| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiangong Zhang, Qinqin Zhu, Xun Shi, Yang Huang, Linlin Yan, Guozheng Zhang, Lei Pei, Jiahuan Liu, Xiaowei Han, Xisong Zh. NIR-II light therapy improves cognitive performance in MPTP induced Parkinson's disease rat models: A preliminary experimental study. Heliyon. vol 10. issue 12. 2024-07-08. PMID:38975234. |
the multiple fluorescence immunohistochemistry analysis trend plot showed that the activated microglia and astrocytes in the hippocampus were highest in mptp-induced pd untreated group, moderate in mptp-induced pd treatment group, and lowest in the control group. |
2024-07-08 |
2024-07-11 |
rat |
| Jiangong Zhang, Qinqin Zhu, Xun Shi, Yang Huang, Linlin Yan, Guozheng Zhang, Lei Pei, Jiahuan Liu, Xiaowei Han, Xisong Zh. NIR-II light therapy improves cognitive performance in MPTP induced Parkinson's disease rat models: A preliminary experimental study. Heliyon. vol 10. issue 12. 2024-07-08. PMID:38975234. |
our data indicates that nir-ii illumination improves learning and cognitive impairment as well as coordination and balance abilities in pd rats by downregulating the activation of microglia and astrocytes in the hippocampus. |
2024-07-08 |
2024-07-11 |
rat |
| Jing Bian, Chunxu Liu, Xiang Li, Xiaoye Qin, Feng Wang, Lina Xuan, Weimin Zhan. Electroacupuncture improves the learning and memory abilities of rats with PSCI by attenuating the TLR4/NF-κB/NLRP3 signaling pathway on the hippocampal microglia. Neuroreport. 2024-06-27. PMID:38935074. |
electroacupuncture improves the learning and memory abilities of rats with psci by attenuating the tlr4/nf-κb/nlrp3 signaling pathway on the hippocampal microglia. |
2024-06-27 |
2024-06-29 |
rat |
| Jing Bian, Chunxu Liu, Xiang Li, Xiaoye Qin, Feng Wang, Lina Xuan, Weimin Zhan. Electroacupuncture improves the learning and memory abilities of rats with PSCI by attenuating the TLR4/NF-κB/NLRP3 signaling pathway on the hippocampal microglia. Neuroreport. 2024-06-27. PMID:38935074. |
this study aims to investigate how electroacupuncture regulates the learning and memory abilities of poststroke cognitive impairment (psci) rats through the tlr4/nf-κb/nlrp3 signaling pathway on the hippocampal microglia. |
2024-06-27 |
2024-06-29 |
rat |
| Jing Bian, Chunxu Liu, Xiang Li, Xiaoye Qin, Feng Wang, Lina Xuan, Weimin Zhan. Electroacupuncture improves the learning and memory abilities of rats with PSCI by attenuating the TLR4/NF-κB/NLRP3 signaling pathway on the hippocampal microglia. Neuroreport. 2024-06-27. PMID:38935074. |
its mechanism was related to inhibiting the expression of the tlr4/nf-κb/nlrp3 signaling pathway, attenuating the release of inflammatory factors, and regulating the activation of hippocampal microglia in the brain. |
2024-06-27 |
2024-06-29 |
rat |
| Jia-Rui Zhang, Shi-Yu Shen, Zu-Qi Shen, Shu-Yuan Yin, Ke Ye, Wei Li, Hao-Yuan Li, Ling-Feng Liang, Yan-Qing Wang, Xiao-Yun Guo, Jin Y. Role of mitochondria-associated membranes in the hippocampus in the pathogenesis of depression. Journal of affective disorders. 2024-06-24. PMID:38914161. |
pathological changes, such as microglia activation in the hippocampus frequently occur in individuals with animal models of depression; however, they may share a common cellular mechanism, such as endoplasmic reticulum (er) stress and mitochondrial dysfunction. |
2024-06-24 |
2024-06-27 |
Not clear |
| Hooman Hatami, Vahid Reza Askari, Vafa Baradaran Rahimi, Md Saquib Hasnain, Amit Kumar Naya. The Dilemma of Insulin Delivery into the Brain: A Comprehensive Review. Current drug delivery. 2024-06-24. PMID:38910469. |
