Urdhva Raval, Weiting Lyu, Qing-Li Wu, Li Shen, James Simon, Robert Sebra, Giulio Maria Pasinett. Permethrin exposure primes neuroinflammatory stress response to drive depression-like behavior through microglial activation in a mouse model of Gulf War Illness. Journal of neuroinflammation. vol 21. issue 1. 2024-09-14. PMID:39272155. |
to elucidate the transcriptional networks impacted within distinct microglia populations linked to depression-like behavior in mice exposed to both permethrin and stress, we conducted a single-cell rna sequencing analysis using 21,566 single nuclei collected from the hippocampus of mice. |
2024-09-14 |
2024-09-16 |
mouse |
| Shu Qing Zhang, Xiao Yu Wang, Shen Lin Liu, Ching Yuan Hu, Yong Hong Men. Phlorizin ameliorates cognitive and behavioral impairments via the microbiota-gut-brain axis in high-fat and high-fructose diet-induced obese male mice. Brain, behavior, and immunity. 2024-09-14. PMID:39277023. |
in addition, phlorizin improved the hffd-induced decrease in synaptic plasticity, neuroinflammation, and excessive activation of microglia in the hippocampus. |
2024-09-14 |
2024-09-18 |
mouse |
| Matthew Napier, Ashish Kumar, Natasha Szulist, Dale Martin, Angela L Scot. P2X7 expression patterns in the developing Fmr1-knockout mouse hippocampus. Hippocampus. 2024-09-13. PMID:39269925. |
we then evaluated the cell-specific expression of p2x7 with immunofluorescence and found differences between wt and fmr1 ko mice in p2x7 colocalization with hippocampal microglia and neurons. |
2024-09-13 |
2024-09-16 |
mouse |
| Giuseppe D Ciccotosto, Ali I Mohammed, Rita Paolini, Elly Bijlsma, Su Toulson, James Holden, Eric C Reynolds, Stuart G Dashper, Catherine A Butle. Chronic Oral Inoculation of Porphyromonas gingivalis and Treponema denticola Induce Different Brain Pathologies in a Mouse Model of Alzheimer Disease. The Journal of infectious diseases. vol 230. issue Supplement_2. 2024-09-10. PMID:39255392. |
p. gingivalis alone significantly increased all 7 brain pathologies examined: neuronal damage, activation of astrocytes and microglia, expression of inflammatory cytokines interleukin 1β (il-1β) and interleukin 6 and production of amyloid-β plaques and hyperphosphorylated tau, in the hippocampus, cortex and midbrain, compared to control mice. |
2024-09-10 |
2024-09-13 |
mouse |
| Giuseppe D Ciccotosto, Ali I Mohammed, Rita Paolini, Elly Bijlsma, Su Toulson, James Holden, Eric C Reynolds, Stuart G Dashper, Catherine A Butle. Chronic Oral Inoculation of Porphyromonas gingivalis and Treponema denticola Induce Different Brain Pathologies in a Mouse Model of Alzheimer Disease. The Journal of infectious diseases. vol 230. issue Supplement_2. 2024-09-10. PMID:39255392. |
t. denticola alone significantly increased neuronal damage, activation of astrocytes and microglia, and expression of il-1β, in the hippocampus, cortex and midbrain, compared to control mice. |
2024-09-10 |
2024-09-13 |
mouse |
| Giuseppe D Ciccotosto, Ali I Mohammed, Rita Paolini, Elly Bijlsma, Su Toulson, James Holden, Eric C Reynolds, Stuart G Dashper, Catherine A Butle. Chronic Oral Inoculation of Porphyromonas gingivalis and Treponema denticola Induce Different Brain Pathologies in a Mouse Model of Alzheimer Disease. The Journal of infectious diseases. vol 230. issue Supplement_2. 2024-09-10. PMID:39255392. |
coinoculation of p. gingivalis with t. denticola significantly increased activation of astrocytes and microglia in the hippocampus, cortex and midbrain, and increased production of hyperphosphorylated tau and il-1β in the hippocampus only. |
2024-09-10 |
2024-09-13 |
mouse |