the ubiquitous distribution of insulin receptors on various brain cells, such as neurons, microglia, astrocytes, and oligodendrocytes, and their differential localization across various brain regions, including the hippocampus, hypothalamus, and olfactory bulb, collectively underscore the crucial involvement of insulin in the modulation of cerebral functions. |
2024-06-24 |
2024-06-26 |
human |
| D K Avrova, L V Bayunova, N F Avrova, I O Zakharov. The Effect of Intranasal Administration of Gangliosides on the Viability of CA1 Hippocampal Neurons in Rat Two-Vessel Occlusion Model of Forebrain Ischemia/Reperfusion Injury. Bulletin of experimental biology and medicine. 2024-06-21. PMID:38907060. |
the immunohistochemical reaction of specific antibodies to marker proteins of activated microglia (iba1) and astrocytes (gfap) in hippocampal slices revealed the neuroprotective effect of exogenous gangliosides which can be mostly explained by their ability to suppress neuroinflammation and gliosis. |
2024-06-21 |
2024-06-24 |
rat |
| Haojie Zhu, Hainan Pan, Yunli Fang, Hanxiao Wang, Zhuo Chen, Wenfeng Hu, Lijuan Tong, Jie Ren, Xu Lu, Chao Huan. Apoptosis-induced decline in hippocampal microglia mediates the development of depression-like behaviors in adult mice triggered by unpredictable stress during adolescence. European journal of pharmacology. 2024-06-21. PMID:38906239. |
apoptosis-induced decline in hippocampal microglia mediates the development of depression-like behaviors in adult mice triggered by unpredictable stress during adolescence. |
2024-06-21 |
2024-06-24 |
mouse |
| Haojie Zhu, Hainan Pan, Yunli Fang, Hanxiao Wang, Zhuo Chen, Wenfeng Hu, Lijuan Tong, Jie Ren, Xu Lu, Chao Huan. Apoptosis-induced decline in hippocampal microglia mediates the development of depression-like behaviors in adult mice triggered by unpredictable stress during adolescence. European journal of pharmacology. 2024-06-21. PMID:38906239. |
one mechanism for the promotion of depression by chronic stress in adulthood is the loss of hippocampal microglia. |
2024-06-21 |
2024-06-24 |
mouse |
| Haojie Zhu, Hainan Pan, Yunli Fang, Hanxiao Wang, Zhuo Chen, Wenfeng Hu, Lijuan Tong, Jie Ren, Xu Lu, Chao Huan. Apoptosis-induced decline in hippocampal microglia mediates the development of depression-like behaviors in adult mice triggered by unpredictable stress during adolescence. European journal of pharmacology. 2024-06-21. PMID:38906239. |
since deleterious stress in adolescence also activates microglia, we investigated the dynamic changes of microglia in the hippocampus in mice exposed to chronic unpredictable stress (cus) in adolescence. |
2024-06-21 |
2024-06-24 |
mouse |
| Haojie Zhu, Hainan Pan, Yunli Fang, Hanxiao Wang, Zhuo Chen, Wenfeng Hu, Lijuan Tong, Jie Ren, Xu Lu, Chao Huan. Apoptosis-induced decline in hippocampal microglia mediates the development of depression-like behaviors in adult mice triggered by unpredictable stress during adolescence. European journal of pharmacology. 2024-06-21. PMID:38906239. |
our results showed that 12 days of cus stimulation in adolescence induced typical depression-like behaviors in adult mice, which were accompanied by a significant decrease and dystrophy of microglia in the dentate gyrus of the hippocampus. |
2024-06-21 |
2024-06-24 |
mouse |
| Haojie Zhu, Hainan Pan, Yunli Fang, Hanxiao Wang, Zhuo Chen, Wenfeng Hu, Lijuan Tong, Jie Ren, Xu Lu, Chao Huan. Apoptosis-induced decline in hippocampal microglia mediates the development of depression-like behaviors in adult mice triggered by unpredictable stress during adolescence. European journal of pharmacology. 2024-06-21. PMID:38906239. |
further analysis showed that this decrease in microglia was mediated by the initial response of microglia to unpredictable stress in the dentate gyrus of the hippocampus and their subsequent apoptosis. |
2024-06-21 |
2024-06-24 |
mouse |
| Jia-Rui Zhang, Shi-Yu Shen, Meng-Ying Zhai, Zu-Qi Shen, Wei Li, Ling-Feng Liang, Shu-Yuan Yin, Qiu-Qin Han, Bing Li, Yu-Qiu Zhang, Jin Y. Augmented microglial endoplasmic reticulum-mitochondria contacts mediate depression-like behavior in mice induced by chronic social defeat stress. Nature communications. vol 15. issue 1. 2024-06-18. PMID:38890305. |
csds induced er stress, mams' modifications, mitochondrial damage, and the formation of the ip3r3-grp75-vdac1 complex at the er-mitochondria interface in hippocampal microglia, all concomitant with depression-like behaviors. |
2024-06-18 |
2024-06-21 |
mouse |
| Le-le Wang, Huan Wang, Si-Jin Lin, Xing-Yu Xu, Wen-Juan Hu, Jia Liu, Hai-Yan Zhan. ABBV-744 alleviates LPS-induced neuroinflammation via regulation of BATF2-IRF4-STAT1/3/5 axis. Acta pharmacologica Sinica. 2024-06-11. PMID:38862817. |
furthermore, we observed that administration of abbv-744 significantly alleviated lps-induced activation of microglia and transcriptional levels of pro-inflammatory factors tnf-α and il-1β in mouse hippocampus and cortex. |
2024-06-11 |
2024-06-14 |
mouse |
| Abudurousuli Adili, Aerken Dilihumaer, Huhu Zhu, Huifang Tan. Research progress on phosphodiesterase 4 inhibitors in central nervous system diseases. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. 2024-06-11. PMID:38860393. |
pde4 inhibitors play a role in depression; autism spectrum and huntington's disease by inhibiting the advanced glycation end product receptor (rage), tlr4 and nlrp3 pathways in the hippocampus, reducing the activation of microglia and the production of interleukin-1β, down-regulating hmgb1/rage signaling pathway and inhibiting inflammatory factors and increase the nociception threshold. |
2024-06-11 |
2024-06-14 |
Not clear |
| Houyu Zhao, Kun Liang, Zeyuan Yu, Yukun Wen, Jin Shi, Tingting Zhang, Xuhua Yu, Yiqun Fang, Xianpeng Z. Hyperbaric oxygen preconditioning rescues prolonged underwater exercise-induced hippocampal dysfunction by regulating microglia activation and polarization. Neuroscience research. 2024-06-07. PMID:38848903. |
hyperbaric oxygen preconditioning rescues prolonged underwater exercise-induced hippocampal dysfunction by regulating microglia activation and polarization. |
2024-06-07 |
2024-06-10 |
rat |
| Houyu Zhao, Kun Liang, Zeyuan Yu, Yukun Wen, Jin Shi, Tingting Zhang, Xuhua Yu, Yiqun Fang, Xianpeng Z. Hyperbaric oxygen preconditioning rescues prolonged underwater exercise-induced hippocampal dysfunction by regulating microglia activation and polarization. Neuroscience research. 2024-06-07. PMID:38848903. |
the results demonstrated that pue triggers anxiety-like behaviors, cognitive impairment accompanied by hippocampal dysfunction, microglia activation and neuroinflammation. |
2024-06-07 |
2024-06-10 |
rat |
| Sean D Carey, Katherine Conant, Kathleen A Maguire-Zeis. Short-term exposure to HIV Tat induces glial activation and changes in perineuronal nets. The European journal of neuroscience. 2024-06-06. PMID:38844747. |
moreover, direct injection of tat protein into mouse hippocampus increases the expression of astrocyte and microglia markers as well as mmp-9. |
2024-06-06 |
2024-06-10 |
mouse |
| Seokjo Kang, Emily Y Ko, Amelia E Andrews, Juliana E Shin, Karina J Nance, Pijus K Barman, Peter S Heeger, Willard M Freeman, Bérénice A Benayoun, Helen S Goodridg. Microglia undergo sex-dimorphic transcriptional and metabolic rewiring during aging. Journal of neuroinflammation. vol 21. issue 1. 2024-06-06. PMID:38840206. |
rna-sequencing of hippocampal microglia revealed more aging-associated changes in female microglia than male microglia, and more sex differences in old microglia than young microglia. |
2024-06-06 |
2024-06-08 |
mouse |